responsible for Bacitracin, Neomycin, and Polymyxin B (Ophthalmic) Overview Side Effects Dosage Professional Pregnancy More User Reviews Support Group Q & A Pricing & Coupons Pronunciation (bas i TRAY sin, nee oh MYE sin, & pol i MIKS in bee) Index Terms Neomycin, Bacitracin, and Polymyxin B Polymyxin B, Bacitracin, and Neomycin Slideshow Red, Irritated, Watering Eyes? Chances Are You ve Got Pink Eye Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Ointment, Ophthalmic: Neo-Polycin: Bacitracin 400 units, neomycin 3.5 mg, and polymyxin B 10,000 units per g (3.5 g) Generic: Bacitracin 400 units, neomycin 3.5 mg, and polymyxin B 10,000 units per g (3.5 g) Brand Names: U.S. Neo-Polycin Pharmacologic Category Antibiotic, Ophthalmic Pharmacology Bacitracin: Inhibits bacterial cell wall synthesis by preventing transfer of mucopeptides into the growing cell wall. Neomycin: Interferes with bacterial protein synthesis by binding to 30S ribosomal subunits. Polymyxin B: Binds to phospholipids, alters permeability, and damages the bacterial cytoplasmic membrane permitting leakage of intracellular constituents. Use: Labeled Indications Ocular infections: Treatment of superficial external ocular infections (eg, conjunctivitis, keratitis, keratoconjunctivitis, blepharitis, blepharoconjunctivitis) caused by susceptible organisms. Contraindications Hypersensitivity to neomycin, polymyxin B, bacitracin, or any component of the formulation Dosing: Adult Ocular infections: Ophthalmic: Apply every 3 to 4 hours for 7 to 10 days. Dosing: Geriatric Refer to adult dosing. Dosing: Pediatric Conjunctivitis (off-label): Limited data available: Children and Adolescents: Ophthalmic: Ointment: Apply 0.5 inch ribbon every 3 to 4 hours for acute infections, or 2 to 3 times per day for mild to moderate infections, for 7 to 10 days (Pichichero 2011). Dosing: Renal Impairment There are no dosage adjustments provided in the manufacturer s labeling. Dosing: Hepatic Impairment There are no dosage adjustments provided in the manufacturer s labeling. Administration For ophthalmic use only; not for injection into the eye. Avoid contamination of the tip of the ointment tube. Storage Store at room temperature. Drug Interactions There are no known significant interactions. Adverse Reactions Frequency not defined. Dermatologic: Reddening, allergic contact dermatitis Local: Itching, failure to heal, swelling, irritation Ophthalmic: Conjunctival edema Miscellaneous: Anaphylaxis Warnings/Precautions Concerns related to adverse effects: Neomycin sensitization: Neomycin may cause cutaneous sensitization. Symptoms of neomycin sensitization include itching, reddening, edema, and failure to heal. Discontinuation of product and avoidance of similar products should be considered. Ocular effects: May retard corneal wound healing. Superinfection: Prolonged use may lead to overgrowth of nonsusceptible organisms, including fungi. If superinfection is suspected, institute appropriate alternative therapy. Other warnings/precautions: Appropriate use: For topical ophthalmic use only. Do not introduce directly into anterior chamber of the eye. Inadvertent contamination of multiple-dose ophthalmic tube tip has caused bacterial keratitis. Pregnancy Risk Factor C Pregnancy Considerations Animal reproduction studies have not been conducted with this combination. Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Have patient report immediately to prescriber vision changes, eye pain, severe eye irritation, or eye discharge (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Next Pregnancy Warnings Print this page Add to My Med List More about bacitracin/neomycin/polymyxin b ophthalmic Side Effects During Pregnancy Dosage Information Support Group Pricing & Coupons En Español 2 Reviews Add your own review/rating Drug class: ophthalmic anti-infectives Consumer resources Bacitracin, neomycin, and polymyxin B ophthalmic Bacitracin, Neomycin, and Polymyxin B (Ophthalmic) Neomycin, polymyxin b, and bacitracin Ophthalmic (Advanced Reading) Professional resources Neomycin, Polymyxin B, Bacitracin Ophthalmic Ointment (FDA) Other brands: Neo-Polycin , Neocidin Related treatment guides Blepharitis Hordeolum Keratitis Blepharoconjunctivitis Conjunctivitis, Bacterial Keratoconjunctivitis Antibiotics 101 Everything you need to know about antibiotics: List of Common Antibiotics & Types Antibiotics & Drinking Alcohol - Is it Safe? Antibiotics For UTI - What Are My Options? Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Bacitracin / neomycin / polymyxin b ophthalmic Rating 2 User Reviews 9.5 /10 2 User Reviews 9.5 Rate it! Manufacturer Bausch & Lomb Inc. Drug Class Ophthalmic anti-infectives Related Drugs ophthalmic anti-infectives azithromycin ophthalmic , ciprofloxacin ophthalmic , levofloxacin ophthalmic , erythromycin ophthalmic , gentamicin ophthalmic Blepharitis Maxitrol , Blephamide , Pred-G , Cortisporin Ophthalmic Suspension , Neo-Poly-Dex , More... Conjunctivitis, Bacterial azithromycin ophthalmic , ciprofloxacin ophthalmic , levofloxacin ophthalmic , erythromycin ophthalmic , gentamicin ophthalmic , More... Keratitis prednisone , triamcinolone , prednisolone ophthalmic , dexamethasone ophthalmic , Decadron , More... 3 more conditions... hiking
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