footage palbociclib Generic Name: palbociclib (PAL boe SYE klib) Brand Name: Ibrance Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A What is palbociclib? Palbociclib is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Palbociclib is used in men and women to treat certain types of advanced breast cancer that has spread to other parts of the body. In postmenopausal women, palbociclib is given in combination with a hormonal medicine called letrozole (Femara). In others, palbociclib is given together with fulvestrant (Faslodex). Palbociclib may also be used for purposes not listed in this medication guide. Slideshow Mammogram Memos: What You Need To Know What is the most important information I should know about palbociclib? Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use. What should I discuss with my healthcare provider before taking palbociclib? You should not use palbociclib if you are allergic to it. To make sure palbociclib is safe for you, tell your doctor if you have: liver disease; or kidney disease. Do not use palbociclib if you are pregnant. It could harm the unborn baby. Use effective birth control to prevent pregnancy while you are using this medicine and for at least 3 weeks after your last dose. You may need to have a negative pregnancy test before starting this treatment. It is not known whether palbociclib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using this medicine. How should I take palbociclib? Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Palbociclib is given in a 28-day treatment cycle, and you may only need to take the medicine during the first 3 weeks of each cycle. Your doctor will determine how long to treat you with palbociclib. Take with food. Take the medicine at the same time each day. Do not crush, chew, break, or open a palbociclib capsule. Swallow it whole. If you vomit after taking the medicine, wait until the next day to take your next dose. Do not use a broken or damaged pill. Palbociclib can lower blood cells that help your body fight infections and help your blood to clot. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Store at room temperature away from moisture and heat. What happens if I miss a dose? Skip the missed dose and do not take the medicine again until your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking palbociclib? Grapefruit and grapefruit juice may interact with palbociclib and lead to unwanted side effects. Avoid the use of grapefruit products while taking palbociclib. Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection. Palbociclib side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; blisters or ulcers in your mouth, red or swollen gums, trouble swallowing; low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; low red blood cells (anemia)--pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating; or signs of a blood clot in the lung--chest pain, sudden cough, wheezing, rapid breathing, coughing up blood. Your cancer treatments may be delayed or permanently discontinued if you have certain side effects. Common side effects may include: nausea, vomiting, diarrhea, loss of appetite; mouth sores, decreased sense of taste; weakness, feeling tired; numbness, tingling, or burning pain in your arms, legs, hands or feet; abnormal liver function tests; cold symptoms such as stuffy nose, sneezing, sore throat; nosebleed; or dry skin, temporary hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) Palbociclib dosing information Usual Adult Dose for Breast Cancer: 28-day cycle: 125 mg orally once a day for 21 consecutive days followed by 7 days off treatment Comments: Take with food in combination with letrozole 2.5 mg orally once a day throughout the 28-day cycle. Use: In combination with letrozole for the treatment of postmenopausal women with estrogen receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced breast cancer as initial endocrine-based therapy What other drugs will affect palbociclib? Other drugs may interact with palbociclib, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about palbociclib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 27 Reviews Add your own review/rating Drug class: CDK 4/6 inhibitors Consumer resources Palbociclib Palbociclib (Advanced Reading) Other brands: Ibrance Professional resources Palbociclib (AHFS Monograph) Palbociclib (Wolters Kluwer) Related treatment guides Breast Cancer Breast Cancer, Metastatic Where can I get more information? Your pharmacist can provide more information about palbociclib. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 2.01. Date modified: December 03, 2017 Last reviewed: April 13, 2017 Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class CDK 4 / 6 inhibitors Related Drugs Breast Cancer, Metastatic anastrozole , tamoxifen , letrozole , Arimidex , Femara , Xeloda , Taxol , capecitabine , Ibrance , Herceptin , Faslodex , Taxotere , More... Breast Cancer methotrexate , anastrozole , tamoxifen , letrozole , Arimidex , Femara , exemestane , fluorouracil , Xeloda , Taxol , capecitabine , Aromasin , More... Palbociclib Rating 27 User Reviews 6.6 /10 27 User Reviews 6.6 Rate it! Help and Support Looking for answers? 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