and actually rifapentine (Oral route) rif-a-PEN-teen Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Priftin Available Dosage Forms: Tablet Therapeutic Class: Antitubercular Chemical Class: Rifamycin Slideshow Men's Health Month And Movember: Raising The Profile Of Men's Health One Stache At A Time Uses For rifapentine Rifapentine is used in combination with other medicines to treat active tuberculosis in adults and children 12 years of age and older. It is also used to treat inactive (latent) tuberculosis in adults and children 2 years of age and older. Rifapentine is an antibiotic and works to kill or prevent the growth of bacteria. It will not help against viruses. rifapentine is available only with your doctor's prescription. Before Using rifapentine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifapentine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to rifapentine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of rifapentine to treat active tuberculosis in children younger than 12 years of age, nor to treat inactive tuberculosis in children younger than 2 years of age. Safety and efficacy have not been established in these age groups. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifapentine in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding Studies suggest that this medication may alter milk production or composition. If an alternative to this medication is not prescribed, you should monitor the infant for side effects and adequate milk intake. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rifapentine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rifapentine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Artemether Delamanid Lurasidone Maraviroc Ranolazine Rilpivirine Using rifapentine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Amprenavir Apremilast Bedaquiline Bortezomib Ceritinib Cholera Vaccine, Live Clarithromycin Cobicistat Darunavir Dolutegravir Doxorubicin Doxorubicin Hydrochloride Liposome Efavirenz Elvitegravir Enzalutamide Erlotinib Etravirine Exemestane Fosamprenavir Idelalisib Indinavir Irinotecan Irinotecan Liposome Ketoconazole Lapatinib Ledipasvir Linagliptin Lopinavir Macitentan Mifepristone Naloxegol Nelfinavir Netupitant Nevirapine Nifedipine Nilotinib Nimodipine Olaparib Panobinostat Pazopanib Perampanel Piperaquine Ponatinib Regorafenib Ritonavir Romidepsin Saquinavir Simeprevir Sorafenib Sunitinib Tasimelteon Tenofovir Alafenamide Ticagrelor Tipranavir Tofacitinib Tolvaptan Ulipristal Vandetanib Velpatasvir Vilazodone Vincristine Vincristine Sulfate Liposome Vortioxetine Using rifapentine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acenocoumarol Acetyldigoxin Alprazolam Amiodarone Amitriptyline Betamethasone Bisoprolol Carbamazepine Carteolol Carvedilol Chloramphenicol Chlorpropamide Ciprofloxacin Clofibrate Cyclosporine Dapsone Delavirdine Deslanoside Desogestrel Dexamethasone Diazepam Dicumarol Dienogest Digitoxin Digoxin Disopyramide Doxycycline Drospirenone Estradiol Cypionate Estradiol Valerate Ethinyl Estradiol Ethynodiol Diacetate Etonogestrel Fluconazole Fludrocortisone Fosphenytoin Gallopamil Glyburide Haloperidol Hydrocortisone Levonorgestrel Levothyroxine Lorcainide Medroxyprogesterone Acetate Mestranol Metildigoxin Metoprolol Mexiletine Nitrazepam Norelgestromin Norethindrone Norgestimate Norgestrel Nortriptyline Ospemifene Phenprocoumon Phenytoin Prednisone Propafenone Propranolol Quinidine Quinine Repaglinide Sildenafil Talinolol Temazepam Tertatolol Theophylline Tocainide Tolbutamide Triazolam Valproic Acid Warfarin Zidovudine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of rifapentine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse, or history of May increase risk for more serious side effects. Elevated liver enzymes or Liver disease Use with caution. May make these conditions worse. Porphyria Avoid use of rifapentine in patients with this condition. Proper Use of rifapentine Take rifapentine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects. rifapentine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Take rifapentine with food. Swallow the tablet whole. Do not crush, break, or chew it. If you cannot swallow the tablet, you may crush it and add it to a small amount of semi-solid food. Take it immediately and do not store it for later use. To help clear up your infection completely, it is very important that you keep using rifapentine for the full time of treatment , even if you begin to feel better after a few weeks. If you have TB, you might have to take rifapentine for several months. It is important that you not miss any doses. Dosing The dose of rifapentine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rifapentine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For the treatment of active tuberculosis: Adults and children 12 years of age and older 600 milligrams (mg) two times a week with an interval of not less than 3 days (72 hours) between doses. Then, 600 mg once a week taken for 4 months with isoniazid or other medicines. Children younger than 12 years of age Use and dose must be determined by your doctor. For the treatment of latent tuberculosis: Adults and children 12 years of age and older Dose is based on body weight and must be determined by your doctor. The dose is usually up to 900 milligrams (mg) once a week taken with isoniazid for 12 weeks. Children 2 to 11 years of age Dose is based on body weight and must be determined by your doctor. The dose is usually 300 to 900 mg once a week taken with isoniazid for 12 weeks. Children younger than 2 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of rifapentine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using rifapentine It is very important that your doctor check your progress at regular visits to make sure rifapentine is working properly. Blood tests may be needed to check for unwanted effects. If your symptoms do not improve within 2 to 3 weeks, or if they become worse, check with your doctor. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. rifapentine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor if you have a rash, itching, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, fever or chills, lightheadedness, dizziness, or fainting, puffiness or swellings of the eyelids or around the eyes, or unusual bleeding, bruising, or weakness. If these side effects occur, get emergency help at once. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. Liver problems may be more likely to occur if you drink alcoholic beverages regularly while you are taking rifapentine. Also, the regular use of alcohol may keep rifapentine from working properly. You should not drink alcoholic beverages while you are taking rifapentine. Rifapentine will cause the urine, stools, saliva, sputum, sweat, and tears to turn reddish-orange to reddish-brown. This is to be expected while you are taking rifapentine. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. It is best not to wear soft contact lenses while taking rifapentine. Hard contact lenses are not discolored by rifapentine. If you have any questions about this, check with your doctor. rifapentine may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using rifapentine. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor. Rifapentine can lower the number of white blood cells in your blood temporarily, increasing the chance of getting infection. It can also lower the number of platelets, which are necessary for proper blood clotting. These problems may result in a greater chance of getting certain infections, slow healing, and bleeding of the gums. Be careful when using a regular toothbrush, dental floss, or a toothpick. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. Before you have any medical tests, tell the doctor in charge that you are taking rifapentine. The results of some tests may be affected by rifapentine. Birth control pills may not work properly if you take them while you are taking rifapentine. Unplanned pregnancies may occur. Use a different means of birth control while you are taking rifapentine. If you have any questions about this, check with your doctor. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. rifapentine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Blood in the urine joint pain lower back or side pain swelling of the feet or lower legs Less common Aggressive reaction black, tarry stools blood in the stools nausea pinpoint red spots on the skin severe abdominal or stomach pain sore throat and fever unusual bleeding or bruising unusual tiredness or weakness vomiting yellow eyes or skin Rare Diarrhea dizziness increase in blood pressure severe or continuing headaches Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Acne constipation loss of appetite Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about rifapentine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: rifamycin derivatives Consumer resources Rifapentine Other brands: Priftin Professional resources Rifapentine (AHFS Monograph) Rifapentine (Wolters Kluwer) Related treatment guides Tuberculosis, Active Tuberculosis, Latent} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Rifamycin derivatives Related Drugs Tuberculosis, Latent rifampin , isoniazid , pyrazinamide , Rifadin , Nydrazid , Rimactane , Priftin , More... Tuberculosis, Active ciprofloxacin , Levaquin , levofloxacin , rifampin , moxifloxacin , Avelox , isoniazid , ethambutol , amikacin , gatifloxacin , More... Rifapentine Rating No Reviews - Be the first! 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