brought on estramustine (Oral route) es-tra-MUS-teen Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Emcyt Available Dosage Forms: Capsule Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Estrogen Chemical Class: Nitrogen Mustard Slideshow Women's Health: Separating Fact From Fiction Uses For estramustine Estramustine belongs to the general group of medicines called antineoplastics. It is used to treat some cases of prostate cancer. Estramustine is a combination of two medicines, an estrogen and mechlorethamine. The way that estramustine works against cancer is not completely understood. However, it seems to interfere with the growth of cancer cells, which are eventually destroyed. Estramustine is available only with your doctor's prescription. Before Using estramustine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For estramustine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to estramustine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Geriatric Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of estramustine in the elderly with use in other age groups. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking estramustine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using estramustine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bupropion Donepezil Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using estramustine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use estramustine, or give you special instructions about the use of food, alcohol, or tobacco. Dairy Food Other Medical Problems The presence of other medical problems may affect the use of estramustine. Make sure you tell your doctor if you have any other medical problems, especially: Asthma or Epilepsy or Mental depression (or history of) or Migraine headaches or Kidney disease Fluid retention sometimes caused by estramustine may worsen these conditions Blood clots (or history of) or Stroke (or history of) or Recent heart attack or stroke May be worsened because of blood vessel problems caused by estramustine Chickenpox (including recent exposure) or Herpes zoster (shingles) Risk of severe disease affecting other parts of the body Diabetes mellitus (sugar diabetes) Estramustine may change the amount of antidiabetic medicine needed Gallbladder disease (or history of) May be worsened by estramustine Heart or blood vessel disease Estramustine can cause circulation problems Jaundice or hepatitis (or history of) or other liver disease Effects, including liver problems, may be increased Stomach ulcer May be aggravated by estramustine Proper Use of estramustine Use estramustine only as directed by your doctor. Do not use more or less of it, and do not use it more often than your doctor ordered. The exact amount of medicine you need has been carefully worked out. Taking too much may increase the chance of side effects, while taking too little may not improve your condition. Do not take estramustine within 1 hour before or 2 hours after meals or after the time you take milk, milk formulas, or other dairy products, since they may keep the medicine from working properly. estramustine commonly causes nausea and sometimes causes vomiting. However, it may have to be taken for several weeks to months to be effective. Even if you begin to feel ill, do not stop using estramustine without first checking with your doctor. Ask your health care professional for ways to lessen these effects. If you vomit shortly after taking a dose of estramustine, check with your doctor. You will be told whether to take the dose again or to wait until the next scheduled dose. Dosing The dose of estramustine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of estramustine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Missed Dose If you miss a dose of estramustine, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store in the refrigerator. Do not freeze. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Precautions While Using estramustine It is very important that your doctor check your progress at regular visits to make sure that the medicine is working properly and does not cause unwanted effects. While you are being treated with estramustine, and after you stop treatment with it, do not have any immunizations (vaccinations) without your doctor's approval. Estramustine may lower your body's resistance and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not take oral polio vaccine since there is a chance they could pass the polio virus on to you. Also, avoid persons who have recently taken oral polio vaccine. Do not get close to them and do not stay in the same room with them for very long. If you cannot take these precautions, you should consider wearing a protective face mask that covers the nose and mouth. estramustine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Black, tarry stools blood in urine or stools cough or hoarseness fever or chills headaches (severe or sudden) loss of coordination (sudden) lower back or side pain painful or difficult urination pains in chest, groin, or leg (especially calf of leg) pinpoint red spots on skin shortness of breath (sudden, for no apparent reason) slurred speech (sudden) unusual bleeding or bruising vision changes (sudden) weakness or numbness in arm or leg Check with your doctor as soon as possible if any of the following side effects occur: More common Swelling of feet or lower legs Rare Skin rash or fever unusual tiredness or weakness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Breast tenderness or enlargement decreased interest in sex diarrhea nausea Less common Trouble in sleeping vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. 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Next Side Effects Print this page Add to My Med List More about estramustine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: hormones/antineoplastics Consumer resources Estramustine Other brands: Emcyt Professional resources Estramustine Phosphate Sodium (AHFS Monograph) Estramustine (Wolters Kluwer) Related treatment guides Prostate Cancer} Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Hormones / antineoplastics Mitotic inhibitors Related Drugs Prostate Cancer estradiol , Premarin , Estrace , bicalutamide , Casodex , Eligard , Xtandi , Zytiga , leuprolide , Taxotere , Lupron Depot , conjugated estrogens , docetaxel , Firmagon , Trelstar , enzalutamide , Zoladex , abiraterone , degarelix , Menest , flutamide , flax , Delestrogen , More... 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