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turn into [4:4 ng/mL during the 84-week treatment period. A total of 725 hypogonadal men received intramuscular testosterone undecanoate in a total of 7 controlled clinical trials. In these clinical trials, the dose and dose frequency of intramuscular testosterone undecanoate varied from 750 mg to 1000 mg, and from every 9 weeks to every 14 weeks. Several of these clinical trials incorporated additional doses upon initiation of therapy (e.g., loading doses). In addition to those adverse reactions noted in Table 1, the following adverse events were reported by at least 3% of patients in these trials, irrespective of the investigator s assessment of relationship to study medication: sinusitis, prostatitis, arthralgia, nasopharyngitis, upper respiratory tract infection, bronchitis, back pain, hypertension, diarrhea and headache. Pulmonary Oil Microembolism (POME) and Anaphylaxis in Controlled Clinical Studies Adverse events attributable to pulmonary oil microembolism and anaphylaxis were reported in a small number of patients in controlled clinical trials. In the 84-week clinical trial of Aveed, 1 patient experienced a mild coughing fit lasting 10 minutes after his third injection, which was retrospectively attributed to POME. In another clinical trial of intramuscular testosterone undecanoate (1000 mg), a hypogonadal male patient experienced the urge to cough and respiratory distress at 1 minute after his tenth injection, which was also retrospectively attributed to POME. During a review that involved adjudication of all cases meeting specific criteria, 9 POME events in 8 patients and 2 events of anaphylaxis among 3,556 patients treated with intramuscular testosterone undecanoate in 18 clinical trials were judged to have occurred. 6.2 Postmarketing Experience The following adverse reactions have been identified during post-approval use of Aveed. Because the reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Pulmonary Oil Microembolism (POME) and Anaphylaxis Serious pulmonary oil microembolism (POME) reactions, involving cough, urge to cough, dyspnea, hyperhidrosis, throat tightening, chest pain, dizziness, and syncope, have been reported to occur during or immediately after the injection of intramuscular testosterone undecanoate 1000 mg (4 mL) in post-approval use outside the United States. The majority of these events lasted a few minutes and resolved with supportive measures; however, some lasted up to several hours and some required emergency care and/or hospitalization. In addition to serious POME reactions, episodes of anaphylaxis, including life-threatening reactions, have also been reported to occur following the injection of intramuscular testosterone undecanoate in post-approval use outside of the United States. Both serious POME reactions and anaphylaxis have been reported to occur after any injection of testosterone undecanoate during the course of therapy, including after the first dose. Other Events The following treatment emergent adverse events or adverse reactions have been identified during post-marketing clinical trials and during post-approval use of intramuscular testosterone undecanoate. In most cases, the dose being used was 1000 mg. Blood and Lymphatic System Disorders: polycythemia, thrombocytopenia Cardiac Disorders: angina pectoris, cardiac arrest, cardiac failure, coronary artery disease, coronary artery occlusion, myocardial infarction, tachycardia Ear and Labyrinth Disorders: sudden hearing loss, tinnitus Endocrine Disorders: hyperparathyroidism, hypoglycemia Gastrointestinal Disorders: abdominal pain upper, diarrhea, vomiting General Disorders and Administrative Site Conditions: chest pain, edema peripheral, injection site discomfort, injection site hematoma, injection site irritation, injection site pain, injection site reaction, malaise, paresthesia, procedural pain Immune System Disorders: anaphylactic reaction, anaphylactic shock, asthma, dermatitis allergic, hypersensitivity, leukocytoclastic vasculitis Infections and Infestations: injection site abscess, prostate infection Investigations: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, blood glucose increased, blood pressure increased, blood prolactin increased, blood testosterone decreased, blood testosterone increased, blood triglycerides increased, gamma-glutamyltransferase increased, hematocrit increased, intraocular pressure increased, liver function test abnormal, prostate examination abnormal, prostatic specific antigen increased, transaminases increased Metabolism and Nutrition Disorders: diabetes mellitus, fluid retention, hyperlipidemia, hypertriglyceridemia Musculoskeletal and Connective Tissue Disorders: musculoskeletal chest pain, musculoskeletal pain, myalgia, osteopenia, osteoporosis, systemic lupus erythematosus Neoplasms Benign, Malignant and Unspecified (including cysts and polyps): prostate cancer, prostatic intraepithelial neoplasia Nervous System Disorders: stroke, cerebrovascular insufficiency, reversible ischemic neurological deficiency, transient ischemic attack Psychiatric Disorders: aggression, anxiety, depression, insomnia, irritability, Korsakoff s psychosis non-alcoholic, male orgasmic disorder, nervousness, restlessness, sleep disorder Renal and Urinary Disorders: calculus urinary, dysuria, hematuria, nephrolithiasis, pollakiuria, renal colic, renal pain, urinary tract disorder Reproductive System and Breast Disorders: azoospermia, benign prostatic hyperplasia, breast induration, breast pain, erectile dysfunction, gynecomastia, libido decreased, libido increased, prostate induration, prostatitis, spermatocele, testicular pain Respiratory, Thoracic and Mediastinal Disorders: asthma, chronic obstructive pulmonary disease, cough, dysphonia, dyspnea, hyperventilation, obstructive airway disorder, pharyngeal edema, pharyngolaryngeal pain, pulmonary microemboli, pulmonary embolism, respiratory distress, rhinitis, sleep apnea syndrome, snoring Skin and Subcutaneous Tissue Disorders: acne, alopecia, angioedema, angioneurotic edema, dermatitis allergic, erythema, hyperhidrosis, pruritus, rash Vascular Disorders: cerebral infarction, cerebrovascular accident, circulatory collapse, deep venous thrombosis, hot flush, hypertension, syncope, thromboembolism, thrombosis, venous insufficiency. Drug Interactions 7.1 Insulin Changes in insulin sensitivity or glycemic control may occur in patients treated with androgens. In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, may necessitate a decrease in the dose of anti-diabetic medication. 7.2 Oral Anticoagulants Changes in anticoagulant activity may be seen with androgens, therefore more frequent monitoring of international normalized ratio (INR) and prothrombin time are recommended in patients taking warfarin, especially at the initiation and termination of androgen therapy. 7.3 Corticosteroids The concurrent use of testosterone with corticosteroids may result in increased fluid retention and requires careful monitoring, particularly in patients with cardiac, renal or hepatic disease. USE IN SPECIFIC POPULATIONS 8.1 Pregnancy Pregnancy Category X: Aveed is contraindicated in pregnant women or in women who may become pregnant. Testosterone is teratogenic and may cause fetal harm . Exposure of a fetus to androgens, such as testosterone, may result in varying degrees of virilizations. If this drug is used in pregnancy or if the patient becomes pregnant while taking this drug, the patient should be made aware of the potential hazard to the fetus. 8.3 Nursing Mothers Although it is not known how much testosterone transfers into human milk, Aveed is contraindicated in nursing women because of the potential for serious adverse reactions in nursing infants . 8.4 Pediatric Use Safety and effectiveness of Aveed in pediatric patients less than 18 years old have not been established. Improper use may result in acceleration of bone age and premature closure of epiphyses. 8.5 Geriatric Use There have not been sufficient numbers of geriatric patients in controlled clinical studies with Aveed to determine whether efficacy or safety in those over 65 years of age differs from younger subjects. Of the153 patients enrolled in the pivotal clinical study utilizing Aveed, 26 (17.0%) were over 65 years of age. Additionally, there are insufficient long-term safety data in geriatric patients to assess the potentially increased risk of cardiovascular disease and prostate cancer . Geriatric patients treated with androgens may also be at risk for worsening of signs and symptoms of BPH [see Warnings and Precautions ( 5.3 )] . 8.6 Renal Impairment No studies were conducted in patients with renal impairment. 8.7 Hepatic Impairment No studies were conducted in patients with hepatic impairment. Drug Abuse and Dependence 9.1 Controlled Substance Aveed contains testosterone, a Schedule III controlled substance in the Controlled Substances Act. 9.2 Abuse Drug abuse is intentional non-therapeutic use of a drug, even once, for its rewarding psychological and physiological effects. Abuse and misuse of testosterone are seen in male and female adults and adolescents. Testosterone, often in combination with other anabolic androgenic steroids (AAS), and not obtained by prescription through a pharmacy, may be abused by athletes and bodybuilders. There have been reports of misuse of men taking higher doses of legally obtained testosterone than prescribed and continuing testosterone despite adverse events or against medical advice. Abuse-Related Adverse Reactions Serious adverse reactions have been reported in individuals who abuse anabolic androgenic steroids, and include cardiac arrest, myocardial infarction, hypertrophic cardiomyopathy, congestive heart failure, cerebrovascular accident, hepatotoxicity, and serious psychiatric manifestations, including major depression, mania, paranoia, psychosis, delusions, hallucinations, hostility and aggression. The following adverse reactions have also been reported in men: transient ischemic attacks, convulsions, hypomania, irritability, dyslipidemias, testicular atrophy, subfertility, and infertility. The following additional adverse reactions have been reported in women: hirsutism, virilization, deepening of voice, clitoral enlargement, breast atrophy, male-pattern baldness, and menstrual irregularities. The following adverse reactions have been reported in male and female adolescents: premature closure of bony epiphyses with termination of growth, and precocious puberty. Because these reactions are reported voluntarily from a population of uncertain size and may include abuse of other agents, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. 9.3 Dependence Behaviors Associated with Addiction Continued abuse of testosterone and other anabolic steroids, leading to addiction is characterized by the following behaviors: Taking greater dosages than prescribed Continued drug use despite medical and social problems due to drug use Spending significant time to obtain the drug when supplies of the drug are interrupted Giving a higher priority to drug use than other obligations Having difficulty in discontinuing the drug despite desires and attempts to do so Experiencing withdrawal symptoms upon abrupt discontinuation of use Physical dependence is characterized by withdrawal symptoms after abrupt drug discontinuation or a significant dose reduction of a drug. Individuals taking supratherapeutic doses of testosterone may experience withdrawal symptoms lasting for weeks or months which include depressed mood, major depression, fatigue, craving, restlessness, irritability, anorexia, insomnia, decreased libido and hypogonadotropic hypogonadism. Drug dependence in individuals using approved doses of testosterone for approved indications has not been documented. . Overdosage There have been no reports of overdosage in the Aveed clinical trials. There is one report of acute overdosage with use of an approved injectable testosterone product: this subject had serum testosterone levels of up to 11,400 ng/dL with a cerebrovascular accident. Treatment of overdosage would consist of discontinuation of Aveed together with appropriate symptomatic and supportive care. Aveed Description Aveed (testosterone undecanoate) injection contains testosterone undecanoate (17β-undecanoyloxy-4-androsten-3-one) which is an ester of the androgen, testosterone. Testosterone is formed by cleavage of the ester side chain of testosterone undecanoate. Testosterone undecanoate is a white to off-white crystalline substance. The empirical formula of testosterone undecanoate is C 30 H 48 O 3 and a molecular weight of 456.7. The structural formula is: FIGURE 2: Testosterone Undecanoate C 30 H 48 O 3 MW: 456.7 Aveed is a clear, yellowish, sterile oily solution containing testosterone undecanoate, a testosterone ester, for intramuscular injection. Each single use vial contains 3 mL of 250 mg/mL testosterone undecanoate solution in a mixture of 1500 mg of benzyl benzoate and 885 mg of refined castor oil. Aveed - Clinical Pharmacology 12.1 Mechanism of Action Endogenous androgens, including testosterone and dihydrotestosterone (DHT) are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include the growth and maturation of prostate, seminal vesicles, penis, and scrotum; the development of male hair distribution, such as facial, pubic, chest, and axillary hair; laryngeal enlargement, vocal cord thickening, and alterations in body musculature and fat distribution. Male hypogonadism, a clinical syndrome resulting from insufficient secretion of testosterone, has two main etiologies. Primary hypogonadism is caused by defects of the gonads, such as Klinefelter s syndrome or Leydig cell aplasia, whereas secondary hypogonadism is the failure of the hypothalamus (or pituitary) to produce sufficient gonadotropins (FSH, LH). 12.3 Pharmacokinetics Absorption Aveed 750 mg delivers physiologic amounts of testosterone, producing circulation testosterone concentrations that approximate normal concentrations (300-1000 ng/dL) seen in healthy men. Testosterone esters in oil injected intramuscularly are absorbed from the lipid phase. Cleavage of the undecanoic acid side chain of Aveed by tissue esterases releases testosterone. Following intramuscular injection of 750 mg of Aveed, serum testosterone concentrations reach a maximum after a median of 7 days (range 4 42 days) then slowly decline (Figure 3). Steady state serum testosterone concentration was achieved with the 3 rd injection of Aveed at 14 weeks. Figure 3 shows the mean serum total testosterone concentration-time profile during the 3 rd injection interval (at steady state, 14-24 weeks) for hypogonadal men (less than 300 ng/dL) given 750 mg Aveed at initiation, at 4 weeks, and every 10 weeks thereafter. Intramuscular injection of 750 mg of Aveed generates mean steady state serum total testosterone concentrations in the normal range for 10 weeks. FIGURE 3: Mean (SD) Serum Total Testosterone Concentrations (ng/dL) at 14-24 Weeks Distribution Circulating testosterone is chiefly bound in the serum to sex hormone-binding globulin (SHBG) and albumin. Approximately 40% of testosterone in plasma is bound to SHBG, 2% remains unbound (free), and the rest is loosely bound to albumin and other proteins. Metabolism Testosterone undecanoate is metabolized to testosterone via ester cleavage of the undecanoate group. The mean (SD) maximum concentration of testosterone undecanoate was 90.9 (68.8) ng/dL on Day 4 following injection of Aveed. Testosterone undecanoate was nearly undetectable 42 days following injection of Aveed. Testosterone is metabolized to various 17-keto steroids through two different pathways. The major active metabolites of testosterone are estradiol and DHT. DHT concentrations increased in parallel with testosterone concentrations during Aveed treatment. Average DHT concentrations during a dosing interval ranged from 244 to 451 ng/dL. The mean DHT:T ratios ranged from 0.05 to 0.07. Excretion There is considerable variation in the half-life of testosterone as reported in the literature, ranging from 10 to 100 minutes. About 90% of a testosterone dose given intramuscularly is excreted in the urine as glucuronic and sulfuric acid-conjugates of testosterone or as metabolites. About 6% of a dose is excreted in the feces, mostly in the unconjugated form. Inactivation of testosterone occurs primarily in the liver. Effect of Body Weight and Body Mass Index (BMI) Analysis of serum testosterone concentrations from 117 hypogonadal men in the 84-week clinical study of Aveed indicated that serum testosterone concentrations achieved were inversely correlated with the patient s body weight. In 60 patients with pretreatment body weight of 100 kg, the mean ( SD) serum testosterone average concentration was 426 104 ng/dL. A higher serum testosterone average concentration (568 139 ng/dL) was observed in 57 patients weighing 65 to 100 kg. A similar trend was also observed for maximum serum testosterone concentrations. In 70 patients with pretreatment body mass index of >30 kg/m 2 , the mean ( SD) serum testosterone average concentration was 445 116 ng/dL. Higher serum testosterone average concentrations (579 101 ng/dL and 567 155ng/dL) were observed in patients with BMIs]} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy 3 CSA Schedule Moderate abuse potential Approval History Drug history at FDA WADA Class Anti-Doping Classification Manufacturer Endo Pharmaceuticals Inc. Drug Class Androgens and anabolic steroids Related Drugs androgens and anabolic steroids testosterone , AndroGel , Depo-Testosterone , Axiron , Androderm Hypogonadism, Male testosterone , AndroGel , Depo-Testosterone , Axiron , Androderm , Testim , HCG , Fortesta , Testopel , methyltestosterone , Pregnyl , Ovidrel , chorionic gonadotropin (hcg) , Novarel , Gonal-f , Delatestryl , Natesto , Android , Striant , Methitest , Halotestin , Follistim , Chorex , More... Aveed Rating 4 User Reviews 5.2 /10 4 User Reviews 5.2 Rate it!} } traditional


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you will likely Winter depression (or winter blues) is a common affliction for those who live in our northern climate. Its clinical name is seasonal affective disorder (SAD) and up to 5 percent of the population (especially in northern states) may suffer from it. Seasonal affective disorder is characterized by feelings of sadness and depression that occur in the fall or winter months when the temperatures being to drop and the days grow shorter. The depressive episode is often associated with excessive eating, sleeping, and weight gain. Depressive symptoms begin in the fall or winter and persist until the spring. Women are twice to three times more likely to suffer from the winter blues than men. Seasonal affective disorder can also impact people during the summer months ( the summer blues ), too, but it is less common. People suffering from SAD either are unable to function or function minimally during the season in which their disorder occurs. Seasonal affective disorder shares several symptoms with other forms of depression including lethargy, sadness, hopelessness, anxiety and social withdrawal. Strategies to Help Seasonal Affective Disorder There are many effective treatments for winter depression , some of which you can do to help yourself. Increasing your daily exposure to as much natural light as possible can be helpful to many. Any time that you have the opportunity to gain access to more sunlight in the winter months, you should try to do so. Taking a walk throughout the day (even if you don t normally do so), sitting next to a south-facing window at your office, in a classroom, or at home will increase your sunlight exposure. Exercising next to a window or outdoors (when possible) is another activity that can help. Although it may be difficult to do, maintaining your schedule and lifestyle will help to keep the depression at bay. A regular pattern of sleep is the most important thing to maintain. It may be helpful, for instance, to have your bedroom lights on a timer to turn on a half-hour before you wake. This may help in waking at a regular time every morning, when it is still dark outside in the winter months. Light therapy has shown to be an effective treatment for seasonal affective disorder. While you can purchase expensive, specialized light therapy lighting fixtures for your home or office, some inexpensive alternatives are also available. Another lighting technique to try is to replace commonly used light bulbs in your home with brighter full spectrum (also known as broad spectrum) light bulbs. While more expensive than regular light bulbs, these bulbs provide light that is similar to natural sunlight. You can learn more about effective treatments for seasonal affective disorder . If none of these techniques seem to help your depressive symptoms, you should consider consulting your family physician or a mental health professional. The winter blues are a form of depression and can be readily treated with medications or psychotherapy when other self-help methods aren t effective. Don t be afraid to talk about this condition with a professional, it s nothing to be ashamed or afraid of. With a little effort, the winter blues can be beaten. More Facts About Seasonal Affective Disorder SAD sufferers crave additional sleep, experience daytime drowsiness, and gain a good deal of weight, often feeling irresistible cravings for sweets. Four to six percent of the general population will experience SAD. Women are four times more likely than men to develop SAD. SAD is more common among the young (ages 20 to 50) with a general decrease in symptoms with age. Risk of the condition increases significantly with geographic residence, with increased prevalence at higher latitudes. For example, the incidence of SAD among people living in Florida is one percent, while those living in northern latitudes, such as Alaska or New Hampshire, have a rate of approximately 10 percent. In addition to light therapy, treatment for SAD may also include psychiatric medications, such as an antidepressant . Exercise and stress management also help to lessen the symptoms of SAD. Additional Articles on SAD Shedding Light on Winter Depression Are You SAD This Winter? Coping with Seasonal Affective Disorder 10 Things You Don t Know About Seasonal Affective Disorder Treatment of Seasonal Affective Disorder Additional online resources for SAD Read more about depression now Related Articles About John M. Grohol, Psy.D. Dr. John Grohol is the founder & CEO of Psych Central. He is also an author, researcher, and expert in mental health online, and has been writing about online behavior, mental health and psychology issues -- as well as the intersection of technology and human behavior -- since 1992. Dr. Grohol sits on the editorial board of the journal Computers in Human Behavior and is a founding board member and treasurer of the Society for Participatory Medicine. View all posts by John M. Grohol, Psy.D. Hot Topics Today 1 PTSD Patients Show Heightened Sensitivity to Deviant Sounds 2 Developing the Evidence Base for Mindfulness Therapies 3 Dominant Hand May Begin in Womb 4 5 Types of People Who Are Naturally Attracted to Each Other 5 What's a Narcissist's Punishment? Most Popular News PTSD Patients Show Heightened Sensitivity to Deviant Sounds Dominant Hand May Begin in Womb Developing the Evidence Base for Mindfulness Therapies Bipolar or Depression? Heart Test May Help Tell the Difference Avatar Therapy May Ease Schizophrenia Symptoms Join Over 195,000 Subscribers to Our Weekly Newsletter Find a Therapist Enter ZIP or postal code shots


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without delay Edecrin Generic Name: ethacrynic acid (eth a KRIN ik AS id) Brand Name: Edecrin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons What is Edecrin (ethacrynic acid)? Ethacrynic acid is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine. Ethacrynic acid is used to treat fluid retention (edema) in people with congestive heart failure, liver disease, or a kidney disorder such as nephrotic syndrome. Ethacrynic acid may also be used for purposes not listed in this medication guide. Slideshow Binge Eating Disorder: Beyond Overeating What is the most important information I should know about Edecrin (ethacrynic acid)? You should not use ethacrynic acid if you are unable to urinate, or if you have recently had severe watery diarrhea. What should I discuss with my healthcare provider before taking Edecrin (ethacrynic acid)? You should not use ethacrynic acid if you are allergic to it, or if: you are unable to urinate; or you have recently had severe watery diarrhea. To make sure ethacrynic acid is safe for you, tell your doctor if you have: cirrhosis or other liver disease; heart disease; an electrolyte imbalance (such as low levels of potassium or magnesium in your blood); kidney disease; gout; or if you are on a low-salt diet. Ethacrynic acid is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medicine. It is not known whether ethacrynic acid passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. Ethacrynic acid is not approved for use by anyone younger than 18 years old. How should I take Edecrin (ethacrynic acid)? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Take this medicine after a meal, unless your doctor tells you otherwise. Ethacrynic acid will make you urinate more often and you may get dehydrated easily. Follow your doctor's instructions about using potassium supplements or getting enough salt and potassium in your diet. While using ethacrynic acid, you may need frequent blood tests and weight checks. Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include dry mouth, increased thirst, mood changes, confusion, ringing in your ears, loss of appetite, vomiting, muscle pain or weakness, lack of energy, fast heartbeats, and little or no urination. What should I avoid while taking Edecrin (ethacrynic acid)? Avoid becoming dehydrated. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking ethacrynic acid. What are the possible side effects of Edecrin (ethacrynic acid) Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: weight loss; severe or watery diarrhea; hearing problems, feeling of fullness in your ear; severe weakness, muscle cramps, numbness or tingling; a light-headed feeling, like you might pass out; sudden numbness or weakness, problems with speech or balance, chest pain, coughing up blood; low potassium--leg cramps, constipation, irregular heartbeats, fluttering in your chest, increased thirst or urination, numbness or tingling, muscle weakness or limp feeling; or low sodium--headache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady. Common side effects may include: nausea, vomiting, diarrhea, or other stomach discomfort; trouble swallowing; loss of appetite; blurred vision; fever, chills; or headache, feeling tired. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Edecrin (ethacrynic acid)? Tell your doctor about all your current medicines and any you start or stop using, especially: digoxin, digitalis; lithium; blood pressure medications; an antibiotic (including those given through an IV); a blood thinner--warfarin, Coumadin, Jantoven; NSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others; or steroid medicine--prednisone, dexamethasone, and others. This list is not complete. Other drugs may interact with ethacrynic acid, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Next Side Effects Print this page Add to My Med List More about Edecrin (ethacrynic acid) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Generic Availability Drug class: loop diuretics Consumer resources Edecrin Edecrin (Advanced Reading) Other brands: Sodium Edecrin Professional resources Edecrin (FDA) Ethacrynic Acid (AHFS Monograph) Related treatment guides Ascites Edema Nonobstructive Oliguria Pulmonary Edema Renal Failure Where can I get more information? Your pharmacist can provide more information about ethacrynic acid. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 9.01. Date modified: December 03, 2017 Last reviewed: July 14, 2016 Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug 10 + years Approval History FDA approved 1967 WADA Class Anti-Doping Classification Manufacturer Valeant Pharmaceuticals International, Inc. Drug Class Loop diuretics Related Drugs Nonobstructive Oliguria furosemide , Lasix , torsemide , Demadex , dopamine , ethacrynic acid , More... Renal Failure furosemide , Lasix , torsemide , Demadex , ethacrynic acid , Sodium Edecrin , More... Ascites furosemide , Lasix , triamterene , torsemide , bumetanide , Bumex , More... Pulmonary Edema furosemide , Lasix , bumetanide , Bumex , ethacrynic acid , Sodium Edecrin , More... 1 more conditions... Edecrin Rating 1 User Review 8.0 /10 1 User Review 8.0 Rate it! Edecrin Images Edecrin 50 mg (EDECRIN MSD 90) View all images Help and Support Looking for answers? Ask a question or go join the Edecrin support group to connect with others who have similar interests. with your


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absolutely RotaTeq Generic Name: Rotavirus Oral Vaccine (ROE ta VI russ) Brand Name: RotaTeq Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Uses of RotaTeq: It is used to prevent very bad stomach problems caused by rotavirus infection. Slideshow Seasoned Pro: Be Mindful of These Winter Health Hazards What do I need to tell my doctor BEFORE I take RotaTeq? If your child is allergic to any drugs like this one or any other drugs, foods, or other substances. Tell the doctor about the allergy and what signs your child had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If your child has any of these health problems: Birth defect of the stomach or bowel (like Meckel diverticulum) that has not been fixed by surgery, loose stools (diarrhea) or is throwing up, or severe combined immunodeficiency disease (SCID). If your child has ever had a very bad type of bowel blockage or twisting (intussusception). This medicine may interact with other drugs or health problems. Tell the doctor and pharmacist about all of your child's drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for your child to take RotaTeq (rotavirus oral vaccine) with all of his/her drugs and health problems. Do not start, stop, or change the dose of any drug your child takes without checking with the doctor. What are some things I need to know or do while I take RotaTeq? For all patients taking this medicine: Tell all of your child's health care providers that your child is taking RotaTeq. This includes your child's doctors, nurses, pharmacists, and dentists. If your child has a latex allergy, talk with the doctor. This medicine may not protect all people who use it. Talk with the doctor. Tell the doctor if your child will be in close contact with people who have a weak immune system. This includes people with cancer, immune system problems, or who take drugs that weaken the immune system. There is a chance of spreading the vaccine virus to these people. If your child is pregnant or breast-feeding a baby: Tell the doctor if your child is pregnant or becomes pregnant. You will need to talk about the benefits and risks of your child using this drug while pregnant. Tell the doctor if your child is breast-feeding a baby. You will need to talk about any risks to the baby. How is this medicine (RotaTeq) best taken? Give this medicine as ordered by your child's doctor. Read all information given to you. Follow all instructions closely. It is given by mouth only. What do I do if I miss a dose? Call your child's doctor to find out what to do. Dosage Information (comprehensive) What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child's doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Wheezing or coughing. Ear pain. The chance of a very bad type of bowel blockage or twisting may be raised in infants and children after taking RotaTeq. Most of the time, this has happened within 7 days after the first dose. Sometimes, this can happen up to many weeks after the last dose. Call the doctor right away if your child has blood in the stools; high fever; or very bad loose stools (diarrhea), throwing up, or stomach pain. Rarely, a very bad health problem called Kawasaki disease has happened with this medicine. This health problem can affect the heart and can be deadly if left untreated. Call the doctor right away if your child has high fever, rash, red eyes or mouth, swollen glands, or swelling in the arms or legs. What are some other side effects of RotaTeq? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child's doctor or get medical help if any of these side effects or any other side effects bother your child or do not go away: Feeling fussy. Runny nose. Fever. Not hungry. Throwing up. Crying that is not normal. Loose stools (diarrhea). Sore throat. These are not all of the side effects that may occur. If you have questions about side effects, call your child's doctor. Call your child's doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out RotaTeq? If you need to store RotaTeq at home, talk with your child's doctor, nurse, or pharmacist about how to store it. Consumer Information Use and Disclaimer If your child's symptoms or health problems do not get better or if they become worse, call your child's doctor. Do not share your child's drug with others and do not give anyone else's drug to your child. Keep a list of all your child's drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your child's doctor. Talk with your child's doctor before giving your child any new drug, including prescription or OTC, natural products, or vitamins. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take RotaTeq or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to RotaTeq. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about RotaTeq (rotavirus vaccine) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: viral vaccines Consumer resources Rotateq RotaTeq (Advanced Reading) Other brands: Rotarix Professional resources Rotateq (FDA) Rotavirus Vaccine Live Oral (AHFS Monograph) Related treatment guides Gastroenteritis Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug RotaTeq Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Manufacturer Merck & Co., Inc. Drug Class Viral vaccines Related Drugs Gastroenteritis doxycycline , ceftriaxone , Rocephin , ampicillin , Vibramycin , Monodox , Doryx , Vibra-Tabs , Doryx MPC , Morgidox , Omnipen-N , Rotarix , Principen , rotavirus vaccine , More... worrying


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barely enough Immune Checkpoint Inhibitors: Boosting the Cancer Battle Medically reviewed on Sep 27, 2017 by L. Anderson, PharmD . Previous 1 of 17 Next View as slideshow What is Immunotherapy? You've probably heard about the new groundbreaking type of "immunotherapy" drugs used to treat and kill cancer. Immunotherapy has been the subject of numerous news articles and TV specials. Former President Jimmy Carter received one of these medications, Keytruda - fortunately with great success - for his skin cancer (also called melanoma) that had spread to his brain. These groundbreaking new treatments are adding months - or even years - to the lives of patients who have cancer. In fact, for some patients, their tumors seem to disappear. One cancer immunotherapy class is called the Immune Checkpoint Inhibitors, and they are making headlines in the medical world. Linked: Our Immune System and Cancer Our immune system is simply an amazing piece of human biology. The immune system helps to guard the body from infections due to bacteria, viruses, and yes, even cancer. This immune gatekeeper has a memory, too, and it can remember and 'recognize' when foreign invaders, such as cancer, attempt to inhabit our body. However, the immune system is not perfect in fighting these intruders, and researchers are making great progress to learn why. It appears some tumors can 'turn off' the ability of cancer-fighting cells such as T-cells (a type of white blood cell) to attack these unwelcome guests. But the new immunotherapy drug class called "Immune Checkpoint Inhibitors" is fighting back. Drugs in this group include agents such as Opdivo, Keytruda, Tecentriq, Bavencio and Imfinzi. What makes them so special? Cancer Types Targeted by Immunotherapy If you've been affected by cancer -- either yourself or a family member -- take time to learn more about these breakthrough treatments. Advances are being made in cancers such as metastatic melanoma (skin cancer that has spread) non-small cell lung cancer (NSCLC) renal cell carcinoma (kidney cancer) Hodgkin's lymphoma head and neck cancer bladder cancer liver cancer stomach cancer Many other types of cancer are also under research. While not every patient will have a response, it is important to investigate your alternatives with your doctor. Joining a groundbreaking research trial might even be an option. This could give you the opportunity to use an investigational medication that is not available otherwise. Immune Checkpoint Inhibitors: Releasing the Brakes The immune system needs to be able to tell the difference between foreign invaders and heathy tissue so that our needed cells and organs are not attacked. To do this, our immune system has a set of "brakes", like a bike, that can help it to stop and go. When the immune system "brakes" are "off", it attacks cells that are foreign invaders, like cancer. Our immune system is very good at this, but cancer is sneaky and can fool the "brakes" to stop. When the T-cell is stopped ("brakes" are on) it can't fight the cancer. However, this group of drugs known as Immune Checkpoint Inhibitors release the "brakes" so the T-cells can now "go" find and kill the cancer. Some of these checkpoints are called PD-1, PD-L1, and CTLA-4 receptors, which are protein receptors on cell surfaces. Drugs that target these checkpoints -- turning "off" the "brakes" -- hold great promise and are now used to fight cancer. FDA-Approved Immune Checkpoint Inhibitors Yervoy (ipilimumab) from Bristol Myers Squibb, targets CTLA-4 and is used for advanced melanoma (skin cancer) Keytruda (pembrolizumab) from Merck, targets PD-1 and is used for advanced melanoma, non-small cell lung cancer (NSCLC), Hodgkin's lymphoma, head and neck cancer, microsatellite instability-high cancer, and gastric cancer Opdivo (nivolumab) from Bristol-Myers Squibb, targets PD-1 and is used for advanced melanoma, advanced NSCLC, advanced renal cell cancer, bladder cancer, Hodgkin's Lymphoma, squamous cell carcinoma of the head and neck, liver cancer Tecentriq (atezolizumab) from Genentech, targets PD-L1 and is used for advanced bladder cancer and NSCLC Other recent approvals included Bavencio (avelumab) for Merkel cell carcinoma, a rare type of skin cancer and urothelial carcinoma (bladder cancer), and Imfinzi (durvalumab), also for bladder cancer. Quite often these drugs are used after traditional cancer treatment has failed, but as research advances they are increasingly gaining first-line indications. Yervoy (ipilimumab) Yervoy , known generically as ( ipilimumab ), is a monoclonal antibody that attaches to the T-lymphocyte antigen 4 (CTLA-4) protein receptor to inhibit CTLA-4. This releases the "brakes" and helps to activate our immune system to attack cancer. Melanoma is more likely to spread (metastasize) than other forms of skin cancer, and is increasing in incidence. Yervoy was the first immune checkpoint inhibitor to be FDA-approved in March of 2011 for the treatment of late-stage melanoma (skin cancer), and has since been approved to reduce the risk of melanoma returning after surgery. Yervoy is given by intravenous injection every 3 weeks or 12 weeks. Common reported side effects include rash, diarrhea, fatigue, itching, headache, nausea and weight loss. Severe immune-mediated side effects can also occur with Yervoy, which may result in the need for treatment discontinuation. Opdivo (nivolumab) Opdivo , known generically as nivolumab , is also an immune checkpoint inhibitor. However, Opdivo acts at a different receptor than Yervoy, and is known as a programmed death receptor-1 (PD-1) blocking antibody. Opdivo was first approved in December 2014 to treat advanced melanoma, but since then has been cleared by the FDA to also treat advanced lung cancer, advanced kidney cancer, bladder cancer, Hodgkin's lymphoma, squamous cell head and neck cancer, in combination with Yervoy for certain forms of melanoma (skin cancer) that has spread throughout the body, and hepatocellular carcinoma (liver cancer). Opdivo is given as an intravenous injection. Common side effects might include rash, itching, cough, upper respiratory tract infections, and fluid retention (edema). Severe immune-mediated side effects, a problem with all of these drugs, can occur. Keytruda (pembolizumab) Keytruda , generic name pembolizumab , might sound familiar to you. Approved in September, 2014, this was the immunotherapy successfully received by former President Jimmy Carter to fight off brain cancer due to metastatic melanoma (skin cancer that has spread). Like Opdivo, Keytruda is PD-1 blocking antibody. Keytruda is FDA-approved to treat: metastatic melanoma (including as a first-line agent) metastatic non-small cell lung cancer (NSCLC) first-line treatment of metastatic nonsquamous non-small cell lung cancer (NSCLC) irrespective of PD-L1 expression Hodgkin's lymphoma head and neck cancer microsatellite instability-high cancer gastric cancer Keytruda is also undergoing research for many other cancer types. Keytruda is given via intravenous (IV) infusion, with common side effects including edema (water retention) fatigue, itching, constipation, diarrhea, rash, and nausea. Infusion reactions with flu-like symptoms such as chills, fever, headache and weakness may occur, too, plus the immune mediated adverse reactions seen with other checkpoint inhibitors. Tecentriq (atezolizumab) Tecentriq , generic name atezolizumab was approved in May 2016 and was the first PD-1/PD-L1 inhibitor. Tecentriq is approved to treat the most common type of bladder cancer known as urothelial carcinoma. Tecentriq is also approved by the FDA for treatment of certain types of advanced non-small cell lung cancer (NSCLC). Like other checkpoint inhibitors, Tecentriq is given by an intravenous infusion. In studies, common side effects included fatigue, decreased appetite, nausea, urinary tract infection, fever, and constipation. Tencentriq also has the potential to cause infection and more serious, but less common, immune-mediated side effects that involve healthy organs, including the lungs, colon and endocrine system. Another PD-L1 blocker, Imfinzi (durvalumab) from AstraZeneca, was FDA-approved in May 2017 for the treatment of patients with advanced urothelial carcinoma (bladder cancer) who have ongoing disease despite use of platinum-containing chemotherapy with or without surgery. Bavencio (avelumab) Bavencio (avelumab), also a PD-L1 blocking antibody, received accelerated FDA-approval in March 2017 for the treatment of patients with metastatic Merkel cell carcinoma (MCC). Bavencio is the first FDA-approved treatment for metastatic MCC and is used in patients 12 years and older including those who have not received prior chemotherapy. MCC is rare form of skin cancer most common in older patients. It appears as painless pink, red, or purple bump, often on the face, head or neck area. Most patients can get the tumor removed surgically, but more than 30% will eventually develop disease recurrence. Approval of Bavencio was based on a study of 88 patients with metastatic MCC who had previously received chemotherapy. In 33% of patients, complete or partial shrinkage of their tumors occurred, with a response lasting for more than 12 months in 45% of patients. Common side effects include fatigue, muscle pain, diarrhea, nausea, infusion-related reactions, and rash, among others. In May 2017, Bavencio was given accelerated approval to treat urothelial carcinoma (bladder cancer), as well. Imfinzi (durvalumab) Imfinzi (durvalumab) was approved in May 2017 for the treatment of patients with advanced urothelial carcinoma (bladder cancer) who have disease progression despite use of platinum-containing chemotherapy with or without surgery. Imfinzi is an anti-PD-L1 in the same class of drugs as Tecentriq (atezolizumab) and Bavencio (avelumab). In clinical trials, Imfinzi had an objective response rate (ORR) of 17%, regardless of PD-L1 status, with an ORR of 26.3% in patients with PD-L1 high-expressing tumors. Among 31 patients who responded to treatment, 14 patients (45%) had ongoing responses of at least 6 months and 5 patients (16%) at least 12 months. Of all evaluable patients, 2.7% achieved complete response. How Well Do Checkpoint Inhibitors Work? Some, but not all people, can have a positive response with checkpoint inhibitors. How well they work for an individual patient will be based on many factors: the type of cancer, whether they express certain genetic markers on their tumors, their overall health at the time of treatment, previous treatments, and their ability to tolerate the side effects of the medication. In some patients, tumors have regressed and disappeared with checkpoint inhibitors. But this does not necessarily mean they are "cured", that the cancer won't return, or that everyone will respond. For example, of those people who received Keytruda in one clinical trial for melanoma, roughly 24 percent had their tumors shrink (partially or fully) lasting at least 1.4 to 8.5 months, and continued beyond this period in most patients. Unfortunately, this means that 76 percent of patients did not respond to the treatment. But this can be variable -- cancer treatment is very individual. It's important to discuss your expected treatment outcomes with your doctor. Other Types of Cancer Immunotherapy Research is very active in the area of cancer immunotherapy treatments. Immune checkpoint inhibitors are only one type of immunotherapy for treating cancer. Many other types of immunotherapy exist , some still under research in clinical trials and not yet approved: Monoclonal Antibodies Cancer Vaccines Cytokines Other monoclonal antibodies Oncolytic viruses Chimeric antigen receptor (CAR) T-cell therapy Is An Oral Checkpoint Inhibitor On the Horizon? Although research is early, in June 2016, Curis Inc. submitted an investigational new drug (IND) application to the FDA for CA-170, the first orally available immune checkpoint inhibitor designed to selectively target and inhibit both PD-L1 and VISTA (V-domain Immunoglobulin Suppressor of T-cell Activation) checkpoint regulators of immune activation. CA-170 is called a PD-L1/VISTA antagonist. Additional details of the trial can be found at www.clinicaltrials.gov (NCT02812875). Currently, all checkpoint inhibitors are monoclonal antibodies that require intravenous (IV) infusion. However, CA-170 is being developed as an oral medication that could be used alone or in combination with other cancer treatments. Early toxicology studies show it to be safe when given in a once-daily oral dosing regimen. Curis is currently investigating CA-170 in a Phase 1 trial in patients with advanced solid tumors and lymphomas . Combining Checkpoint Inhibitors Metastatic melanoma is particularly aggressive, and the use of dual immune checkpoint inhibition is a novel approach to treat cancer. Opdivo and Yervoy are immune checkpoint inhibitors that target different but complementary checkpoint pathways (PD-1 and CTLA-4). Future research will focus on combining many of these treatments. Research is also looking at the possibility of combining CAR T cell therapy with checkpoint inhibition to extend the activity of CAR T cell. In January 2016, the combined use of Opdivo and Yervoy was FDA-approved for unresectable (can't be removed with surgery) or metastatic (spreading in the body) melanoma regardless of BRAF (genetic) mutational status . The Phase III study, known as the CheckMate-067 , was the first study to show the success of combining two immunotherapies. In the study, the Opdivo + Yervoy regimen prolonged progression-free survival (PFS; survival time without the melanoma worsening) by a median of 11.5 months. Opdivo used alone (monotherapy) could prolong PFS by a median of 6.9 months, with 2.9 months for Yervoy used alone. A complete response (cancer undetectable) was seen in 8.9% of patients receiving the combined regimen. Rare safety issues with the combined use of Opdivo + Yervoy, such as serious heart side effects, were reported in Nov. 2016: sudden cardiac arrest and rapid heartbeat with organ failure were fatal. How Can I Learn More About Immunotherapy Clinical Trials? Your doctor might recommend that you consider enrollment is one of the many ongoing clinical trials evaluating immunotherapy. Or maybe you want to look for one yourself? This might give you the ability to receive a medication that you could not otherwise obtain. It's important to talk to your health care providers about the risks and benefits of clinical trials and if it might be a possibility. However, joining a clinical trial is not the right choice for everyone. To learn more about available clinical trials, you can look at the National Cancer Institute's (NCI) Clinical Trial Finder on their website. Here you can search by cancer type, zip code, and even age to help further define which trials might be right for you. Your doctor might be able to recommend other clinical trials, too. Cancer Is Smart. But We Are Smarter. Cancer is very clever. It can learn how to evade the natural systems we have in our bodies that are there to protect us. It can set up shop from head to toe and try to evade detection. But over many years, researchers have toiled to learn about the immune system and how it's linked to cancer. Now this hard work is paying off. Newer cancer treatments with fewer side effects and easier dosing regimens are extending survival time for some patients. But more work needs to be done, and initiatives like the Cancer Moonshot led by former Vice President Joe Biden can boost this worldwide battle. To stay up-to-date with the latest news and approvals for cancer immunotherapy, consider joining the Drugs.com Cancer Support Group and join individual groups that discuss new immunotherapies like Keytruda or Opdivo. Ask questions , lend support, and raise awareness to those who may have similar cancer concerns as yours. Finished: Immune Checkpoint Inhibitors: Boosting the Cancer Battle NEXT UP The Ferocity of Chemotherapy - Does The End Justify The Means? Chemotherapy and cancer - you rarely say one without the other. But today, new therapies are making great strides against cancer, and dealing with the side effects of treatments is DON'T MISS Seasonal Allergies: Top Prevention Tips Here, review how to safely pick the allergy medicine that may be right for you. View all slides as one page Print this page Sources Opdivo Prescription Labeling. Bristol-Myers Squibb. Accessed March 23, 2017 at http://packageinserts.bms.com/pi/pi_opdivo.pdf Merck s Keytruda (pembrolizumab) demonstrates superior progression-free and overall survival compared to chemotherapy as first line treatment in patients with advanced non-small cell lung cancer. [Press release.] Accessed March 23, 2017 at http://www.mercknewsroom.com/news-release/oncology-newsroom/mercks-keytruda%C2%A0pembrolizumab-demonstrates-superior-progression-free- Gadgeel SM, Stevenson J, Langer C, et al. Pembrolizumab (pembro) plus chemotherapy as front-line therapy for advanced NSCLC: KEYNOTE-021 cohorts A-C. J Clin Oncol 34, 2016 (suppl; abstr 9016). Curis Announces FDA Acceptance of Investigational New Drug Application for CA-170, the First Orally Available Small Molecule to Target and Inhibit Immune Checkpoints. Drugs.com June 1, 2016. Accessed March 23, 2017 at https://www.drugs.com/clinical_trials/curis-announces-fda-acceptance-investigational-new-application-ca-170-first-orally-available-small-17108.html Opdivo (nivolumab) FDA Approved for the Treatment of Hodgkin Lymphoma. Drugs.com. May 17, 2016. Accessed March 23, 2017 at https://www.drugs.com/newdrugs/opdivo-nivolumab-fda-approved-hodgkin-lymphoma-4383.html Curis Inc. Pipeline. CA-170: Oral, small molecule, PD-L1/VISTA Antagonist. Accessed March 23, 2017 at http://www.curis.com/pipeline/pipeline-overview. West H. Immune Checkpoint Inhibitors. JAMA Oncol. 2015;1(1):115. doi:10.1001/jamaoncol.2015.0137. Accessed March 23, 2017 at http://oncology.jamanetwork.com/article.aspx?articleid=2174768 Centerwatch. Tecentriq. Accessed March 23, 2017 at http://www.centerwatch.com/drug-information/fda-approved-drugs/drug/100149/tecentriq-atezolizumab Shoustari A, et al. Principles of Cancer Immunotherapy. UpToDate.com Updated Nov. 2, 2015. Accessed November 11, 2016 at http://www.uptodate.com. MD Anderson Cancer Center. News Release. 9/25/2015. Breakthrough study demonstrates survival advantage with immune checkpoint inhibitor for advanced kidney cancer patients. Accessed March 23, 2017 at https://www.mdanderson.org/newsroom/2015/09/breakthrough-study-demonstrates-survival-advantage-with-immune-c.html American Cancer Society. Cancer Immunotherapy. Accessed March 23, 2017 at http://www.cancer.org/treatment/treatmentsandsideeffects/treatmenttypes/immunotherapy/immunotherapy-what-is-immunotherapy The Parker Institute for Cancer Immunotherapy. One technology to treat all cancers. Accessed March 23, 2017 at http://www.parkerici.org/cancer-immunotherapy ClinicalTrials.gov. U.S. National Institutes of Health. Accessed March 23, 2017 at https://clinicaltrials.gov/ct2/show/NCT02142738 Merck. Research Pipeline. http://www.merck.com/research/pipeline/pipeline-standalone-research.html. Accessed March 23, 2017 Yervoy (ipilimumab). Revised 10/2015. Accessed March 23, 2017 at http://packageinserts.bms.com/pi/pi_yervoy.pdf} FDA Consumer Updates Depression: FDA-Approved Medications May Help Dealing with ADHD: What You Need to Know Making Decisions for Your Health: Getting the Info You Need FDA: Cutting-Edge Technology Sheds Light on Antibiotic Resistance More FDA updates} } recognized


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an excellent Coricidin HBP Cough/Cold Generic Name: Dextromethorphan and Chlorpheniramine Tablets (deks troe meth OR fan & klor fen IR a meen) Brand Name: Coricidin HBP Cough/Cold, QC Cough/Cold Overview Side Effects Dosage Interactions Reviews More Drug Images Support Group Q & A Pricing & Coupons Uses of Coricidin HBP Cough/Cold: It is used to ease allergy signs. It is used to relieve coughing. Slideshow OTC Medication Use In Pregnancy: Wise or Worrisome? What do I need to tell my doctor BEFORE I take Coricidin HBP Cough/Cold? If you have an allergy to dextromethorphan, chlorpheniramine, or any other part of Coricidin HBP Cough/Cold (dextromethorphan and chlorpheniramine tablets). If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking this medicine within 14 days of those drugs can cause very bad high blood pressure. If you have a cough with a lot of mucous. If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema. This is not a list of all drugs or health problems that interact with Coricidin HBP Cough/Cold. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Coricidin HBP Cough/Cold? Tell all of your health care providers that you take Coricidin HBP Cough/Cold. This includes your doctors, nurses, pharmacists, and dentists. Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects. Do not take this medicine for longer than you were told by your doctor. Avoid driving and doing other tasks or actions that call for you to be alert until you see how Coricidin HBP Cough/Cold affects you. Avoid drinking alcohol while taking this medicine. Talk with your doctor before you use other drugs and natural products that slow your actions. Use with care in children. Talk with the doctor. Do not use to make a child sleepy. Talk with the doctor. Different brands of Coricidin HBP Cough/Cold may have different doses for children. Talk with the doctor before giving this medicine to a child. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Coricidin HBP Cough/Cold while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Coricidin HBP Cough/Cold) best taken? Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take with or without food. Take with food if it causes an upset stomach. What do I do if I miss a dose? If you take Coricidin HBP Cough/Cold on a regular basis, take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times this medicine is taken on an as needed basis. Do not take more often than told by the doctor. Dosage Information (comprehensive) What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. What are some other side effects of Coricidin HBP Cough/Cold? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Feeling sleepy. Feeling nervous and excitable. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Coricidin HBP Cough/Cold? Store at room temperature. Protect from light. Store in a dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Coricidin HBP Cough/Cold (dextromethorphan and chlorpheniramine tablets), please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Coricidin HBP Cough/Cold. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Coricidin HBP Cough/Cold. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about Coricidin HBP Cough & Cold (chlorpheniramine / dextromethorphan) Side Effects Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 5 Reviews Add your own review/rating Drug class: upper respiratory combinations Consumer resources Coricidin HBP Cough & Cold Other brands: Dimetapp Children's Long Acting Cough Plus Cold , QC Cough/Cold , Robitussin Children's Cough & Cold Long-Acting , Scot-Tussin DM , ... +4 more Related treatment guides Cough and Nasal Congestion Drug Status OTC Availability Over the counter C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Coricidin HBP Cough & Cold Rating 5 User Reviews 4.0 /10 5 User Reviews 4.0 Rate it! Drug Class Upper respiratory combinations Related Drugs Cough and Nasal Congestion Promethazine VC with Codeine , Bromfed DM , Mucinex D , Vanacof , Deconex , codeine / phenylephrine / promethazine , Resperal-DM , Vicks NyQuil Severe Cold & Flu , Vicks Nyquil Cough , Deconex DMX , Crantex , Robitussin Allergy & Cough , Tussin CF , Dimetapp Children's Cold & Cough , Robitussin Nighttime Cough DM , Mucinex Fast-Max Severe Congestion & Cough , Relasin-HC , Tusnel , More... Coricidin HBP Cough & Cold Images Coricidin HBP Cough & Cold chlorpheniramine maleate 4 mg / dextromethorphan hydrobromide 30 mg (C C+C ) View larger images thrust back


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there is not Coricidin HBP Cough & Cold Generic Name: chlorpheniramine and dextromethorphan (klor feh NEER a meen and DEX troe meh THOR fan) Brand Name: Children's NyQuil Cold & Cough, Coricidin HBP Cough & Cold, Dimetapp Long Acting Cough Plus Cold, Robitussin Pediatric Cough & Cold Long-Acting, Triaminic Cough & Runny Nose, Tricodene Sugar Free Overview Side Effects Dosage Interactions Reviews More Drug Images Support Group Q & A Pricing & Coupons What is Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Chlorpheniramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Dextromethorphan is a cough suppressant. It affects the signals in the brain that trigger cough reflex. Chlorpheniramine and dextromethorphan is a combination medicine used to treat sneezing, runny nose, watery eyes, hives, skin rash, itching, and cough caused by allergies, the common cold, or the flu. Dextromethorphan will not treat a cough that is caused by smoking, asthma, or emphysema. Chlorpheniramine and dextromethorphan may also be used for purposes not listed in this medication guide. Slideshow Over the Counter Cold Remedies - Which One is Right For You? What is the most important information I should know about Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. What should I discuss with my healthcare provider before taking Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially: asthma or COPD, cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis; a blockage in your stomach or intestines; glaucoma; kidney disease; liver disease; diabetes; heart disease or high blood pressure; a thyroid disorder; cough with mucus, or cough caused by emphysema or chronic bronchitis; enlarged prostate or urination problems; or if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K). It is not known whether chlorpheniramine and dextromethorphan will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant. This medication may pass into breast milk and may harm a nursing baby. Antihistamines may also slow breast milk production. Do not use this medicine without your doctor's advice if you are breast-feeding a baby. Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU). How should I take Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cough or cold medicine is usually taken only for a short time until your symptoms clear up. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Measure liquid medicine with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. The chewable tablet must be chewed before you swallow it. Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze. What happens if I miss a dose? Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Ask a doctor or pharmacist before using any other cold, allergy, or sleep medication. Chlorpheniramine and dextromethorphan are contained in many combination medicines. Taking certain products together can cause you to get too much of a certain medicine. Check the label to see if a medicine contains an antihistamine or cough suppressant (antitussive). This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. Drinking alcohol can increase certain side effects of chlorpheniramine. Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: fast, slow, or uneven heart rate; severe dizziness or anxiety, feeling like you might pass out; mood changes, severe headache; fever; tremor, seizure (convulsions); little or no urinating; or easy bruising or bleeding, unusual weakness. Common side effects may include: mild dizziness, drowsiness; dry mouth, nose, or throat; constipation, diarrhea; blurred vision; or feeling nervous, restless, or irritable. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Coricidin HBP Cough & Cold (chlorpheniramine and dextromethorphan)? Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide. Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking chlorpheniramine and dextromethorphan with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Next Side Effects Print this page Add to My Med List More about Coricidin HBP Cough & Cold (chlorpheniramine / dextromethorphan) Side Effects Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 5 Reviews Add your own review/rating Drug class: upper respiratory combinations Consumer resources Coricidin HBP Cough/Cold Other brands: Dimetapp Children's Long Acting Cough Plus Cold , QC Cough/Cold , Robitussin Children's Cough & Cold Long-Acting , Scot-Tussin DM , ... +4 more Related treatment guides Cough and Nasal Congestion Where can I get more information? Your pharmacist can provide more information about chlorpheniramine and dextromethorphan. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 5.09. Date modified: December 03, 2017 Last reviewed: July 01, 2013} Drug Status OTC Availability Over the counter C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Upper respiratory combinations Related Drugs Cough and Nasal Congestion Promethazine VC with Codeine , Bromfed DM , Mucinex D , Vanacof , Deconex , codeine / phenylephrine / promethazine , Vicks NyQuil Severe Cold & Flu , Resperal-DM , Vicks Nyquil Cough , Deconex DMX , Crantex , Robitussin Allergy & Cough , Tussin CF , Mucinex Fast-Max Severe Congestion & Cough , Relasin-HC , Dimetapp Children's Cold & Cough , Robitussin Nighttime Cough DM , Tusnel , More... Coricidin HBP Cough & Cold Rating 5 User Reviews 4.0 /10 5 User Reviews 4.0 Rate it! Coricidin HBP Cough & Cold Images Coricidin HBP Cough & Cold chlorpheniramine maleate 4 mg / dextromethorphan hydrobromide 30 mg (C C+C ) View larger images Related Questions & Answers Coricidin HBP Cough/Cold - what happens if you take to many? Coricidin HBP Cough/Cold - Walmart in Grand Junction, CO says they can't get this medication? Addicted to Coricidin HBP Cough/Cold, trying to quit & have bloating & face puffiness, anyone else? Coricidin HBP Cough/Cold - By any chance can you overdose on CC? Read more questions} } newcomers


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pricey Aveeno Generic Name: topical emollients (TOP i kal ee MOL i ents) Brand Name: AlphaSoft, Aquaphor, Aveeno, Baby Lotion, Baby Oil, Bag Balm, Blistex Lip Balm, Carmex, CeraVe, Cetaphil Lotion, Chap Stick, Corn Huskers Lotion, Curel Moisture Lotion, Eucerin, Gold Bond Ultimate Healing, Keri Lotion, K-Y Jelly, Lubriderm, Mederma, Moisturel, Natural Ice, Neutrogena Lotion, Nivea, Nutraderm, Pacquin, Phisoderm, Pretty Feet & Hands, Replens, Soft Sense, St. Ives, Vaseline Intensive Care Overview Side Effects Reviews Q & A More What are Aveeno (topical emollients)? Emollients are substances that moisten and soften your skin. Topical (for the skin) emollients are used to treat or prevent dry skin. Topical emollients are sometimes contained in products that also treat acne, chapped lips, diaper rash, cold sores, or other minor skin irritation. There are many brands and forms of topical emollients available and not all are listed on this leaflet. Topical emollients may also be used for purposes not listed in this medication guide. Slideshow Seasoned Pro: Be Mindful of These Winter Health Hazards What is the most important information I should know about Aveeno (topical emollients)? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before using Aveeno (topical emollients)? You should not use a topical emollient if you are allergic to it. Topical emollients will not treat or prevent a skin infection. Ask a doctor or pharmacist if it is safe for you to use this medicine if you have: deep wounds or open sores; swelling, warmth, redness, oozing, or bleeding; large areas of skin irritation; any type of allergy; or if you are pregnant or breast-feeding. How should I use Aveeno (topical emollients)? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Clean the skin where you will apply the topical emollient. It may help to apply this product when your skin is wet or damp. Follow directions on the product label. Shake the product container if recommended on the label. Apply a small amount of topical emollient to the affected area and rub in gently. If you are using a stick, pad, or soap form of topical emollient, follow directions for use on the product label. Do not use this product over large area of skin. Do not apply a topical emollient to a deep puncture wound or severe burn without medical advice. If your skin appears white or gray and feels soggy, you may be applying too much topical emollient or using it too often. Some forms of topical emollient may be flammable and should not be used near high heat or open flame, or applied while you are smoking. Store as directed away from moisture, heat, and light. Keep the bottle, tube, or other container tightly closed when not in use. What happens if I miss a dose? Since this product is used as needed, it does not have a daily dosing schedule. Seek medical advice if your condition does not improve after using a topical emollient. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Aveeno (topical emollients)? Avoid getting topical emollients in your eyes, nose, or mouth. If this does happen, rinse with water. Avoid exposure to sunlight or tanning beds. Some topical emollients can make your skin more sensitive to sunlight or UV rays. Aveeno (topical emollients) side effects Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using the topical emollient and call your doctor if you have severe burning, stinging, redness, or irritation where the product was applied. Less serious side effects are more likely, and you may have none at all. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Aveeno (topical emollients)? It is not likely that other drugs you take orally or inject will have an effect on topically applied emollients. But many drugs can interact with each other. Tell each of your health care providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products. Next Side Effects Print this page Add to My Med List More about Aveeno (emollients topical) Side Effects Support Group En Español 2 Reviews Add your own review/rating Drug class: topical emollients Consumer resources Other brands: Eucerin , Aquaphor , CeraVe , Cetaphil Lotion , ... +59 more Other Formulations Aveeno Anti-Itch Aveeno Daily Moisturizing Related treatment guides Dry Skin Where can I get more information? Your pharmacist can provide more information about topical emollients. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 4.02. Last reviewed: December 10, 2013 Date modified: December 03, 2017 Drug Status Rx OTC Availability Rx and/or OTC N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Manufacturer Johnson & Johnson Drug Class Topical emollients Related Drugs Dry Skin Lac-Hydrin , Eucerin , ammonium lactate topical , AmLactin , Aquaphor , urea topical , CeraVe , Cetaphil Lotion , lanolin topical , Carmol , EpiCeram , Laclotion , Biafine , Replens , Latrix , Emulsion SB , Lubriderm , HylatopicPlus , Mederma , More... Aveeno Rating 2 User Reviews 4.5 /10 2 User Reviews 4.5 Rate it! Related Questions & Answers Aveeno Anti-Itch - what happens if baby swallowed aveeno soothing diaper rash cream? After having used Vectical Ointment for psoriasis for about a month or so, I experienced a facial? Is aveeno anti itch cream may apply to one year old child? Opdivo - How to treat severe itching all over the body? Nivolumab - has anyone got a rash from opdivo and what if anything helps with it? Read more questions you may want


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Photo :DSM-IV Diagnostic Codes
song These are the diagnostic codes used by the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV). They are for personal or research use only, and we provide them here for educational purposes only. Miscellaneous Adjustment Disorders Alcohol Amphetamine Attention-Deficit/Hyperactivity Disorder Bipolar I Disorder (depressed) Bipolar I Disorder (manic) Bipolar I Disorder (mixed) Bipolar I Disorder (single) Caffeine Cannabis Cocaine Dementia of the Alzheimer s Type (early onset) Dementia of the Alzheimer s Type (late onset) Factitious Disorder Gender Identity Disorder Hallucinogen Inhalant Major Depressive Disorder (recurrent) Major Depressive Disorder (single episode) Medication-Induced Neuroleptic-Induced Nicotine Opioid Other/Unknown Substance Pain Disorder Panic Disorder Phencyclidine Psychotic Disorder Schizophrenia Sedative, Hypnotic, or Anxiolytic Sleep Disorder Vascular Dementia Miscellaneous NOS = Not Otherwise Specified. V62.3 Academic Problem V62.4 Acculturation Problem 308.3 Acute Stress Disorder Adjustment Disorders 309.9 Unspecified 309.24 With Anxiety 309.0 With Depressed Mood 309.3 With Disturbance of Conduct 309.28 With Mixed Anxiety and Depressed Mood 309.4 With Mixed Disturbance of Emotions and Conduct V71.01 Adult Antisocial Behavior 995.2 Adverse Effects of Medication NOS 780.9 Age-Related Cognitive Decline 300.22 Agoraphobia Without History of Panic Disorder Alcohol 305.00 Abuse 303.90 Dependence 291.8 -Induced Anxiety Disorder 291.8 -Induced Mood Disorder 291.1 -Induced Persisting Amnestic Disorder 291.2 -Induced Persisting Dementia 291.5 -Induced Psychotic Disorder, With Delusions 291.3 -Induced Psychotic Disorder, With Hallucinations 291.8 -Induced Sexual Dysfunction 291.8 -Induced Sleep Disorder 303.00 Intoxication 291.0 Intoxication Delirium 291.9 -Related Disorder NOS 291.8 Withdrawal 291.0 Withdrawal Delirium 294.0 Amnestic Disorder Due to [Indicate the General Medical Condition] 294.8 Amnestic Disorder NOS Amphetamine (or Amphetamine-Like) 305.70 Abuse 304.40 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 -Induced Sexual Dysfunction 292.89 -Induced Sleep Disorder 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 292.0 Withdrawal 307.1 Anorexia Nervosa 301.7 Antisocial Personality Disorder 293.89 Anxiety Disorder Due to [Indicate the General Medical Condition] 300.00 Anxiety Disorder NOS 299.80 Asperger s Disorder Attention-Deficit/Hyperactivity Disorder 314.01 Combined Type 314.01 Predominantly Hyperactive-Impulsive Type 314.00 Predominantly Inattentive Type 314.9 Attention-Deficit/Hyperactivity Disorder NOS 299.00 Autistic Disorder 301.82 Avoidant Personality Disorder V62.82 Bereavement 296.80 Bipolar Disorder NOS Bipolar Disorders Bipolar I Disorder, Most Recent Episode Depressed 296.56 In Full Remission 296.55 In Partial Remission 296.51 Mild 296.52 Moderate 296.53 Severe Without Psychotic Features 296.54 Severe With Psychotic Features 296.50 Unspecified 296.40 Bipolar I Disorder, Most Recent Episode Hypomanic Bipolar I Disorder, Most Recent Episode Manic 296.46 In Full Remission 296.45 In Partial Remission 296.41 Mild 296.42 Moderate 296.43 Severe Without Psychotic Features 296.44 Severe With Psychotic Features 296.40 Unspecified Bipolar I Disorder, Most Recent Episode Mixed 296.66 In Full Remission 296.65 In Partial Remission 296.61 Mild 296.62 Moderate 296.63 Severe Without Psychotic Features 296.64 Severe With Psychotic Features 296.60 Unspecified 296.7 Bipolar I Disorder, Most Recent Episode Unspecified Bipolar I Disorder, Single Manic Episode 296.06 In Full Remission 296.05 In Partial Remission 296.01 Mild 296.02 Moderate 296.03 Severe Without Psychotic Features 296.04 Severe With Psychotic Features 296.00 Unspecified 296.89 Bipolar II Disorder 300.7 Body Dysmorphic Disorder V62.89 Borderline Intellectual Functioning 301.83 Borderline Personality Disorder 780.59 Breathing-Related Sleep Disorder 298.8 Brief Psychotic Disorder 307.51 Bulimia Nervosa Caffeine 292.89 -Induced Anxiety Disorder 292.89 -Induced Sleep Disorder 305.90 Intoxication 292.9 -Related Disorder NOS Cannabis 305.20 Abuse 304.30 Dependence 292.89 -Induced Anxiety Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 293.89 Catatonic Disorder Due to [Indicate the General Medical Condition] 299.10 Childhood Disintegrative Disorder V71.02 Child or Adolescent Antisocial Behavior 307.22 Chronic Motor or Vocal Tic Disorder 307.45 Circadian Rhythm Sleep Disorder Cocaine 305.60 Abuse 304.20 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 -Induced Sexual Dysfunction 292.89 -Induced Sleep Disorder 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 292.0 Withdrawal 294.9 Cognitive Disorder NOS 307.9 Communication Disorder NOS 312.8 Conduct Disorder 300.11 Conversion Disorder 301.13 Cyclothymic Disorder 293.0 Delirium Due to [Indicate the General Medical Condition] 780.09 Delirium NOS 297.1 Delusional Disorder 290.10 Dementia Due to Creutzfeldt-Jakob Disease 294.1 Dementia Due to Head Trauma 294.9 Dementia Due to HIV Disease 294.1 Dementia Due to Huntington s Disease 294.1 Dementia Due to Parkinson s Disease 290.10 Dementia Due to Pick s Disease 294.1 Dementia Due to [Indicate Other General Medical Condition] 294.8 Dementia NOS Dementia of the Alzheimer s Type, With Early Onset 290.10 Uncomplicated 290.11 With Delirium 290.12 With Delusions 290.13 With Depressed Mood Dementia of the Alzheimer s Type, With Late Onset 290.0 Uncomplicated 290.3 With Delirium 290.20 With Delusions 290.21 With Depressed Mood 301.6 Dependent Personality Disorder 300.6 Depersonalization Disorder 311 Depressive Disorder NOS 315.4 Developmental Coordination Disorder 799.9 Diagnosis Deferred on Axis II 799.9 Diagnosis or Condition Deferred on Axis I 313.9 Disorder of Infancy, Childhood, or Adolescence NOS 315.2 Disorder of Written Expression 312.9 Disruptive Behavior Disorder NOS 300.12 Dissociative Amnesia 300.15 Dissociative Disorder NOS 300.13 Dissociative Fugue 300.14 Dissociative Identity Disorder 302.76 Dyspareunia (Not Due to a General Medical Condition) 307.47 Dyssomnia NOS 300.4 Dysthymic Disorder Eating Disorders 307.50 Eating Disorder NOS 787.6 Encopresis, With Constipation and Overflow Incontinence 307.7 Encopresis, Without Constipation and Overflow Incontinence 307.6 Enuresis (Not Due to a General Medical Condition) 302.4 Exhibitionism 315.31 Expressive Language Disorder Factitious Disorder 300.19 With Combined Psychological and Physical Signs and Symptoms 300.19 With Predominantly Physical Signs and Symptoms 300.16 With Predominantly Psychological Signs and Symptoms 300.19 Factitious Disorder NOS 307.59 Feeding Disorder of Infancy or Early Childhood 625.0 Female Dyspareunia Due to [Indicate the General Medical Condition] 625.8 Female Hypoactive Sexual Desire Disorder Due to [Indicate the General edical Condition] 302.73 Female Orgasmic Disorder 302.72 Female Sexual Arousal Disorder 302.81 Fetishism 302.89 Frotteurism Gender Identity Disorder 302.85 in Adolescents or Adults 302.6 in Children 302.6 Gender Identity Disorder NOS Anxiety Disorders 300.02 Generalized Anxiety Disorder Hallucinogen 305.30 Abuse 304.50 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 Intoxication 292.81 Intoxication Delirium 292.89 Persisting Perception Disorder 292.9 -Related Disorder NOS 301.50 Histrionic Personality Disorder 307.44 Hypersomnia related to [Indicate the Axis I or Axis II Disorder] 302.71 Hypoactive Sexual Desire Disorder 300.7 Hypochondriasis 313.82 Identity Problem 312.30 Impulse-Control Disorder NOS Inhalant 305.90 Abuse 304.60 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.82 -Induced Persisting Dementia 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 307.42 Insomnia Related to [Indicate the Axis I or Axis II Disorder] 312.34 Intermittent Explosive Disorder 312.32 Kleptomania 315.9 Learning Disorder NOS Major Depressive Disorder Major Depressive Disorder, Recurrent 296.36 In Full Remission 296.35 In Partial Remission 296.31 Mild 296.32 Moderate 296.33 Severe Without Psychotic Features 296.34 Severe With Psychotic Features 296.30 Unspecified Major Depressive Disorder, Single Episode 296.26 In Full Remission 296.25 In Partial Remission 296 21 Mild 296.22 Moderate 296.23 Severe Without Psychotic Features 296.24 Severe With Psychotic Features 296.20 Unspecified 608.89 Male Dyspareunia Due to [Indicate the General Medical Condition] 302.72 Male Erectile Disorder 607.84 Male Erectile Disorder Due to [Indicate the General Medical Condition] 608.89 Male Hypoactive Sexual Desire Disorder Due to [Indicate the General Medical Condition] 302.74 Male Orgasmic Disorder V65.2 Malingering 315.1 Mathematics Disorder Medication-Induced 333.90 Movement Disorder NOS 333.1 Postural Tremor 293.9 Mental Disorder NOS Due to [Indicate the General Medical Condition] 319 Mental Retardation, Severity Unspecified 317 Mild Mental Retardation 315.31 Mixed Receptive-Expressive Language Disorder 318.0 Moderate Mental Retardation 293.83 Mood Disorder Due to [Indicate the General Medical Condition] 296.90 Mood Disorder NOS 301.81 Narcissistic Personality Disorder 347 Narcolepsy V61.21 Neglect of Child 995.5 Neglect of Child (if focus of attention is on victim) Neuroleptic-Induced 333.99 Acute Akathisia 333.7 Acute Dystonia 332.1 Parkinsonism 333.82 Tardive Dyskinesia 333.92 Neuroleptic Malignant Syndrome Nicotine 305.10 Dependence 292.9 -Related Disorder NOS 292.0 Withdrawal 307.47 Nightmare Disorder V71.09 No Diagnosis on Axis II V71.09 No Diagnosis or Condition on Axis I V15.81 Noncompliance With Treatment 300.3 Obsessive-Compulsive Disorder 301.4 Obsessive-Compulsive Personality Disorder V62.2 Occupational Problem Opioid 305.50 Abuse 304.00 Dependence 292.84 -Induced Mood Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 -Induced Sexual Dysfunction 292.89 -Induced Sleep Disorder 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 292.0 Withdrawal 313.81 Oppositional Defiant Disorder 625.8 Other Female Sexual Dysfunction Due to [Indicate the General Medical Condition] 608.89 Other Male Sexual Dysfunction Due to [Indicate the General Medical Condition] Other (or Unknown) Substance 305.90 Abuse 304.90 Dependence 292.89 -Induced Anxiety Disorder 292.81 -Induced Delirium 292.84 -Induced Mood Disorder 292.83 -Induced Persisting Amnestic Disorder 292.82 -Induced Persisting Dementia 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 -Induced Sexual Dysfunction 292.89 -Induced Sleep Disorder 292.89 Intoxication 292.9 -Related Disorder NOS 292.0 Withdrawal Pain Disorder 307.89 Associated With Both Psychological Factors and a General Medical Condition 307.80 Associated With Psychological Factors Panic Disorder 300.21 With Agoraphobia 300.01 Without Agoraphobia 301.0 Paranoid Personality Disorder 302.9 Paraphilia NOS 307.47 Parasomnia NOS V61.20 Parent-Child Relational Problem V61.1 Partner Relational Problem 312.31 Pathological Gambling 302.2 Pedophilia 310.1 Personality Change Due to [Indicate the General Medical Condition] 301.9 Personality Disorder NOS 299.80 Pervasive Developmental Disorder NOS V62.89 Phase of Life Problem Phencyclidine (or Phencyclidine-Like) 305.90 Abuse 304.90 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 315.39 Phonological Disorder V61.1 Physical Abuse of Adult 995.81 Physical Abuse of Adult (if focus of attention is on victim) V61.21 Physical Abuse of Child 995.5 Physical Abuse of Child (if focus of attention is on victim) 307.52 Pica 304.80 Polysubstance Dependence 309.81 Posttraumatic Stress Disorder 302.75 Premature Ejaculation 307.44 Primary Hypersomnia 307.42 Primary Insomnia 318.2 Profound Mental Retardation 316 Psychological Factors Affecting Medical Condition Psychotic Disorder Due to [Indicate the General Medical Condition] 293.81 With Delusions 293.82 With Hallucinations 298.9 Psychotic Disorder NOS 312.33 Pyromania 313.89 Reactive Attachment Disorder of Infancy or Early Childhood 315.00 Reading Disorder V62.81 Relational Problem NOS V61.9 Relational Problem Related to a Mental Disorder or General Medical Condition V62.89 Religious or Spiritual Problem 299.80 Rett s Disorder 307.53 Rumination Disorder 295.70 Schizoaffective Disorder 301.20 Schizoid Personality Disorder Schizophrenia 295.20 Catatonic Type 295.10 Disorganized Type 295.30 Paranoid Type 295.60 Residual Type 295.90 Undifferentiated Type 295.40 Schizophreniform Disorder 301.22 Schizotypal Personality Disorder Sedative, Hypnotic, or Anxiolytic 305.40 Abuse 304.10 Dependence 292.89 -Induced Anxiety Disorder 292.84 -Induced Mood Disorder 292.83 -Induced Persisting Amnestic Disorder 292.82 -Induced Persisting Dementia 292.11 -Induced Psychotic Disorder, With Delusions 292.12 -Induced Psychotic Disorder, With Hallucinations 292.89 -Induced Sexual Dysfunction 292.89 -Induced Sleep Disorder 292.89 Intoxication 292.81 Intoxication Delirium 292.9 -Related Disorder NOS 292.0 Withdrawal 292.81 Withdrawal Delirium 313.23 Selective Mutism 309.21 Separation Anxiety Disorder 318.1 Severe Mental Retardation V61.1 Sexual Abuse of Adult 995.81 Sexual Abuse of Adult (if focus of attention is on victim) V61.21 Sexual Abuse of Child 995.5 Sexual Abuse of Child (if focus of attention is on victim) 302.79 Sexual Aversion Disorder 302.9 Sexual Disorder NOS 302.70 Sexual Dysfunction NOS 302.83 Sexual Masochism 302.84 Sexual Sadism 297.3 Shared Psychotic Disorder V61.8 Sibling Relational Problem Sleep Disorder Due to [Indicate the General Medical Condition] 780.54 Hypersomnia Type 780.52 Insomnia Type 780.59 Mixed Type 780.59 Parasomnia Type 307.46 Sleep Terror Disorder 307.46 Sleepwalking Disorder 300.23 Social Phobia 300.81 Somatization Disorder 300.81 Somatoform Disorder NOS 300.29 Specific Phobia 307.3 Stereotypic Movement Disorder 307.0 Stuttering 307.20 Tic Disorder NOS 307.23 Tourette s Disorder 307.21 Transient Tic Disorder 302.3 Transvestic Fetishism 312.39 Trichotillomania 300.81 Undifferentiated Somatoform Disorder 300.9 Unspecified Mental Disorder (nonpsychotic) 306.51 Vaginismus (Not Due to a General Medical Condition) Vascular Dementia 290.41 With Delirium 290.42 With Delusions 290.43 With Depressed Mood 302.82 Voyeurism} APA Reference Grohol, J. (2017). DSM-IV Diagnostic Codes. Psych Central . Retrieved on November 30, 2017, from https://psychcentral.com/disorders/dsm-iv-diagnostic-codes/} Hot Topics Today 1 How to Understand Gaslighting 2 Mobile Apps Can Help Manage and Support Mental, Emotional Health 3 Eating Nuts May Strengthen Some Brain Waves 4 Bipolar or Depression? Heart Test May Help Tell the Difference 5 Boosting Brain Activity May Buffer Against Anxiety Most Popular News Mobile Apps Can Help Manage and Support Mental, Emotional Health Eating Nuts May Strengthen Some Brain Waves Boosting Brain Activity May Buffer Against Anxiety Bipolar or Depression? Heart Test May Help Tell the Difference For Older Women, Every Movement Counts Toward Health Join Over 195,000 Subscribers to Our Weekly Newsletter Find a Therapist Enter ZIP or postal code} that each one


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