identical aliskiren, amlodipine, and hydrochlorothiazide (Oral route) a-lis-KYE-ren, am-LOE-di-peen BES-i-late, hye-droe-klor-oh-THYE-a-zide Oral route(Tablet) Discontinue aliskiren/amlodipine/hydrochlorothiazide as soon as possible if pregnancy occurs. Drugs that act directly on the renin-angiotensin system can be toxic or fatal to a fetus . Overview Side Effects Professional Interactions Pregnancy More User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Amturnide Available Dosage Forms: Tablet Therapeutic Class: Antihypertensive Pharmacologic Class: Renin Inhibitor Chemical Class: Amlodipine Slideshow FDA-Approved Weight Loss Drugs: Can They Help You? Uses For aliskiren, amlodipine, and hydrochlorothiazide Aliskiren, amlodipine, and hydrochlorothiazide is a combination of medicines that may be used alone or with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure will reduce the risk of strokes and heart attacks. Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax and this decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen that go to the heart is increased. Amlodipine is a calcium channel blocker. It affects the movement of calcium into the cells of the heart and blood vessels. As a result, amlodipine relaxes the blood vessels and increases the supply of blood and oxygen to the heart while reducing its workload. Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower blood pressure. aliskiren, amlodipine, and hydrochlorothiazide is available only with your doctor's prescription. Before Using aliskiren, amlodipine, and hydrochlorothiazide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aliskiren, amlodipine, and hydrochlorothiazide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to aliskiren, amlodipine, and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of aliskiren, amlodipine, and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aliskiren, amlodipine, and hydrochlorothiazide combination in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aliskiren, amlodipine, and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aliskiren, amlodipine, and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Azilsartan Azilsartan Medoxomil Benazepril Candesartan Captopril Dofetilide Enalapril Enalaprilat Eprosartan Fosinopril Irbesartan Lisinopril Losartan Moexipril Olmesartan Medoxomil Perindopril Quinapril Ramipril Telmisartan Trandolapril Valsartan Using aliskiren, amlodipine, and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Acetyldigoxin Amiodarone Amphetamine Amtolmetin Guacil Arsenic Trioxide Aspirin Atazanavir Benzphetamine Bromfenac Bufexamac Celecoxib Ceritinib Choline Salicylate Clarithromycin Clonixin Clopidogrel Conivaptan Cyclophosphamide Cyclosporine Dantrolene Deslanoside Dexibuprofen Dexketoprofen Dextroamphetamine Diclofenac Diflunisal Digitalis Digitoxin Digoxin Dipyrone Domperidone Droperidol Droxicam Eliglustat Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Flecainide Floctafenine Flufenamic Acid Flurbiprofen Ibuprofen Idelalisib Indomethacin Itraconazole Ketanserin Ketoprofen Ketorolac Lacosamide Levomethadyl Lisdexamfetamine Lithium Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Methamphetamine Methotrexate Metildigoxin Morniflumate Nabumetone Naproxen Nepafenac Netupitant Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Ouabain Oxaprozin Oxyphenbutazone Parecoxib Phenylbutazone Piketoprofen Piperaquine Piroxicam Proglumetacin Propyphenazone Proquazone Proscillaridin Rofecoxib Salicylic Acid Salsalate Simeprevir Simvastatin Sodium Salicylate Sotalol Sulindac Tacrolimus Tegafur Telaprevir Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Valdecoxib Using aliskiren, amlodipine, and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aminolevulinic Acid Bepridil Carbamazepine Cholestyramine Furosemide Ginkgo Gossypol Indinavir Licorice Rifampin Topiramate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aliskiren, amlodipine, and hydrochlorothiazide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aliskiren, amlodipine, and hydrochlorothiazide, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of aliskiren, amlodipine, and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially: Angioedema (swelling of the face, mouth, arms, legs, or throat), history of May increase the risk of this condition occurring again. Anuria (not able to pass urine) or Diabetes patients who are also taking certain blood pressure medicines such as angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) or Kidney disease, moderate or Sulfa drug allergy (e.g., sulfamethoxazole, sulfasalazine, Azulfidine , Bactrim , Septra ) Should not be used in patients with these conditions. Asthma, history of May increase likelihood of having an allergic reaction. Diabetes or Kidney problems May increase risk of having high potassium in the blood. Electrolyte imbalances (e.g., high or low levels of calcium, magnesium, potassium, or sodium in the body) or Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or Glaucoma, secondary angle closure or Gout or Hyperlipidemia (high cholesterol or fats in the blood) or Liver disease or Myopia (changes in the eyeball causing vision problems), acute or Systemic lupus erythematosus (SLE) Use with caution. May make these conditions worse. Heart or blood vessel disease (e.g., severe obstructive coronary artery disease) Use with caution. May increase the risk of experiencing chest pain or heart attacks. Proper Use of aliskiren, amlodipine, and hydrochlorothiazide aliskiren, amlodipine, and hydrochlorothiazide should not be the first medicine you use to treat your condition . It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects. aliskiren, amlodipine, and hydrochlorothiazide comes with a patient information insert. Read the information carefully and make sure you understand it before taking aliskiren, amlodipine, and hydrochlorothiazide. Ask your doctor if you have any questions. In addition to the use of aliskiren, amlodipine, and hydrochlorothiazide, treatment for your high blood pressure may include weight control and a change in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Remember that aliskiren, amlodipine, and hydrochlorothiazide will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life . If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Take aliskiren, amlodipine, and hydrochlorothiazide the same way every day. This means take it at the same time and take it consistently with or without food. High-fat meals may decrease absorption of aliskiren, amlodipine, and hydrochlorothiazide. Dosing The dose of aliskiren, amlodipine, and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aliskiren, amlodipine, and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For high blood pressure: Adults Your doctor will determine your starting dose and may increase your dose as needed. However, the dose is usually not more than 300 milligrams (mg) of aliskiren, 10 mg of amlodipine, and 25 mg of hydrochlorothiazide once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of aliskiren, amlodipine, and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the medicine in its original container. Precautions While Using aliskiren, amlodipine, and hydrochlorothiazide It is very important that your doctor check your progress at regular visits to make sure aliskiren, amlodipine, and hydrochlorothiazide is working properly. Blood and urine tests may be needed to check for unwanted effects. Using aliskiren, amlodipine, and hydrochlorothiazide while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using aliskiren, amlodipine, and hydrochlorothiazide, tell your doctor right away. Call your doctor right away if you have swelling of the face, arms, legs, eyes, lips, or tongue, or problems with swallowing or breathing. These are symptoms of a condition called angioedema. You should not use aliskiren, amlodipine, and hydrochlorothiazide (unless your doctor specifically tells you to) if you are also receiving cyclosporine (Gengraf , Neoral , Sandimmune ), itraconazole (Sporanox ), or lithium (Eskalith , Lithobid ). Dizziness, lightheadedness, or fainting may occur after the first dose, especially if you have been taking a diuretic (water pill). Make sure you know how you react to the medicine before you drive, use machines, or do other things that could be dangerous if you are dizzy or not alert . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, call your doctor right away . Check with your doctor right away if you become sick while taking aliskiren, amlodipine, and hydrochlorothiazide, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. aliskiren, amlodipine, and hydrochlorothiazide may worsen the symptoms of angina (chest pain) or cause a heart attack, especially in patients with severe heart or blood vessel disease. Check with your doctor right away if you are having chest pain or discomfort, fast or irregular heartbeat, nausea or vomiting, pain or discomfort in the arms, jaw, back, or neck. shortness of breath, or sweating. Hyperkalemia (high potassium in the blood) may occur while you are using aliskiren, amlodipine, and hydrochlorothiazide. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Do not use supplements or salt substitutes containing potassium without first checking with your doctor . Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). aliskiren, amlodipine, and hydrochlorothiazide may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor. Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure. aliskiren, amlodipine, and hydrochlorothiazide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloating or swelling of the face, arms, hands, lower legs, or feet rapid weight gain tingling of the hands or feet unusual weight gain or loss Less common Dizziness Rare Blurred vision confusion dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position sweating unusual tiredness or weakness Incidence not known Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Acid or sour stomach fever headache itching skin lack or loss of strength muscle aches rash sore throat stomach discomfort, upset, or pain stuffy or runny nose Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about aliskiren/amlodipine/hydrochlorothiazide Side Effects During Pregnancy Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: miscellaneous antihypertensive combinations Consumer resources Aliskiren, Amlodipine, and Hydrochlorothiazide Other brands: Amturnide Professional resources Aliskiren, Amlodipine, and Hydrochlorothiazide (Wolters Kluwer) Related treatment guides High Blood Pressure} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Drug Class Miscellaneous antihypertensive combinations Related Drugs High Blood Pressure amlodipine , lisinopril , hydrochlorothiazide , furosemide , losartan , metoprolol , atenolol , Lasix , Norvasc , valsartan , enalapril , Diovan , Cozaar , Benicar , Toprol-XL , Bystolic , irbesartan , Lopressor , hydrochlorothiazide / lisinopril , hydrochlorothiazide / triamterene , Maxzide , Zestril , Dyazide , More... 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potential aliskiren, amlodipine, and hydrochlorothiazide (Oral route) addiction
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