it is necessary clofarabine (Intravenous route) kloe-FAR-a-been Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Clolar Available Dosage Forms: Solution Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Antimetabolite Chemical Class: Purine Nucleoside Analog Slideshow Leukemia Symptoms And Lessons: Is A Solution In Sight? Uses For clofarabine Clofarabine injection is used to treat acute lymphoblastic leukemia (ALL), a cancer of the white blood cells, in patients who have already used at least 2 other cancer medicines. Clofarabine is an antineoplastic (cancer) medicine. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Since the growth of normal cells may also be affected by clofarabine, other unwanted effects can occur. Before you begin treatment, talk to your doctor about the benefits of clofarabine as well as the possible risks of using it. clofarabine is to be given only by or under the immediate supervision of your doctor. Before Using clofarabine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For clofarabine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to clofarabine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clofarabine injection in children 1 year of age and older. Geriatric Appropriate studies on the relationship of age to the effects of clofarabine injection have not been performed in the geriatric population. Safety and efficacy have not been established in elderly patients 65 years of age. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving clofarabine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using clofarabine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Rotavirus Vaccine, Live Rubella Virus Vaccine, Live Varicella Virus Vaccine Using clofarabine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adenovirus Vaccine Bacillus of Calmette and Guerin Vaccine, Live Cholera Vaccine, Live Influenza Virus Vaccine, Live Poliovirus Vaccine, Live Smallpox Vaccine Typhoid Vaccine Yellow Fever Vaccine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of clofarabine. Make sure you tell your doctor if you have any other medical problems, especially: Anemia (low red blood cells) or Bleeding problems (eg, hemorrhage) or Infection (eg, bacteria, fungus, virus) or Liver disease or Neutropenia (low white blood cells) or Thrombocytopenia (low platelets in the blood) Use with caution. May make these conditions worse. Kidney disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of clofarabine You will receive clofarabine while you or your child are in a hospital or cancer treatment center. A doctor or other trained health professional will give you clofarabine. clofarabine is given through a needle placed in one of your veins. While you are receiving clofarabine, it is important that you drink extra fluids so you will pass more urine. This will help prevent unwanted effects on the kidney. Precautions While Using clofarabine It is very important that your doctor check the progress of you or your child at regular visits to make sure that clofarabine is working properly. Blood and urine tests may be needed to check for unwanted effects. Using clofarabine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. Clofarabine can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you have fever or chills, a cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail and toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. clofarabine may cause a serious type of reaction called the tumor lysis syndrome. This syndrome may cause you to have high amounts of uric acid in the blood (hyperuricemia). Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness. Call your doctor right away if you have dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, a fast or irregular heartbeat, trouble breathing, or swelling of the hands, ankles, feet, or lower legs. These may be symptoms of rare but serious conditions called capillary leak syndrome or systemic inflammatory response syndrome (SIRS). Check with your doctor right away if you have stomach pain, pale stools, or dark urine, a loss of appetite, or yellow eyes or skin. These could be symptoms of a serious liver problem. clofarabine may cause acute kidney failure. Tell your doctor right away if you have decrease in how much or how often you urinate, confusion, dizziness, headache, rapid weight gain, seizures, or swelling of your hands, ankles, or feet after receiving clofarabine. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. clofarabine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Abdominal or stomach pain or tenderness area rash black, tarry stools bleeding gums blood in the urine or stools bloody nose blurred vision burning or stinging of the skin chest pain chills clay-colored stools cold or flu-like symptoms confusion cough or hoarseness dark urine decreased urine output diarrhea difficult or labored breathing dilated neck veins dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position facial swelling fainting fast, pounding, or irregular heartbeat or pulse feeling of warmth fever flushing, redness of the skin headache irregular breathing itching in the genital area itching or skin rash joint pain, stiffness, or swelling lightheadedness loss of appetite lower back or side pain nausea nervousness pain painful cold sores or blisters on the lips, nose, eyes, or genitals painful or difficult urination pale skin pinpoint red spots on the skin pounding in the ears rapid, shallow breathing redness of the face, neck, arms, and occasionally, upper chest redness, swelling, or skin pain scaling of the skin on the hands and feet severe abdominal or stomach cramps with pain slow or fast heartbeat small red or purple spots on the skin sneezing sore throat sores, ulcers, or white spots on the lips or in the mouth sweating swelling of the ankles, feet, or lower legs swelling or inflammation of the mouth swollen glands tenderness tightness in the chest tingling of the hands and feet troubled breathing with exertion ulcers, sores, or white spots in the mouth unpleasant breath odor unusual bleeding or bruising unusual tiredness or weakness unusually warm skin vomiting vomiting of blood warmth on the skin watery and severe diarrhea, which may also be bloody weight gain yellow eyes or skin Less common Agitation bloating blue lips and fingernails chest pain or discomfort cloudy urine constipation coughing that sometimes produces a pink frothy sputum darkened urine decrease or increase in the amount of urine decreased level of consciousness depression difficult, fast, or noisy breathing, sometimes with wheezing dry mouth general feeling of discomfort or illness hives hostility hyperventilation increased sweating indigestion irritability muscle aches and pains muscle twitching pain or tenderness around the eyes and cheekbones pains in the stomach, side, or abdomen, possibly radiating to the back rapid weight gain restlessness seizures (convulsions) shaking shivering stuffy or runny nose swelling of the eyelids, face, lips, or hands trouble sleeping Incidence not known Blistering, peeling, or loosening of the skin red irritated eyes red skin lesions, often with a purple center Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Back pain bone pain bruises on the skin cracked lips difficulty with moving difficulty with swallowing discouragement dry skin fear feeling sad or empty feeling unusually cold injection site pain itching, pain, redness, swelling, tenderness, or warmth on the skin at the injection site lack or loss of strength loss of interest or pleasure muscle pain or stiffness pain in the limbs pain in the rectum right upper stomach pain and fullness skin discoloration sore mouth or tongue swollen joints tiredness trouble concentrating unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness unusually warm skin weight loss white patches with diaper rash Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about clofarabine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: antimetabolites Consumer resources Clofarabine Other brands: Clolar Professional resources Clofarabine (AHFS Monograph) Clofarabine Injection (FDA) Clofarabine (Wolters Kluwer) Related treatment guides Acute Lymphoblastic Leukemia} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antimetabolites Related Drugs Acute Lymphoblastic Leukemia methotrexate , Gleevec , mercaptopurine , imatinib , Adriamycin , doxorubicin , Sprycel , Trexall , dasatinib , Purinethol , Kymriah , Besponsa , Iclusig , Blincyto , ponatinib , Purixan , clofarabine , Xatmep , Oncaspar , Marqibo , pegaspargase , tisagenlecleucel , teniposide , asparaginase erwinia chrysanthemi , More... 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