changes Simbrinza (Ophthalmic) Generic Name: brimonidine and brinzolamide (Ophthalmic route) bri-MOE-ni-deen TAR-trate, brin-ZOE-la-mide Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Simbrinza Available Dosage Forms: Suspension Therapeutic Class: Ophthalmologic Agent Pharmacologic Class: Brimonidine Slideshow Easy On The Eye - 8 Tips for Maintaining Good Eyesight Uses For Simbrinza Brimonidine and brinzolamide ophthalmic (eye) drops is used to treat increased pressure in the eye caused by open-angle glaucoma or a condition called ocular hypertension. Both eye conditions are caused by high pressure in your eye and can lead to pain from pressure in your eye and then can eventually harm your vision. This medicine can help you keep your sight by reducing the pressure in your eye and stopping eye pain. This medicine is available only with your doctor's prescription. Before Using Simbrinza In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Use of Simbrinza is not recommended in children younger than 2 years of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of Simbrinza in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Ceritinib Idelalisib Memantine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Allergy to sulfa drugs Use with caution. May increase risk for more serious side effects. Bacterial eye infection (eg, keratitis) or Cerebral or coronary insufficiency or Cornea (part of the eye) problems, history of or Depression or Eye infection or Eye surgery, recent or Heart or blood vessel disease (eg, thromboangiitis obliterans) or Liver disease or Orthostatic hypotension or Raynaud's phenomenon Use with caution. May make these conditions worse. Kidney disease, severe Should not be used in patients with this condition. Proper Use of Simbrinza Your eye doctor will tell you how much of this medicine to use and how often. Do not use more medicine or use it more often than your doctor tells you to. If you normally wear soft contact lenses, remove them before you use this medicine. Wait at least 15 minutes before putting the contact lenses back in. To use the eye drops: Wash your hands with soap and water. Shake the eye drops well just before each use. Lie down or tilt your head back. With your index finger, pull down the lower lid of your eye to form a pocket. Hold the dropper close to your eye with the other hand. Drop the correct number of drops into the pocket made between your lower lid and eyeball. Gently close your eyes. Place your index finger over the inner corner of your eye for 1 minute. If you think you did not get the drop of medicine into your eye properly, repeat the process with another drop. Do not rinse or wipe the dropper or allow it to touch anything, including your eye. Put the cap on the bottle right away. Wash your hands after using the eye drops to remove any medicine. Do not use this medicine if the solution changes color or becomes cloudy. Never touch the applicator tip to any surface, including the eye, and keep the container tightly closed. This will keep the medicine as germ-free as possible. If your doctor ordered two different eye drops to be used together, wait at least 5 minutes between the times you apply the medicines. This will help to keep the second medicine from washing out the first one. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For ophthalmic dosage form (eye drops): For glaucoma or hypertension of the eye: Adults Use one drop in the affected eye three times a day. Children 2 years of age and older Use and dose must be determined by your doctor. Children younger than 2 years of age Use is not recommended. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. You may also keep the medicine in the refrigerator. Do not freeze. Precautions While Using Simbrinza It is important that your doctor check your or your child's progress at regular visits to make sure that this medicine is working properly and is not causing unwanted effects. If itching, redness, swelling, or other signs of eye or eyelid irritation occur, check with your doctor. These signs may mean that you are allergic to brimonidine or brinzolamide. Serious allergic reactions may occur while using this medicine. Check with your doctor right away if you or your child have any of the following symptoms: black, tarry stools, blistering, peeling, or loosening of the skin, chills, dark urine, joint or muscle pain, rash, red skin lesions, often with a purple center, sores, ulcers, or white spots in the mouth or on the lips, unusual bleeding or bruising, unusual tiredness or weakness, or yellow eyes or skin. If you hurt your eye, develop an eye infection, or need to have an eye surgery, talk with your doctor right away. Your doctor may want you or your child to use a new bottle of eye drops to help prevent an eye infection or keep an infection from getting worse. You should not use this medicine together with acetazolamide (Ak-Zol , Diamox ), dorzolamide (Cosopt , Trusopt ), or methazolamide (Neptazane ). Using these medicines together may increase risk for unwanted effects . This medicine may cause some people to have blurred vision for a short time. Be careful when driving, using machines, or doing anything else that could be dangerous if you cannot see properly. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Simbrinza Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Blurred vision discoloration of the white part of the eye eye irritation or redness Less common Decreased vision eye pain eyes sensitive to light red, sore eyes Rare Burning, dry, or itching eyes discharge or excessive tearing hives or welts redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid skin rash Incidence not known Chest pain or discomfort constricted, pinpoint, or small pupils (black part of the eye) fast, pounding, or irregular heartbeat or pulse fever hoarseness irritation itching joint pain, stiffness, or swelling lightheadedness, dizziness, or fainting redness of the skin shortness of breath slow or irregular heartbeat swelling of the eyelids, face, lips, hands, or feet tearing throbbing pain tightness in the chest troubled breathing or swallowing unusual tiredness Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Confusion dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position muscle cramps or pain numbness, tingling, pain, or weakness in the hands or feet seizures sweating trembling weakness and heaviness of the legs Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Burning and stinging sensation change in color vision change in taste difficulty seeing at night drowsiness feeling of having something in the eye headache increase in blood flow to the whites of the eyes increased sensitivity of the eyes to sunlight lack or loss of strength loss of taste paleness of the eye or inner lining of the eyelid redness and tiny bumps on the lining of the eyelid Less common Dry eyes dry mouth muscle pain runny nose sneezing stuffy nose trouble sleeping Rare Acid or sour stomach belching body aches or pain congestion cough crusting in the corner of the eye diarrhea double vision dryness or soreness of the throat excessive muscle tone hair loss or thinning of the hair heartburn hoarseness indigestion muscle stiffness muscle tension or tightness nausea stomach discomfort, upset, or pain tender, swollen glands in the neck tightness in the chest voice changes Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about Simbrinza (brimonidine / brinzolamide ophthalmic) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 4 Reviews Add your own review/rating Drug class: ophthalmic glaucoma agents Consumer resources Simbrinza Professional resources Simbrinza (FDA) Related treatment guides Glaucoma, Open Angle Intraocular Hypertension} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Manufacturer Novartis Pharmaceuticals Corporation Drug Class Ophthalmic glaucoma agents Related Drugs Glaucoma, Open Angle timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan , epinephrine ophthalmic , Alphagan , dorzolamide ophthalmic , pilocarpine ophthalmic , Cosopt , Azopt , More... Intraocular Hypertension timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan , Combigan , Alphagan , dorzolamide ophthalmic , pilocarpine ophthalmic , Cosopt , Azopt , More... Simbrinza Rating 4 User Reviews 9.7 /10 4 User Reviews 9.7 Rate it! Related Questions & Answers How does Azopt and Simbrinza compare? Read more questions} } to 15
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