and adaptability diphenhydramine and phenylephrine Generic Name: diphenhydramine and phenylephrine (DYE fen HYE dra meen and FEN il EFF rin) Brand Name: Children's Triacting Night Time, Delsym Children's Night Time Cough & Cold, Dimetapp Nighttime Cold & Congestion, Dytan-D, PediaCare Children's Allergy & Cold, Robitussin Night Time Cough & Cold, Triaminic Night Time Cold & Cough, ...show all 23 brand names Diphentann-D, D-Tann, Uni-Tann D, Aldex-CT, Diphenmax D, Triaminic Night Time Cold & Cough, Alahist LQ, Robitussin Night Time Cough & Cold, Robitussin Night Time Cough & Cold Pediatric, PediaCare Children's Allergy & Cold, Dimetapp Nighttime Cold & Congestion, Robitussin Night Time Cough & Cold Children's, Delsym Children's Nighttime Cough and Cold (obsolete), Zoden PD, Benadryl-D Children's Allergy & Sinus, Delsym Children's Night Time Cough & Cold Overview Side Effects Dosage Interactions Pregnancy More User Reviews Drug Images Support Group Q & A What is diphenhydramine and phenylephrine? Diphenhydramine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Diphenhydramine and phenylephrine is a combination medicine used to treat symptoms of the common cold or seasonal allergies, including sneezing, runny or stuffy nose, and itchy, watery eyes. Diphenhydramine and phenylephrine may also be used for purposes not listed in this medication guide. Slideshow Seasoned Pro: Be Mindful of These Winter Health Hazards What is the most important information I should know about diphenhydramine and phenylephrine? Do not use this medicine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine. You should not use antihistamine medication to make a child sleepy. What should I discuss with my healthcare provider before taking diphenhydramine and phenylephrine? You should not use this medicine if you are allergic to diphenhydramine or phenylephrine. Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. Ask a doctor or pharmacist if it is safe for you to use this medicine if you have other medical conditions, especially: asthma or COPD, cough with mucus, or cough caused by smoking, emphysema, or chronic bronchitis; kidney or liver disease; high blood pressure, heart disease; enlarged prostate, urination problems; glaucoma; diabetes; or a thyroid disorder. It is not known whether diphenhydramine and phenylephrine will harm an unborn baby. Do not use this medicine without your doctor's advice if you are pregnant. It is not known whether diphenhydramine and phenylephrine passes into breast milk or if it could affect a nursing baby. Antihistamines and decongestants may also slow breast milk production. Ask a doctor before using this medicine if you are breast-feeding. Artificially sweetened liquid medicine may contain phenylalanine. Check the medication label if you have phenylketonuria (PKU). How should I take diphenhydramine and phenylephrine? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Cold or allergy medicine is usually taken only for a short time until your symptoms clear up. Do not give this medicine to a child younger than 6 years old. Always ask a doctor before giving cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. You should not use antihistamine medication to make a child sleepy. The chewable tablet must be chewed before swallowing. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Call your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache, cough, or skin rash. If you need surgery or medical tests, tell the doctor ahead of time if you have taken a cold medicine within the past few days. Store at room temperature away from moisture and heat. What happens if I miss a dose? Since cold or allergy medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking diphenhydramine and phenylephrine? This medication may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol with this medicine can cause side effects. Ask a doctor or pharmacist before using any other cold, allergy, or sleep medicine. Many combination medicines contain diphenhydramine (Benadryl) or phenylephrine. Taking certain products together can cause you to get too much of this medicine. Diphenhydramine and phenylephrine side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Stop using this medicine and call your doctor at once if you have: severe dizziness or nervousness; severe drowsiness; or little or no urination. Side effects such as dry mouth, constipation, and confusion may be more likely in older adults. Common side effects may include: dizziness, drowsiness; dry mouth, nose, or throat; blurred vision; or feeling restless or excited (especially in children). This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088. Side Effects (complete list) Diphenhydramine and phenylephrine dosing information Usual Adult Dose for Allergic Rhinitis: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 1 to 2 tablets orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release: 5 to 10 mL orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours Usual Adult Dose for Cold Symptoms: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 1 to 2 tablets orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release: 5 to 10 mL orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours Usual Adult Dose for Sinusitis: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 1 to 2 tablets orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension, extended release: 5 to 10 mL orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 20 mL orally every 4 to 6 hours, not to exceed 120 mL in 24 hours Usual Pediatric Dose for Allergic Rhinitis: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 13 yrs or older: 1 to 2 tablets orally every 12 hours 6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension: 13 yrs or older: 5 to 10 mL orally every 12 hours 6 to 12 yrs: 2.5 to 5 mL orally every 12 hours 2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release: 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours. diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours 6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid: 6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip: 6 to 11 yrs: dissolve 1 strip on tongue Usual Pediatric Dose for Cold Symptoms: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 13 yrs or older: 1 to 2 tablets orally every 12 hours 6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension: 13 yrs or older: 5 to 10 mL orally every 12 hours 6 to 12 yrs: 2.5 to 5 mL orally every 12 hours 2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release: 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours. diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours 6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid: 6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip: 6 to 11 yrs: dissolve 1 strip on tongue Usual Pediatric Dose for Sinusitis: diphenhydrAMINE-phenylephrine 25 mg-10 mg oral tablet: diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral tablet, chewable, extended release: 13 yrs or older: 1 to 2 tablets orally every 12 hours 6 to 12 yrs: 1/2 to 1 tablet orally every 12 hours diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral suspension: 13 yrs or older: 5 to 10 mL orally every 12 hours 6 to 12 yrs: 2.5 to 5 mL orally every 12 hours 2 to less than 6 yrs: 1.25 to 2.5 mL orally every 12 hours diphenhydrAMINE-phenylephrine 6.25 mg-6.25 mg/5 mL oral suspension, extended release: 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 6 doses in 24 hours. diphenhydrAMINE-phenylephrine 25 mg-7.5 mg/5 mL oral liquid: 12 yrs or older: 5 mL orally every 4 to 6 hours, not to exceed 30 mL in 24 hours 6 to 11 yrs: 2.5 mL orally every 4 to 6 hours, not to exceed 15 mL in 24 hours diphenhydrAMINE-phenylephrine 6.25 mg-2.5 mg/5 mL oral liquid: 12 yrs or older: 20 mL orally every 4 hours, not to exceed 120 mL in 24 hours 6 to 11 yrs: 10 mL orally every 4 hours, not to exceed 60 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg/5 mL oral liquid: 6 to 11 yrs: 5 mL orally every 4 hours, not to exceed 30 mL in 24 hours diphenhydrAMINE-phenylephrine 12.5 mg-5 mg oral disintegrating strip: 6 to 11 yrs: dissolve 1 strip on tongue What other drugs will affect diphenhydramine and phenylephrine? Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide. Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking diphenhydramine and phenylephrine with a sleeping pill, opioid pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Next Side Effects Print this page Add to My Med List More about diphenhydramine/phenylephrine Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: upper respiratory combinations Consumer resources Diphenhydramine/Phenylephrine Chewable Tablets Diphenhydramine and Phenylephrine Liquid, Solution, and Syrup Diphenhydramine and Phenylephrine Oral Strips Other brands: Alahist LQ , Children's Triacting Night Time , D-Tann , Delsym Children's Night Time Cough & Cold , ... +7 more Related treatment guides Cold Symptoms Allergic Rhinitis Sinusitis Where can I get more information? Your pharmacist can provide more information about diphenhydramine and phenylephrine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 3.01. Date modified: December 03, 2017 Last reviewed: August 01, 2017} Drug Status Rx OTC Availability Rx and/or OTC C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug WADA Class Anti-Doping Classification Drug Class Upper respiratory combinations Related Drugs Allergic Rhinitis prednisone , Zyrtec , promethazine , fluticasone nasal , loratadine , cetirizine , Flonase , triamcinolone , More... Sinusitis prednisone , ciprofloxacin , amoxicillin , azithromycin , Augmentin , Zithromax , Levaquin , More... Cold Symptoms diphenhydramine , Benadryl , Promethazine DM , chlorpheniramine , echinacea , Tussionex Pennkinetic , Banophen , Benadryl Allergy , More... Diphenhydramine / phenylephrine Rating 1 User Review 9.0 /10 1 User Review 9.0 Rate it! Diphenhydramine / phenylephrine Images Diphenhydramine / phenylephrine systemic 25 mg / 10 mg (TCL 124 ) View larger images Help and Support Looking for answers? 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