most commonly carbidopa, entacapone, and levodopa (Oral route) lee-voe-DOE-pa, kar-bi-DOE-pa, en-TAK-a-pone Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Stalevo 100 Stalevo 125 Stalevo 150 Stalevo 200 Stalevo 50 Stalevo 75 Available Dosage Forms: Tablet Therapeutic Class: Antiparkinsonian Pharmacologic Class: Dopamine Precursor Slideshow 11 Signs of Alzheimer's Disease - Or Are You Just Getting Older? Uses For carbidopa, entacapone, and levodopa Carbidopa, entacapone, and levodopa combination is used to treat Parkinson's disease, sometimes called shaking palsy. Parkinson's disease is a disorder of the central nervous system (brain and spinal cord). Dopamine is a naturally occurring substance in the brain that helps provide control of movement and activities such as walking and talking. In patients with Parkinson's disease, there is not enough dopamine in some parts of the brain. Levodopa (a component of carbidopa, entacapone, and levodopa) enters the brain and helps replace the missing dopamine, which allows people to function better. By increasing the amount of dopamine in the brain, levodopa helps control symptoms and helps you to perform daily activities such as dressing, walking, and handling utensils. carbidopa, entacapone, and levodopa is a combination of three different medicines. carbidopa, entacapone, and levodopa is known as a levodopa therapy. The difference between carbidopa, entacapone, and levodopa and other levodopa treatments is that carbidopa, entacapone, and levodopa contains entacapone. Entacapone helps levodopa last longer by blocking a substance called COMT enzyme. This enzyme breaks down levodopa before it reaches the brain. When less levodopa is broken down, more is available to the brain. Increased availability of levodopa may lead to smoother and steadier levels of dopamine in the brain, which may provide better symptom control for longer periods each day. This may lead to improvement in daily activities. carbidopa, entacapone, and levodopa is available only with your doctor's prescription. Before Using carbidopa, entacapone, and levodopa In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For carbidopa, entacapone, and levodopa, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to carbidopa, entacapone, and levodopa or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of carbidopa, entacapone, and levodopa combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date in elderly patients up to age 75 years have not demonstrated geriatric-specific problems that would limit the usefulness of carbidopa, entacapone, and levodopa combination in the elderly. However, elderly patients are more likely to have age-related kidney, liver, and cardiovascular insufficiency, which may require extra caution. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking carbidopa, entacapone, and levodopa, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using carbidopa, entacapone, and levodopa with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amisulpride Bromopride Clorgyline Furazolidone Iproniazid Isocarboxazid Linezolid Methylene Blue Moclobemide Nialamide Pargyline Phenelzine Procarbazine Sulpiride Toloxatone Tranylcypromine Using carbidopa, entacapone, and levodopa with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Apomorphine Bitolterol Bupropion Desipramine Dobutamine Dopamine Epinephrine Fluvastatin Glimepiride Glipizide Glyburide Irbesartan Isoetharine Isoniazid Isoproterenol Losartan Methyldopa Nateglinide Norepinephrine Rosiglitazone Tolbutamide Venlafaxine Voriconazole Warfarin Using carbidopa, entacapone, and levodopa with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Droxidopa Fosphenytoin Indinavir Iron Kava Metoclopramide Phenylalanine Phenytoin Spiramycin Tyrosine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using carbidopa, entacapone, and levodopa with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use carbidopa, entacapone, and levodopa, or give you special instructions about the use of food, alcohol, or tobacco. High Protein Food Other Medical Problems The presence of other medical problems may affect the use of carbidopa, entacapone, and levodopa. Make sure you tell your doctor if you have any other medical problems, especially: Asthma or Biliary obstruction or blockage or Colitis (inflammation of the colon) or Depression, history of or Dyskinesia (abnormal muscle movements) or Endocrine or metabolic disease or Heart attack, history of or Heart or blood vessel disease, severe or Heart rhythm problems (eg, ventricular tachycardia) or Hypotension (low blood pressure) or Kidney disease or Liver disease or Lung disease, severe or Psychosis (mental disorder), or history of or Wide-angle glaucoma (eye pressure problem) Use with caution. May make these conditions worse. Melanoma (skin tumor), history of or Narrow angle glaucoma (eye pressure problem) or Skin lesions, undiagnosed (rashes that involve changes in color or texture of the skin) Should not be used in patients with these conditions. Peptic ulcer, history of May increase risk of stomach or bowel hemorrhage. Proper Use of carbidopa, entacapone, and levodopa Take carbidopa, entacapone, and levodopa exactly as directed , and every time that you are supposed to take it. It is important that you do not stop taking your medicine unless ordered by your doctor. It is also important to not start taking other medicines for your Parkinson's disease without first talking with your doctor. Swallow the tablet whole. Do not crush, chew, or break it. You may take the tablet with or without food. Since protein may interfere with the body's response to levodopa, high protein diets should be avoided. Intake of normal amounts of protein should be spaced equally throughout the day, or taken as directed by your doctor. You may experience a wearing-off effect towards the end of the dosing interval. You should tell your doctor if you have problems with this that affect your every day life. Your doctor may want to adjust your dose. carbidopa, entacapone, and levodopa begins to release its ingredients 30 minutes after you take it. If you are taking multivitamin tablets or plan to start taking them, discuss this first with your doctor. Iron salts (in vitamins) may keep carbidopa, entacapone, and levodopa from working properly. Dosing The dose of carbidopa, entacapone, and levodopa will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of carbidopa, entacapone, and levodopa. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage forms (capsules or tablets): For Parkinson's disease: Adults The starting dose is usually the same as the current dose you are taking. If you are starting carbidopa, entacapone, and levodopa for the first time, your doctor may want to start you on a carbidopa and levodopa combination with entacapone and gradually switch you over to this combination. Do not use more than 6 to 8 tablets in a 24-hour period. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of carbidopa, entacapone, and levodopa, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using carbidopa, entacapone, and levodopa It is very important that your doctor check your progress at regular visits to allow changes in your dose and to check for any unwanted effects. Do not take carbidopa, entacapone, and levodopa if you have taken a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan ], phenelzine [Nardil ] or tranylcypromine [Parnate ]) in the past 2 weeks. Do not stop taking carbidopa, entacapone, and levodopa without first checking with your doctor . Your doctor may want you to gradually reduce the amount you are taking before stopping completely. Check with your doctor right away if you are having convulsions (seizures), difficulty with breathing, a fast heartbeat, a high fever, high or low blood pressure, increased sweating, loss of bladder control, severe muscle stiffness, unusually pale skin, or tiredness. These could be symptoms of a serious condition called neuroleptic malignant syndrome (NMS). carbidopa, entacapone, and levodopa may cause dizziness, drowsiness, trouble in controlling movements, or trouble in concentrating or seeing clearly. It may even cause you to fall asleep without warning while you drive, talk, or eat. Make sure you know how you react to carbidopa, entacapone, and levodopa before you drive, use machines, or do other jobs that require you to be alert, well-coordinated, or able to think or see well . Dizziness, lightheadedness, or fainting may occur with carbidopa, entacapone, and levodopa, especially when you get up from a lying or sitting position suddenly. These symptoms are more likely to occur when you begin taking carbidopa, entacapone, and levodopa, or when the dose is increased. Getting up slowly may also help. If this problem continues or gets worse, check with your doctor. carbidopa, entacapone, and levodopa will add to the effects of other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds, sedatives, tranquilizers, or sleeping medications, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your medical doctor or dentist before taking any of the above while you are taking carbidopa, entacapone, and levodopa . carbidopa, entacapone, and levodopa may cause diarrhea, and in some cases it can be severe. It can occur months after starting carbidopa, entacapone, and levodopa. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. If you develop any unusual or strange thoughts and behavior while receiving carbidopa, entacapone, and levodopa, be sure to discuss it with your doctor. Other changes might be confusion, worsening of depression, visual hallucinations (seeing things that are not there), suicidal thoughts, and unusual excitement, nervousness, or irritability. Check with your doctor right away if you have dark-colored urine, fever, muscle cramps or spasms, muscle pain or stiffness, or unusual tiredness or weakness. These may be symptoms of a condition called rhabdomyolysis. Check with your doctor right away if you are having shortness of breath, chest tightness, or any type of breathing problem while being treated with carbidopa, entacapone, and levodopa. It is important that your doctor check your skin regularly for signs of a skin cancer called melanoma. If you notice any unusual red, brown, or black spots on your skin, talk to your doctor right away. It is possible that a dark color (red, brown, or black) may appear in saliva, urine, or sweat after taking carbidopa, entacapone, and levodopa. The color may cause some of your garments to become discolored. This is normal and nothing to worry about. It is possible that you may become nauseous, especially when you are first starting your medicine. Some people who have used carbidopa, entacapone, and levodopa had unusual changes in their behavior. Talk with your doctor right away if you start having problems with gambling or an increased interest in sex while using carbidopa, entacapone, and levodopa. Before you have any medical tests, tell the medical doctor in charge that you are taking carbidopa, entacapone, and levodopa. The results of some tests may be affected by carbidopa, entacapone, and levodopa. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. carbidopa, entacapone, and levodopa Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common-Entacapone Twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs Incidence not known-Carbidopa and Levodopa and/or Levodopa alone Bleeding gums bloody or black, tarry stools bloody or cloudy urine change in size, shape, or color of an existing mole changes in skin color chest pain, discomfort, or tightness constipation constricted pupil convulsions cough difficult or labored breathing difficulty with speaking drooling drooping eyelid (ptosis) facial dryness fast, irregular, or pounding heartbeat fever with or without chills general feeling of illness hallucinations (seeing, hearing, or feeling things that are not there) hoarseness large, flat, blue, or purplish patches in the skin large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs loss of appetite loss of bladder control lower abdominal or stomach pain lower back or side pain mole that leaks fluid or bleeds muscle cramps or spasms muscle pain or stiffness muscle trembling, jerking, or stiffness nausea pain painful or difficult urination pinpoint red spots on the skin raised red swellings on the skin, the buttocks, legs, or ankles restlessness severe mental changes shakiness and unsteady walk shuffling walk sore throat sores, ulcers, or white spots on the lips or in the mouth sweating swollen glands trembling, or other problems with muscle control or coordination unusual bleeding or bruising unusual tiredness or weakness vomiting Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common-Entacapone Absence of or decrease in body movement diarrhea dizziness urine discoloration Less common-Entacapone Acid or sour stomach anxiety belching bitter, sour, or unusual taste in the mouth bloated burning feeling in the chest or stomach dry mouth excess air or gas in the stomach or intestines fear full feeling heartburn hyperventilation increased sweating indigestion irritability lack or loss of strength passing gas restlessness sleepiness or unusual drowsiness stomach discomfort or upset swollen mouth and tongue tenderness in the stomach area trouble sleeping urge to have bowel movement Incidence not known-Carbidopa and Levodopa and/or Levodopa alone Being forgetful bladder pain blurred vision body aches or pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings burning and upper abdominal or stomach pain burning sensation of the tongue clenching, gnashing, or grinding teeth confusion about identity, place, and time dark saliva dark sweat decreased mental acuity difficulty swallowing discouragement double vision ear congestion enlarged pupils excessive watering of the mouth fainting false or unusual sense of well-being feeling like you will pass out feeling of warmth feeling sad or empty flushing hair loss headache hiccups hives or welts increased blinking increased interest in sexual ability, desire, drive, or performance increased interest in sexual intercourse lack of appetite large, hard skin blisters leg pain loss of voice muscle spasm, especially of the neck and back nasal congestion nightmares numbness pain in the chest below the breastbone painful or prolonged erection of the penis pharyngeal pain pounding in the ears problems with memory or speech redness of the face, neck, arms, and occasionally upper chest runny nose sense of stimulation skin rash sleeplessness slow movement slow or fast heartbeat slow reflexes sneezing swelling tremor, increased trouble concentrating trouble recognizing objects trouble thinking and planning urinary frequency urinary retention weight gain weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about carbidopa/entacapone/levodopa Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 7 Reviews Add your own review/rating Drug class: dopaminergic antiparkinsonism agents Consumer resources Carbidopa, entacapone, and levodopa Levodopa, Carbidopa, and Entacapone Other brands: Stalevo , Stalevo 150 , Stalevo 100 , Stalevo 125 , ... +3 more Professional resources Carbidopa, Levodopa and Entacapone (FDA) Carbidopa, Levodopa and Entacapone Tablets (FDA) Levodopa, Carbidopa, and Entacapone (Wolters Kluwer) Related treatment guides Parkinson's Disease} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Global Pharmaceuticals Mylan Pharmaceuticals Inc. Sandoz Inc. Wockhardt USA LLC Sun Pharmaceutical Industries Inc. Macleods Pharmaceuticals Limited More... Drug Class Dopaminergic antiparkinsonism agents Related Drugs Parkinson's Disease Exelon , ropinirole , pramipexole , Sinemet , Requip , benztropine , carbidopa / levodopa , Mirapex , amantadine , rivastigmine , Azilect , Cogentin , selegiline , trihexyphenidyl , bromocriptine , entacapone , Neupro , Rytary , rasagiline , Stalevo , Artane , carbidopa / entacapone / levodopa , Comtan , belladonna , More... Carbidopa / entacapone / levodopa Rating 7 User Reviews 6.3 /10 7 User Reviews 6.3 Rate it! Carbidopa / entacapone / levodopa Images Carbidopa / entacapone / levodopa systemic 12.5 mg / 200 mg / 50 mg (T1 50 ) View all images Related Questions & Answers Carbidopa/Entacapone/Levodopa - is there financial help for generic stalevo? I have medicare part d? Read more questions} } client
many candidates carbidopa, entacapone, and levodopa (Oral route) ignored
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