over the years Ciclopirox Olamine Class: Hydroxypyridones Chemical Name: 6-Cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridinone compound with 2-aminoethanol (1:1) Molecular Formula: C 12 H 17 NO 2 βC 2 H 7 NO CAS Number: 41621-49-2 Brands: Loprox, Penlac Nail Lacquer Overview Side Effects Dosage Professional Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons Introduction Antifungal; 1 2 3 chemically unrelated to imidazoles or other antifungal agents currently available in US. 4 Slideshow Hives: The What, Where, And Why Of This Bizarre Skin Condition Uses for Ciclopirox Olamine Dermatophytoses and Cutaneous Candidiasis Treatment of tinea pedis, tinea cruris, and tinea corporis caused by Trichophyton mentagrophytes, T. rubrum, Epidermophyton floccosum, or Microsporum canis . 1 25 27 31 66 Efficacy in the treatment of plantar and vesicular types of tinea pedis not established. 28 Oral antifungal agent usually necessary for the treatment of hyperkeratotic areas on palms and soles or chronic moccasin-type tinea pedis. 31 32 36 Oral antifungal agents preferred when tinea corporis or tinea cruris is extensive, dermatophyte folliculitis is present, infection is chronic or does not respond to topical therapy, or patient is immunocompromised or has coexisting disease. 31 32 35 36 37 Treatment of cutaneous candidiasis caused by Candida albicans . 1 66 Pityriasis (Tinea) Versicolor Treatment of pityriasis (tinea) versicolor caused by Malassezia furfur ( Pityrosporum orbiculare or P. ovale ). 1 25 66 Oral antifungal agents preferred in patients who have extensive or severe infections or who fail to respond to or have frequent relapses with topical therapy. 33 34 36 Seborrheic Dermatitis Treatment of seborrheic dermatitis of the scalp. 28 65 Has not been studied in immunocompromised patients (e.g., HIV or transplant patients), 28 65 patients with a history of immunosuppression (e.g., extensive, persistent, or unusual distribution of dermatomycoses; recent or recurring herpes zoster; persistent herpes simplex), 65 or those with diabetic neuropathy. 65 Onychomycosis Treatment of mild to moderate onychomycosis of fingernails and toenails, without lunula involvement, caused by T. rubrum in immunocompetent patients. 40 43 45 49 56 57 58 59 60 Oral antifungal therapy usually preferred for extensive (e.g., >30%) nail involvement. 46 Has not been studied in immunocompromised individuals (e.g., those with insulin-dependent diabetes, diabetic neuropathy, severe plantar/moccasin-type tinea pedis, HIV infection, or solid organ transplantation). 40 Ciclopirox Olamine Dosage and Administration Administration Topical Administration Apply topically to the skin as a cream, 1 gel, 28 lotion, 66 or shampoo 65 and to nails as a solution (nail lacquer). 40 Do not apply to the eye 1 25 28 40 65 66 or administer orally or intravaginally. 23 24 40 65 Avoid contact with mucous membranes. 28 40 65 Cream, Gel, or Lotion Apply a sufficient amount of cream, gel, or lotion in the morning and evening; rub gently into cleansed, affected area and surrounding skin. 1 23 25 31 66 Do not use with occlusive dressings or wrappings. 1 28 66 Shampoo If contact with eye(s) occurs, rinse thoroughly with water. 65 Solution (Nail Lacquer) Use in conjunction with frequent (e.g., monthly) appointments with a qualified clinician in nail disorders and weekly self-trimming of infected nail(s). 40 Remove any loose nail or nail material (using nail clippers or nail files) before initiating therapy. 40 Apply solution evenly over entire nail bed, undersurface of nail plate (if free of nail bed), and 5 mm of surrounding skin using applicator brush provided by the manufacturer. 40 Avoid contact with skin other than that immediately surrounding the treated nail(s) (because of risk of adverse dermatologic reactions). 40 After applying solution, wait 8 hours before bathing. 40 Allow nail(s) to dry (about 30 seconds) before wearing socks or stockings. 40 Do not apply nail polish or other cosmetic nail products on treated nail(s). 40 Dosage Available as ciclopirox and ciclopirox olamine; dosage expressed in terms of ciclopirox. 1 28 40 65 66 Pediatric Patients Dermatophytoses and Cutaneous Candidiasis Topical Children 10 years of age: Apply 0.77% cream or lotion twice daily. 1 23 25 31 66 If clinical improvement does not occur after 4 weeks of treatment, reevaluate the diagnosis. 1 25 66 Pityriasis (Tinea) Versicolor Topical Children 10 years of age: Apply 0.77% cream or lotion twice daily. 1 23 25 31 66 Clinical improvement usually occurs after 2 weeks of treatment. 1 25 66 Adults Dermatophytoses and Cutaneous Candidiasis Topical Apply 0.77% cream or lotion twice daily. 1 23 25 31 66 Alternatively, in the treatment of interdigital tinea pedis or tinea corporis, apply 0.77% gel twice daily. 28 If clinical improvement does not occur after 4 weeks of treatment, reevaluate the diagnosis. 1 25 66 Pityriasis (Tinea) Versicolor Topical Apply 0.77% cream or lotion twice daily. 1 23 25 31 66 Clinical improvement usually occurs after 2 weeks of treatment. 1 25 66 Seborrheic Dermatitis Topical Apply 0.77% gel to affected areas twice daily. 28 Alternatively, apply approximately 5 mL (10 mL for long hair) of 1% shampoo to wet hair and scalp and lather. 65 Allow drug to remain on the scalp for 3 minutes and then rinse. 65 Repeat treatment twice weekly for 4 weeks, with a minimum of 3 days between applications. 65 If clinical improvement does not occur after 4 weeks of treatment, reevaluate the diagnosis. 65 Onychomycosis Topical Apply 8% topical solution (nail lacquer) once daily (preferably at bedtime). 40 Remove accumulated applications of the drug with alcohol every 7 days; daily removal of solution is not recommended. 40 Initial improvement of symptoms may require 6 months of therapy and up to 48 weeks of continuous comprehensive therapy to achieve clear or almost clear nail(s). 40 Cautions for Ciclopirox Olamine Contraindications Known hypersensitivity to ciclopirox, ciclopirox olamine, or any ingredient in the formulation. 1 25 28 40 65 66 Warnings/Precautions Sensitivity Reactions If irritation or sensitivation occurs, discontinue the drug and initiate appropriate therapy. 1 25 40 66 General Precautions Local Effects Possible pruritus, transient burning sensation, and/or pain at the site of application. 1 28 40 66 Specific Populations Pregnancy Category B. 1 28 65 66 Lactation Not known whether ciclopirox is distributed into milk. 1 28 40 65 66 Use with caution in nursing women. 1 25 28 40 65 66 Pediatric Use Safety and efficacy of topical ciclopirox solution (nail lacquer) not established in children. 40 Safety and efficacy of topical ciclopirox olamine preparations (i.e., cream, lotion) and topical ciclopirox gel not established in children 10 and 16 years of age, respectively. 1 28 66 Insufficient experience with ciclopirox shampoo in children 16 years of age to determine whether pediatric patients respond differently than adults. 65 Geriatric Use No substantial differences in safety and efficacy of ciclopirox topical solution (nail lacquer) relative to younger adults. 40 No substantial differences in safety of ciclopirox shampoo relative to younger adults. 65 Insufficient experience in patients 65 years of age to determine whether efficacy in geriatric patients is different from that in younger adults. 65 Race Insufficient experience in black patients to determine whether they respond differently to ciclopirox shampoo than other races. 65 Common Adverse Effects Local burning sensation or pain; mild, transient erythema. 1 28 40 66 Interactions for Ciclopirox Olamine Systemic Antifungal Agents No studies conducted in patients with onychomycosis to determine whether topical ciclopirox solution might reduce efficacy of systemic antifungals; combined use of the topical solution with a systemic antifungal agent is not recommended. 40 Ciclopirox Olamine Pharmacokinetics Absorption Percutaneous absorption appears to be rapid but minimal following topical application to intact skin. 11 40 Penetration of drug following topical application of 0.77% lotion is equivalent to that of 0.77% cream. 25 27 Systemic absorption of 0.77% gel is higher than that of 0.77% cream. 28 Distribution Extent Penetrates into hair and nail 40 and is absorbed through the epidermis and hair follicles into sebaceous glands and dermis, while a portion remains in the stratum corneum. 1 11 25 66 Crosses the placenta in very small amounts in animals. 11 Plasma Protein Binding Approximately 94 98%. 11 Elimination Metabolism Almost completely conjugated with glucuronic acid; 11 about 1 2% of the drug appears to be metabolized to N -desoxyciclopirox and another unidentified metabolite. 11 Elimination Route Excreted rapidly and almost completely in urine; 11 25 negligible fecal excretion. 1 11 25 66 Half-life Biologic half-life of approximately 1.7 hours following application of 0.77% cream or lotion. 1 11 25 66 Renal elimination half-life of approximately 5.5 hours following application of 0.77% gel. 28 Stability Storage Topical Cream, Gel, or Shampoo 15 30 C. 1 28 65 Lotion 5 25 C. 66 Solution 15 30 C. 40 Keep away from heat and flame. 40 Actions and Spectrum Chelates polyvalent cations (e.g., aluminum, iron), which can result in inhibition of metal-dependent enzymes that are responsible for degradation of peroxides within the fungal cell. 28 40 65 Active in vitro against Trichophyton equinum , 10 T. mentagrophytes , 1 8 9 10 25 27 28 40 66 T. rubrum , 1 8 9 10 25 28 40 66 T. schoenleinii , 8 10 T. tonsurans , 8 10 T. verrucosum , 8 T. violaceum , 8 10 E. floccosum , 1 8 9 10 25 28 66 Microsporum audouinii , 1 8 10 M. canis , 8 10 25 66 C. albicans , 1 8 9 10 25 27 66 and M. furfur ( P. orbiculare ). 1 65 66 Advice to Patients Importance of consulting clinician if treated area becomes irritated (e.g., erythema, pruritus, burning, blistering, swelling, oozing). 1 25 28 40 66 Importance of completing full course of therapy and of contacting clinician if symptoms of skin condition do not improve after 4 weeks of treatment. 1 25 28 66 Six months of therapy may be required for initial improvement of infected nail(s). 40 Importance of adhering to prescribed directions for use, including using the drug only for prescribed indications. 28 40 (See Administration under Dosage and Administration.) If topical solution (nail lacquer) is to be used, provide patient a copy of manufacturer s patient information. 40 Importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed. 1 28 40 65 66 Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses. 1 28 40 65 66 Importance of informing patients of other important precautionary information. 1 28 40 65 66 (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Ciclopirox Routes Dosage Forms Strengths Brand Names Manufacturer Topical Gel 0.77% Loprox (with isopropyl alcohol) Medicis Shampoo 1% Loprox Medicis Solution 8% Penlac Nail Lacquer (with isopropyl alcohol) Dermik Ciclopirox Olamine Routes Dosage Forms Strengths Brand Names Manufacturer Topical Cream 0.77% (of ciclopirox) Loprox (with benzyl alcohol 1%) Medicis Lotion 0.77% (of ciclopirox) Loprox (with benzyl alcohol 1%) Medicis AHFS DI Essentials. Copyright 2017, Selected Revisions July 1, 2005. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. References 1. Medicis Pharmaceutical Corp. Loprox (ciclopirox olamine) cream 0.77% prescribing information. Scottsdale, AZ; 2002 Oct. 2. Hoechst-Roussel Pharmaceuticals, Inc. Pharmacy and therapeutics committee report: Loprox (ciclopirox olamine) cream 1%. Somerville, NJ; 1983 Mar. 3. Dittmar W, Druckey E, Urbach H. Quantitative structure-activity analysis in a series of antimycotically active N -hydroxypyridones. J Med Chem . 1974; 17:753-6. [PubMed 4836409] 4. Anon. New topical antifungal drugs. Med Lett Drugs Ther . 1983; 25:98-100. [PubMed 6621505] 5. Reynolds JEF, ed. Martindale: the extra pharmacopeia. 28th ed. London: The Pharmaceutical Press; 1982:720. 6. Sakurai K, Sakaguchi T, Yamaguchi H et al. Mode of action of 6-cyclohexyl-1-hydroxy-4-methyl-2(1H)-pyridone ethanolamine salt (Hoe 296). Chemotherapy . 1978; 24:68-76. [PubMed 340169] 7. Iwata VK, Yamaguchi H. Studies on the mechanism of antifungal action of ciclopiroxolamine: inhibition of transmembrane transport of amino acid, K + and phosphate in Candida albicans cells. (German) Arzneim-Forsch. 1981; 31:1323-7. 8. Dittmar W, Lohaus G. HOE 296, a new antimycotic compound with a broad antimicrobial spectrum. (German) Arzneim-Forsch. 1973; 23:670-4. 9. Dittmar W, Grau W, Raether W et al. Microbiological laboratory studies with ciclopiroxolamine. (German) Arzneim-Forsch. 1981; 31:1317-22. 10. Sakurai K, Sakaguchi T, Yamaguchi H et al. Antimicrobial activity of Hoe 296, a new synthetic antifungal agent. I. In vitro antimicrobial activity and curative effect against experimental Trichophyton mentagrophytes infection. (Japanese) Jpn J Med Mycol. 1975; 16:35-40. 11. Kellner, HM, Arnold C, Christ OE et al. Studies on pharmacokinetics and biotransformation of the antimycotic drug ciclopiroxolamine in animals and man after topic and systemic application. (German) Arzneim-Forsch. 1981; 31:1337-53. 12. Dittmar W. Penetration and antifungal activity of ciclopiroxolamine in hornified tissue. (German) Arzneim-Forsch. 1981; 31:1353-9. 13. Adam, VW, Peil HG, Savopoulos C et al. Clinical results with the antimycotic agent ciclopiroxolamine. (German) Arzneim-Forsch. 1981; 31:1360-8. 14. Fredriksson T, Savopoulos C. Comparative double-blind study on ciclopiroxolamine cream and placebo cream in dermatophytoses. (German) Arzneim-Forsch. 1981; 31:1376-8. 15. Dittmar VW. Non-European open clinical studies on the efficacy and tolerance of ciclopiroxolamine in dermatomycoses. (German) Arzneim-Forsch. 1981; 31:1381-5. 16. Hoechst-Roussel Pharmaceuticals, Inc. Loprox (ciclopiroxolamine) cream 1% effectiveness and safety. Somerville, NJ; 1983. 17. Torres VJ, Savopoulos C, Dittmar W. Open clinical trial in dermal mycoses of a 1% ciclopiroxolamine solution in polyethylene glycol 400 carried out in FR Germany/Study with shortened therapy. (German) Arzneim-Forsch. 1981; 31:1373-6. 18. Beyer M. Selected double-blind comparative studies on the efficacy and tolerance of ciclopiroxolamine solution and cream. (German) Arzneim-Forsch. 1981; 31:1378-81. 19. Anon. Drugs for athlete s foot and tinea cruris. Med Lett Drugs Ther . 1976; 18:101-2. [PubMed 1036605] 20. Qadripur SA, Horn G, Hohler T. On the local efficacy of ciclopiroxolamine in onychomycoses. (German) Arzneim-Forsch. 1981; 31:1369-72. 21. Sehgal VN. Ciclopirox: a new topical pyrodonium antimycotic agent. A double-blind study in superficial dermatomycoses. Br J Dermatol . 1976; 95:83-8. [PubMed 782504] 22. Peil VHG. Open clinical study on the efficacy and tolerance of ciclopiroxolamine in vulvovaginal candidosis. (German) Arzneim-Forsch. 1981; 31:1366-8. 23. Roney JV (Hoechst-Roussel Pharmaceuticals, Inc., Somerville, NJ): Personal communication; 1984 Mar 12. 24. Reviewers comments (personal observations); 1984 Mar 20. 25. Hoechst-Roussel Pharmaceuticals, Inc. Loprox (ciclopirox olamine) lotion 1% prescribing information (dated 1995 Mar). In Physicians desk reference. 52nd ed. Montvale, NJ: Medical Economics Company Inc; 1998:1221-2. 26. Hoechst-Roussel Pharmaceuticals, Inc. Pharmacy and therapeutics committee report supplement: Loprox (ciclopirox olamine) lotion 1%. Somerville, NJ; 1989 Apr. 27. Aly R, Maibach HI, Bagatell FK et al. Ciclopirox olamine lotion 1%: bioequivalence to ciclopirox olamine cream 1% and clinical efficacy in tinea pedis. Clin Ther . 1989; 11:290-303. [PubMed 2663159] 28. Medicis Pharmaceutical Corp. Loprox (ciclopirox) gel 0.77%. prescribing information. Scottsdale, AZ; 2002 Mar. 29. Hänel H, Smith-Kurtz E, Pastowsky S. Treatment of seborrhoic eczema using an antimycotic with antiphlogistic properties. (German; with English abstract.) Mycoses . 1991; 34 (Suppl):91-3. 30. Schmidt A. Malassezia furfur : a fungus belonging to the physiological skin flora and its relevance in skin disorders. Cutis . 1997; 59:21-4. [PubMed 9013067] 31. Gupta AK, Einarson TR, Summerbell RC et al. An overview of topical antifungal therapy in dermatomycoses: a North American perspective. Drugs . 1998; 55:645-74. [PubMed 9585862] 32. Piérard GE, Arrese JE, Piérard-Franchimont C. Treatment and prophylaxis of tinea infections. Drugs . 1996; 52:209-24. [PubMed 8841739] 33. Sunenshine PJ, Schwartz RA, Janniger CK. Tinea versicolor: an update. Cutis . 1998; 61:65-72. [PubMed 9515210] 34. Assaf RR, Weil ML. The superficial mycoses. Dermatol Clin . 1996; 14:57-67. [PubMed 8821158] 35. Lesher JL. Recent developments in antifungal therapy. Dermatol Clin . 1996; 14:163-9. [PubMed 8821170] 36. Hay RJ. Dermatophytosis and other superficial mycoses. In: Mandel GL, Douglas RG Jr, Bennett JE, eds. Principles and practices of infectious disease. 4th ed. New York: Churchill Livingston; 1995: 2375-86. 37. Drake LA, Dincehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: tinea corporis, tinea cruris, tinea faciei, tinea manuum, and tinea pedis. J Am Acad Dermatol . 1996; 34:282-6. [PubMed 8642094] 38. Drake LA, Dinehart SM, Farmer ER et al. Guidelines of care for superficial mycotic infections of the skin: pityriasis (tinea) versicolor. J Am Acad Dermatol . 1996; 34:287-9. [PubMed 8642095] 39. Reviewers comments (personal observations) on Sulconazole 84:04.08. 40. Dermik Laboratories. Penlac (ciclopirox) 8% topical solution prescribing information. Berwyn, PA; 2003 Jun. 41. Bohn M, Kraemer KT. Dermatopharmacology of ciclopirox nail lacquer solution 8% in the treatment of onychomycosis. J Am Acad Dermatol . 2000; (Suppl):S57-69. [PubMed 11051135] 42. Janssen Pharmaceutica. Sporanox (itraconazole) capsules prescribing information (dated 2000 Jan). In: Physicians desk reference. 55th ed. Montvale, NJ: Medical Economics Company Inc; 2001:1584-7. 43. Gupta AK, Baran R. Ciclopirox nail lacquerl solution 8% in the 21st century. J Am Acad Dermatol . 2000; 43(Suppl):S86-102. 44. Novartis Pharmaceuticals. Lamisil (terbinafine hydrochloride) tablets prescribing information (dated 1999 Nov). In: Physicians desk reference. 55th ed. Montvale, NJ: Medical Economics Company Inc; 2001:2179-81. 45. Anon. Ciclopirox ( Penlac ) nail lacquer for onychomycosis. Med Lett Drugs Ther . 2000; 42:51-2. [PubMed 10859733] 46. Niewerth M, Korting HC. Management of onychomycoses. Drugs . 1999; 58:283-96. [PubMed 10473020] 47. Rodgers P, Bassler M. Treating onychomycosis. Am Fam Physician . 2001; 63:663-72, 677-8. [PubMed 11237081] 48. Reisberger EM, Szeimies RM. Therapy of onychomicosis. (German; with English abstract.) Med Klin . 2000; 95:618-28. 49. Gupta AK. Onychomycosis in the elderly. Drugs Aging . 2000; 16:397-407. [PubMed 10939306] 50. Roberts DT. Onychomycosis: current treatment and future challenges. Br J Dermatol . 1999; 141(Suppl 56):1-4. [PubMed 10730907] 51. Balfour JA, Faulds D. Terbinafine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses. Drugs . 1992; 43:259-84. [PubMed 1372222] 52. Brodell RT, Elewski BE. Clinical Pearl: Systemic antifungal drugs and drug interactions. J Am Acad Dermatol . 1995; 33:259-260. [PubMed 7622654] 53. Anon. Terbinafine for onychomycosis. Med Lett Drugs Ther . 1996; 38:72-4. [PubMed 8699988] 54. Dupin N, Gorin I, Djien V et al. Acute generalized exanthematous pustulosis induced by terbinafine. Arch Dermatol . 1996; 132:1253-4. [PubMed 8859047] 55. Odom RB. New therapies for onychomycosis. J Am Acad Dermatol . 1996; 35:S26-30. [PubMed 8784308] 56. Gupta AK, Malkin K. Ciclopirox nail lacquer and podiatric practice. J Am Podiatr Med Assoc . 2000; 90:502-7. [PubMed 11107711] 57. Gupta AK, Joseph WS. Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States. J Am Podiatr Med Assoc . 2000; 90:495-501. [PubMed 11107710] 58. Gupta AK. Pharmacoeconomic analysis of ciclopirox nail lacquer solution 8% and the new oral antifungal agents used to treat dermatophyte toe onychomycosis in the United States. J Am Acad Dermatol . 2000; 43(Suppl 4):S81-95. 59. Gupta AK, Fleckman P, Baran R. Ciclopirox nail lacquer topical solution 8% in the treatment of toenail onychomycosis. J Am Acad Dermatol . 2000; 43(Suppl 4):S70-80. 60. Gupta AK. Ciclopirox nail lacquer topical solution 8%. Skin Therapy Lett . 2000; 6:1-5. [PubMed 11027420] 61. Baran R, Feuilhade M, Datry A et al. A randomized trial of amorolfine 5% solution nail lacquer combined with oral terbinafine compared with terbinafine alone in the treatment of dermatophytic toenail onychomycoses affecting the matrix region. Br J Dermatol . 2000; 42:1177-83. 62. Bonifaz A, Ibarra G. Onychomycosis in children: treatment with bifonazole-urea. Pediatr Dermatol . 2000; 17:310-4. [PubMed 10990584] 63. Tsuboi R, Unno K, Komatsuzaki H et al. [Topical treatment of onychomycosis by occlusive dressing using bifonazole cream containing 40% urea.] (Japanese with English abstract.) Nippon Ishinkin Gakkai Zasshi . 1998; 39:11-6. 64. Friedman-Birnbaum R, Cohen A, Shemer A et al. Treatment of onychomycosis: a randomized, double-blind comparison study with topical bifonazole-urea ointment alone and in combination with short-duration oral griseofulvin. Int J Dermatol . 1997; 36:67-9. [PubMed 9071624] 65. Medicis Pharmaceutical Corp. Loprox (ciclopirox) shampoo 1% prescribing information. Scottsdale, AZ; 2003 Feb. 66. Medicis Pharmaceutical Corp. Loprox (ciclopirox olamine) lotion 0.77% prescribing information. Scottsdale, AZ; 2002 Feb. Next Pregnancy Warnings Print this page Add to My Med List More about ciclopirox topical Side Effects During Pregnancy or Breastfeeding Dosage Information Support Group Pricing & Coupons En Español 25 Reviews Add your own review/rating Drug class: topical antifungals Consumer resources Ciclopirox topical ... +8 more Professional resources Ciclopirox (FDA) Ciclopirox Gel (FDA) Ciclopirox Lotion (FDA) Ciclopirox Nail Lacquer (FDA) Ciclopirox Shampoo (FDA) ... +3 more Other brands: Penlac , Loprox , Ciclodan , CNL8 Nail Related treatment guides Onychomycosis, Toenail Onychomycosis, Fingernail Seborrheic Dermatitis Cutaneous Candidiasis ... +4 more} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Akorn, Inc. Perrigo Company Sandoz Inc. Taro Pharmaceuticals U.S.A., Inc. Teva Pharmaceuticals USA, Inc. Glenmark Pharmaceuticals Inc., USA Acella Pharmaceuticals, LLC More... Drug Class Topical antifungals Related Drugs Seborrheic Dermatitis prednisone , hydrocortisone topical , ketoconazole topical , dexamethasone , Decadron , Deltasone , More... Onychomycosis, Toenail terbinafine , Lamisil , ciclopirox topical , Penlac , itraconazole , Jublia , More... Tinea Corporis clotrimazole topical , ketoconazole topical , Lotrisone , terbinafine topical , Lamisil , More... Onychomycosis, Fingernail terbinafine , Lamisil , ciclopirox topical , Penlac , itraconazole , griseofulvin , More... 4 more conditions... Ciclopirox topical Rating 25 User Reviews 7.2 /10 25 User Reviews 7.2 Rate it!} } positively
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