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parent [800:<25 mcg/each) of vitamins B1, B2, B3 and B6 Slideshow Sports And Dietary Supplements: From Creatine To Whey MECHANISM OF ACTION: Vitamin B 12 [active] ; Vitamin B 9 [prevention] INDICATIONS: EnLyte is indicated in the treatment of pernicious anemia, and the prevention of vitamin B9 deficiency. WARNINGS: USE OF THIS PRODUCT WITHOUT DIRECT SUPERVISION OF A PHYSICIAN IS DANGEROUS. Some patients afflicted with pernicious anemia may or not respond to the orally ingested vitamin B12, and there is no known way to predict which patients may respond and which patients may cease to respond. Periodic examination and laboratory studies of pernicious anemia patients are essential and recommended. The parenteral administration of (cyano)cobalamin or vitamin B12, is generally recognized as a fully effective treatment of pernicious anemia. Parenteral alkyl-cobalamin preparations have not been and are not authorized for use except by or on the prescription of a physician. ADVERSE REACTIONS: Allergic sensitization has been reported following both oral and parenteral administration of vitamin B 9 . DOSAGE AND ADMINISTRATION: The adult dose is one capsule daily preferably on an empty stomach. Do not exceed recommended dose. Call your medical practitioner about side effects. You may report side effects by calling 866-280-5961. HOW SUPPLIED: Oval, brownish-orange softgel capsule with ENL 7 on one side, in bottles of 30 with NDC 64661-711-30. STORAGE: Store at 20 -25 C (68 -77 F). Protect from light and moisture as contact with moisture may produce surface discoloration and/or erosion. KEEP OUT OF THE REACH OF CHILDREN. Tamper Evident:Do not use if seal is broken or missing. MANUFACTURED FOR: JayMac Pharmaceuticals, LLC; Sunset, LA 70584. MANUFACTURED AND/OR PACKAGED IN USA/CANADA. PATENTS: US Patent No 7,935,365; and other patent applications pending. TRADEMARKS: EnLyte is a registered mark of JayMac Pharmaceuticals. DeltaFolate is a use-trademark of JayMac Pharmaceuticals. Rev August 2017 PACKAGE LABEL.PRINCIPAL DISPLAY PANEL - 30 MULTIPHASIC SOFTGELS Bottle Label NDC 64661- 711 -30†† R x EnLyte with DeltaFolateTM (2.5mg F-THF, 1mg PteGlu CR, 7mg Me-THF-Mg) ANTI-PERNICIOUS ANEMIA B12 - PREPARATION with B12-cofactor levomefolic acid, magnesium salt JAYMAC Pharmaceuticals, LLC SOFTGELS (30ct BOTTLE) Presciption Hematinic Drug for Therapeutics Use EnLyte leucovorin, folic acid, levomefolate magnesium, ferrous cysteine glycinate, 1,2-docosahexanoyl-sn-glycero-3-phosphoserine calcium, 1,2-icosapentoyl-sn-glycero-3-phosphoserine calcium, phosphatidyl serine, pyridoxal 5-phosphate, flavin adenine dinucleotide, nadh, cobamamide, cocarboxylase (thiamine pyrophosphate), magnesium ascorbate, zinc ascorbate, magnesium l-threonate and betaine capsule, delayed release pellets Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:64661-711 Route of Administration ORAL DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength LEUCOVORIN (LEUCOVORIN) LEUCOVORIN 2.5 mg FOLIC ACID (FOLIC ACID) FOLIC ACID 1 mg LEVOMEFOLATE MAGNESIUM (LEVOMEFOLIC ACID) LEVOMEFOLIC ACID 7 mg FERROUS CYSTEINE GLYCINATE (FERROUS CATION) FERROUS CYSTEINE GLYCINATE 13.6 mg 1,2-DOCOSAHEXANOYL-SN-GLYCERO-3-PHOSPHOSERINE CALCIUM (1,2-DOCOSAHEXANOYL-SN-GLYCERO-3-PHOSPHOSERINE) 1,2-DOCOSAHEXANOYL-SN-GLYCERO-3-PHOSPHOSERINE CALCIUM 6.4 mg 1,2-ICOSAPENTOYL-SN-GLYCERO-3-PHOSPHOSERINE CALCIUM (1,2-ICOSAPENTOYL-SN-GLYCERO-3-PHOSPHOSERINE) 1,2-ICOSAPENTOYL-SN-GLYCERO-3-PHOSPHOSERINE CALCIUM 800 ug PHOSPHATIDYL SERINE (PHOSPHATIDYL SERINE) PHOSPHATIDYL SERINE 12 mg PYRIDOXAL PHOSPHATE ANHYDROUS (PYRIDOXAL PHOSPHATE ANHYDROUS) PYRIDOXAL PHOSPHATE ANHYDROUS 25 ug FLAVIN ADENINE DINUCLEOTIDE (FLAVIN ADENINE DINUCLEOTIDE) FLAVIN ADENINE DINUCLEOTIDE 25 ug NADH (NADH) NADH 25 ug COBAMAMIDE (COBAMAMIDE) COBAMAMIDE 50 ug COCARBOXYLASE (COCARBOXYLASE) COCARBOXYLASE 25 ug MAGNESIUM ASCORBATE (ASCORBIC ACID) MAGNESIUM ASCORBATE 24 mg ZINC ASCORBATE (ASCORBIC ACID) ZINC ASCORBATE 1 mg MAGNESIUM L-THREONATE (THREONIC ACID, L-) MAGNESIUM L-THREONATE 1 mg BETAINE (BETAINE) BETAINE 500 ug CITRIC ACID MONOHYDRATE (ANHYDROUS CITRIC ACID) ANHYDROUS CITRIC ACID 1.83 mg SODIUM CITRATE (SODIUM CATION) SODIUM CITRATE 3.67 mg Inactive Ingredients Ingredient Name Strength ANNATTO GELATIN GLYCERIN LECITHIN, SUNFLOWER OLIVE OIL PIPERINE WATER UBIDECARENONE YELLOW WAX Product Characteristics Color BROWN (annatto) Score no score Shape OVAL Size 14mm Flavor ORANGE (creamy orange) Imprint Code ENL Contains Packaging # Item Code Package Description 1 NDC:64661-711-30 30 CAPSULE, DELAYED RELEASE PELLETS in 1 BOTTLE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date unapproved drug other 10/01/2011 Labeler - Jaymac Pharmaceuticals LLC (830767260) Registrant - Jaymac Pharmaceuticals LLC (830767260) Revised: 09/2017 Jaymac Pharmaceuticals LLC Next Interactions Print this page Add to My Med List More about EnLyte (multivitamin with iron) Side Effects During Pregnancy Dosage Information Drug Interactions Pricing & Coupons 1 Review Add your own review/rating Drug class: iron products Consumer resources Professional resources Other brands: Dialyvite , Integra Plus , Ferralet 90 , Ferrex 28 , ... +19 more Related treatment guides Vitamin/Mineral Supplementation and Deficiency Anemia> ] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx OTC Availability Rx and/or OTC C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Iron products Vitamin and mineral combinations Related Drugs iron products ferrous sulfate , Feosol Original , Iron-150 , Dialyvite vitamin and mineral combinations multivitamin , Citracal + D Anemia pyridoxine , Procrit , Revlimid , Vitamin B6 , Epogen , Iron-150 , Dialyvite , epoetin alfa , Integra , lenalidomide , More... Vitamin / Mineral Supplementation and Deficiency folic acid , ferrous sulfate , ergocalciferol , Vitamin D2 , Zinc , thiamine , Drisdol , selenium , More... EnLyte Rating 1 User Review 1.0 /10 1 User Review 1.0 Rate it! is certain


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leading Gadoxetate Generic Name: Gadoxetate (gad OX e tate) Brand Name: Eovist Overview Side Effects Dosage Interactions Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Warning This medicine raises the chance of a health problem called nephrogenic systemic fibrosis (NSF) in some people. This may lead to very bad and sometimes deadly skin, muscle, and organ problems. Call your doctor right away if you have skin burning, itching, swelling, or scaling; red or dark spots on the skin; or hard or tight skin. Call your doctor right away if you have stiff joints, muscle weakness, or hip or rib pain. Call your doctor right away if you have trouble moving, bending, or straightening your arms, hands, legs, or feet. Before using gadoxetate, talk with your doctor if you have any of these health problems: High blood pressure, high blood sugar (diabetes), kidney disease, or liver disease. Tell your doctor if you have recently taken a drug like this one. If you are 60 or older, use this medicine with care. You could have more side effects. Your blood work may need to be checked. Talk with your doctor. Uses of Gadoxetate: It is used during an MRI (magnetic resonance imaging) test. Slideshow Men's Health Month And Movember: Raising The Profile Of Men's Health One Stache At A Time What do I need to tell my doctor BEFORE I take Gadoxetate? If you have an allergy to gadoxetate, gadolinium, or any other part of gadoxetate. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Gadoxetate? Tell all of your health care providers that you take gadoxetate. This includes your doctors, nurses, pharmacists, and dentists. Very bad and sometimes deadly allergic side effects have rarely happened. Talk with your doctor. Kidney failure has happened with this medicine in people who already had kidney problems. Talk with the doctor. This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take gadoxetate. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Gadoxetate) best taken? Use gadoxetate as ordered by your doctor. Read all information given to you. Follow all instructions closely. It is given as a shot into a vein. What do I do if I miss a dose? Call your doctor to find out what to do. Dosage Information (comprehensive) What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Very bad dizziness or passing out. Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain. This medicine may cause tissue damage if the drug leaks from the vein. Tell your nurse if you have any redness, burning, pain, swelling, blisters, skin sores, or leaking of fluid where the drug is going into your body. What are some other side effects of Gadoxetate? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Headache. Upset stomach. Change in taste. Feeling hot. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Gadoxetate? If you need to store this medicine at home, talk with your doctor, nurse, or pharmacist about how to store it. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about gadoxetate, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about gadoxetate. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using gadoxetate. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about gadoxetate disodium Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group En Español 2 Reviews Add your own review/rating Drug class: magnetic resonance imaging contrast media Consumer resources Gadoxetate Gadoxetate Intravenous (Advanced Reading) Other brands: Eovist Professional resources Related treatment guides Liver Magnetic Resonance Imaging Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Gadoxetate disodium Rating 2 User Reviews 6.0 /10 2 User Reviews 6.0 Rate it! Drug Class Magnetic resonance imaging contrast media Related Drugs Liver Magnetic Resonance Imaging Eovist , More... beat back


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Photo :I have an younger skinny brother who is 12 and I m 13. He has a bigger flaccid penis than me and gets more girls than me. I m bigger and wider than him in body size, should I be ashamed?
permitted I have an younger skinny brother who is 12 and I m 13. He has a bigger flaccid penis than me and gets more girls than me. I m bigger and wider than him in body size, should I be ashamed? Posted under Uncategorized . Updated 23 November 2016. +Related Content I haven t had one girlfriend this year and I get depressed sometimes. He has had 4 girlfriends this year. I just need help, I m not thinking anything suicidal or harming myself but I just need emotional help. I masturbate a lot, so I don t know if that effects anything. The most important thing for you to know is that your attractiveness to girls has nothing to do with penis size. The most important things are your smile, your interest in them and your friendliness toward them. It is normal at your age to have concerns about your developing body. It is also a time when you are trying to develop social skills to be attractive to others. Your body will develop all by itself and may take a few more years to fully develop. To develop social skills, try being friendly, patient and being a good listener. Those qualities are very attractive socially. Don t worry about masturbating . It does not affect anything unless you are spending more time masturbating than being with other people. Tags: body image , masturbation , penis unnoticed


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Photo :CAR T-Cell Therapy: A Healthcare Professional's Guide Introduction - The Tumor
that i'm wondering CAR T-Cell Therapy: A Healthcare Professional's Guide Introduction - The Tumor Medically reviewed on Oct 22, 2017 by L. Anderson, PharmD . Previous 1 of 6 Next View as slideshow A Tumor: Defined When you hear the word tumor, you automatically think of cancer. But what really is a tumor? A tumor, or neoplasm, is a mass of abnormal tissue that arises when cells divided uncontrollably. However, tumors aren't always a cancer. Tumors can be benign or malignant . Benign tumors are usually harmless, localized to one area, and are non-cancerous. Benign tumors do not spread but may grow larger, obstructing organs or other structures. Examples of common benign tumors include lipomas , which are composed of fat cells, and angiomas, which consists of small blood vessels. Malignant tumors (cancer) have the ability to invade surrounding tissues, metastasize (spread throughout the body), and cause significant illness or death. Malignant Tumor Types From a histological standpoint, there are over 100 different types of cancer. A cancer is not always a solid tumor mass. Hematologic cancers can form, too, as with leukemia which begins in the blood-forming tissue of the bone marrow. Examples include: Sarcomas - arise from bone and soft tissue; examples include osteosarcoma and Kaposi sarcoma. Carcinomas - most common form of cancer that arises from epithelial cells; examples include basal cell carcinoma and adenocarcinomas (breast, prostate). Lymphomas - begins in lymphocytes (B or T cells); includes non-Hodgkin lymphoma and Hodgkin lymphoma. Leukemias - start in the blood-forming tissue of the bone marrow; examples are Acute lymphocytic leukemia (ALL) and Chronic lymphocytic leukemia (CLL). Melanomas - originates in melanocyte (pigment) cells leading to skin or eye cancers. Myelomas - begin in immune cells called plasma cells that build up in the bone marrow; multiple myeloma results in bone tumors throughout the body. The Cancer Cell vs. the Normal Cell: What's the Difference? Cancer cells are less specialized than a normal, healthy cell, and do not have specific biological functions. This allows them to continue dividing and invade surrounding tissues. Cancer cells can evade apoptosis - the signal that alerts cells to begin programmed cell death and stop dividing. Cancer cells can take advantage of their microenvironment - for example, they can signal the beginning of angiogenesis when surrounding cells grow blood vessels to help feed the cancer cells. Cancer cells also can escape or "hide" from the immune system, which normally removes damaged or abnormal cells from the body. In fact, with immunotherapy researchers are now learning how to harness the power of the body's immune system to target and kill cancer cells. Genetic Drivers of Cancerous Tumor Growth All cancers have a genetic basis and can occur sporadically or be inherited. The three main cancer-causing genes (oncogenes) that contribute to cancer formation are: Proto-Oncogenes : These genes are involved in normal cell differentiation and growth; however, a DNA change can result in these cells growing abnormally and surviving. Tumor Suppressor Genes : Normally, these genes also help to control cell growth and division, but mutations can result in cells transforming to malignancies. DNA Repair Genes : These genes are responsible for fixing damaged DNA within the cell. However, when these genes are mutated, the cell can develop multiple DNA alterations, giving rise to cancerous cells. How Do Tumors Escape From the Immune System? The immune system is simply an amazing part of human biology that has built in mechanisms to clear the body of foreign substances, including cancer cells. However, sometimes things go awry. Common mechanisms that tumors might activate to escape from immune cell clearance include: Loss or a change in antigens on the tumor. Tumors can lose the major histocompatibility complex (MHC), a group of genes that normally tell the intracellular machinery to transfer tumor antigens to the surface for T-cell recognition. Tumors may be able to create a protective environment altering cytokines (e.g., interferon, interleukin, and growth factors) that block tumor antigen recognition by the T-cell. Tumors can increase the expression of PD-1 and PD-L1 immune checkpoint molecules that deplete the cancer-clearing T-cell activity. Boosting the Immune System With Immunotherapy Promising immunotherapy drug treatments are now approved, under FDA review, or being developed to augment the immune system and fight off these cancerous tumors. Cancer immunotherapy treatments include: Monoclonal Antibodies Immune Checkpoint Inhibitors (PD-1/PD-L1, and CTLA-4) Cancer Vaccines Cytokines Oncolytic viruses Chimeric antigen receptor (CAR) T-cell therapy Finished: CAR T-Cell Therapy: A Healthcare Professional's Guide: Introduction - The Tumor NEXT UP Checkpoint Inhibitors & Advanced Cancers: A Healthcare Professional's Guide The breakthrough cancer treatments known as Immune Checkpoint Inhibitors are making headlines with new uses almost daily. These drugs -- Yervoy, Opdivo, Keytruda, Tecentriq, Bavencia, and Imfinzi -- are extending DON'T MISS Seasonal Allergies: Top Prevention Tips Here, review how to safely pick the allergy medicine that may be right for you. View all slides as one page Print this page Sources Connolly JL, Schnitt SJ, Wang HH, et al. Tumor Structure and Tumor Stroma Generation. In: Kufe DW, Pollock RE, Weichselbaum RR, et al., editors. Holland-Frei Cancer Medicine. 6th edition. Hamilton (ON): BC Decker; 2003. Accessed October 22, 2017 from https://www.ncbi.nlm.nih.gov/books/NBK13447/ What is Cancer? National Cancer Institute (NIH). Accessed October 22, 2017 at https://www.cancer.gov/about-cancer/understanding/what-is-cancer Mandal A. Cancer Pathophysiology. News Medical. Accessed October 22, 2017 at http://www.news-medical.net/health/Cancer-Pathophysiology.aspx Kakarla S, Gottschalk S. CAR T Cells for Solid Tumors: Armed and Ready to Go? Cancer J. 2014; 20:151-55. AccessedOctober 22, 2017 at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050065/ Targeted Cancer Therapies. National Cancer Institute (NIH). Accessed October 22, 2017 at https://www.cancer.gov/about-cancer/treatment/types/targeted-therapies/targeted-therapies-fact-sheet Shoushtari A, Snyder Charen A, Postow A, et al. Up to Date: Principles of Cancer Immunotherapy. Accessed October 22, 2017 at https://www.uptodate.com/contents/principles-of-cancer-immunotherapy CAR T-Cell Therapy: Engineering Patients' Immune Cells to Treat Their Cancers. National Cancer Institute (NIH). Accessed October 22, 2017 at https://www.cancer.gov/about-cancer/treatment/research/car-t-cells Chimeric Antigen Receptor (CAR) T-Cell Therapy. The Leukemia & Lymphoma Society (LLS). Accessed October 22, 2017 at https://www.lls.org/treatment/types-of-treatment/immunotherapy/chimeric-antigen-receptor-car-t-cell-therapy The Genetics of Cancer. National Cancer Institute (NIH). April 2015. Accessed October 22, 2017 at https://www.cancer.gov/about-cancer/causes-prevention/genetics FDA Consumer Updates Depression: FDA-Approved Medications May Help Dealing with ADHD: What You Need to Know Making Decisions for Your Health: Getting the Info You Need FDA: Cutting-Edge Technology Sheds Light on Antibiotic Resistance More FDA updates respectable


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doing a little clofazimine (Oral route) kloe-FAZ-i-meen Overview Side Effects Professional Interactions Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Compare Alternatives Commonly used brand name(s) In the U.S. Lamprene Available Dosage Forms: Capsule Therapeutic Class: Leprostatic Slideshow The Deadly Seven: Where Are These Diseases Now? Uses For clofazimine Clofazimine is taken to treat leprosy (Hansen's disease). It is sometimes given with other medicines for leprosy. When clofazimine is used to treat flare-ups'' of leprosy, it may be given with a cortisone-like medicine. Clofazimine may also be used for other problems as determined by your doctor. clofazimine is available only with your doctor's prescription. Before Using clofazimine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For clofazimine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to clofazimine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on clofazimine have been done only in adult patients, and there is no specific information comparing use of clofazimine in children with use in other age groups. Geriatric Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of clofazimine in the elderly with use in other age groups. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking clofazimine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using clofazimine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bedaquiline Using clofazimine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aluminum Hydroxide Fosphenytoin Magnesium Hydroxide Phenytoin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using clofazimine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use clofazimine, or give you special instructions about the use of food, alcohol, or tobacco. Orange Juice Other Medical Problems The presence of other medical problems may affect the use of clofazimine. Make sure you tell your doctor if you have any other medical problems, especially: Liver disease Clofazimine may on rare occasion cause hepatitis and liver disease Stomach or intestinal problems, history of Clofazimine often causes some stomach upset, but on rare occasion may cause severe, sharp abdominal pain and burning, which may be a sign of a serious side effect Proper Use of clofazimine Clofazimine should be taken with meals or milk. To help clear up your leprosy completely, it is very important that you keep taking clofazimine for the full time of treatment , even if you begin to feel better after a few months. You may have to take it every day for as long as 2 years to life. If you stop taking clofazimine too soon, your symptoms may return. clofazimine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. Also, it is best to take each dose at the same time every day. If you need help in planning the best time to take your medicine, check with your health care professional. Dosing The dose of clofazimine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of clofazimine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For the treatment of leprosy (Hansen's disease) : Adults and teenagers: 50 to 100 milligrams once a day. clofazimine must be taken with other medicines for the treatment of Hansen's disease. Children: Dose must be determined by the doctor. Missed Dose If you miss a dose of clofazimine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using clofazimine If your symptoms do not improve within 1 to 3 months, or if they become worse, check with your doctor. It may take up to 6 months before the full benefit of clofazimine is seen. Clofazimine may cause pink or red to brownish-black discoloration of the skin within a few weeks after you start taking it. Because of the skin discoloration, some patients may become depressed. The discoloration will go away when you stop taking clofazimine. However, it may take several months or years for the skin to clear up completely. If skin discoloration causes you to feel very depressed or to have thoughts of suicide, check with your doctor immediately. clofazimine may cause some people to become dizzy, drowsy, or less alert than they are normally. Make sure you know how you react to clofazimine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or are not alert or able to see well. If these reactions are especially bothersome, check with your doctor. Clofazimine may cause your skin to become more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking clofazimine: Stay out of direct sunlight, especially between the hours of 10:00 a.m. and 3:00 p.m., if possible. Wear protective clothing, including a hat. Also, wear sunglasses. Apply a sun block product that has a skin protection factor (SPF) of at least 15. Some patients may require a product with a higher SPF number, especially if they have a fair complexion. If you have any questions about this, check with your health care professional. Apply a sun block lipstick that has an SPF of at least 15 to protect your lips. Do not use a sunlamp or tanning bed or booth. If you have a severe reaction, check with your doctor . Clofazimine may also cause dry, rough, or scaly skin. A skin cream, lotion, or oil may help to treat this problem. clofazimine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Bloody or black, tarry stools colicky or burning abdominal or stomach pain mental depression yellow eyes or skin may be an orange color if already have a pink to brownish-black skin or eye discoloration Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea dry, rough, or scaly skin loss of appetite nausea or vomiting pink or red to brownish-black discoloration of skin and eyes skin rash and itching Less common or rare Changes in taste dryness, burning, itching, or irritation of the eyes increased sensitivity of skin to sunlight Clofazimine commonly causes discoloration of the feces, lining of the eyelids, sputum, sweat, tears, and urine. Usually this side effect does not require medical attention, but the discoloration may not go away. However, clofazimine may also cause bloody or black, tarry stools. This side effect may be a symptom of serious bleeding problems that do require medical attention. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about clofazimine Side Effects During Pregnancy or Breastfeeding Drug Interactions Compare Alternatives Support Group 0 Reviews Add your own review/rating Drug class: leprostatics Consumer resources Clofazimine Other brands: Lamprene Professional resources Clofazimine (AHFS Monograph) Related treatment guides Leprosy Leprosy, Dapsone-Resistant Leprosy, Dapsone-Sensitive Leprosy, Erythema Nodosum Leprosum} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Leprostatics Related Drugs Leprosy, Dapsone-Resistant Lamprene , More... Leprosy, Erythema Nodosum Leprosum thalidomide , Thalomid , Lamprene , More... Leprosy rifampin , dapsone , Rifadin , Lamprene , Rimactane , More... Leprosy, Dapsone-Sensitive Lamprene , More... Clofazimine Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Related Questions & Answers Clofazimine - is it used in treating skin pigmentation also? During breastfeeding can take dapsone, rifampicine and clofazimine? Where can I buy Clofazimine in the US? Read more questions} } encouraged


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it is necessary Apomorphine Ampules Generic Name: Apomorphine Ampules (a poe MOR feen) Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Uses of Apomorphine Ampules: It is used to treat Parkinson's disease. What do I need to tell my doctor BEFORE I take Apomorphine Ampules? If you have an allergy to apomorphine or any other part of this medicine (apomorphine ampules). If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you are taking any of these drugs: Alosetron, dolasetron, granisetron, ondansetron, or palonosetron. This is not a list of all drugs or health problems that interact with this medicine. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine (apomorphine ampules) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Slideshow View Frightful (But Dead Serious) Drug Side Effects What are some things I need to know or do while I take Apomorphine Ampules? Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists. Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine (apomorphine ampules) affects you. To lower the chance of feeling dizzy or passing out, rise slowly if you have been sitting or lying down. Be careful going up and down stairs. Do not stop taking this medicine all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop this medicine (apomorphine ampules), you will want to slowly stop it as ordered by your doctor. Avoid drinking alcohol while taking this medicine. Talk with your doctor before you use other drugs and natural products that slow your actions. Have blood work checked as you have been told by the doctor. Talk with the doctor. Check blood pressure and heart rate as the doctor has told you. Talk with the doctor. If you are allergic to sulfites, talk with your doctor. Some products have sulfites. Do not give this medicine (apomorphine ampules) as a shot into a vein. Blood clots (in the lungs) have happened when this medicine was given as a shot into a vein. Talk with your doctor. An unsafe heartbeat that is not normal (long QT on ECG) has happened with this medicine (apomorphine ampules). Chest pain, heart attack, and sudden deaths have also rarely happened in people taking this medicine. Talk with the doctor. The chance of a type of skin cancer called melanoma may be raised in people with Parkinson's disease. It is not known if this medicine (apomorphine ampules) may also raise the chance. Have skin exams while you take this medicine. Talk with your doctor. Other drugs will be given with this medicine (apomorphine ampules) to help avoid side effects. The chance of falling is raised with this medicine. Falls may lead to very bad problems like head injury and broken bones. The chance of falling is higher in older people. Talk with the doctor. Call your doctor right away if you have a painful erection (hard penis) or an erection that lasts for longer than 4 hours. This may happen even when you are not having sex. If this is not treated right away, it may lead to lasting sex problems and you may not be able to have sex. If you are 65 or older, use this medicine (apomorphine ampules) with care. You could have more side effects. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Apomorphine Ampules) best taken? Use this medicine (apomorphine ampules) as ordered by your doctor. Read all information given to you. Follow all instructions closely. It is given as a shot into the fatty part of the skin. If you will be giving yourself the shot, your doctor or nurse will teach you how to give the shot. Follow how to use as you have been told by the doctor or read the package insert. Do not use if the solution is cloudy, leaking, or has particles. Do not use if solution changes color. Wash your hands before and after use. Move the site where you give the shot with each shot. Do not give into red or irritated skin. Throw away needles in a needle/sharp disposal box. Do not reuse needles or other items. When the box is full, follow all local rules for getting rid of it. Talk with a doctor or pharmacist if you have any questions. If it has been more than 7 days since your last dose, call your doctor to find out how to restart. What do I do if I miss a dose? Call your doctor to find out what to do. Dosage Information (comprehensive) What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of a urinary tract infection (UTI) like blood in the urine, burning or pain when passing urine, feeling the need to pass urine often or right away, fever, lower stomach pain, or pelvic pain. Signs of dehydration like dry skin, mouth, or eyes; thirst; fast heartbeat; dizziness; fast breathing; or confusion. Weakness on 1 side of the body, trouble speaking or thinking, change in balance, drooping on one side of the face, or blurred eyesight. Very bad dizziness or passing out. Feeling confused. Very upset stomach or throwing up. A skin lump or growth. Change in color or size of a mole. Strong urges that are hard to control (such as eating, gambling, sex, or spending money). Mood changes. Change in the way you act. Trouble controlling body movements that is new or worse. Hallucinations (seeing or hearing things that are not there). Sweating a lot. A heartbeat that does not feel normal. Shortness of breath, a big weight gain, or swelling in the arms or legs. Chest pain or pressure or a fast heartbeat. Bruising or dark areas of skin. Some people have fallen asleep during activities like driving, eating, or talking. Some people did not feel sleepy and felt alert right before falling asleep. This has happened up to 1 year after this medicine was started. If you fall asleep during activities, do not drive or do other tasks or actions that call for you to be alert while you take this medicine (apomorphine ampules). Call your doctor right away if this happens or you feel very sleepy. What are some other side effects of Apomorphine Ampules? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Upset stomach or throwing up. Runny nose. Yawning. Irritation where the shot is given. Dizziness. Feeling sleepy. Headache. Joint pain. Not able to sleep. Back pain. Feeling tired or weak. Hard stools (constipation). Loose stools (diarrhea). These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Apomorphine Ampules? Store at room temperature. Follow how to store closely. Read the package insert that comes with this medicine. If you have questions about how to store this medicine (apomorphine ampules), talk with your pharmacist. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take this medicine (apomorphine ampules) or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine (apomorphine ampules). This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about apomorphine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 4 Reviews Add your own review/rating Drug class: dopaminergic antiparkinsonism agents Consumer resources Apomorphine Apomorphine Cartridges and Pens Apomorphine Subcutaneous (Advanced Reading) Other brands: Apokyn Professional resources Apomorphine Hydrochloride (AHFS Monograph) Apomorphine (Wolters Kluwer) Related treatment guides Parkinson's Disease Tardive Dyskinesia} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Apomorphine Rating 4 User Reviews 7.5 /10 4 User Reviews 7.5 Rate it! Drug Class Dopaminergic antiparkinsonism agents Related Drugs Parkinson's Disease Exelon , ropinirole , pramipexole , Sinemet , Requip , benztropine , carbidopa / levodopa , Mirapex , amantadine , rivastigmine , Azilect , Cogentin , selegiline , trihexyphenidyl , bromocriptine , entacapone , Neupro , Rytary , rasagiline , Stalevo , Artane , carbidopa / entacapone / levodopa , Comtan , belladonna , More... Related: Parkinson's Disease} } is important


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cures The symptoms of mania include: elevated mood, inflated self-esteem, decreased need for sleep, racing thoughts, difficulty maintaining attention, increase in goal-directed activity, and excessive involvement in pleasurable activities. These manic symptoms significantly impact a person's daily living. What is a manic episode? A manic episode is not a disorder in and of itself, but rather is diagnosed as a part of a condition called bipolar disorder . A manic episode is a mood state characterized by period of at least one week where an elevated, expansive, or unusually irritable mood exists. A person experiencing a manic episode is usually engaged in significant goal-directed activity beyond their normal activities. People describe a manic mood as feeling very euphoric, on top of the world, and being able to do or accomplish anything. The feeling is like extreme optimism but on steroids. Sometimes the manic mood is more irritable than it is elevated, especially if the person s wishes are curtailed or denied altogether. Often a person in the midst of mania will engage in multiple projects at the same time, with little premeditation or thought going into them, and finishing none of them. They may work on these projects at all hours of the day, with little regard for sleep or rest. A person s change in mood is typically associated with manic symptoms that should be observable by others (e.g., friends or relatives of the individual) and must be uncharacteristic of the individual s usual state or behavior. In other words, they re acting in a way that isn t typical of themselves, and other people recognize it. The manic feelings the person experiences should be severe enough to cause difficulty or impairment in their ability to function at work, with friends or family, at school, or other important areas in their life. Symptoms also cannot be the result of substance use or abuse (e.g., alcohol, drugs, medications) or caused by a general medical condition. Specific Symptoms of a Manic Episode In order for a manic episode to be diagnosed, three (3) or more of the following symptoms must be present: Inflated self-esteem or grandiosity Decreased need for sleep (e.g., one feels rested after only 3 hours of sleep) More talkative than usual or pressure to keep talking Flight of ideas or subjective experience that thoughts are racing Attention is easily drawn to unimportant or irrelevant items Increase in goal-directed activity (either socially, at work or school; or sexually) or psychomotor agitation Excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments) Inflated self-esteem is typically present, ranging from uncritical self-confidence to marked grandiosity, and may reach delusional proportions. Individuals may give advice on matters about which they have no special knowledge (e.g., how to run the United Nations). Despite lack of any particular experience or talent, the individual may embark on writing a novel or composing a symphony or seek publicity for some impractical invention. Grandiose delusions are common (e.g., having a special relationship to God or to some public figure from the political, religious, or entertainment world). Almost invariably, there is a decreased need for sleep . The person usually awakens several hours earlier than usual, feeling full of energy. When the sleep disturbance is severe, the person may go for days without sleep and yet not feel tired. Manic speech is typically pressured, loud, rapid, and difficult to interrupt. Individuals may talk nonstop, sometimes for hours on end, and without regard for others wishes to communicate. Speech is sometimes characterized by joking, punning, and amusing irrelevancies. The individual may become theatrical, with dramatic mannerisms and singing. Sounds rather than meaningful conceptual relationships may govern word choice (i.e., clanging). If the person s mood is more irritable than expansive, speech may be marked by complaints, hostile comments, or angry tirades. The individual s thoughts may race , often at a rate faster than can be articulated. Some individuals with manic episodes report that this experience resembles watching two or three television programs simultaneously. Frequently there is flight of ideas evidenced by a nearly continuous flow of accelerated speech, with abrupt changes from one topic to another. For example, while talking about a potential business deal to sell computers, a salesperson may shift to discussing in minute detail the history of the computer chip, the industrial revolution, or applied mathematics. When flight of ideas is severe, speech may become disorganized and incoherent. A person in a manic episode may easily lose attention . Distractibility is evidenced by an inability to screen out irrelevant external stimuli (e.g., the interviewer s tie, background noises or conversations, or furnishings in the room). There may be a reduced ability to differentiate between thoughts that are germane to the topic and thoughts that are only slightly relevant or clearly irrelevant. The increase in goal-directed activity often involves excessive planning of, and excessive participation in, multiple activities (e.g., sexual, occupational, political, religious). Increased sexual drive, fantasies, and behavior are often present. The person may simultaneously take on multiple new business ventures without regard for the apparent risks or the need to complete each venture satisfactorily. Almost invariably, there is increased sociability (e.g., renewing old acquaintances or calling friends or even strangers at all hours of the day or night), without regard to the intrusive, domineering, and demanding nature of these interactions. Individuals may also display psychomotor agitation or restlessness by pacing or by holding multiple conversations simultaneously (e.g., by telephone and in person at the same time). Some individuals write a torrent of letters on many different topics to friends, public figures, or the media. Expansiveness, unwarranted optimism, grandiosity, and poor judgment often lead to an imprudent involvement in pleasurable activities such as buying sprees, reckless driving, foolish business investments, and sexual behavior unusual for the person, even though these activities are likely to have painful consequences. The individual may purchase many unneeded items (e.g., 20 pairs of shoes, expensive antiques) without the money to pay for them. Unusual sexual behavior may include infidelity or indiscriminate sexual encounters with strangers. People who experience a manic episode are often diagnosed with a type of bipolar disorder . This post has been updated according to DSM-5. Related Topics: Mania Quiz Bipolar Screening Test Bipolar Quiz Symptoms of Bipolar Disorder Online Bipolar Resources Related Hot Topics Today 1 How to Understand Gaslighting 2 Mobile Apps Can Help Manage and Support Mental, Emotional Health 3 Eating Nuts May Strengthen Some Brain Waves 4 Bipolar or Depression? Heart Test May Help Tell the Difference 5 Boosting Brain Activity May Buffer Against Anxiety Most Popular News Mobile Apps Can Help Manage and Support Mental, Emotional Health Eating Nuts May Strengthen Some Brain Waves Boosting Brain Activity May Buffer Against Anxiety Bipolar or Depression? Heart Test May Help Tell the Difference For Older Women, Every Movement Counts Toward Health Join Over 195,000 Subscribers to Our Weekly Newsletter Find a Therapist Enter ZIP or postal code instance


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at nighttime The symptoms of narcissistic personality disorder include: grandiose sense of importance, preoccupation with unlimited success, belief that one is special and unique, often exploitative of others, lacks empathy, is arrogant, and is jealous of others. These symptoms cause significant distress in the person's life. Narcissistic personality disorder is characterized by a long-standing pattern of grandiosity (either in fantasy or actual behavior), an overwhelming need for admiration, and usually a complete lack of empathy toward others. People with this disorder often believe they are of primary importance in everybody s life or to anyone they meet. While this pattern of behavior may be appropriate for a king in 16th century England, it is generally considered inappropriate for most ordinary people today. Some people refer to this disorder as simply narcissism. People with narcissistic personality disorder often display snobbish, disdainful, or patronizing attitudes. For example, an individual with this disorder may complain about a clumsy waiter s rudeness or stupidity or conclude a medical evaluation with a condescending evaluation of the physician. In laypeople terms, someone with this disorder may be described simply as a narcissist or as someone with narcissism. Both of these terms generally refer to someone with narcissistic personality disorder, but the casual use of these terms doesn t mean a person would actually qualify for the diagnosis. Only a trained mental health professional can diagnosis this concern. A personality disorder like narcissistic personality disorder is a disorder characterized by an enduring pattern of inner experience and behavior that deviates from the norm of the individual s culture. The pattern is seen in two (2) or more of the following areas: Thinking (cognition) Emotions or feelings (affect) How they interact with others (interpersonal functioning) Impulse control The enduring behavior pattern is inflexible and pervasive across a broad range of personal and social situations. It typically leads to significant distress or impairment in social, work, or other areas of functioning. The pattern is stable and of long duration, and its onset can typically be traced back to early adulthood or adolescence. Symptoms of Narcissistic Personality Disorder In order for a person to be diagnosed with narcissistic personality disorder (NPD) they must meet five or more of the following symptoms: Has a grandiose sense of self-importance (e.g., exaggerates achievements and talents, expects to be recognized as superior without commensurate achievements) Is preoccupied with fantasies of unlimited success, power, brilliance, beauty, or ideal love Believes that he or she is special and unique and can only be understood by, or should associate with, other special or high-status people (or institutions) Requires excessive admiration Has a very strong sense of entitlement , e.g., unreasonable expectations of especially favorable treatment or automatic compliance with his or her expectations Is exploitative of others , e.g., takes advantage of others to achieve his or her own ends Lacks empathy , e.g., is unwilling to recognize or identify with the feelings and needs of others Is often envious of others or believes that others are envious of him or her Regularly shows arrogant, haughty behaviors or attitudes Because personality disorders describe long-standing and enduring patterns of behavior, they are most often diagnosed in adulthood. It is uncommon for them to be diagnosed in childhood or adolescence, because a child or teen is under constant development, personality changes, and maturation. However, if it is diagnosed in a child or teen, the features must have been present for at least 1 year. Narcissistic personality disorder is more prevalent in males than females, and is thought to occur in around 6 percent of the general population, according to research. Like most personality disorders, NPD typically will decrease in intensity with age, with many people experiencing few of the most extreme symptoms by the time they are in the 40s or 50s. Learn more about the symptoms and characteristics of someone with narcissistic personality disorder . How is Narcissistic Personality Disorder Diagnosed? Personality disorders such as NPD are typically diagnosed by a trained mental health professional, such as a psychologist or psychiatrist. Family physicians and general practitioners are generally not trained or well-equipped to make this type of psychological diagnosis. So while you can initially consult a family physician about this problem, they should refer you to a mental health professional for diagnosis and treatment. There are no laboratory, blood or genetic tests that are used to diagnose personality disorder. Many people with this disorder don t seek out treatment. People with personality disorders, in general, do not often seek out treatment until the disorder starts to significantly interfere or otherwise impact a person s life. This most often happens when a person s coping resources are stretched too thin to deal with stress or other life events. A diagnosis for narcissistic personality disorder is made by a mental health professional comparing your symptoms and life history with those listed here. They will make a determination whether your symptoms meet the criteria necessary for a personality disorder diagnosis. Causes of Narcissistic Personality Disorder Researchers today don t know what causes NPD. There are many theories, however, about the possible causes of narcissistic personality disorder. Most professionals subscribe to a biopsychosocial model of causation that is, the causes are likely due to biological and genetic factors, social factors (such as how a person interacts in their early development with their family and friends and other children), and psychological factors (the individual s personality and temperament, shaped by their environment and learned coping skills to deal with stress). This suggests that no single factor is responsible rather, it is the complex and likely intertwined nature of all three factors that are important. If a person has this personality disorder, research suggests that there is a slightly increased risk for this disorder to be passed down to their children. Treatment of Narcissistic Personality Disorder Treatment of narcissistic personality disorder typically involves long-term psychotherapy with a therapist that has experience in treating this kind of personality disorder. Medications may also be prescribed to help with specific troubling and debilitating symptoms. For more information about treatment, please see narcissistic personality disorder treatment . Narcissistic Personality Disorder Resources Treatment of Narcissistic Personality Disorder Narcissistic Personality Quiz Related Hot Topics Today 1 How to Understand Gaslighting 2 Mobile Apps Can Help Manage and Support Mental, Emotional Health 3 Eating Nuts May Strengthen Some Brain Waves 4 Bipolar or Depression? Heart Test May Help Tell the Difference 5 Boosting Brain Activity May Buffer Against Anxiety Most Popular News Mobile Apps Can Help Manage and Support Mental, Emotional Health Eating Nuts May Strengthen Some Brain Waves Boosting Brain Activity May Buffer Against Anxiety Bipolar or Depression? Heart Test May Help Tell the Difference For Older Women, Every Movement Counts Toward Health Join Over 195,000 Subscribers to Our Weekly Newsletter Find a Therapist Enter ZIP or postal code is very


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Enlon-Plus Generic Name: edrophonium chloride and atrophine sulfate Dosage Form: injection, solution Dosage Professional Interactions Reviews Q & A More Pricing & Coupons Rx only Enlon-Plus Description Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection, for intravenous use, is a sterile, nonpyrogenic, nondepolarizing neuromuscular relaxant antagonist. Enlon-Plus is a combination drug containing a rapid acting acetylcholinesterase inhibitor, edrophonium chloride, and an anticholinergic, atropine sulfate. Chemically, edrophonium chloride is ethyl (m-hydroxyphenyl) dimethylammonium chloride; its structural formula is: Molecular Formula: C 10 H 16 ClNO Molecular Weight: 201.70 Chemically, atropine sulfate is: endo-( )-alpha-(hydroxymethyl)-8-methyl-8-azabicyclo [3.2.1]oct-3-yl benzeneacetate sulfate (2:1) monohydrate. Its structural formula is: Molecular Formula: (C 17 H 23 NO 3 ) 2 •H 2 SO 4 •H 2 O Molecular Weight: 694.84 Enlon-Plus contains in each mL of sterile solution: 5 mL Ampule: 10 mg edrophonium chloride and 0.14 mg atropine sulfate compounded with 2.0 mg sodium sulfite as a preservative and buffered with sodium citrate and citric acid. The pH range is 4.0-5.0. Slideshow Shingles: Settling The Score Enlon-Plus - Clinical Pharmacology Pharmacodynamics Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection is a combination of an anticholinesterase agent, which antagonizes the action of nondepolarizing neuromuscular blocking drugs, and a parasympatholytic (anticholinergic) drug, which prevents the muscarinic effects caused by inhibition of acetylcholine breakdown by the anticholinesterase. Edrophonium chloride antagonizes the effect of nondepolarizing neuromuscular blocking agents primarily by inhibiting or inactivating acetylcholinesterase. By inactivating the acetylcholinesterase enzyme, acetylcholine is not hydrolyzed as rapidly by acetylcholinesterase and is thereby allowed to accumulate. The greater quantity of acetylcholine reaching the sites of nicotinic cholinergic postjunctional receptors improves transmission of impulses across the myoneural junction. The concomitant, unavoidable accumulation of acetylcholine at the sites of muscarinic cholinergic transmission occurring at the parasympathetic, postganglionic receptors of the autonomic nervous system, may cause bradycardia, bronchoconstriction, increased secretions, and other parasympathomimetic side effects. The magnitude of these muscarinic side effects can be expected to vary from patient to patient depending upon the amount of vagal nerve activity present. Atropine sulfate counteracts these side effects. Intravenous edrophonium chloride in doses of 0.5 to 1.0 mg/kg promptly antagonizes the effects of nondepolarizing muscle relaxants reaching the maximum antagonism within 1.2 minutes. A plateau of maximal antagonism is sustained for 70 minutes 1 . Intravenous atropine sulfate has an immediate effect on heart rate which reaches a peak in 2 to 16 minutes and lasts 170 minutes after an average 0.02 mg/kg dose. Pharmacokinetics EDROPHONIUM CHLORIDE Edrophonium chloride given intravenously shows first order elimination in a two compartment open pharmacokinetic model 3 . Onset of reversal of muscle relaxant induced depression in twitch tension occurs within three minutes. Edrophonium is primarily renally excreted with 67% of the dose appearing in the urine 4 . Hepatic metabolism and biliary excretion have also been demonstrated in animals 4,8 . While infants and children have been shown to have a reduced plasma half-life and an increased clearance of edrophonium, doses in children are not significantly different from adults on a mg/kg basis although they are more variable in effect. Conversely, elderly subjects (>75 years old) have a prolonged plasma half-life and a reduced clearance. Studies have shown that in spite of these changes the onset and duration of action is unchanged in these patients. Table of Pharmacokinetic Values for Edrophonium Chloride Population T1/2β hr S.D. VD L/kg S.D. Cl mL/kg/min S.D. N Ref. T1/2β = Elimination half-life VD = Volume of distribution Cl = Clearance * No adjustments of edrophonium dosage are required because elimination of non-depolarizing muscle relaxants is similarly decreased. † Values for anephric patients were calculated using a non-compartmental model. ‡ From a study using a different, less sensitive HPLC method and fitting C vs T data to a biexponential curve. Adults 1.8 0.6 1.1 0.2 9.6 2.7 10 3 Anephric Patients * † 3.4 1.0 0.68 0.13 2.7 1.4 6 4 Infants (3 wks-11 mos) 1.2 0.5 1.2 0.2 17.8 1.2 4 5 Children (1-6 yr) 1.6 0.5 1.2 0.7 14.2 7.3 4 5 Adults ‡ 0.9 0.3 1.1 0.6 13.3 5 5 6 Elderly * (over 75 yr) ‡ 1.4 0.3 0.6 0.1 5.1 1 5 6 ATROPINE SULFATE Atropine sulfate given intravenously shows first order elimination in a two compartment open model 7 . Approximately 57% of a dose of atropine appears in the urine as unchanged drug. Tropine is the primary hepatic metabolite of atropine and it accounts for approximately 30% of the dose 2 . Atropine is only 14 9% bound to plasma proteins 7 . Atropine clearance in children under 2 years old and in the elderly is decreased in relation to normal healthy adults. Table of Pharmacokinetic Values for Atropine Sulfate Population T1/2β hr S.D. VD L/kg S.D. Cl mL/kg/min S.D. N Ref. T1/2β = Elimination half-life VD = Volume of distribution Cl = Clearance * No dose adjustment required because the cardiovascular effect of atropine is diminished in the elderly. Adults 3.0 0.9 1.6 0.4 6.8 2.9 8 7 Children (0.08-10 yrs) 4.8 3.5 2.2 1.5 6.4 3.9 13 7 Elderly * (65-75 yrs) 10.0 7.3 1.8 1.2 2.9 1.9 10 7 Indications and Usage for Enlon-Plus Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection is recommended as a reversal agent or antagonist of nondepolarizing neuromuscular blocking agents. It is not effective against depolarizing neuromuscular blocking agents. It is also useful if used adjunctively in the treatment of respiratory depression caused by curare overdosage. The appropriateness of the specific fixed ratio of edrophonium and atropine contained in Enlon-Plus has not been evaluated in myasthenia gravis. Therefore, Enlon-Plus is not recommended for use in the differential diagnosis of this condition. Contraindications Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection is not to be used in patients with known hypersensitivity to either of the components, or in patients with intestinal or urinary obstruction of mechanical type. Atropine sulfate is contraindicated in the presence of acute glaucoma, adhesions (synechiae) between the iris and lens of the eye, and pyloric stenosis. Warnings Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection should be used with caution in patients with bronchial asthma or cardiac arrhythmias. Cardiac arrest has been reported to occur in digitalized patients as well as in jaundiced subjects receiving cholinesterase inhibitors. In patients with cardiovascular disease, given anesthesia with narcotic and nitrous oxide without a potent inhalational agent, there is increased risk for clinically significant bradycardia. In patients receiving beta-adrenergic blocking agents there is increased risk for excessive bradycardia from unopposed parasympathetic vagal tone. Such patients should receive atropine sulfate alone prior to Enlon-Plus. Isolated instances of respiratory arrest have also been reported following the administration of edrophonium chloride. Additional atropine sulfate (1 mg) should be available for immediate use to counteract severe cholinergic reaction which may occur in hypersensitive individuals when Enlon-Plus is used. Enlon-Plus contains sodium sulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible people. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic people. There is a potential for tissue irritation by extravascular injection. Precautions General As with any antagonist of nondepolarizing muscle relaxants, adequate recovery of voluntary respiration and neuromuscular transmission must be obtained prior to the discontinuation of respiratory assistance. Should a patient develop "anticholinesterase insensitivity" for brief or prolonged periods, the patient should be carefully monitored and the dosage of anticholinesterase drugs reduced or withheld until the patient again becomes sensitive to them. Use with caution in patients with prostatic hypertrophy and in debilitated patients with chronic lung disease. When used in therapeutic doses, atropine can cause dryness of the mouth. This effect is additive when the product is administered with other drugs that can cause dryness of the mouth. Since atropine sulfate slows gastric emptying and gastrointestinal motility, it may interfere with the absorption of other medications. The effect of atropine on dryness of the mouth may be increased if it is given with other drugs that have anticholinergic action (tricyclic antidepressants, antipsychotics, some antihistamines, and antiparkinsonism drugs). Drug Interactions Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection should not be administered prior to the administration of any nondepolarizing muscle relaxants. It should be administered with caution to patients with symptoms of myasthenic weakness who are also on anticholinesterase drugs. Anticholinesterase overdosage (cholinergic crisis) symptoms may mimic underdosage (myasthenic weakness), so the use of this drug may worsen the condition of these patients (see OVERDOSAGE section for treatment). Narcotic analgesics, except when combined with potent inhaled anesthetics, appear to potentiate the effect of edrophonium on the sinus node and conduction system, increasing both the frequency and duration of bradycardia. In patients with cardiovascular disease, given anesthesia with narcotic and nitrous oxide without a potent inhalational agent, there is increased risk for clinically significant bradycardia. In patients receiving beta-adrenergic blocking agents there is increased risk for excessive bradycardia from unopposed parasympathetic vagal tone. Such patients should receive atropine sulfate alone prior to Enlon-Plus. Compared to muscle relaxants with some vagolytic activity, muscle relaxants with no vagolytic effects, i.e. vecuronium, may be associated with a slightly higher incidence of vagotonic effects such as bradycardia and first-degree heart block when reversed with Enlon-Plus. Pregnancy Category C Animal reproduction studies have not been conducted with Enlon-Plus. It is also not known whether Enlon-Plus can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Enlon-Plus should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Labor and Delivery The effect of Enlon-Plus on the mother and fetus, on the duration of labor or delivery, in the possibility that a forceps delivery or other intervention or resuscitation of the newborn will be necessary, is not known. The effect of the combination drug on the later growth, development and functional maturation of the child is also unknown. Nursing Mothers The safety of Enlon-Plus during lactation in humans has not been established. Pediatric Use Safety and effectiveness in pediatric patients have not been established. Pediatric patients may have increased vagal tone. The effect of fixed ratios of edrophonium and atropine on heart rate in such patients has not been evaluated. Geriatric Use Clinical studies of Enlon-Plus did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Adverse Reactions Cardiovascular: Arrhythmias Frequency >10%: junctional rhythm, bradycardia, tachycardia; Frequency 3-10%: first and second degree A-V block, P Wave changes, atrial premature contractions; Frequency 1-3%: third degree A-V block, ventricular premature contractions; Frequency less than 1%: 3 second R-R interval. Of the patients who experienced any arrhythmias, 85% had the onset within two minutes, 74% no longer had any arrhythmias after 10 minutes. Arrhythmias related to increased vagal tone, bradycardia, second and third degree heart block respond to treatment with 0.2-0.4 mg of atropine I.V. (Bigeminy or ventricular ectopy may be treated with lidocaine 50 mg I.V.). Adverse experiences reported for anticholinesterase agents such as edrophonium chloride, but not observed in the 235 patients studied with Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection: Cardiovascular: Nonspecific EKG changes, fall in cardiac output leading to hypotension; Respiratory: Increased tracheobronchial secretions, laryngospasm, bronchiolar constriction and respiratory muscle paralysis; Neurologic: Convulsions, dysarthria, dysphonia, and dysphagia; Gastrointestinal: Nausea, vomiting, increased peristalsis, increased gastric and intestinal secretions, diarrhea, abdominal cramps; Musculoskeletal: Weakness and fasciculations; Miscellaneous: Increased urinary frequency, diaphoresis, increased lacrimation, pupillary constriction, diplopia, and conjunctival hyperemia. Untoward reactions to atropine sulfate generally are dose-related. Individual tolerance varies greatly but systemic doses of 0.5 to 10 mg are likely to produce the following effects, which were not observed in the 235 patients treated with Enlon-Plus: NEUROLOGIC: Speech disturbances and restlessness with asthenia; DERMATOLOGIC: Flushed, dry skin, formation of a scarlatiniform rash; MISCELLANEOUS: Dryness of the nose and mouth, thirst, blurred vision, photophobia, slight mydriasis. Atropine may produce fever through inhibition of heat loss by evaporation. Overdosage Muscarinic symptoms (nausea, vomiting, diarrhea, sweating, increased bronchial and salivary secretions and bradycardia) may appear with overdosage (cholinergic crisis) of Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection, but may be managed by the use of additional atropine sulfate. Obstruction of the airway by bronchial secretions can arise and may be managed with suction (especially if tracheostomy has been performed). Should edrophonium chloride overdosage occur: 1. Maintain respiratory exchange. 2. Monitor cardiac function. Appropriate measures should be taken if convulsions occur or shock is present. Principal manifestations of overdosage (poisoning) with atropine sulfate are delirium, tachycardia and fever. In the treatment of atropine poisoning, respiratory assistance and symptomatic support are indicated. Death is usually due to paralysis of the medullary centers. In the clinical studies performed with Enlon-Plus, there were no reported overdoses and therefore no clinical information is available regarding overdosing with Enlon-Plus. Enlon-Plus Dosage and Administration Dosages of Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection range from 0.05-0.1 mL/kg given slowly over 45 seconds to 1 minute at a point of at least 5% recovery of twitch response to neuromuscular stimulation (95% block). The dosage delivered is 0.5-1.0 mg/kg of edrophonium chloride and 0.007-0.014 mg/kg of atropine sulfate. A total dosage of 1.0 mg/kg of edrophonium chloride should rarely be exceeded. Response should be monitored carefully and assisted or controlled ventilation secured. Satisfactory reversal permits adequate voluntary respiration and neuromuscular transmission (as tested with a peripheral nerve stimulator). Recurarization has not been reported after satisfactory reversal has been attained. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. How is Enlon-Plus Supplied Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) Injection should be stored at 20 to 25 C (68 to 77 F). [See USP Controlled Room Temperature.] NDC 67457-192-05 5 mL Single-Dose Ampule, Box of 10 REFERENCES 1. Cronnelly R, Morris RB, Miller RD: Edrophonium: Duration of action and atropine requirement in humans during halothane anesthesia. Anesthesiology 1982;57:261-266. 2. Hinderling PH, Gundert-Remy U, Schmidlin O, Heinzel G: Integrated pharmacokinetics and pharmacodynamics of atropine in healthy humans. I: Pharmacokinetics; II: Pharmacodynamics. J Pharmaceutical Sci 1985; 74:I-703-710; II-711-717. 3. Morris RB, Cronnelly R, Miller RD, Stanski DR, Fahey MR: Pharmacokinetics of edrophonium and neostigmine when antagonizing d- tubocurarine neuromuscular blockade in man. Anesthesiology 1981;54:399-402. 4. Morris RB, Cronnelly R, Miller RD, Stanski DR, Fahey MR: Pharmacokinetics of edrophonium in anephric and renal transplant patients. Br J Anaesth 1981;53:1311-1313. 5. Fisher DM, Cronnelly R, Sharma M, Miller RD: Clinical pharmacology of edrophonium in infants and children. Anesthesiology 1984; 61:428-433. 6. Silverberg PA, Matteo RS, Ornstein E, Young WL, Diaz J: Pharmacokinetics and pharmacodynamics of edrophonium in the elderly. Anesth Analg 1986;65:S142. 7. Virtanen R, Kanto J, Iisalo E, Iisalo EU, Salo M, Sjovall S: Pharmacokinetic studies on atropine with special reference to age. Acta Anaesthesiol Scand 1982;26:297-300. 8. Back DJ, Calvey TN: Excretion of 14 C-edrophonium and its metabolites in bile: role of the liver cell and the peribiliary vascular plexus. Br J Pharmacol., 1972; 44:534. Enlon-Plus is a registered trademark of Mylan Teoranta. Manufactured for: Mylan Institutional LLC Rockford, IL 61103 U.S.A. Manufactured by: Akorn Inc. Lake Forest, IL 60045 U.S.A. BEPOON Rev. 01/13 REVISED JANUARY 2013 MI:ENLOPS:R2 PRINCIPAL DISPLAY PANEL - 5 mL Ampule NDC 67457-192-05 Enlon-Plus (edrophonium chloride, USP and atropine sulfate, USP) injection 10 mg/mL edrophonium chloride 0.14 mg/mL atropine sulfate For Intravenous Use Rx only 10 x 5 mL Single-Dose Ampules Each mL contains: edrophonium chloride, USP 10 mg; atropine sulfate, USP 0.14 mg; sodium citrate (dihydrate), USP; citric acid (anhydrous), USP; sodium sulfite, ACS 2.0 mg; water for injection, USP qs 1 mL. Enlon-Plus is a registered trademark of Mylan Teoranta Usual Dosage: See accompanying prescribing information. Store at 20 to 25 C (68 to 77 F). [See USP Controlled Room Temperature.] Manufactured for: Mylan Institutional LLC Rockford, IL 61103 U.S.A. MI:192:10C:R2 Made in U.S.A. BEPAAC Rev. 01/13 Mylan.com ENLON PLUS edrophonium chloride and atropine sulfate injection, solution Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:67457-192 Route of Administration INTRAVENOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength Edrophonium Chloride (Edrophonium) Edrophonium Chloride 10 mg in 1 mL Atropine Sulfate (Atropine) Atropine Sulfate 0.14 mg in 1 mL Inactive Ingredients Ingredient Name Strength Sodium Sulfite 2 mg in 1 mL Sodium Citrate 13.2 mg in 1 mL Citric Acid Monohydrate 8.2 mg in 1 mL Water Packaging # Item Code Package Description 1 NDC:67457-192-05 10 AMPULE in 1 CARTON 1 NDC:67457-192-00 5 mL in 1 AMPULE Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA019678 11/06/1991 Labeler - Mylan Institutional LLC (790384502) Revised: 01/2013 Mylan Institutional LLC Next Interactions Print this page Add to My Med List More about Enlon-Plus (atropine / edrophonium) Dosage Information Drug Interactions Support Group Pricing & Coupons 0 Reviews Add your own review/rating Drug class: cholinergic muscle stimulants Other Formulations Enlon Related treatment guides Reversal of Nondepolarizing Muscle Relaxants} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Cholinergic muscle stimulants Related Drugs cholinergic muscle stimulants pyridostigmine , Mestinon , neostigmine , Prostigmin , Prostigmin Bromide Reversal of Nondepolarizing Muscle Relaxants pyridostigmine , Mestinon , neostigmine , sugammadex , edrophonium , Bridion , Reversol , Mestinon Timespan , More... 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deadlock Siliq Generic Name: brodalumab (broe DAL ue mab) Brand Name: Siliq Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons What is brodalumab? Brodalumab is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Brodalumab is used to treat moderate to severe plaque psoriasis in adults. Brodalumab is usually given after other psoriasis medicines have been tried without success. Brodalumab is available only from a certified pharmacy under a special program called Siliq REMS. You must be registered in the program and understand the risks and benefits of taking this medicine. Brodalumab may also be used for purposes not listed in this medication guide. Slideshow Humira: One Drug, Nine Uses, Billions of Dollars What is the most important information I should know about brodalumab? Some people have thoughts about suicide while taking this medicine. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as mood changes, anxiety, or depression. Brodalumab is available only from a certified pharmacy under a special program. What should I discuss with my healthcare provider before using brodalumab? You should not use brodalumab if you are allergic to it, or if you have: Crohn's disease. To make sure brodalumab is safe for you, tell your doctor if you have: an active or chronic infection; a history of tuberculosis; or a history of anxiety, depression, mental illness, or a mood disorder. Tell your doctor if you have ever had tuberculosis, if anyone in your household has tuberculosis, or if you have recently traveled to an area where tuberculosis is common. Your doctor may perform tests to make sure you do not have tuberculosis or other infections. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. It is not known whether brodalumab passes into breast milk or if it could affect the nursing baby. Tell your doctor if you are breast-feeding. Brodalumab is not approved for use by anyone younger than 18 years old. How is brodalumab given? Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended. Brodalumab is injected under the skin. You may be shown how to use injections at home. Do not give yourself this medicine if you do not understand how to use the injection and properly dispose of used needles and syringes. Brodalumab is usually given once a week for 3 weeks, and then once every 2 weeks thereafter. Follow your doctor's dosing instructions very carefully. Read all instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions. Do not shake the medicine. Prepare your dose only when you are ready to give an injection. Do not use the medicine if it looks cloudy or has large particles in it. Call your pharmacist for new medicine. Store prefilled syringes in their original container in the refrigerator. Protect from light and do not freeze. Take the medicine out of the refrigerator and allow it to reach room temperature for 30 minutes before injecting your dose. Do heat the medicine in a microwave oven or place it into hot water. Leave the needle cap in place while the medicine warms to room temperature. You may store a syringe for up to 14 days at room temperature. Keep the syringe in its original container and protect it from heat and light. Any syringe warmed to room temperature should not be placed back into a refrigerator. Each single-use prefilled syringe is for one use only. Throw away after one use, even if there is still some medicine left in it after injecting your dose. Use a disposable needle and syringe only once. Follow any state or local laws about throwing away used needles and syringes. Use a puncture-proof "sharps" disposal container (ask your pharmacist where to get one and how to throw it away). Keep this container out of the reach of children and pets. Brodalumab can lower blood cells that help your body fight infections. You may get an infection more easily. Call your doctor if you have signs of infection such as fever, chills, flu symptoms, diarrhea, painful urination, and skin warmth or redness. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve after 12 weeks of using brodalumab. Brodalumab comes with a Medication Guide and a Patient Wallet Card that lists the symptoms of a serious side effect. Read this information carefully and carry the Wallet Card with you at all times so you will know what symptoms to watch for. What happens if I miss a dose? Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking brodalumab? Avoid injecting brodalumab into skin that is bruised or tender, or skin that is affected by psoriatic plaques (red, thick, or scaly). Do not receive a "live" vaccine while using brodalumab. The vaccine may not work as well during this time, and may not fully protect you from disease. Live vaccines include measles, mumps, rubella (MMR), polio, rotavirus, typhoid, yellow fever, varicella (chickenpox), zoster (shingles), and nasal flu (influenza) vaccine. Brodalumab side effects Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: suicidal thoughts; unusual changes in mood or behavior; new or worsening anxiety or depression; increased urination, pain or burning when you urinate; skin sores with warmth, redness, or swelling; stomach cramps, loss of appetite, diarrhea or constipation, bloody or watery stools; low white blood cell counts--fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing; signs of an ear infection--ear pain or full feeling, trouble hearing, drainage from the ear; or signs of other infections--fever, chills, sweating, sore throat, trouble swallowing, body aches, breathing problems, diarrhea, stomach pain. Common side effects may include: muscle or joint pain; nausea, diarrhea; flu-like symptoms; headache, tiredness; sore throat, mouth pain; or pain, redness, bruising, itching, or bleeding where the medicine was injected. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect brodalumab? Other drugs may interact with brodalumab, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about Siliq (brodalumab) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 2 Reviews Add your own review/rating Drug class: interleukin inhibitors Consumer resources Siliq Siliq (Advanced Reading) Professional resources Siliq (AHFS Monograph) Siliq (FDA) Related treatment guides Plaque Psoriasis Where can I get more information? Your pharmacist can provide more information about brodalumab. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.01. Date modified: December 03, 2017 Last reviewed: March 29, 2017} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Valeant Pharmaceuticals International, Inc. Drug Class Interleukin inhibitors Related Drugs Plaque Psoriasis Humira , dexamethasone , methylprednisolone , betamethasone topical , Enbrel , Remicade , Otezla , adalimumab , calcipotriene topical , infliximab , etanercept , Cosentyx , Taclonex , Dovonex , Calcitrene , Taltz , apremilast , Tremfya , Renflexis , Enstilar , secukinumab , Inflectra , Erelzi , ixekizumab , More... Siliq Rating 2 User Reviews 10 /10 2 User Reviews 10 Rate it! Related Questions & Answers What is the Siliq REMS Program? Read more questions} } final result


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