service or product aliskiren and hydrochlorothiazide (Oral route) a-lis-KYE-ren, hye-droe-klor-oh-THYE-a-zide Oral route(Tablet) When pregnancy is detected, discontinue aliskiren/hydrochlorothiazide as soon as possible, since drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Tekturna HCT Available Dosage Forms: Tablet Therapeutic Class: Antihypertensive Pharmacologic Class: Renin Inhibitor Chemical Class: Thiazide Slideshow Ladies A Moment: 10 Health Screenings That All Women Need Uses For aliskiren and hydrochlorothiazide Aliskiren and hydrochlorothiazide combination is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Lowering blood pressure will reduce the risk of strokes and heart attacks. Aliskiren is a renin inhibitor. It works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart. Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure. aliskiren and hydrochlorothiazide is available only with your doctor's prescription. Before Using aliskiren and hydrochlorothiazide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For aliskiren and hydrochlorothiazide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to aliskiren and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of aliskiren and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of aliskiren and hydrochlorothiazide combination in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking aliskiren and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aliskiren and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Azilsartan Azilsartan Medoxomil Benazepril Candesartan Captopril Dofetilide Enalapril Enalaprilat Eprosartan Fosinopril Irbesartan Lisinopril Losartan Moexipril Olmesartan Medoxomil Perindopril Quinapril Ramipril Telmisartan Trandolapril Valsartan Using aliskiren and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Acetyldigoxin Amphetamine Amtolmetin Guacil Arsenic Trioxide Aspirin Benzphetamine Bromfenac Bufexamac Celecoxib Choline Salicylate Clonixin Cyclophosphamide Cyclosporine Deslanoside Dexibuprofen Dexketoprofen Dextroamphetamine Diclofenac Diflunisal Digitalis Digitoxin Digoxin Dipyrone Droperidol Droxicam Eliglustat Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Flecainide Floctafenine Flufenamic Acid Flurbiprofen Ibuprofen Indomethacin Itraconazole Ketanserin Ketoprofen Ketorolac Levomethadyl Lisdexamfetamine Lithium Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Methamphetamine Methotrexate Metildigoxin Morniflumate Nabumetone Naproxen Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Ouabain Oxaprozin Oxyphenbutazone Parecoxib Phenylbutazone Piketoprofen Piroxicam Proglumetacin Propyphenazone Proquazone Proscillaridin Rofecoxib Salicylic Acid Salsalate Simeprevir Sodium Salicylate Sotalol Sulindac Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Valdecoxib Using aliskiren and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aminolevulinic Acid Bepridil Carbamazepine Cholestyramine Furosemide Ginkgo Gossypol Licorice Rifampin Topiramate Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using aliskiren and hydrochlorothiazide with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use aliskiren and hydrochlorothiazide, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of aliskiren and hydrochlorothiazide. Make sure you tell your doctor if you have any other medical problems, especially: Airway surgery, history of At risk for severe complications from angioedema (swelling of the face, lips, tongue, throat, arms, or legs). Angioedema, history of May increase the risk of this condition occurring again. Anuria (not able to pass urine) or Diabetes patients who are also taking certain blood pressure medicines such as angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) or Sulfa drug allergy (e.g., sulfamethoxazole, Bactrim , Septra ) Should not be used in patients with these conditions. Asthma, history of May increase likelihood of having an allergic reaction. Diabetes or Kidney problems May increase risk of having high potassium in the blood. Electrolyte imbalance (e.g., high or low levels of calcium, magnesium, potassium, or sodium in the body) or Fluid imbalances (caused by dehydration, vomiting, or diarrhea) or Glaucoma, secondary angle closure or Gout or Hyperlipidemia (high cholesterol or fats in the blood) or Liver disease or Myopia, acute (changes in the eyeball causing vision problems) or Systemic lupus erythematosus (SLE) Use with caution. May make these conditions worse. Heart failure, severe Heart attack, history Use may lead to kidney problems. Proper Use of aliskiren and hydrochlorothiazide aliskiren and hydrochlorothiazide should not be the first medicine you use to treat your condition . It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects. aliskiren and hydrochlorothiazide comes with a patient information insert. Read the information carefully and make sure you understand it before taking aliskiren and hydrochlorothiazide. Ask your doctor if you have any questions. In addition to the use of aliskiren and hydrochlorothiazide, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet. Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well. Remember that aliskiren and hydrochlorothiazide will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life . If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease. Take aliskiren and hydrochlorothiazide the same way every day. This means take it at the same time and take it consistently with or without food. Dosing The dose of aliskiren and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of aliskiren and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For high blood pressure: Adults At first, one tablet containing 150 milligrams (mg) of aliskiren and 12.5 mg of hydrochlorothiazide once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 300 mg of aliskiren and 25 mg of hydrochlorothiazide once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of aliskiren and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep the tablets in its original container in a dry place. Precautions While Using aliskiren and hydrochlorothiazide It is very important that your doctor check your progress at regular visits to make sure aliskiren and hydrochlorothiazide is working properly. Blood tests may be needed to check for unwanted effects. Using aliskiren and hydrochlorothiazide while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away. aliskiren and hydrochlorothiazide may cause serious allergic reactions, including anaphylaxis and angioedema. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, lips, tongue, or throat while you are using aliskiren and hydrochlorothiazide. You should not use aliskiren and hydrochlorothiazide (unless your doctor specifically tells you to) if you are also receiving cyclosporine (Gengraf , Neoral , Sandimmune ), itraconazole (Sporanox ), or lithium (Eskalith , Lithobid ). Dizziness, lightheadedness, or fainting may occur after the first dose, especially if you have been taking a diuretic (water pill). Make sure you know how you react to the medicine before you drive, use machines, or do other things that could be dangerous if you are dizzy or not alert . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. If you faint, stop using aliskiren and hydrochlorothiazide until you have talked to your doctor . Check with your doctor if you become sick while taking aliskiren and hydrochlorothiazide, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. Hyperkalemia (high potassium in the blood) may occur while you are using aliskiren and hydrochlorothiazide. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium . Check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Do not take other medicines unless they have been discussed with your doctor. This especially includes nonprescription medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may increase your blood pressure. aliskiren and hydrochlorothiazide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Chills cough diarrhea fever general feeling of discomfort or illness headache joint pain loss of appetite muscle aches and pains nausea runny nose shivering sore throat sweating trouble sleeping unusual tiredness or weakness vomiting Incidence not known Difficulty with swallowing dizziness fast heartbeat hives itching large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue shortness of breath skin rash tightness in the chest Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Coma confusion decreased urine output drowsiness dry mouth fainting increase in heart rate increased thirst irregular heartbeat irritability lightheadedness muscle cramps numbness, tingling, pain, or weakness in the hands or feet rapid breathing seizures sunken eyes swelling of the face, ankles, or hands trembling weak pulse weakness and heaviness of the legs wrinkled skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Difficulty with moving feeling of constant movement of self or surroundings lack or loss of strength muscle stiffness sensation of spinning Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about aliskiren/hydrochlorothiazide Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 4 Reviews Add your own review/rating Drug class: miscellaneous antihypertensive combinations Consumer resources Hydrochlorothiazide and aliskiren Aliskiren and Hydrochlorothiazide Other brands: Tekturna HCT Professional resources Aliskiren and Hydrochlorothiazide (Wolters Kluwer) Related treatment guides High Blood Pressure} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Drug Class Miscellaneous antihypertensive combinations Related Drugs High Blood Pressure amlodipine , lisinopril , hydrochlorothiazide , furosemide , losartan , metoprolol , atenolol , Lasix , Norvasc , valsartan , enalapril , Diovan , Cozaar , Benicar , Toprol-XL , Bystolic , irbesartan , Lopressor , hydrochlorothiazide / lisinopril , hydrochlorothiazide / triamterene , Maxzide , Zestril , Dyazide , More... Aliskiren / hydrochlorothiazide Rating 4 User Reviews 8.8 /10 4 User Reviews 8.8 Rate it! Help and Support Looking for answers? Ask a question or go join the aliskiren / hydrochlorothiazide support group to connect with others who have similar interests.} } a terribly
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