lack of understanding Baciguent topical Generic Name: Bacitracin topical Class: Antibacterials VA Class: DE101 CAS Number: 1405-87-4 Overview Side Effects Professional Breastfeeding Reviews More Support Group Q & A Introduction Polypeptide antibiotic. Uses for Baciguent Superficial Skin Infections Topically (alone or in combination with other anti-infectives) to prevent or treat superficial skin infections caused by susceptible organisms. a May be useful for preventing infection in minor skin injuries (e.g., cuts, scrapes, burns). a Role of topical anti-infectives for treatment of superficial skin infections has not been fully elucidated. a Self-medication with topical anti-infectives to treat superficial skin infections currently is not recommended. a Treatment of serious or extensive skin infections usually requires systemic anti-infective therapy. a Slideshow Flagyl Side Effects and What You Can Do About Them Baciguent Dosage and Administration Administration Apply ointment or powder topically to cleansed area. a May cover affected area with a sterile bandage following use of ointments, powders, or sprays. a Has been used for topical compresses in 0.9% sodium chloride injection or sterile water for injection (250 1000 units/mL). a Dosage Adults Superficial Skin Infections Topical Ointment: Apply amount equal to the surface area of a fingertip to the affected area 1 3 times daily. a Powder: Use a light dusting on affected area 1 3 times daily. a Prescribing Limits Maximum 1 week of use unless directed by a physician. a Cautions for Baciguent Contraindications Known history of hypersensitivity to bacitracin or any ingredients in the formulations. a Avoid use in atopic individuals. a Warnings/Precautions Sensitivity Reactions Rashes and allergic anaphylactoid reactions have occurred, but topical application has low order of toxicity. a If itching, burning, inflammation, or other signs of sensitivity occur, discontinue use and consult a clinician. a Sensitivity to neomycin also may indicate sensitivity to bacitracin. a Patch testing (e.g., 1% bacitracin in petrolatum) may be useful in diagnosing suspected allergic contact dermatitis when hypersensitivity to other topical antibiotics (e.g., neomycin) is suspected. a General Precautions Overgrowth of nonsusceptible organisms, particularly Candida , may occur; institute appropriate therapy if superinfection occurs. a Topical use of bacitracin should not replace appropriate surgical management or other measures. a Consider systemic anti-infective therapy if a deep-seated infection is present. a Corticosteroids in topical anti-infective combination preparations may mask the clinical signs of bacterial, fungal, or viral infections, or may suppress hypersensitivity reactions to the antibiotics or other ingredients in the formulations; weigh benefits against risks. a Use of Fixed Combination When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents. Specific Populations Pregnancy Category C. b Lactation Not known whether topical bacitracin is distributed into milk. b Baciguent Pharmacokinetics Absorption Bioavailability Not absorbed to any appreciable extent from intact or denuded skin, wounds, or mucous membranes. a Stability Storage Topical Ointment 15 30°C. a Powder 2 15°C; protect from direct sunlight. a Compatibility For information on systemic interactions resulting from concomitant use, see Interactions. Topical Vehicle Compatibility Compatible a Lanolin Paraffins Petrolatum White wax Incompatible Water-miscible bases Mixture Compatibility Incompatible a Benzalkonium chloride Benzoates Cetylpyridinium chloride Heavy metal salts Salicylates Sodium lauryl sulfate Tannates Actions and Spectrum Polypeptide antibiotic produced by Bacillus subtilis; consists of 3 separate compounds, bacitracin A (chief constituent), B, and C. a Bactericidal or bacteriostatic, depending on concentration attained at infection site and infecting organism s susceptibility. a Inhibits bacterial cell-wall synthesis, damages the bacterial plasma membrane and is active against protoplasts. a Active against many gram-positive organisms such as staphylococci (including some penicillin-resistant staphylococci), streptococci, anaerobic cocci, corynebacteria, and clostridia; in vitro, bacitracin 0.05 5 mcg/mL inhibits most susceptible strains of Staphylococcus aureus . a Active against gonococci, meningococci, and fusobacteria, but not most other gram-negative organisms. a Also active against Actinomyces israelii, Treponema pallidum, and T. vincenti. a The activity of bacitracin is not impaired by blood, pus, necrotic tissue, or large inocula. a In susceptible bacteria, bacitracin resistance seldom occurs; if it does occur, it emerges slowly. a Staphylococci, including penicillin-resistant staphylococci, are increasingly becoming resistant. a No cross-resistance with other antibiotics. a Advice to Patients Importance of discontinuing bacitracin and consulting a clinician if itching, burning, inflammation, or other signs of sensitivity occur. a Importance of understanding that topical bacitracin preparations are intended for external use only. a Importance of not using in the eyes or applying over large areas of the body. Importance of first consulting a clinician when considering use for self-medication for deep or puncture wounds, animal bites, or serious burns. a Importance of discontinuing use and consulting a clinician if condition persists or worsens when used to prevent infection in minor skin injuries (e.g., cuts, scrapes, burns). a Importance of not using for >1 week unless directed by a clinician. a Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Importance of informing patients of other important precautionary information. a (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Bacitracin Routes Dosage Forms Strengths Brand Names Manufacturer Bulk Powder* Topical Ointment 500 units/g* Baciguent Lee Pharmaceuticals * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Bacitracin Combinations Routes Dosage Forms Strengths Brand Names Manufacturer Topical Ointment 400 units/g with Neomycin Sulfate 0.5% (0.35% of neomycin) and Polymyxin B Sulfate 5000 units (of polymyxin B) per g* Triple Antibiotic Ointment Alpharma, Pfeiffer Bacitracin Zinc Routes Dosage Forms Strengths Brand Names Manufacturer Bulk Powder Topical Ointment 500 units (of bacitracin) per g Bacitracin Zinc Ointment Alpharma, Rugby * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Bacitracin Zinc Combinations Routes Dosage Forms Strengths Brand Names Manufacturer Topical Ointment 400 units (of bacitracin) per g with Neomycin Sulfate 0.5% (0.35% of neomycin) and Polymyxin B Sulfate 5000 units (of polymyxin B) per g Neosporin Pfizer Triple Antibiotic Ointment 500 units (of bacitracin) per g with Lidocaine 4%, Neomycin Sulfate 0.5% (0.35% of neomycin), and Polymyxin B Sulfate 10,000 units (of polymyxin B) per g* Bactine First Aid Antibiotic Plus Anesthetic Bayer Campho-Phenique First Aid Antibiotic Plus Pain Reliever Maximum Strength Bayer Mycitracin Plus Pain Reliever (with parabens) J&J Consumer Spectrocin Plus Numark Triple Antibiotic Extra IVAX Triple Antibiotic Plus Ointment Maximum Strength Alpharma, G&W, Major Triple Antibiotic with Lidocaine Ointment Maximum Strength Clay-Park, Moore 500 units (of bacitracin) per g with Neomycin Sulfate 0.5% (0.35% of neomycin) and Polymyxin B Sulfate 10,000 units (of polymyxin B) per g Mycitracin Triple Antibiotic First Aid Ointment Maximum Strength (with parabens) J&J Consumer 500 units (of bacitracin) per g with Polymyxin B Sulfate 10,000 units (of polymyxin B) per g and Pramoxine Hydrochloride 1% Betadine Brand First Aid Antibiotics + Pain Reliever Purdue Frederick 500 units (of bacitracin) per g, with Neomycin Sulfate 0.5% (0.35% of neomycin), Polymyxin B Sulfate 10,000 units (of polymyxin B) per g, and Pramoxine Hydrochloride 1% Neosporin Plus Maximum Strength First Aid Antibiotic/Pain Relieving Ointment Pfizer 500 units (of bacitracin) per g with Polymyxin B Sulfate 10,000 units (of polymyxin B) per g Bacitracin-Polymyxin Ointment Clay-Park, Major, Rugby Band-Aid with Antibiotic Ointment J&J Consumer Betadine Brand First Aid Antibiotics + Moisturizer Ointment Purdue Frederick Double Antibiotic Ointment Fougera Polysporin Ointment Pfizer Powder 500 units (of bacitracin) per g with Polymyxin B Sulfate 10,000 units (of polymyxin B) per g Polysporin Powder Pfizer Anti-infective combinations including bacitracin are also commercially available in combination with corticosteroids for topical use. AHFS DI Essentials. Copyright 2017, Selected Revisions July 1, 2005. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. References a. AHFS drug information 2004. McEvoy GK, ed. Bacitracin. Bethesda, MD: American Society of Health-System Pharmacists; 2004:3305-6. b. Briggs GG, Freeman RK, Yaffe SJ. Drugs in pregnancy and lactation. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2002: 120/b. Next Breastfeeding Warnings Print this page Add to My Med List More about Baciguent (bacitracin topical) Side Effects Breastfeeding Support Group En Español 0 Reviews Add your own review/rating Drug class: topical antibiotics Consumer resources Baciguent Professional resources Bacitracin topical (AHFS Monograph) Related treatment guides Bacterial Skin Infection} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx OTC Availability Rx and/or OTC N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Drug Class Topical antibiotics Related Drugs Bacterial Skin Infection Bactrim , sulfamethoxazole / trimethoprim , Bactrim DS , bacitracin topical , tetracycline topical , Septra , Neosporin , SMZ-TMP DS , Septra DS , Triple Antibiotic , Co-trimoxazole , Sulfatrim , Polysporin First Aid Antibiotic Ointment , Cortisporin Cream , Cotrim , Antibiotic Plus Pain Relief , Sulfatrim Pediatric , Cortisporin Ointment , Neo-Synalar , More... 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