put off Sinus Pain & Pressure Generic Name: acetaminophen and phenylephrine (a SEET a MIN oh fen and FEN il EFF rin) Brand Name: Alka-Seltzer Plus Cold and Sinus, Contac Cold+Flu Non-Drowsy, Excedrin Sinus Headache Caplet, Mapap Sinus Congestion and Pain, QlearQuil Daytime Sinus & Congestion, Robitussin Nasal Relief, Sinus Congestion and Pain Daytime Cool Ice, Sinus Pain & Pressure, Sudafed PE Sinus Headache, Theraflu Daytime Severe Cold, Tylenol Sinus Congestion and Pain Overview Side Effects Dosage Interactions Pregnancy More User Reviews Drug Images Support Group Q & A Pricing & Coupons What is Sinus Pain & Pressure (acetaminophen and phenylephrine)? Acetaminophen is a pain reliever and a fever reducer. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Acetaminophen and phenylephrine is a combination medicine used to treat headache, fever, body aches, stuffy nose, and sinus congestion caused by allergies, the common cold, or the flu. Acetaminophen and phenylephrine may also be used for purposes not listed in this medication guide. Slideshow Seasonal Allergies: Top Prevention Tips What is the most important information I should know about Sinus Pain & Pressure (acetaminophen and phenylephrine)? Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes). In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. What should I discuss with my healthcare provider before taking Sinus Pain & Pressure (acetaminophen and phenylephrine)? You should not use this medicine if you are allergic to acetaminophen (Tylenol) or phenylephrine. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, and tranylcypromine. Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially: liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day; high blood pressure, heart disease, coronary artery disease; overactive thyroid; pheochromocytoma (an adrenal gland tumor); or if you take an anti-depressant. It is not known whether acetaminophen and phenylephrine will harm an unborn baby. Do not use cough or cold medicine without a doctor's advice if you are pregnant. Acetaminophen and phenylephrine may pass into breast milk and may harm a nursing baby. Decongestants may also slow breast milk production. Do not use cough or cold medicine without a doctor's advice if you are pregnant. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. How should I take Sinus Pain & Pressure (acetaminophen and phenylephrine)? Use exactly as directed on the label, or as prescribed by your doctor. Do not use for longer than recommended. Cold medicine is usually taken only for a short time until your symptoms clear up. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Dissolve one packet of the powder in at least 4 ounces of water. Stir this mixture and drink all of it right away. Drop the effervescent tablets into a glass of water (at least 4 ounces, or one-half cup). Stir this mixture and drink all of it right away. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. What happens if I miss a dose? Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes. What should I avoid while taking Sinus Pain & Pressure (acetaminophen and phenylephrine)? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while taking acetaminophen. Sinus Pain & Pressure (acetaminophen and phenylephrine) side effects Get emergency medical help if you have any of these signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen. Stop using the medicine and call your doctor at once if you have: fast, slow, or uneven heart rate; confusion, hallucinations; tremor, seizure (convulsions); little or no urinating; nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes); or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, seizure). Common side effects may include: dizziness, weakness; mild headache; mild nausea, diarrhea, upset stomach; runny nose; feeling nervous, restless, or anxious; or sleep problems (insomnia). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Sinus Pain & Pressure (acetaminophen and phenylephrine)? Other drugs may interact with acetaminophen and phenylephrine, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about acetaminophen/phenylephrine Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons 3 Reviews Add your own review/rating Drug class: upper respiratory combinations Consumer resources Acetaminophen and phenylephrine Acetaminophen and Phenylephrine Suspension Acetaminophen and Phenylephrine Tablets Acetaminophen and Phenylephrine Capsules Acetaminophen and Phenylephrine Powder Packet Other brands: Sudafed PE Pressure + Pain , Alka-Seltzer Plus Cold and Sinus , Sinus Congestion and Pain Daytime Cool Ice , Vicks QlearQuil Daytime Sinus & Congestion , ... +6 more Related treatment guides Sinus Symptoms Nasal Congestion Where can I get more information? Your pharmacist can provide more information about acetaminophen and phenylephrine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 2.02. Date modified: December 03, 2017 Last reviewed: September 08, 2014} Drug Status OTC Availability Over the counter N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug WADA Class Anti-Doping Classification Drug Class Upper respiratory combinations Related Drugs Sinus Symptoms Nasonex , mometasone nasal , Alka-Seltzer Plus Cold , Deconex , Advil Cold and Sinus , Norel AD , Crantex , naproxen / pseudoephedrine , More... Nasal Congestion sodium chloride nasal , epinephrine topical , pseudoephedrine , phenylephrine , Afrin , doxylamine , Sudafed Congestion , Claritin-D , loratadine / pseudoephedrine , Loratadine-D 24 Hour , Saline Nasal Mist , More... Acetaminophen / phenylephrine Rating 3 User Reviews 7.8 /10 3 User Reviews 7.8 Rate it! Acetaminophen / phenylephrine Images Acetaminophen / phenylephrine systemic 325 mg / 5 mg (44-466 ) View all images Help and Support Looking for answers? 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