discovering dupilumab (Subcutaneous route) doo-PIL-ue-mab Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Dupixent Available Dosage Forms: Solution Therapeutic Class: Dermatological Agent Pharmacologic Class: Monoclonal Antibody Slideshow 7 First Aid Kit Must Haves For Your Medicine Cabinet Uses For dupilumab Dupilumab injection is used alone or in combination with other medicines (eg, topical corticosteroids) to treat moderate to severe atopic dermatitis. dupilumab is available only with your doctor's prescription. Before Using dupilumab In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For dupilumab, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to dupilumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of dupilumab injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dupilumab injection in the elderly. Safety and efficacy have not been established. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking dupilumab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using dupilumab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adenovirus Vaccine Bacillus of Calmette and Guerin Vaccine, Live Cholera Vaccine, Live Influenza Virus Vaccine, Live Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Poliovirus Vaccine, Live Rotavirus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Vaccine Typhoid Vaccine Varicella Virus Vaccine Yellow Fever Vaccine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of dupilumab. Make sure you tell your doctor if you have any other medical problems, especially: Asthma, history of or Parasitic infection Use with caution. It is not known if dupilumab may affect patients with these conditions. Conjunctivitis (pink eye) or Keratitis (inflammation of the cornea of the eye) Use with caution. May make these conditions worse. Proper Use of dupilumab A nurse or other trained health professional will give you dupilumab. dupilumab is given as a shot under your skin, usually in the thigh or abdomen (stomach) area. dupilumab should come with patient information leaflet. Read and follow these instructions carefully. Ask your doctor if you have any questions. Dupixent may sometimes be given at home to patients who do not need to be in a hospital or clinic. If you are using dupilumab at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine. If you use Dupixent at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Do not inject into skin areas that are tender, damaged, bruised, or scarred. If the medicine in the prefilled syringe has changed color, or if you see particles in it, do not use it. Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. Dosing The dose of dupilumab will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of dupilumab. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form (prefilled syringe): For moderate to severe atopic dermatitis: Adults At first, 600 milligrams (mg) (two 300 mg injections) injected under the skin at different injection sites. Then, your dose will be reduced to 300 mg every 2 weeks. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of dupilumab, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store in the refrigerator. Do not freeze. Protect the medicine from direct light. Keep the medicine in the original package until you are ready to use it. Precautions While Using dupilumab It is very important that your doctor check you at regular visits to make sure dupilumab is working properly. Blood tests may be needed to check for unwanted effects. dupilumab may cause serious allergic reactions, including generalized urticaria or serum sickness. Tell your doctor right away if you have a feeling of discomfort, fever, inflammation of the joints, hives, itching, muscle aches, rash, or swollen lymph glands. Check with your doctor right away if you have redness, irritation, or itching of eye, eyelid, or inner lining of eyelid. These could be symptoms of eye problems, including conjunctivitis or keratitis. Do not have any live vaccines (immunizations) while you are being treated with dupilumab. Check with your doctor before having any vaccines. dupilumab Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Blistering or crusting of the skin itchiness, redness of the eyes excessive tearing painful cold sores or blisters on the lips, nose, eyes, or genitals reddening of the skin scaly patches on the skin sores or white patches on the lips, mouth, or throat Less common Burning or dry eyes fever pain, swelling of the eye or eyelid Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about dupilumab Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 32 Reviews Add your own review/rating Drug class: interleukin inhibitors Consumer resources Dupilumab Other brands: Dupixent Professional resources Dupilumab (AHFS Monograph) Related treatment guides Atopic Dermatitis Eczema} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Interleukin inhibitors Related Drugs Atopic Dermatitis prednisone , fluticasone topical , triamcinolone topical , hydrocortisone topical , dexamethasone , methylprednisolone , clobetasol topical , betamethasone topical , doxepin topical , mometasone topical , Kenalog , fluocinonide topical , More... Eczema prednisone , fluticasone topical , triamcinolone topical , hydrocortisone topical , dexamethasone , clobetasol topical , doxepin topical , mometasone topical , Kenalog , fluocinonide topical , desonide topical , More... Dupilumab Rating 32 User Reviews 8.2 /10 32 User Reviews 8.2 Rate it! Help and Support Looking for answers? Ask a question or go join the dupilumab support group to connect with others who have similar interests.} } prior to
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