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awoke A-G Profen (Oral) Generic Name: ibuprofen (Oral route) eye-bue-PROE-fen Overview Side Effects Dosage Interactions Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Oral route(Tablet;Suspension;Capsule, Liquid Filled;Tablet, Chewable) NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Ibuprofen is contraindicated for the treatment of peri-operative pain in the setting of coronary artery bypass graft (CABG) surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal . Commonly used brand name(s) In the U.S. Addaprin Advil A-G Profen Bufen Genpril Haltran Ibu Ibu-2 Ibu-200 Ibu-4 Ibu-6 Ibu-8 Ibuprohm Ibu-Tab I-Prin Midol Motrin Nuprin Proprinal Q-Profen In Canada Actiprofen Advil Children's Advil Pediatric Children's Motrin Children's Motrin Berry Flavor Children's Motrin Bubble Gum Flavor Children's Motrin Grape Flavor Equate Children's Ibuprofen - Berry Equate Children's Ibuprofen - Berry - Dye Free Infants' Motrin Option+ Children's Ibuprofen - Berry Option+ Children's Ibuprofen - Grape Available Dosage Forms: Suspension Tablet Capsule, Liquid Filled Tablet, Chewable Capsule Therapeutic Class: Analgesic Pharmacologic Class: NSAID Chemical Class: Propionic Acid (class) Slideshow Chronic Pain Management: A Healthcare Professional's Guide Uses For A-G Profen Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain, and helps to relieve symptoms of arthritis (osteoarthritis, rheumatoid arthritis, or juvenile arthritis), such as inflammation, swelling, stiffness, and joint pain. This medicine does not cure arthritis and will help you only as long as you continue to take it . In addition, ibuprofen can be used to treat fever, menstrual cramps, and other conditions as determined by your doctor . This medicine is available both over-the-counter (OTC) and with your doctor's prescription . Before Using A-G Profen In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of ibuprofen in children below 6 months of age. Safety and efficacy have not been established . Geriatric Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of ibuprofen in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require adjustment of dosage in patients receiving ibuprofen . Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Ketorolac Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab Aceclofenac Acemetacin Acenocoumarol Amiloride Amineptine Amitriptyline Amitriptylinoxide Amoxapine Amtolmetin Guacil Anagrelide Apixaban Ardeparin Argatroban Aspirin Balsalazide Bemiparin Bendroflumethiazide Benzthiazide Betamethasone Betrixaban Bismuth Subsalicylate Bivalirudin Bromfenac Budesonide Bufexamac Bumetanide Cangrelor Celecoxib Certoparin Chlorothiazide Chlorthalidone Choline Magnesium Trisalicylate Choline Salicylate Cilostazol Citalopram Clomipramine Clonixin Clopamide Clopidogrel Cortisone Cyclopenthiazide Cyclosporine Dabigatran Etexilate Dalteparin Danaparoid Deflazacort Desipramine Desirudin Desmopressin Desvenlafaxine Dexamethasone Dexibuprofen Dexketoprofen Diazoxide Dibenzepin Diclofenac Diflunisal Digoxin Dipyridamole Dipyrone Dothiepin Doxepin Droxicam Duloxetine Edoxaban Enoxaparin Eplerenone Epoprostenol Eptifibatide Escitalopram Ethacrynic Acid Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Feverfew Floctafenine Flufenamic Acid Fluocortolone Fluoxetine Flurbiprofen Fluvoxamine Fondaparinux Furosemide Ginkgo Gossypol Heparin Hydrochlorothiazide Hydrocortisone Hydroflumethiazide Ibuprofen Iloprost Imipramine Indapamide Indomethacin Ketoprofen Lepirudin Levomilnacipran Lithium Lofepramine Lornoxicam Loxoprofen Lumiracoxib Magnesium Salicylate Meadowsweet Meclofenamate Mefenamic Acid Melitracen Meloxicam Mesalamine Methotrexate Methyclothiazide Methylprednisolone Metolazone Milnacipran Morniflumate Nabumetone Nadroparin Naproxen Nefazodone Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Nortriptyline Olsalazine Opipramol Oxaprozin Oxyphenbutazone Paramethasone Parecoxib Parnaparin Paroxetine Pemetrexed Pentosan Polysulfate Sodium Pentoxifylline Phenindione Phenprocoumon Phenylbutazone Phenyl Salicylate Piketoprofen Piroxicam Polythiazide Pralatrexate Prasugrel Prednisolone Prednisone Proglumetacin Propyphenazone Proquazone Protein C Protriptyline Reboxetine Reviparin Rivaroxaban Rofecoxib Salicylamide Salicylic Acid Salsalate Sertraline Sibutramine Sodium Salicylate Spironolactone Sulfasalazine Sulindac Tacrolimus Tenoxicam Tianeptine Tiaprofenic Acid Ticagrelor Ticlopidine Tinzaparin Tirofiban Tolfenamic Acid Tolmetin Torsemide Treprostinil Triamterene Trichlormethiazide Trimipramine Trolamine Salicylate Valdecoxib Venlafaxine Vilazodone Vorapaxar Vortioxetine Warfarin Xipamide Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Alacepril Amikacin Atenolol Azilsartan Azilsartan Medoxomil Benazepril Betaxolol Bisoprolol Candesartan Captopril Carteolol Carvedilol Celiprolol Cilazapril Delapril Enalapril Enalaprilat Eprosartan Esmolol Fosinopril Imidapril Irbesartan Labetalol Levobunolol Lisinopril Losartan Metipranolol Metoprolol Moexipril Nadolol Nebivolol Olmesartan Oxprenolol Penbutolol Pentopril Perindopril Pindolol Practolol Propranolol Quinapril Ramipril Sotalol Spirapril Telmisartan Temocapril Timolol Trandolapril Valsartan Zofenopril Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or Asthma or Bleeding problems or Blood clots or Edema (fluid retention or body swelling) or Heart attack, history of or Heart disease (e.g., congestive heart failure) or High blood pressure or Kidney disease or Liver disease (e.g., hepatitis) or Stomach or intestinal ulcers or bleeding or Stroke, history of Use with caution. This medicine may make these conditions worse . Aspirin sensitivity, history of This medicine should NOT be used in patients with this condition . Diabetes Use with caution. The suspension form of this medicine contains sugar . Heart surgery (e.g., coronary artery bypass graft [CABG] surgery) This medicine should NOT be used to relieve pain right before or after the surgery . Proper Use of ibuprofen This section provides information on the proper use of a number of products that contain ibuprofen. It may not be specific to A-G Profen. Please read with care. For safe and effective use of this medicine, do not take more of it, do not take it more often, and do not take it for a longer time than ordered by your doctor. Taking too much of this medicine may increase the chance of unwanted effects, especially in elderly patients . When used for severe or continuing arthritis, this medicine must be taken regularly as ordered by your doctor in order for it to help you. This medicine usually begins to work within one week, but in severe cases up to two weeks or even longer may pass before you begin to feel better. Also, several weeks may pass before you feel the full effects of this medicine . To lessen stomach upset, you may take this medicine with food or milk . Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets and suspension): For fever: Children over 2 years of age Use and dose must be determined by your doctor. Children 6 months of age up to 2 years Dose is based on body weight and body temperature, and must be determined by your doctor. For fever lower than 102.5 F (39.2 C), the dose usually is 5 milligrams (mg) per kilogram (kg) (about 2.2 mg per pound) of body weight. For higher fever, the dose usually is 10 mg per kg (about 4.5 mg per pound) of body weight. The medicine may be given every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age Use and dose must be determined by your doctor . For menstrual cramps: Adults 400 milligrams (mg) every four hours, as needed. Children Use and dose must be determined by your doctor . For mild to moderate pain: Adults and teenagers 400 milligrams (mg) every four to six hours, as needed. Children over 6 months of age Dose is based on body weight and must be determined by your doctor. The dose usually is 10 milligrams (mg) per kilogram (kg) of body weight every six to eight hours, as needed, up to 40 mg per kg per day. Infants younger than 6 months of age Use and dose must be determined by your doctor . For osteoarthritis and rheumatoid arthritis: Adults and teenagers 1200 milligrams (mg) up to 3200 mg per day divided into three or four equal doses. Children Dose is based on body weight and must be determined by your doctor. The dose usually is 30 milligrams (mg) to 40 mg per kilogram (kg) of body weight per day, divided into three or four doses. Infants younger than 6 months of age Use and dose must be determined by your doctor . Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Ask your healthcare professional how you should dispose of any medicine you do not use. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using A-G Profen It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects . This medicine may raise your risk of having a heart attack or stroke. This is more likely in people who already have heart disease. People who use this medicine for a long time might also have a higher risk . This medicine may cause bleeding in your stomach or intestines. These problems can happen without warning signs. This is more likely if you have had a stomach ulcer in the past, if you smoke or drink alcohol regularly, if you are over 60 years old, if you are in poor health, or if you are using certain other medicines (a steroid or a blood thinner) . Serious skin reactions can occur during treatment with this medicine. Check with your doctor right away if you have any of the following symptoms while taking this medicine: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red skin lesions, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness . Possible warning signs of some serious side effects that can occur during treatment with this medicine may include swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, tarry stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; yellow skin or eyes; decreased urination; bleeding or bruising; and/or skin rash. Also, signs of serious heart problems could occur such as chest pain, tightness in chest, fast or irregular heartbeat, unusual flushing or warmth of skin, weakness, or slurring of speech. Stop taking this medicine and check with your doctor immediately if you notice any of these warning signs . This medicine may also cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin or other nonsteroidal anti-inflammatory drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in skin color of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swelling of the eyelids or around the eyes. If these effects occur, get emergency help at once . Some people who have used this medicine had symptoms of meningitis. If you have fever, headache, nausea, vomiting, and stiff neck or back while using this medicine, check with your doctor right away . Using this medicine while you are pregnant can harm your unborn baby. If you think you have become pregnant while using this medicine, tell your doctor right away . Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after your treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor) . Before having any kind of surgery or medical tests, tell your doctor that you are taking this medicine. It may be necessary for you to stop treatment for a while, or to change to a different nonsteroidal anti-inflammatory drug before your procedure . A-G Profen Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal pain acid or sour stomach belching bloating cloudy urine decrease in amount of urine decrease in urine output or decrease in urine-concentrating ability diarrhea difficulty having a bowel movement (stool) excess air or gas in stomach or intestines full feeling heartburn indigestion itching skin pain or discomfort in chest, upper stomach, or throat pale skin passing gas nausea noisy, rattling breathing rash with flat lesions or small raised lesions on the skin shortness of breath swelling of face, fingers, hands, feet, lower legs, or ankles troubled breathing at rest troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness vomiting weight gain Less common Abdominal cramps stomach soreness or discomfort Rare Agitation back, leg, or stomach pains bleeding gums blistering, peeling, loosening of skin blood in urine or stools bloody, black, or tarry stools blurred vision burning feeling in chest or stomach change in vision chest pain chills clay-colored stools coma confusion constipation cough or hoarseness dark urine decreased urine output depression difficulty breathing difficulty swallowing dilated neck veins dizziness dry mouth extreme fatigue fast, irregular, pounding, or racing heartbeat or pulse fever with or without chills frequent urination general body swelling general feeling of tiredness or weakness hair loss, thinning of hair headache hives or welts hostility impaired vision increased blood pressure increased volume of pale, dilute urine irregular breathing irritability itching joint or muscle pain lab results that show problems with liver lethargy light-colored stools loss of appetite lower back or side pain muscle twitching nosebleeds painful or difficult urination pains in stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue rash red skin lesions, often with a purple center red, irritated eyes redness of skin seizures severe abdominal pain, cramping, burning severe and continuing nausea sore throat sores, ulcers, or white spots in mouth or on lips stiff neck or back stomach upset stupor swollen or painful glands tenderness in stomach area thirst tightness in chest unpleasant breath odor upper right abdominal pain vomiting of blood vomiting of material that looks like coffee grounds wheezing yellow eyes and skin Symptoms of overdose Bluish lips or skin difficulty sleeping disorientation dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly drowsiness to profound coma hallucination lightheadedness or fainting mood or other mental changes muscle tremors not breathing rapid, deep breathing restlessness slow or irregular heartbeat stomach cramps sudden fainting sweating Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Continuing ringing or buzzing or other unexplained noise in ears hearing loss nervousness Rare Crying depersonalization discouragement dry eyes dysphoria euphoria feeling sad or empty lack of appetite loss of interest or pleasure mental depression paranoia quick to react or overreact rapidly changing moods runny nose sleepiness or unusual drowsiness sleeplessness sneezing stuffy nose trouble concentrating trouble sleeping unable to sleep Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about A-G Profen (ibuprofen) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: nonsteroidal anti-inflammatory agents Consumer resources Other brands: Advil , Motrin , IBU , Motrin IB , ... +22 more Professional resources Ibuprofen (AHFS Monograph) Ibuprofen Tablets (FDA) Related treatment guides Aseptic Necrosis Back Pain Chronic Myofascial Pain Costochondritis ... +18 more} Drug Status Rx OTC Availability Rx and/or OTC Pregnancy Category Risk depends on usage N/A CSA Schedule Not a controlled drug Drug Class Nonsteroidal anti-inflammatory agents Related Drugs Back Pain tramadol , naproxen , Cymbalta , aspirin , ibuprofen , More... Sciatica acetaminophen , Tylenol , naproxen , cyclobenzaprine , aspirin , ibuprofen , More... Chronic Myofascial Pain naproxen , ibuprofen , amitriptyline , Aleve , Advil , Naprosyn , More... Gout, Acute naproxen , ibuprofen , Aleve , Advil , colchicine , Medrol , More... 18 more conditions... A-G Profen Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the A-G Profen support group to connect with others who have similar interests.} } work from home


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obligations A-Methapred Injection Generic Name: methylprednisolone sodium succinate Dosage Form: injection, powder, lyophilized, for solution Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A NOT FOR USE IN NEONATES. CONTAINS BENZYL ALCOHOL. For INTRAVENOUS or INTRAMUSCULAR USE Rx only The A-Methapred brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available . A-Methapred Injection Description A-METHAPRED Sterile Powder is an anti-inflammatory glucocorticoid, which contains methylprednisolone sodium succinate as the active ingredient. A-METHAPRED is available in several strengths and packages for intravenous or intramuscular administration. 40 mg Single-Dose Vial Each mL (when mixed) contains methylprednisolone sodium succinate equivalent to 40 mg methylprednisolone; also 1.6 mg monobasic sodium phosphate anhydrous; 17.46 mg dibasic sodium phosphate anhydrous; 25 mg lactose anhydrous; 8.8 mg benzyl alcohol added as preservative. 125 mg Single-Dose Vial Each 2 mL (when mixed) contains methylprednisolone sodium succinate equivalent to 125 mg methylprednisolone; also 1.6 mg monobasic sodium phosphate anhydrous; 17.4 mg dibasic sodium phosphate anhydrous; 17.6 mg benzyl alcohol added as preservative. When necessary, the pH of each formula was adjusted with sodium hydroxide so that the pH of the reconstituted solution is within the USP specified range of 7 to 8 and the tonicities are, for the 40 mg per mL solution, 0.50 osmolar; for the 125 mg per 2 mL, 0.40 osmolar; (Isotonic saline = 0.28 osmolar). The chemical name for methylprednisolone sodium succinate is pregna-1,4-diene-3,20-dione,21-(3-carboxy-1-oxo-propoxy)-11,17-dihydroxy-6-methyl-monosodium salt, (6α, 11β), and the molecular weight is 496.53. The structural formula is represented below: A-METHAPRED (methylprednisolone sodium succinate for injection, USP) sterile powder contains methylprednisolone sodium succinate as the active ingredient. Methylprednisolone sodium succinate, USP, is the sodium succinate ester of methylprednisolone. Methylprednisolone sodium succinate, USP, occurs as a white, or nearly white, odorless hygroscopic, amorphous solid. It is very soluble in water and in alcohol; it is insoluble in chloroform and is very slightly soluble in acetone. Methylprednisolone sodium succinate is so extremely soluble in water that it may be administered in a small volume of diluent and is especially well suited for intravenous use in situations in which high blood levels of methylprednisolone are required rapidly. IMPORTANT Use only Bacteriostatic Water For Injection with Benzyl Alcohol when reconstituting A-METHAPRED . Use within 48 hours after mixing. Slideshow Are You IBD Aware? Crohn's and Colitis, Explained A-Methapred Injection - Clinical Pharmacology Glucocorticoids, naturally occurring and synthetic, are adrenocortical steroids that are readily absorbed from the gastrointestinal tract. Naturally occurring glucocorticoids (hydrocortisone and cortisone), which also have salt-retaining properties, are used as replacement therapy in adrenocortical deficiency states. Their synthetic analogs are primarily used for their potent anti-inflammatory effects in disorders of many organ systems. Glucocorticoids cause profound and varied metabolic effects. In addition, they modify the body s immune response to diverse stimuli. Methylprednisolone is a potent anti-inflammatory steroid with greater anti-inflammatory potency than prednisolone and even less tendency than prednisolone to induce sodium and water retention. Methylprednisolone sodium succinate has the same metabolic and anti-inflammatory actions as methylprednisolone. When given parenterally and in equimolar quantities, the two compounds are equivalent in biologic activity. Following the intravenous injection of methylprednisolone sodium succinate, demonstrable effects are evident within one hour and persist for a variable period. Excretion of the administered dose is nearly complete within 12 hours. Thus, if constantly high blood levels are required, injections should be made every 4 to 6 hours. This preparation is also rapidly absorbed when administered intramuscularly and is excreted in a pattern similar to that observed after intravenous injection. Indications and Usage for A-Methapred Injection When oral therapy is not feasible, and the strength, dosage form and route of administration of the drug reasonably lend the preparation to the treatment of the condition, A-METHAPRED sterile powder is indicated for intravenous or intramuscular use in the following conditions: Allergic states: Control of severe or incapacitating allergic conditions intractable to adequate trials of conventional treatment in asthma, atopic dermatitis, contact dermatitis, drug hypersensitivity reactions, perennial or seasonal allergic rhinitis, serum sickness, transfusion reactions. Dermatologic diseases: Bullous dermatitis herpetiformis, exfoliative erythroderma, mycosis fungoides, pemphigus, severe erythema multiforme (Stevens-Johnson syndrome). Endocrine disorders: Primary or secondary adrenocortical insufficiency (hydrocortisone or cortisone is the drug of choice; synthetic analogs may be used in conjunction with mineralocorticoids where applicable; in infancy, mineralocorticoid supplementation is of particular importance), congenital adrenal hyperplasia, hypercalcemia associated with cancer, nonsuppurative thyroiditis. Gastrointestinal diseases: To tide the patient over a critical period of the disease in regional enteritis (systemic therapy) and ulcerative colitis. Hematologic disorders: Acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia (Diamond-Blackfan anemia), idiopathic thrombocytopenic purpura in adults (intravenous administration only; intramuscular administration is contraindicated), pure red cell aplasia, selected cases of secondary thrombocytopenia. Miscellaneous: Trichinosis with neurologic or myocardial involvement, tuberculous meningitis with subarachnoid block or impending block when used concurrently with appropriate antituberculous chemotherapy. Neoplastic diseases: For the palliative management of leukemias and lymphomas. Nervous System: Acute exacerbations of multiple sclerosis; cerebral edema associated with primary or metastatic brain tumor, or craniotomy. Ophthalmic diseases: Sympathetic ophthalmia, uveitis and ocular inflammatory conditions unresponsive to topical corticosteroids. Renal diseases: To induce diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus. Respiratory diseases: Berylliosis, fulminating or disseminated pulmonary tuberculosis when used concurrently with appropriate antituberculous chemotherapy, idiopathic eosinophilic pneumonias, symptomatic sarcoidosis. Rheumatic disorders: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in acute gouty arthritis; acute rheumatic carditis; ankylosing spondylitis; psoriatic arthritis; rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance therapy). For the treatment of dermatomyositis, temporal arteritis, polymyositis, and systemic lupus erythematosus. Contraindications A-METHAPRED sterile powder is contraindicated: - in systemic fungal infections and patients with known hypersensitivity to the product and its constituents. - for intrathecal administration. Reports of severe medical events have been associated with this route of administration. Intramuscular corticosteroid preparations are contraindicated for idiopathic thrombocytopenic purpura. Additional contraindication for the use of A-METHAPRED sterile powder preserved with benzyl alcohol: Formulations preserved with benzyl alcohol are contraindicated for use in premature infants. (See WARNINGS and PRECAUTIONS, Pediatric Use . ) Warnings Serious Neurologic Adverse Reactions with Epidural Administration Serious neurologic events, some resulting in death, have been reported with epidural injection of corticosteroids. Specific events reported include, but are not limited to, spinal cord infarction, paraplegia, quadriplegia, cortical blindness, and stroke. These serious neurologic events have been reported with and without use of fluoroscopy. The safety and effectiveness of epidural administration of corticosteroids have not been established, and corticosteroids are not approved for this use. General Reconstituted A-METHAPRED contains benzyl alcohol, which is potentially toxic when administered locally to neural tissue. Exposure to excessive amounts of benzyl alcohol has been associated with toxicity (hypotension, metabolic acidosis), particularly in neonates, and an increased incidence of kernicterus, particularly in small preterm infants. There have been rare reports of deaths, primarily in preterm infants, associated with exposure to excessive amounts of benzyl alcohol. The amount of benzyl alcohol from medications is usually considered negligible compared to that received in flush solutions containing benzyl alcohol. Administration of high dosages of medications containing this preservative must take into account the total amount of benzyl alcohol administered. The amount of benzyl alcohol at which toxicity may occur is not known. If the patient requires more than the recommended dosages or other medications containing this preservative, the practitioner must consider the daily metabolic load of benzyl alcohol from these combined sources (see PRECAUTIONS, Pediatric Use ). Injection of methylprednisolone may result in dermal and/or subdermal changes forming depressions in the skin at the injection site. In order to minimize the incidence of dermal and subdermal atrophy, care must be exercised not to exceed recommended doses in injections. Injection into the deltoid muscle should be avoided because of a high incidence of subcutaneous atrophy. Rare instances of anaphylactoid reactions have occurred in patients receiving corticosteroid therapy (see ADVERSE REACTIONS ). Increased dosage of rapidly acting corticosteroids is indicated in patients on corticosteroid therapy who are subjected to any unusual stress before, during, and after the stressful situation. Results from one multicenter, randomized, placebo controlled study with methylprednisolone hemisuccinate, an IV corticosteroid, showed an increase in early (at 2 weeks) and late (at 6 months) mortality in patients with cranial trauma who were determined not to have other clear indications for corticosteroid treatment. High doses of systemic corticosteroids, including A-METHAPRED , should not be used for the treatment of traumatic brain injury. Cardio-renal Average and large doses of corticosteroids can cause elevation of blood pressure, salt and water retention, and increased excretion of potassium. These effects are less likely to occur with the synthetic derivatives except when used in large doses. Dietary salt restriction and potassium supplementation may be necessary. All corticosteroids increase calcium excretion. Literature reports suggest an apparent association between use of corticosteroids and left ventricular free wall rupture after a recent myocardial infarction; therefore, therapy with corticosteroids should be used with great caution in these patients. Endocrine Hypothalamic-pituitary adrenal (HPA) axis suppression. Cushing s syndrome, and hyperglycemia. Monitor patients for these conditions with chronic use. Corticosteroids can produce reversible HPA axis suppression with the potential for glucocorticosteroid insufficiency after withdrawal of treatment. Drug induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Infections General Patients who are on corticosteroids are more susceptible to infections than are healthy individuals. There may be decreased resistance and inability to localize infection when corticosteroids are used. Infections with any pathogen (viral, bacterial, fungal, protozoan or helminthic) in any location of the body may be associated with the use of corticosteroids alone or in combination with other immunosuppressive agents. These infections may be mild, but can be severe and at times fatal. With increasing doses of corticosteroids, the rate of occurrence of infectious complications increases. Corticosteroids may also mask some signs of current infection. Do not use intraarticularly, intrabursally or for intratendinous administration for local effect in the presence of acute local infection. A study has failed to establish the efficacy of methylprednisolone sodium succinate in the treatment of sepsis syndrome and septic shock. The study also suggests that treatment of these conditions with methylprednisolone sodium succinate may increase the risk of mortality in certain patients (i.e., patients with elevated serum creatinine levels or patients who develop secondary infections after methylprednisolone sodium succinate). Fungal infections Corticosteroids may exacerbate systemic fungal infections and therefore should not be used in the presence of such infections unless they are needed to control drug reactions. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure (see CONTRAINDICATIONS , PRECAUTIONS, Drug Interactions , Amphotericin B injection and potassium-depleting agents ). Special pathogens Latent disease may be activated or there may be an exacerbation of intercurrent infections due to pathogens, including those caused by Amoeba, Candida, Cryptococcus, Mycobacterium, Nocardia, Pneumocystis, Toxoplasma. It is recommended that latent amebiasis or active amebiasis be ruled out before initiating corticosteroid therapy in any patient who has spent time in the tropics or in any patient with unexplained diarrhea. Similarly, corticosteroids should be used with great care in patients with known or suspected Strongyloides (threadworm) infestation. In such patients, corticosteroid-induced immunosuppression may lead to Strongyloides hyperinfection and dissemination with widespread larval migration, often accompanied by severe enterocolitis and potentially fatal gram-negative septicemia. Corticosteroids should not be used in cerebral malaria. There is currently no evidence of benefit from steroids in this condition. Tuberculosis The use of corticosteroids in active tuberculosis should be restricted to those cases of fulminating or disseminated tuberculosis in which the corticosteroid is used for the management of the disease in conjunction with an appropriate antituberculous regimen. If corticosteroids are indicated in patients with latent tuberculosis or tuberculin reactivity, close observation is necessary as reactivation of the disease may occur. During prolonged corticosteroid therapy these patients should receive chemoprophylaxis. Vaccination Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids. Killed or inactivated vaccines may be administered. However, the response to such vaccines can not be predicted. Immunization procedures may be undertaken in patients who are receiving corticosteroids as replacement therapy, e.g., for Addison s disease. Viral infections Chicken pox and measles can have a more serious or even fatal course in pediatric and adult patients on corticosteroids. In pediatric and adult patients who have not had these diseases, particular care should be taken to avoid exposure. The contribution of the underlying disease and/or prior corticosteroid treatment to the risk is also not known. If exposed to chicken pox, prophylaxis with varicella zoster immune globulin (VZIG) may be indicated. If exposed to measles, prophylaxis with immunoglobulin (IG) may be indicated. (See the respective package inserts for complete VZIG and IG prescribing information.) If chicken pox develops, treatment with antiviral agents should be considered. Neurologic Reports of severe medical events have been associated with the intrathecal route of administration (see ADVERSE REACTIONS , Gastrointestinal and Neurologic/Psychiatric ). Ophthalmic Use of corticosteroids may produce posterior subcapsular cataracts, glaucoma with possible damage to the optic nerves, and may enhance the establishment of secondary ocular infections due to bacteria, fungi, or viruses. The use of oral corticosteroids is not recommended in the treatment of optic neuritis and may lead to an increase in the risk of new episodes. Corticosteroids should be used cautiously in patients with ocular herpes simplex because of corneal perforation. Corticosteroids should not be used in active ocular herpes simplex. Precautions General This product, like many other steroid formulations, is sensitive to heat. Therefore, it should not be autoclaved when it is desirable to sterilize the exterior of the vial. The lowest possible dose of corticosteroid should be used to control the condition under treatment. When reduction in dosage is possible, the reduction should be gradual. Since complications of treatment with glucocorticoids are dependent on the size of the dose and the duration of treatment, a risk/benefit decision must be made in each individual case as to dose and duration of treatment and as to whether daily or intermittent therapy should be used. Kaposi s sarcoma has been reported to occur in patients receiving corticosteroid therapy, most often for chronic conditions. Discontinuation of corticosteroids may result in clinical improvement. Cardio-renal As sodium retention with resultant edema and potassium loss may occur in patients receiving corticosteroids, these agents should be used with caution in patients with congestive heart failure, hypertension, or renal insufficiency. Endocrine Drug-induced secondary adrenocortical insufficiency may be minimized by gradual reduction of dosage. This type of relative insufficiency may persist for months after discontinuation of therapy; therefore, in any situation of stress occurring during that period, hormone therapy should be reinstituted. Since mineralocorticoid secretion may be impaired, salt and/or a mineralocorticoid should be administered concurrently. Metabolic clearance of corticosteroids is decreased in hypothyroid patients and increased in hyperthyroid patients. Changes in thyroid status of the patient may necessitate adjustment in dosage. Gastrointestinal Steroids should be used with caution in active or latent peptic ulcers, diverticulitis, fresh intestinal anastomoses, and nonspecific ulcerative colitis, since they may increase the risk of a perforation. Signs of peritoneal irritation following gastrointestinal perforation in patients receiving corticosteroids may be minimal or absent. There is an enhanced effect due to decreased metabolism of corticosteroids in patients with cirrhosis. Musculoskeletal Corticosteroids decrease bone formation and increase bone resorption both through their effect on calcium regulation (i.e., decreasing absorption and increasing excretion) and inhibition of osteoblast function. This, together with a decrease in the protein matrix of the bone secondary to an increase in protein catabolism, and reduced sex hormone production, may lead to inhibition of bone growth in pediatric patients and the development of osteoporosis at any age. Special consideration should be given to patients at increased risk of osteoporosis (i.e., postmenopausal women) before initiating corticosteroid therapy. Local injection of a steroid into a previously infected site is not usually recommended. Neurologic-psychiatric Although controlled clinical trials have shown corticosteroids to be effective in speeding the resolution of acute exacerbations of multiple sclerosis, they do not show that corticosteroids affect the ultimate outcome or natural history of the disease. The studies do show that relatively high doses of corticosteroids are necessary to demonstrate a significant effect. (See DOSAGE AND ADMINISTRATION .) An acute myopathy has been observed with the use of high doses of corticosteroids, most often occurring in patients with disorders of neuromuscular transmission (e.g., myasthenia gravis), or in patients receiving concomitant therapy with neuromuscular blocking drugs (e.g., pancuronium). This acute myopathy is generalized, may involve ocular and respiratory muscles, and may result in quadriparesis. Elevations of creatine kinase may occur. Clinical improvement or recovery after stopping corticosteroids may require weeks to years. Psychic derangements may appear when corticosteroids are used, ranging from euphoria, insomnia, mood swings, personality changes and severe depression to frank psychotic manifestations. Also, existing emotional instability or psychotic tendencies may be aggravated by corticosteroids. Ophthalmic Intraocular pressure may become elevated in some individuals. If steroid therapy is continued for more than 6 weeks, intraocular pressure should be monitored. Information for Patients Patients should be warned not to discontinue the use of corticosteroids abruptly or without medical supervision, to advise any medical attendants that they are taking corticosteroids and to seek medical advice at once should they develop fever or other signs of infection. Persons who are on corticosteroids should be warned to avoid exposure to chicken pox or measles. Patients should also be advised that if they are exposed, medical advice should be sought without delay. Drug Interactions Aminoglutethimide: Aminoglutethimide may lead to a loss of corticosteroid-induced adrenal suppression. Amphotericin B injection and potassium-depleting agents: When corticosteroids are administered concomitantly with potassium-depleting agents (i.e., amphotericin-B, diuretics), patients should be observed closely for development of hypokalemia. There have been cases reported in which concomitant use of amphotericin B and hydrocortisone was followed by cardiac enlargement and congestive heart failure. Antibiotic s : Macrolide antibiotics have been reported to cause a significant decrease in corticosteroid clearance (see PRECAUTIONS, Drug Interactions , Hepatic Enzyme Inhibitors ). Anticholinesterases: Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy. Anticoagulants, oral: Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports. Therefore, coagulation indices should be monitored frequently to maintain the desired anticoagulant effect. Antidiabetics: Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required. Antitubercular drugs: Serum concentrations of isoniazid may be decreased. Cholestyramine: Cholestyramine may increase the clearance of corticosteroids. Cyclosporine: Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with this concurrent use. Digitalis glycosides: Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia. Estrogens, including oral contraceptives: Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect. Hepatic Enzyme Inducers (e.g., barbiturates, phenytoin, carbamazepine, rifampin): Drugs which induce cytochrome P450 3A4 enzyme activity may enhance the metabolism of corticosteroids and require that the dosage of the corticosteroid be increased. Hepatic Enzyme Inhibitors (e.g., ketoconazole, macrolide antibiotics such as erythromycin and troleandomycin): Drugs which inhibit cytochrome P450 3A4 have the potential to result in increased plasma concentrations of corticosteroids. Ketoconazole: Ketoconazole has been reported to significantly decrease the metabolism of certain corticosteroids by up to 60%, leading to an increased risk of corticosteroid side effects. Nonsteroidal anti-inflammatory agents (NSAIDs): Concomitant use of aspirin (or other nonsteroidal anti-inflammatory agents) and corticosteroids increases the risk of gastrointestinal side effects. Aspirin should be used cautiously in conjunction with corticosteroids in hypoprothrombinemia. The clearance of salicylates may be increased with concurrent use of corticosteroids. Skin tests: Corticosteroids may suppress reactions to skin tests. Vaccines: Patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response. Corticosteroids may also potentiate the replication of some organisms contained in live attenuated vaccines. Routine administration of vaccines or toxoids should be deferred until corticosteroid therapy is discontinued if possible (see WARNINGS, Infections , Vaccination ). Carcinogenesis, Mutagenesis, Impairment of Fertility No adequate studies have been conducted in animals to determine whether corticosteroids have a potential for carcinogenesis or mutagenesis. Steroids may increase or decrease motility and number of spermatozoa in some patients. Pregnancy: Teratogenic effects: Pregnancy Category C. Corticosteroids have been shown to be teratogenic in many species when given in doses equivalent to the human dose. Animal studies in which corticosteroids have been given to pregnant mice, rats, and rabbits have yielded an increased incidence of cleft palate in the offspring. There are no adequate and well-controlled studies in pregnant women. Corticosteroids should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Infants born to mothers who have received corticosteroids during pregnancy should be carefully observed for signs of hypoadrenalism. This product contains benzyl alcohol as a preservative. Benzyl alcohol can cross the placenta. See PRECAUTIONS, Pediatric Use . Nursing Mothers Systemically administered corticosteroids appear in human milk and could suppress growth, interfere with endogenous corticosteroid production, or cause other untoward effects. Because of the potential for serious adverse reactions in nursing infants from corticosteroids, a decision should be made whether to continue nursing, or discontinue the drug, taking into account the importance of the drug to the mother. Pediatric Use This product contains benzyl alcohol as a preservative. Benzyl alcohol, a component of this product, has been associated with serious adverse events and death, particularly in pediatric patients. The gasping syndrome , (characterized by central nervous system depression, metabolic acidosis, gasping respirations, and high levels of benzyl alcohol and its metabolites found in the blood and urine) has been associated with benzyl alcohol dosages >99 mg/kg/day in neonates and low-birth-weight neonates. Additional symptoms may include gradual neurological deterioration, seizures, intracranial hemorrhage, hematologic abnormalities, skin breakdown, hepatic and renal failure, hypotension, bradycardia, and cardiovascular collapse. Although normal therapeutic doses of this product ordinarily delivers amounts of benzyl alcohol that are substantially lower than those reported in association with the gasping syndrome , the minimum amount of benzyl alcohol at which toxicity may occur is not known. The risk of benzyl alcohol toxicity depends on the quantity administered and the hepatic capacity to detoxify the chemical. Premature and low-birth-weight infants, as well as patients receiving high dosages, may be more likely to develop toxicity. Practitioners administering this and other medications containing benzyl alcohol should consider the combined daily metabolic load of benzyl alcohol from all sources. The efficacy and safety of corticosteroids in the pediatric population are based on the well established course of effect of corticosteroids which is similar in pediatric and adult populations. Published studies provide evidence of efficacy and safety in pediatric patients for the treatment of nephrotic syndrome (>2 years of age), and aggressive lymphomas and leukemias (>1 month of age). Other indications for pediatric use of corticosteroids, e.g., severe asthma and wheezing, are based on adequate and well-controlled trials conducted in adults, on the premises that the course of the diseases and their pathophysiology are considered to be substantially similar in both populations. The adverse effects of corticosteroids in pediatric patients are similar to those in adults (see ADVERSE REACTIONS ). Like adults, pediatric patients should be carefully observed with frequent measurements of blood pressure, weight, height, intraocular pressure, and clinical evaluation for the presence of infection, psychosocial disturbances, thromboembolism, peptic ulcers, cataracts, and osteoporosis. Pediatric patients who are treated with corticosteroids by any route, including systemically administered corticosteroids, may experience a decrease in their growth velocity. This negative impact of corticosteroids on growth has been observed at low systemic doses and in the absence of laboratory evidence of HPA axis suppression (i.e., cosyntropin stimulation and basal cortisol plasma levels). Growth velocity may therefore be a more sensitive indicator of systemic corticosteroid exposure in pediatric patients than some commonly used tests of HPA axis function. The linear growth of pediatric patients treated with corticosteroids should be monitored, and the potential growth effects of prolonged treatment should be weighed against clinical benefits obtained and the availability of treatment alternatives. In order to minimize the potential growth effects of corticosteroids, pediatric patients should be titrated to the lowest effective dose. Geriatric Use Clinical studies did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adverse Reactions The following adverse reactions have been reported with methylprednisolone or other corticosteroids: Allergic reactions: Allergic or hypersensitivity reactions, anaphylactoid reaction, anaphylaxis, angioedema. Cardiovascular: Bradycardia, cardiac arrest, cardiac arrhythmias, cardiac enlargement, circulatory collapse, congestive heart failure, fat embolism, hypertension, hypertrophic cardiomyopathy in premature infants, myocardial rupture following recent myocardial infarction (see WARNINGS ), pulmonary edema, syncope, tachycardia, thromboembolism, thrombophlebitis, vasculitis. Dermatologic: Acne, allergic dermatitis, burning or tingling (especially in the perineal area, after intravenous injection), cutaneous and subcutaneous atrophy, dry scaly skin, ecchymoses and petechiae, edema, erythema, hyperpigmentation, hypopigmentation, impaired wound healing, increased sweating, rash, sterile abscess, striae, suppressed reactions to skin tests, thin fragile skin, thinning scalp hair, urticaria. Endocrine: Decreased carbohydrate and glucose tolerance, development of cushingoid state, glycosuria, hirsutism, hypertrichosis, increased requirements for insulin or oral hypoglycemic agents in diabetes, manifestations of latent diabetes mellitus, menstrual irregularities, secondary adrenocortical and pituitary unresponsiveness (particularly in times of stress, as in trauma, surgery, or illness), suppression of growth in pediatric patients. Fluid and electrolyte disturbances: Congestive heart failure in susceptible patients, fluid retention, hypokalemic alkalosis, potassium loss, sodium retention. Gastrointestinal: Abdominal distenti responsibilities


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doing a little A-Methapred (Injection) Generic Name: methylprednisolone (Injection route) meth-il-pred-NIS-oh-lone Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A The A-Methapred brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available . Commonly used brand name(s) In the U.S. A-Methapred Depo-Medrol SoluMEDROL Available Dosage Forms: Powder for Solution Solution Suspension Therapeutic Class: Endocrine-Metabolic Agent Pharmacologic Class: Adrenal Glucocorticoid Slideshow Fact or Fiction? The Top 15 Osteoarthritis Myths Uses For A-Methapred Methylprednisolone injection provides relief for inflamed areas of the body. It is used to treat a number of different conditions, such as inflammation (swelling), severe allergies, adrenal problems, arthritis, asthma, blood or bone marrow problems, eye or vision problems, lupus, skin conditions, kidney problems, ulcerative colitis, and flare-ups of multiple sclerosis. Methylprednisolone is a corticosteroid (cortisone-like medicine or steroid). It works on the immune system to help relieve swelling, redness, itching, and allergic reactions. This medicine is available only with your doctor's prescription. Before Using A-Methapred In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of methylprednisolone injection in children. However, pediatric patients are more likely to have slower growth and bone problems if methylprednisolone injection is used for a long time. Recommended doses should not be exceeded, and the patient should be carefully monitored during therapy. Depo-Medrol and some strengths of Solu-Medrol injection should not be used in premature infants. Both brands of methylprednisolone injection contain benzyl alcohol, which may cause serious unwanted effects in premature infants. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of methylprednisolone injection in the elderly. However, elderly patients are more likely to have liver, kidney, or heart problems, which may require caution and an adjustment in the dose for elderly patients receiving methylprednisolone injection. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Desmopressin Rotavirus Vaccine, Live Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Aldesleukin Amtolmetin Guacil Bemiparin Bromfenac Bufexamac Bupropion Celecoxib Choline Salicylate Clonixin Dexibuprofen Dexketoprofen Diclofenac Diflunisal Dipyrone Droxicam Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Flurbiprofen Ibuprofen Indomethacin Ketoprofen Ketorolac Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Morniflumate Nabumetone Nadroparin Naproxen Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Oxaprozin Oxyphenbutazone Parecoxib Phenylbutazone Piketoprofen Piroxicam Pixantrone Pranoprofen Proglumetacin Propyphenazone Proquazone Rofecoxib Salicylic Acid Salsalate Sodium Salicylate Sulindac Telaprevir Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Valdecoxib Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acenocoumarol Alcuronium Aprepitant Aspirin Atracurium Carbamazepine Clarithromycin Cyclosporine Dalfopristin Diltiazem Erythromycin Fluindione Gallamine Hexafluorenium Ketoconazole Licorice Metocurine Mibefradil Nefazodone Phenobarbital Primidone Quinupristin Rifampin Saiboku-To Troleandomycin Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Brain injury, traumatic or Cerebral malaria or Fungal infections, systemic or Herpes simplex eye infection, active or Idiopathic thrombocytopenic purpura (low platelet count) Should not be given to patients with these conditions. Cataracts or Congestive heart failure or Cushing's syndrome (adrenal gland problem) or Depression or Diabetes or Emotional problems or Eye infection or Glaucoma or Heart attack, recent or Heart disease or Hyperglycemia (high blood sugar) or Hypertension (high blood pressure) or Liver disease (eg, cirrhosis, hepatitis) or Mental illness or Myasthenia gravis (severe muscle weakness) or Osteoporosis (weak bones) or Stomach or bowel problems (eg, diverticulitis, ulcers, ulcerative colitis) or Thyroid problems or Tuberculosis, inactive Use with caution. May make these conditions worse. Infection (bacteria, virus, fungus, parasite, or protozoa) May decrease your body's ability to fight infection. Proper Use of methylprednisolone This section provides information on the proper use of a number of products that contain methylprednisolone. It may not be specific to A-Methapred. Please read with care. A nurse or other trained health professional will give you this medicine. This medicine may be given through a needle placed in one of your veins, as a shot into a muscle or joint, or as a shot into a lesion on your skin. Your doctor may give you a few doses of this medicine until your condition improves, and then switch you to an oral medicine that works the same way. If you have any concerns about this, talk to your doctor. Precautions While Using A-Methapred Your doctor will check your progress closely while you are receiving this medicine . This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. If you are using this medicine for a long time, the skin at the injection site may become slightly depressed or wrinkled. Talk to your doctor if you notice any of these changes at the injection site: depressed or indented skin, or pain, redness, or sloughing (peeling) of the skin. This medicine may cause an allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. If you are using this medicine for a long time, tell your doctor about any extra stress or anxiety in your life, including other health concerns and emotional stress. Your dose of this medicine might need to be changed for a short time while you have extra stress. Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. Talk to your doctor right away if you have more than one of these symptoms while you are using this medicine: blurred vision, dizziness or fainting, a fast, irregular, or pounding heartbeat, increased thirst or urination, irritability, or unusual tiredness or weakness. This medicine may cause you to get more infections than usual. Avoid people who are sick or have infections and wash your hands often. If you are exposed to chickenpox or measles, tell your doctor right away. If you start to have a fever, chills, sore throat, or any other sign of an infection, call your doctor right away. Tell your doctor if you or your child have recently spent time in a tropical climate or have unexplained diarrhea before receiving this medicine. While you are being treated with methylprednisone injection, do not have any immunizations (vaccines) without your doctor's approval . Methylprednisone may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor. Check with your doctor right away if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. This medicine might cause thinning of the bones (osteoporosis) or slow growth in children if used for a long time. Tell your doctor if you have any bone pain or if you have an increased risk for osteoporosis. If your child is using this medicine, tell the doctor if you think your child is not growing properly. This medicine may cause changes in mood or behavior for some patients. Tell your doctor right away if you have depression, mood swings, a false or unusual sense of well-being, trouble with sleeping, or personality changes while using this medicine. Make sure any doctor or dentist who treats you knows that you are using this medicine. This medicine may affect the results of certain skin tests. Do not stop using this medicine suddenly without checking first with your doctor . Your doctor may want you or your child to gradually reduce the amount you are using before stopping it completely. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. A-Methapred Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Aggression agitation blurred vision decrease in the amount of urine dizziness fast, slow, pounding, or irregular heartbeat or pulse headache mental depression mood changes noisy, rattling breathing numbness or tingling in the arms or legs pounding in the ears swelling of the fingers, hands, feet, or lower legs trouble thinking, speaking, or walking troubled breathing at rest weight gain Rare Cough difficulty with swallowing hives, itching, or skin rash puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue tightness in the chest trouble breathing unusual tiredness or weakness Incidence not known Abdominal or stomach cramping and/or burning (severe) abdominal or stomach pain backache bloody, black, or tarry stools dark urine darkening of the skin decrease in height decreased vision diarrhea eye pain eye tearing general feeling of illness general tiredness or weakness facial hair growth in females fainting fever or chills flushed, dry skin fractures fruit-like breath odor full or round face, neck, or trunk heartburn and/or indigestion (severe and continuous) hoarseness increased hunger increased thirst increased urination light-colored stools loss of appetite loss of sexual desire or ability lower back or side pain menstrual irregularities muscle pain or tenderness muscle wasting or weakness nausea pain in the back, ribs, arms, or legs painful or difficult urination sore throat sweating trouble healing trouble sleeping unexplained weight loss unusual tiredness or weakness upper right abdominal or stomach pain vision changes vomiting vomiting of material that looks like coffee grounds yellow eyes and skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Increased appetite Incidence not known Abnormal fat deposits on the face, neck, and trunk acne dry scalp lightening of normal skin color pain, redness, or hard skin at the injection site pitting or depression of the skin at the injection site red face reddish purple lines on the arms, face, legs, trunk, or groin swelling of the stomach area thinning of the scalp hair Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about A-Methapred (methylprednisolone) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: glucocorticoids Consumer resources A-Methapred injection A-methapred Other brands: Medrol , Medrol Dosepak , MethylPREDNISolone Dose Pack , Solu-Medrol , ... +2 more Professional resources A-Methapred Injection (FDA) Methylprednisolone Sodium Succinate (AHFS Monograph) Related treatment guides Adrenogenital Syndrome Allergic Rhinitis Asthma Asthma, acute ... +9 more} Drug Status Availability Discontinued Pregnancy Category Risk depends on usage N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Pfizer Inc. Drug Class Glucocorticoids Related Drugs Inflammatory Conditions prednisone , hydrocortisone , prednisolone , Medrol , dexamethasone , methylprednisolone , More... Allergic Rhinitis prednisone , Zyrtec , promethazine , fluticasone nasal , loratadine , cetirizine , More... Asthma prednisone , triamcinolone , montelukast , Singulair , ipratropium , Breo Ellipta , More... Osteoarthritis prednisone , naproxen , Cymbalta , aspirin , ibuprofen , meloxicam , More... 9 more conditions... A-Methapred Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers What is A-Methaped ? And what's it for? Read more questions} } authentic


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plodding away A-25 Generic Name: Vitamin A Tablets and Capsules (VYE ta min aye) Brand Name: A-25, Aquasol A, Vitamin A Fish Overview Side Effects Interactions Reviews Q & A More Uses of A-25: It is used to treat or prevent vitamin A deficiency. It is used to treat some skin problems. Slideshow Don't Believe The Hype: How Multivitamins Conquered The Land Of The Free What do I need to tell my doctor BEFORE I take A-25? If you have an allergy to vitamin A or any other part of A-25 (vitamin A tablets and capsules). If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have too much vitamin A in the blood. This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take A-25? Tell all of your health care providers that you take A-25. This includes your doctors, nurses, pharmacists, and dentists. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant. Do not take more vitamin A than what your doctor told you to take. Taking more than ordered during pregnancy may cause birth defects. Talk with your doctor. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (A-25) best taken? Use A-25 as ordered by your doctor. Read all information given to you. Follow all instructions closely. To gain the most benefit, do not miss doses. Keep taking this medicine as you have been told by your doctor or other health care provider, even if you feel well. What do I do if I miss a dose? Take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. What are some other side effects of A-25? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out A-25? Store at room temperature. Store in a dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about A-25, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about A-25. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using A-25. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about A-25 (vitamin a) Side Effects Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: vitamins Consumer resources A-25 Other brands: Aquasol A , A/Fish Oil Professional resources Vitamin A (AHFS Monograph) Related treatment guides Vitamin A Deficiency Drug Status Rx OTC Availability Rx and/or OTC X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug A-25 Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Drug Class Vitamins Related Drugs Vitamin A Deficiency vitamin a , beta-carotene , Aquasol A , More... and have become


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categorized A-25 Generic Name: vitamin A (VYE ta min A) Brand Name: A-25, A/Fish Oil, Aquasol A Overview Side Effects Interactions Reviews Q & A More What is A-25 (vitamin A)? Vitamin A is found in foods such as liver, milk, cheese, eggs, carrots, squash, dark green and yellow vegetables, and fruits such as cantaloupe or apricots. Vitamin A is important for the eyes and skin, and for normal growth. Vitamin A is used to treat vitamin A deficiency. Vitamin A may also be used for purposes not listed in this medication guide. Slideshow Don't Believe The Hype: How Multivitamins Conquered The Land Of The Free What is the most important information I should know about A-25 (vitamin A)? Never take more than the recommended dose of vitamin A. Avoid taking more than one vitamin product at the same time unless your doctor tells you to. Taking similar vitamin products together can result in a vitamin overdose or serious side effects. An overdose of vitamin A can cause serious or life-threatening side effects. Do not take vitamin A without medical advice if you are pregnant. Vitamin A can cause birth defects if taken in large doses. Before taking vitamin A, tell your doctor about all other medicines you use. What should I discuss with my healthcare provider before taking A-25 (vitamin A)? Before using vitamin A, talk to your doctor, pharmacist, herbalist, or other healthcare provider. You may not be able to use vitamin A if you have certain medical conditions. Do not take vitamin A without medical advice if you are pregnant. Although some vitamin A is needed for the normal development of a baby, vitamin A can cause birth defects if taken in large doses. You may need to use a prenatal vitamin specially formulated for pregnant women. Ask your doctor about taking vitamin A if you are breast-feeding a baby. Your dose needs may be different while you are nursing. How should I take A-25 (vitamin A)? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Swallow the tablet or capsule whole. Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Never take more than the recommended dose of vitamin A. Avoid taking more than one vitamin product at the same time unless your doctor tells you to. Taking similar vitamin products together can result in a vitamin overdose or serious side effects. Your healthcare provider may occasionally change your dose to make sure you get the best results from vitamin A. The recommended dietary allowance of vitamin A increases with age. Follow your healthcare provider's instructions. You may also consult the National Academy of Sciences "Dietary Reference Intake" or the U.S. Department of Agriculture's "Dietary Reference Intake" (formerly "Recommended Daily Allowances" or RDA) listings for more information. Store at room temperature away from light, moisture, and heat. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of vitamin A can cause serious or life-threatening side effects. Overdose symptoms may include nausea, vomiting, loss of appetite, vision changes, hair loss, peeling skin, cracked skin around your mouth, changes in menstrual periods, dizziness, drowsiness, tired feeling, bone or joint pain, severe headache, pain behind your eyes, severe stomach pain, dark urine, or jaundice (yellowing of the skin or eyes). What should I avoid while taking A-25 (vitamin A)? Avoid taking orlistat (alli, Xenical) or mineral oil while you are taking vitamin A. A-25 (vitamin A) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Less serious side effects are more likely to occur, and you may have none at all. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect A-25 (vitamin A)? Do not take vitamin A without your doctor's advice if you are also taking: birth control pills; a blood thinner such as warfarin (Coumadin, Jantoven); bexarotene (Targretin); cholestyramine (Questran, Prevalite); acitretin (Soriatane); tretinoin (Vesanoid); or isotretinoin (Accutane, Sotret, Claravis, Amnesteem). This list is not complete and other drugs may interact with vitamin A. Tell your healthcare provider about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Next Side Effects Print this page Add to My Med List More about A-25 (vitamin a) Side Effects Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: vitamins Consumer resources A-25 Other brands: Aquasol A , A/Fish Oil Professional resources Vitamin A (AHFS Monograph) Related treatment guides Vitamin A Deficiency Where can I get more information? Your pharmacist can provide more information about vitamin A. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Last reviewed: December 14, 2011 Date modified: December 03, 2017 Drug Status Rx OTC Availability Rx and/or OTC X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Drug Class Vitamins Related Drugs Vitamin A Deficiency vitamin a , beta-carotene , Aquasol A , More... A-25 Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers Co-codamol, Should I steer clear? Has anyone tried to taper off seroquel - any suggestions about how to stop the headache? Can I use Norco as a "breakthrough" while taking Methidone and Fentenal? Is this a methadone pill? IS it ok for me to take a 25 mg of trazodone even though I take a 37.5 mg of effexor and 1.5 mg? Read more questions for boosting


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wonderful A-Caro-25 (Oral) Generic Name: beta carotene (Oral route) bay-ta KAR-oh-teen Overview Side Effects Interactions Breastfeeding Reviews More Support Group Q & A Commonly used brand name(s) In the U.S. A-Caro-25 Lumitene Available Dosage Forms: Capsule Capsule, Liquid Filled Liquid Tablet Therapeutic Class: Nutritive Agent Pharmacologic Class: Vitamin A (class) Slideshow Don't Believe The Hype: How Multivitamins Conquered The Land Of The Free Uses For A-Caro-25 Vitamins are compounds that you must have for growth and health. They are needed in small amounts only and are usually available in the foods that you eat. Beta-carotene is converted in the body to vitamin A, which is necessary for healthy eyes and skin. A lack of vitamin A may cause a rare condition called night blindness (problems seeing in the dark). It may also cause dry eyes, eye infections, skin problems, and slowed growth. Your health care professional may treat these problems by prescribing either beta-carotene, which your body can change into vitamin A, or vitamin A for you. Some conditions may increase your need for vitamin A. These include: Cystic fibrosis Diarrhea, continuing Illness, long-term Injury, serious Liver disease Malabsorption problems Pancreas disease Increased need for vitamin A should be determined by your health care professional. Claims that beta-carotene is effective as a sunscreen have not been proven. Although beta-carotene supplements are being studied for their ability to reduce the risk of certain types of cancer and possibly heart disease, there is not enough information to show that this is effective. Beta-carotene may be used to treat other conditions as determined by your doctor. Beta-carotene is available without a prescription. Importance of Diet For good health, it is important that you eat a balanced and varied diet. Follow carefully any diet program your health care professional may recommend. For your specific dietary vitamin and/or mineral needs, ask your health care professional for a list of appropriate foods. If you think that you are not getting enough vitamins and/or minerals in your diet, you may choose to take a dietary supplement. It is documented that people who consume diets high in fruits and vegetables have a reduced risk of heart disease and certain cancers. Fruits and vegetables are rich in beta-carotene and other nutrients that may be beneficial. Beta-carotene is found in carrots; dark-green leafy vegetables, such as spinach and green leaf lettuce; sweet potatoes; broccoli; cantaloupe; and winter squash. The body converts beta-carotene into vitamin A. Ordinary cooking does not destroy beta-carotene. Vitamins alone will not take the place of a good diet and will not provide energy. Your body needs other substances found in food, such as protein, minerals, carbohydrates, and fat. Vitamins themselves often cannot work without the presence of other foods. For example, some fat is needed so that beta-carotene can be absorbed into the body. Before Using A-Caro-25 If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Problems in children have not been documented with intake of normal daily recommended amounts. Geriatric Problems in older adults have not been documented with intake of normal daily recommended amounts. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this dietary supplement. Make sure you tell your doctor if you have any other medical problems, especially: Eating disorders or Kidney disease or Liver disease These conditions may cause high blood levels of beta-carotene, which may increase the chance of side effects Proper Use of beta carotene This section provides information on the proper use of a number of products that contain beta carotene. It may not be specific to A-Caro-25. Please read with care. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For use as a dietary supplement: For oral dosage forms (capsules or chewable tablets): Adults and teenagers: 6 to 15 milligrams (mg) of beta-carotene (the equivalent of 10,000 to 25,000 Units of vitamin A activity) per day. Children: 3 to 6 mg of beta-carotene (the equivalent of 5,000 to 10,000 Units of vitamin A activity) per day. For other uses: For oral dosage forms (capsules or tablets): To treat or prevent a reaction to sun in patients with erythropoietic protoporphyria: Adults and teenagers 30 to 300 milligrams (mg) of beta-carotene (the equivalent of 50,000 to 500,000 Units of vitamin A activity) a day. Children 30 to 150 mg of beta-carotene (the equivalent of 50,000 to 250,000 Units of vitamin A activity) a day. To treat or prevent a reaction to sun in patients with polymorphous light eruption: Adults and teenagers 75 to 180 mg of beta-carotene (the equivalent of 125,000 to 300,000 Units of vitamin A activity) a day. Children 30 to 150 mg of beta-carotene (the equivalent of 50,000 to 250,000 Units of vitamin A activity) a day. If you have high blood levels of vitamin A, your body will convert less beta-carotene to vitamin A. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss taking a vitamin for one or more days there is no cause for concern, since it takes some time for your body to become seriously low in vitamins. However, if your health care professional has recommended that you take this vitamin, try to remember to take it as directed every day. If you miss a dose and you are using it as medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Do not refrigerate. Keep from freezing. Store the dietary supplement in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using A-Caro-25 Use of beta-carotene has been associated with an increased risk of lung cancer in people who smoke or who have been exposed to asbestos. One study of 29,000 male smokers found an 18% increase in lung cancer in the group receiving 20 mg of beta-carotene a day for 5 to 8 years. Another study of 18,000 people found 28% more lung cancers in people with a history of smoking and/or asbestos exposure. These people took 30 mg of beta-carotene in addition to 25,000 Units of retinol (a form of vitamin A) a day for 4 years. However, one study of 22,000 male physicians, some of them smokers or former smokers, found no increase in lung cancer. These people took 50 mg of beta-carotene every other day for 12 years. If you smoke or have a history of smoking or asbestos exposure, you should not take large amounts of beta-carotene supplements for long periods of time. However, foods that are rich in beta-carotene are considered safe and appear to lower the risk of some types of cancer and possibly heart disease. A-Caro-25 Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Yellowing of palms, hands, or soles of feet, and to a lesser extent the face (this may be a sign that your dose of beta-carotene as a nutritional supplement is too high) Rare Diarrhea dizziness joint pain unusual bleeding or bruising Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about A-Caro-25 (beta-carotene) Side Effects Breastfeeding Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: vitamins Consumer resources A-Caro-25 Other brands: B-Caro-T , Caroguard , Lumitene Professional resources Beta Carotene (AHFS Monograph) Related treatment guides Vitamin A Deficiency} Drug Status OTC Availability Over the counter C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Vitamins Related Drugs Vitamin A Deficiency vitamin a , beta-carotene , Aquasol A , More... A-Caro-25 Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the A-Caro-25 support group to connect with others who have similar interests.} } superb


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