facts naloxegol (Oral route) nal-OX-ee-gol Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Movantik Available Dosage Forms: Tablet Pharmacologic Class: Opioid Antagonist Slideshow Treatment of Opioid-Induced Constipation: The Hard Facts Uses For naloxegol Naloxegol is used to treat constipation that is caused by opioids (narcotic pain medicines), in adults with long-lasting pain that is not caused by cancer. naloxegol is available only with your doctor's prescription. Before Using naloxegol In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For naloxegol, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to naloxegol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of naloxegol in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of naloxegol in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking naloxegol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using naloxegol with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Atazanavir Boceprevir Clarithromycin Cobicistat Conivaptan Delavirdine Idelalisib Indinavir Itraconazole Ketoconazole Lopinavir Nefazodone Nelfinavir Posaconazole Ritonavir Saquinavir Telaprevir Telithromycin Tipranavir Voriconazole Using naloxegol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Alvimopan Aprepitant Carbamazepine Ceritinib Ciprofloxacin Crizotinib Darunavir Diltiazem Dronedarone Efavirenz Enzalutamide Erythromycin Etravirine Fluconazole Fosaprepitant Fosphenytoin Imatinib Methylnaltrexone Miconazole Mifepristone Mitotane Nalorphine Naloxone Naltrexone Netupitant Nilotinib Oxcarbazepine Phenytoin Primidone Rifabutin Rifampin Rifapentine Samidorphan St John's Wort Ticagrelor Verapamil Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using naloxegol with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use naloxegol, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of naloxegol. Make sure you tell your doctor if you have any other medical problems, especially: Crohn's disease or Diverticulitis or Ogilvie's syndrome or Peptic ulcer or Stomach or bowel cancer May increase risk for more serious side effects. Kidney disease, moderate to severe Use with caution. The effects may be increased because of slower removal of the medicine from the body. Stomach or bowel blockage, or history of Should not be used in patients with these conditions. Proper Use of naloxegol Take naloxegol exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. naloxegol should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Take naloxegol on an empty stomach at least 1 hour before the first meal of the day or 2 hours after a meal. Swallow the tablet whole. Do not crush, break, or chew it. Stop taking other laxatives before starting treatment with naloxegol. Also, stop taking naloxegol if you have stopped taking narcotic pain medicines. Do not eat grapefruit or drink grapefruit juice while you are using naloxegol. If you have trouble swallowing the tablet, you may crush it and mix it with 120 mL of water and drink it right away. Refill the glass with water, stir, and drink right away to make sure to get full dose of naloxegol. If you have trouble swallowing the tablet, it may also be given through a nasogastric tube : Draw up 30 mL of water into a 60 mL syringe and flush the nasogastric tube. Crush the tablet to a powder and mix it with 60 mL of water in a container. Draw up the mixture using 60 mL syringe and give it through the tube. Add 60 mL of water to the container mixture and use the same 60 mL syringe to flush the tube for any remaining medicine. Dosing The dose of naloxegol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of naloxegol. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For constipation caused by opioids: Adults 25 milligrams (mg) once a day in the morning. Your doctor may adjust your dose as needed. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of naloxegol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using naloxegol It is very important that your doctor check your progress at regular visits . This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it. Do not take naloxegol together with clarithromycin, itraconazole, or ketoconazole. Using these medicines together may cause or worsen opioid withdrawal symptoms, such as anxiety, chills, diarrhea, irritability, stomach pain, sweating, and yawning . Call your doctor right away if you have severe stomach pain or diarrhea while you are using naloxegol. naloxegol may cause a tear (perforation) in your stomach or bowels. Check with your doctor right away if you have a severe stomach pain that does not go away. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. naloxegol Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Abdominal or stomach pain anxiety chills diarrhea increased sweating irritability yawning Incidence not known Bloody, black or tarry stools heartburn indigestion nausea severe abdominal or stomach pain, cramping, or burning trouble breathing vomiting of material that looks like coffee grounds, severe and continuing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bloated excess air or gas in the stomach or bowels full feeling passing gas Less common Headache vomiting Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. 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Next Side Effects Print this page Add to My Med List More about naloxegol Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 153 Reviews Add your own review/rating Drug class: peripheral opioid receptor antagonists Consumer resources Naloxegol Other brands: Movantik Professional resources Naloxegol Oxalate (AHFS Monograph) Naloxegol (Wolters Kluwer) Related treatment guides Opioid-Induced Constipation Constipation, Chronic Constipation, Drug Induced} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Peripheral opioid receptor antagonists Related Drugs Opioid-Induced Constipation Amitiza , Movantik , lubiprostone , Relistor , methylnaltrexone , Symproic , naldemedine , More... Constipation, Chronic Amitiza , Linzess , lactulose , Movantik , linaclotide , GoLYTELY , MoviPrep , lubiprostone , More... Constipation, Drug Induced Amitiza , Movantik , lubiprostone , Relistor , methylnaltrexone , More... Naloxegol Rating 153 User Reviews 4.7 /10 153 User Reviews 4.7 Rate it! Help and Support Looking for answers? Ask a question or go join the naloxegol support group to connect with others who have similar interests.} } of one
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