meal time Carbastat Generic Name: carbachol Dosage Form: injection Side Effects Dosage Professional Interactions Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Carbastat C arbasta t (CARBACHOL INTRAOCULAR SOLUTION, USP) 0.01% Slideshow Easy On The Eye - 8 Tips for Maintaining Good Eyesight DESCRIPTION Carbastat (Carbachol Intraocular Solution, USP) 0.01% is a sterile balanced salt solution of carbachol for intraocular injection. The active ingredient is represented by the structural formula: Established name: Carbachol Chemical name: Ethanaminium, 2-[(aminocarbonyl)oxy]- N,N,N -trimethyl-, chloride. Each mL contains: Active: Carbachol 0.01%. Inactive: Sodium chloride 0.64%, potassium chloride 0.075%, calcium chloride dihydrate 0.048%, magnesium chloride hexahydrate 0.03%, sodium acetate trihydrate 0.39%, sodium citrate dihydrate 0.17%, sodium hydroxide and/or hydrochloric acid to adjust pH (5.0-7.5) and water for injection USP. Carbastat - Clinical Pharmacology Carbachol is a potent cholinergic (parasympathomimetic) agent which produces constriction of the iris and ciliary body resulting in reduction in intraocular pressure. The exact mechanism by which carbachol lowers intraocular pressure is not precisely known. Indications and Usage for Carbastat Intraocular use for obtaining miosis during surgery. In addition, Carbastat (Carbachol Intraocular Solution USP) reduces the intensity of intraocular pressure elevation in the first 24 hours after cataract surgery. Contraindications Should not be used in those persons showing hypersensitivity to any of the components of this preparation. Warnings For single-dose intraocular use only. Discard unused portion. Intraocular carbachol 0.01% should be used with caution in patients with acute cardiac failure, bronchial asthma, peptic ulcer, hyperthyroidism, G.I. spasm, urinary tract obstruction and Parkinson's disease. Precautions Carcinogenesis Studies in animals to evaluate the carcinogenic potential have not been conducted. Pregnancy: Category C. There are no adequate and well controlled studies in pregnant women. Carbastat should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Nursing Mothers It is not known if this medication is excreted in breast milk. Exercise caution when administering to a nursing woman. Pediatric Use Safety and efficacy in pediatric patients have not been established. Adverse Reactions Ocular Corneal clouding, persistent bullous keratopathy, retinal detachment and postoperative iritis following cataract extraction have been reported. Systemic Side effects such as flushing, sweating, epigastric distress, abdominal cramps, tightness in urinary bladder, and headache have been reported with topical or systemic application of carbachol. Carbastat Dosage and Administration Aseptically remove the sterile vial from the blister package by peeling the backing paper and dropping the vial onto a sterile tray. Withdraw the contents into a dry sterile syringe, and replace the needle with an atraumatic cannula prior to intraocular irrigation. No more than one-half milliliter should be gently instilled into the anterior chamber for the production of satisfactory miosis. It may be instilled before or after securing sutures. Miosis is usually maximal within two to five minutes after application. How is Carbastat Supplied Carbastat (Carbachol Intraocular Solution, USP) 0.01% 1.5 mL sterile glass vials in cartons of 12 (12 x 1.5 mL) NDC 58768-735-12 Store at controlled room temperature 15 -30 C (59 -86 F). Rx only Manufactured by OMJ Pharmaceuticals, Inc., San Germán, P.R. 00683 for Novartis Ophthalmics Duluth, GA 30097 5007-D March, 2001 Carbastat carbachol injection, solution Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:58768-735 Route of Administration INTRAOCULAR DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Carbachol (Carbachol) Carbachol 0.1 mg in 1 mL Inactive Ingredients Ingredient Name Strength calcium chloride dihydrate 0.481 mg in 1 mL hydrochloric acid magnesium chloride hexahydrate 0.3 mg in 1 mL potassium chloride 0.75 mg in 1 mL sodium acetate trihydrate 3.9 mg in 1 mL Sodium chloride 6.4 mg in 1 mL sodium citrate dihydrate 1.7 mg in 1 mL sodium hydroxide water Packaging # Item Code Package Description 1 NDC:58768-735-12 12 VIAL, GLASS (12 VIAL) in 1 CARTON 1 1.5 mL (1.5 MILLILITER) in 1 VIAL, GLASS Labeler - Novartis Ophthalmics Revised: 09/2006 Novartis Ophthalmics Next Interactions Print this page Add to My Med List More about Carbastat (carbachol ophthalmic) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: ophthalmic glaucoma agents Consumer resources Professional resources Carbachol (AHFS Monograph) Other brands: Miostat Related treatment guides Intraocular Hypertension Production of Miosis FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Ophthalmic glaucoma agents Related Drugs ophthalmic glaucoma agents timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan Production of Miosis pilocarpine ophthalmic , carbachol ophthalmic , acetylcholine ophthalmic , Isopto Carpine , Miostat , Pilopine HS , Isopto Carbachol , Miochol-E , More... Intraocular Hypertension timolol ophthalmic , Lumigan , latanoprost ophthalmic , Travatan , brimonidine ophthalmic , Xalatan , Combigan , Alphagan , dorzolamide ophthalmic , pilocarpine ophthalmic , Cosopt , Azopt , More... Carbastat Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! physical games
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