destructive Skelid (Oral) Generic Name: tiludronate (Oral route) tye-loo-DROE-nate Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Skelid Available Dosage Forms: Tablet Therapeutic Class: Calcium Regulator Chemical Class: Bisphosphonate Slideshow A Joint Effort: A Provider's Guide To Orthopedic Pain Options Uses For Skelid Tiludronate is used to treat Paget's disease of the bone. This medicine is a bisphosphonate that helps make the bones stronger. This medicine is available only with your doctor's prescription. Before Using Skelid In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of tiludronate in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tiludronate in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Anemia or Blood clotting problems or Cancer or use of cancer medicines or Dental or tooth problems or Infection or Poor oral hygiene Use with caution. May increase risk for a serious side effect with the jaw. Barrett's esophagus or Bone or joint pain or Esophagus problems (e.g., difficulty with swallowing or inflammation) or Muscle pain, severe or Stomach or bowel problems (e.g., gastritis, heartburn or ulcers) Use with caution. May make these conditions worse. Kidney disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of Skelid Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for unwanted effects. Swallow the tablet whole with a large glass (8 ounces) of plain water. Do not drink mineral water, milk, coffee, juice, or any other liquid when you take the tablet. It is best to take this medicine on an empty stomach, either 2 hours before or 2 hours after eating. Do not lie down for at least 30 minutes after taking this medicine. It is important that you eat a well-balanced diet with an adequate amount of calcium and vitamin D while you are taking this medicine. Your doctor can help you choose the best diet for your condition. If you use calcium supplements, mineral supplements, indomethacin, or aspirin, take them either 2 hours before or 2 hours after you take tiludronate. If you use antacids, wait at least 2 hours after your dose before you take the antacid. If you take these medicines together with tiludronate, it may keep the medicine from working properly. Tiludronate takes up to 3 months to work. If you feel that the medicine is not working, talk to your doctor. Do not stop taking the medicine without checking with your doctor. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For treating Paget's disease: Adults 400 milligrams (mg) once a day for at least 3 months. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Ask your healthcare professional how you should dispose of any medicine you do not use. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using Skelid It is very important that your doctor check your progress at regular visits . This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. . This medicine can irritate your esophagus. Stop taking this medicine and call your doctor right away if you have severe heartburn (new or worse than usual), pain with swallowing, chest pain, trouble with swallowing, or feel like food is getting stuck in your esophagus. It is important that you tell all of your doctors or dentist that you are taking tiludronate. Make sure you tell your doctor about any new medical problems, especially with your teeth or jaw. If you have dental procedures while using this medicine, you may have an increased chance for serious jaw problems. Tell your doctor right away if you have any jaw tightness, swelling, numbness, or pain while using this medicine. This medicine can cause muscle or joint pain that in some cases is very severe. Tell your doctor right away if you have bone, joint, or muscle pain while using this medicine. Skelid Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Cough fever head congestion hoarseness or other voice changes nasal congestion runny nose sneezing sore throat Less common Blindness blurred or decreased vision burning, dry, or itching eyes chest pain discharge or excessive tearing eye pain headache redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid swelling of the face, feet, or lower legs unusual weight gain Rare Bladder pain blistering, peeling, or loosening of the skin bloody or cloudy urine difficult, burning, or painful urination dizziness or lightheadedness fainting feeling of constant movement of self or surroundings frequent urge to urinate headache itching red skin lesions, often with a purple center lower back or side pain nervousness pain or swelling in the arms or legs without any injury pounding in the ears sensation of spinning slow or fast heartbeat sores, ulcers, or white spots in the mouth or on the lips Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Abdominal or stomach cramps confusion convulsions difficulty with breathing irregular heartbeats mood or mental changes muscle cramps in the hands, arms, feet, legs, or face numbness and tingling around the mouth, fingertips, or feet shortness of breath tremor Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Back pain body pain (general) diarrhea nausea upset stomach Less common Bone fractures burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings confusion difficulty having a bowel movement (stool) dizziness dry skin hair loss increased thirst increased urination joint pain loss of appetite muscle cramps or spasms muscle pain red or irritated eyes skin rash stomach gas throat pain tooth disorder trouble thinking vomiting Rare Dry mouth fear or nervousness feeling of warmth lack or loss of strength redness of the face, neck, arms and occasionally, upper chest sleepiness or unusual drowsiness stomach pain sleeplessness trouble sleeping unable to sleep unusual tiredness or weakness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about Skelid (tiludronate) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: bisphosphonates Professional resources Skelid (FDA) Related treatment guides Paget's Disease} Drug Status Availability Discontinued C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug 10 + years Approval History FDA approved 1997 Drug Class Bisphosphonates Related Drugs Paget's Disease alendronate , Fosamax , Actonel , Reclast , Zometa , risedronate , zoledronic acid , calcitonin , Miacalcin , Aredia , pamidronate , Fortical , Binosto , etidronate , Aclasta , Miacalcin Nasal , Didronel , tiludronate , More... Skelid Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers Paget's Disease - I was diagnosed with Pagets Disease some years ago. 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