high quality Aluminum Acetate Class: Astringents VA Class: DE900 Chemical Name: Aluminum Acetate Molecular Formula: C 6 H 9 AlO 6 CAS Number: 139-12-8 Brands: Domeboro, Gordon s Boro-Packs, Pedi-Boro Overview Side Effects Professional Reviews Q & A More Introduction Topical astringent and antiseptic; aluminum salt. 1 2 4 5 8 13 15 Slideshow Understanding Insulin: What You Need To Know Uses for Aluminum Acetate Dermatologic Conditions Used topically as self-medication (OTC use) for the temporary relief of minor skin irritations (e.g., insect bites; athlete s foot; poison ivy, poison oak, or poison sumac; rashes due to soaps, detergents, cosmetics, or jewelry). 1 3 5 8 9 12 13 14 15 16 Helps relieve itching and has a cooling and drying effect; particularly useful on wet or weeping lesions. 3 12 14 Used topically for the relief of swelling associated with minor bruises and for reducing foot sweat . 9 15 Aluminum acetate preparations also have been used topically for the relief of a variety of other skin-related conditions, such as eczema 15 , diaper rash 11 13 , acne 15 , and pruritus ani . 13 15 Aluminum Acetate Dosage and Administration Administration Topical Administration Apply aluminum acetate solution topically to the affected area of the skin as a wet dressing or compress or as a soak. 1 2 3 8 9 14 16 All commercially available aluminum acetate-containing preparations are for external use only. 1 5 8 9 13 16 Avoid contact with eyes. 1 5 6 8 9 16 Keep out of reach of children; if ingested, immediately contact local poison control center. 1 8 9 13 16 Reconstitution of Powder for Topical Solution Mix 1 3 packets of Domeboro Powder Packets, Gordon s Boro-Packs, or Pedi-Boro Soak Paks in 16 ounces of water, preferably at cool or room temperature, to obtain modified Burow s solution of buffered aluminum acetate in the following concentrations: 1 2 8 9 14 Number of Packets Dilution Percentage (%) Aluminum Acetate 1 packet 1:40 0.14% 2 packets 1:20 0.28% 3 packets 1:13 0.42% Do not dissolve topical powder in solutions other than water. 2 9 Do not strain or filter reconstituted solution. 1 8 9 The manufacturers of Gordon s Boro-Packs and Pedi-Boro Soak Paks advise to shake well before use. 8 9 Prior to initial use, the manufacturer of Domeboro Powder Packets states that reconstituted solution may be divided into individual portions and stored for later application. 2 (See Storage under Stability.) Discard solution after each use. 1 2 5 8 Once cloth has come into contact with skin, do not re-insert cloth into reconstituted solution for reuse. 2 Dilution of Topical Solution Consult manufacturer s product information or clinician for instructions on the proper dilution of aluminum acetate topical solution or Burow s Solution for topical application to the skin. 14 16 Solutions should not be used without dilution with water. 16 Diluted solutions containing 0.13 0.5% aluminum acetate are commonly used. 14 16 Discard solution after each use. 5 16 Dosage For self-medication for dermatologic conditions, reconstituted or diluted aluminum acetate solutions containing 0.13 0.5% aluminum acetate generally used. 1 2 5 8 9 16 Pediatric Patients Dermatologic Conditions Compress or Wet Dressing Topical Saturate clean, soft, white cloth with solution and gently squeeze and then apply cloth loosely to affected area for 15 30 minutes; repeat as necessary or as directed by a clinician. 1 2 5 8 9 16 17 Soak Topical Soak affected area for 15 30 minutes; repeat 3 times daily or as directed by a clinician. 1 2 5 8 16 17 Adults Dermatologic Conditions Compress or Wet Dressing Topical Saturate clean, soft, white cloth with solution and gently squeeze and then apply cloth loosely to affected area for 15 30 minutes; repeat as necessary or as directed by a clinician. 1 2 5 8 9 16 Soak Topical Soak affected area for 15 30 minutes; repeat 3 times daily or as directed by a clinician. 1 2 5 8 16 Special Populations No special population dosage and administration recommendations at this time. 1 5 8 16 17 Cautions for Aluminum Acetate Contraindications Hypersensitivity to aluminum acetate or to any ingredient in the formulation. 17 Warnings/Precautions Warnings Administration Precautions For external use only. 1 5 8 9 13 16 17 Avoid contact with the eyes. 1 5 6 8 9 16 Importance of discontinuing use and consulting a clinician if condition worsens or symptoms persist for >1 week. 1 5 8 16 Do not cover compress or wet dressing with plastic to prevent evaporation. 1 5 8 16 Prolonged soaking may result in excessive drying of skin. 1 8 17 Concurrent use of soap may reduce astringent action of aluminum acetate. 15 Specific Populations Pregnancy Unknown. 17 Lactation Not known whether topical aluminum acetate is distributed into milk. 17 Pediatric Use Safety and efficacy in pediatric patients appear similar to that in adults. 11 13 15 Keep aluminum acetate preparations out of the reach of children. 1 8 9 13 16 Common Adverse Effects Topical application to the skin: skin irritation, inflammation, and dryness. 1 6 8 14 15 Interactions for Aluminum Acetate Consult with a clinician prior to use with other topical or systemic medications. 2 Collagenase Potential pharmacologic interaction (decreased efficacy of topical collagenase); avoid concomitant use. 7 Aluminum Acetate Pharmacokinetics Absorption Extent Substantial systemic absorption from intact or denuded skin, wounds, or mucous membranes appears unlikely following topical application. 6 Stability Storage Topical Powder for Topical Solution Protect from excessive heat. 1 8 Following reconstitution, unused solution prepared from Domeboro Powder Packets may be stored at room temperature in a clean, capped container for 7 days. 2 (See Administration under Dosage and Administration.) Topical Solution Tight, light-resistant containers at 15 30 C. 6 13 16 Compatibility For information on systemic interactions resulting from concomitant use, see Interactions. Topical Solution Compatibility Compatible Water Actions Aluminum acetate is produced when aluminum sulfate and calcium acetate are mixed in water. 1 Topical solution acts as an astringent by constricting blood vessels. 2 3 12 14 Relieves inflammation and itching; cools and dries skin and wet or weeping skin lesions. 2 3 12 14 Advice to Patients Importance of understanding that topical aluminum acetate preparations are intended for external use only. 1 5 8 9 13 16 Importance of avoiding contact with the eyes. 1 5 6 8 9 16 Importance of discontinuing use and consulting a clinician if condition worsens or symptoms persist for >1 week. 1 5 8 16 Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. 1 8 9 16 Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, dietary supplements, and/or herbal products, as well as any concomitant illnesses. 1 8 9 16 Importance of informing patients of other important precautionary information. 1 8 9 16 (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Aluminum Acetate Routes Dosage Forms Strengths Brand Names Manufacturer Topical Powder for topical solution Domeboro Astringent Solution Powder Packets Bayer Gordon s Boro-Packs Gordon Pedi-Boro Soak Paks Pedinol Pharmacal Solution* Aluminum Acetate Solution Burow s Solution Ion AHFS DI Essentials. Copyright 2017, Selected Revisions May 1, 2008. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. Use is not currently included in the labeling approved by the US Food and Drug Administration. References 1. Bayer HealthCare LLC, Consumer Care Division. Domeboro (aluminum acetate astringent solution) powder packets product information. Accessed from Bayer Consumer Care website (). Accessed on 2007 Aug 08. 2. Bayer HealthCare. Domeboro frequently asked questions. From the Bayer Consumer Care website . Accessed on 2007 Aug 08. 3. Lee NP, Arriola ER. Poison ivy, oak, and sumac dermatitis. West J Med . 1999; 171:354-5. [PubMed 10639874] 4. Budavari S, O Neil MJ, Smith A et al, eds. The Merck index. 13th ed. Whitehouse Station, NJ: Merck & Co, Inc; 2001:60. 5. Food and Drug Administration. Skin protectant drug products for over-the-counter human use. Part A: Astringent drug products. (21 *CFR* Part 347. 2002; 5:270-1. 6. Material Safety Data Sheet: Aluminum acetate solution.From the ScienceLab.com website . Accessed on 2008 Feb 1. 7. Healthpoint Ltd. Collagenase Santyl ointment prescribing information. Fort Worth, TX; 2006 Jun. 8. Pedinol Pharmacal Inc. Pedi-Boro Soak Paks (aluminum acetate astringent solution) product information. Farmingdale, NY; 2006 Sep. 9. Gordon Laboratories. Gordon s Boro-Packs (aluminum acetate astringent solution) product information. Upper Darby, PA; 2003 Dec. 10. Bayer HealthCare LLC, Consumer Care Division: Morristown, NJ; Personal communication. 11. Remmert R. Pediatric dermatitis. Int J Pharm Compounding . 2002; 6:19-21. 12. Moses S. Pruritus. Am Fam Physician . 2003; 68:1135-42. [PubMed 14524401] 13. Anon. Burow s solution. Int J Pharm Compounding . 2005; 9:314. 14. DeSimone EM II, Triplett CA. Consult your pharmacist - OTC Products for relieving itch. US Pharmacist . 1997; 22:1. 15. Bureau of Medicine and Surgery, Department of the Navy. Operational Medicine 2001: Health care in military settings, NAVMED P-5139. Washington, DC; 2001 May 1. 16. Ion Labs, Inc. Burow s Solution (aluminum acetate topical solution) product information. Clearwater, FL; Undated. 17. Reviewers comments (personal communication.) Next User Reviews Print this page Add to My Med List More about aluminum acetate topical Side Effects Support Group 0 Reviews Add your own review/rating Drug class: topical astringents} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx OTC Availability Rx and/or OTC N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Drug Class Topical astringents Recently Approved Lonhala Magnair Lonhala Magnair (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator for... Ozempic Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) analog administered once-weekly for the... Ogivri Ogivri (trastuzumab-dkst) is a HER2 / neu receptor antagonist biosimilar to Herceptin indicated for... Sublocade Sublocade (buprenorphine) is a once-monthly injectable partial opioid agonist formulation for the... 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