moderately Soliqua 100/33 Dosage Generic name: insulin glargine 100U in 1mL, lixisenatide 33ug in 1mL Dosage form: injection, solution Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist. Important Dosage Information The following are important dosing information for SOLIQUA 100/33, a combination of insulin glargine and lixisenatide: Discontinue therapy with lixisenatide or basal insulin prior to initiation of SOLIQUA 100/33. In patients inadequately controlled on less than 30 units of basal insulin or on lixisenatide, the recommended starting dosage of SOLIQUA 100/33 is 15 units (15 units insulin glargine/5 mcg lixisenatide) given subcutaneously once daily. In patients inadequately controlled on 30 to 60 units of basal insulin, the recommended starting dosage of SOLIQUA 100/33 is 30 units (30 units insulin glargine/10 mcg lixisenatide) given subcutaneously once daily. Administer SOLIQUA 100/33 subcutaneously once a day within the hour prior to the first meal of the day. The maximum dosage of SOLIQUA 100/33 is 60 units (60 units insulin glargine/20 mcg lixisenatide) [see Warnings and Precautions (5.5) ]. The SOLIQUA 100/33 Pen delivers doses from 15 to 60 units in a single injection (see Table 1 ) [see Dosage and Administration (2.2) ]. Use alternative antidiabetic products if patients require a SOLIQUA 100/33 daily dosage: below 15 units, or over 60 units Table 1 presents the units insulin glargine and the micrograms of lixisenatide in each dosage of SOLIQUA 100/33. Table 1: Units of Insulin Glargine and Micrograms of Lixisenatide in Each Dosage of SOLIQUA 100/33 SOLIQUA 100/33 (dose window display) * Insulin glargine component dose Lixisenatide component dose Comment * The dose window on the SOLIQUA 100/33 pen displays numbers for the even units and displays lines for the odd units. 2 --- --- Safety test dose not for injection 15 15 units 5 mcg Recommended starting dosage for patients previously treated with lixisenatide or less than 30 units of basal insulin 16 16 units 5.3 mcg 17 17 units 5.7 mcg 18 18 units 6 mcg 19 19 units 6.3 mcg 20 20 units 6.7 mcg 21 21 units 7 mcg 22 22 units 7.3 mcg 23 23 units 7.7 mcg 24 24 units 8 mcg 25 25 units 8.3 mcg 26 26 units 8.7 mcg 27 27 units 9 mcg 28 28 units 9.3 mcg 29 29 units 9.7 mcg 30 30 units 10 mcg Recommended starting dosage for patients previously treated with 30 to 60 units of basal insulin 31 31 units 10.3 mcg 32 32 units 10.7 mcg 33 33 units 11 mcg 34 34 units 11.3 mcg 35 35 units 11.7 mcg 36 36 units 12 mcg 37 37 units 12.3 mcg 38 38 units 12.7 mcg 39 39 units 13 mcg 40 40 units 13.3 mcg 41 41 units 13.7 mcg 42 42 units 14 mcg 43 43 units 14.3 mcg 44 44 units 14.7 mcg 45 45 units 15 mcg 46 46 units 15.3 mcg 47 47 units 15.7 mcg 48 48 units 16 mcg 49 49 units 16.3 mcg 50 50 units 16.7 mcg 51 51 units 17 mcg 52 52 units 17.3 mcg 53 53 units 17.7 mcg 54 54 units 18 mcg 55 55 units 18.3 mcg 56 56 units 18.7 mcg 57 57 units 19 mcg 58 58 units 19.3 mcg 59 59 units 19.7 mcg 60 60 units 20 mcg Maximum daily dosage [see Warnings and Precautions (5.5) ] Titration of SOLIQUA 100/33 After starting with the recommended dosage of SOLIQUA 100/33, based upon prior insulin dose or lixisenatide use [see Dosage and Administration 2.1 ] , titrate the dosage upwards or downwards by two to four units (see Table 2 ) every week based on the patient's metabolic needs, blood glucose monitoring results, and glycemic control goal until the desired fasting plasma glucose is achieved. The dosage of SOLIQUA 100/33 is between 15 to 60 units (see Table 1 ). To minimize the risk of hypoglycemia or hyperglycemia, additional titration may be needed with changes in physical activity, meal patterns (i.e., macronutrient content or timing of food intake), or renal or hepatic function; during acute illness; or when used with other medications [see Warnings and Precautions (5.4) and Drug Interactions (7) ]. Table 2: Recommended Titration of SOLIQUA 100/33 (Every Week) * Self-Monitored Fasting Plasma Glucose SOLIQUA 100/33 Dosage Adjustment * The recommended SOLIQUA 100/33 dosage is between 15 to 60 units (see Table 1 ) Above target range +2 units (2 units of insulin glargine and 0.66 mcg of lixisenatide) to +4 units (4 units insulin glargine and 1.32 mcg lixisenatide) Within target range 0 units Below target range -2 units (2 units of insulin glargine and 0.66 mcg of lixisenatide) to -4 units (4 units of insulin glargine and 1.32 mcg lixisenatide) Missed Doses Instruct patients who miss a dose of SOLIQUA 100/33 to resume the once-daily regimen as prescribed with the next scheduled dose. Do not administer an extra dose or increase the dose to make up for the missed dose. Important Administration Instructions The SOLIQUA 100/33 prefilled pen is for single-patient use only [see Warnings and Precautions (5.3) ] . Train patients on proper use and injection technique before initiating SOLIQUA 100/33. Always check the SOLIQUA 100/33 label before administration [see Warnings and Precautions (5.5) ] Visually inspect for particulate matter and discoloration prior to administration. Only use SOLIQUA 100/33 if the solution is clear and colorless to almost colorless. Inject SOLIQUA 100/33 subcutaneously into the abdominal area, thigh, or upper arm. Rotate injection sites within the same region from one injection to the next to reduce the risk of lipodystrophy [see Adverse Reactions (6.1) ] . Do not administer intravenously, intramuscularly, or via an insulin pump. Do not dilute or mix SOLIQUA 100/33 with any other insulin or solution. Do not split the dose of SOLIQUA 100/33. Next Professional Print this page Add to My Med List More about Soliqua (insulin glargine / lixisenatide) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: antidiabetic combinations Consumer resources Soliqua Soliqua 100/33 Professional resources Soliqua 100/33 (FDA) Related treatment guides Diabetes, Type 2 Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Sanofi-Aventis U.S. LLC Drug Class Antidiabetic combinations Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... Soliqua Rating No Reviews - Be the first! 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