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Photo :Alka-Seltzer Plus Flu/Body
a really Alka-Seltzer Plus Flu/Body Generic Name: Acetaminophen/Dextromethorphan/Pseudoephedrine Capsules And Tablets (a seet a MIN oh fen/dex troe meth OR fan/sue doe eh FED rin) Brand Name: Alka-Seltzer Plus Flu/Body, DayQuil Multi-Symptom Cold/Flu, EQ Daytime Cold/Flu Relief, EQ Flu Relief, EQL Daytime Cold/Flu Relief, ...show all 9 brand names. EQL Severe Cold, GNP Day Time D Cold/Flu, PX Daytime Multi-Symptom, RA Acetaminophen Flu Cold Overview Side Effects Dosage Interactions Pregnancy More User Reviews The Alka-Seltzer Plus Flu/Body brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available . Uses of Alka-Seltzer Plus Flu/Body: It is used to treat nose stuffiness. It is used to relieve coughing. It is used to ease pain and fever. Slideshow OTC Medication Use In Pregnancy: Wise or Worrisome? What do I need to tell my doctor BEFORE I take Alka-Seltzer Plus Flu/Body? If you have an allergy to Alka-Seltzer Plus Flu/Body (acetaminophen/dextromethorphan/pseudoephedrine capsules and tablets) or any part of this medicine. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking Alka-Seltzer Plus Flu/Body within 14 days of those drugs can cause very bad high blood pressure. If you have a cough with a lot of mucous. If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema. This is not a list of all drugs or health problems that interact with this medicine. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Alka-Seltzer Plus Flu/Body with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Alka-Seltzer Plus Flu/Body? Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists. Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects. Do not take Alka-Seltzer Plus Flu/Body for longer than you were told by your doctor. Avoid other sources of acetaminophen. Check labels closely. Too much acetaminophen may cause problems. Very bad and sometimes deadly liver problems have happened with the use of acetaminophen. Some people needed a liver transplant. Liver problems happened most often in people taking more than 4,000 mg (milligrams) in a day. People were often taking more than one drug with acetaminophen in it. Talk with your doctor. Call your doctor right away if you take more than 4,000 mg (milligrams) of acetaminophen in a day, even if you feel well. Talk with your doctor before you drink alcohol. This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine. Different brands of Alka-Seltzer Plus Flu/Body may be for use in different ages of children. Talk with the doctor before giving this medicine to a child. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using Alka-Seltzer Plus Flu/Body while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Alka-Seltzer Plus Flu/Body) best taken? Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely. Take tablet with or without food. Take with food if it causes an upset stomach. What do I do if I miss a dose? If you take Alka-Seltzer Plus Flu/Body on a regular basis, take a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not take 2 doses at the same time or extra doses. Many times this medicine is taken on an as needed basis. Do not take more often than told by the doctor. Dosage Information (comprehensive) What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Not able to pass urine or change in how much urine is passed. A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes. What are some other side effects of Alka-Seltzer Plus Flu/Body? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Dizziness. Feeling nervous and excitable. Not able to sleep. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Alka-Seltzer Plus Flu/Body? Store at room temperature. Protect from heat. Store in a dry place. Do not store in a bathroom. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Alka-Seltzer Plus Flu/Body (acetaminophen/dextromethorphan/pseudoephedrine capsules and tablets), please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about Alka-Seltzer Plus Flu/Body. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using Alka-Seltzer Plus Flu/Body. Review Date: November 1, 2017 Next Side Effects Print this page Add to My Med List More about Alka-Seltzer Plus Flu/Body (acetaminophen / dextromethorphan / pseudoephedrine) Side Effects During Pregnancy Dosage Information Drug Interactions 0 Reviews Add your own review/rating Drug class: upper respiratory combinations Consumer resources Other brands: Vicks Dayquil Daytime Cold/Flu (old formulation) , Daytime Cold , Severe Cold Multi-Symptom , Theraflu (pseudoephedrine) Daytime Severe Cold , ... +2 more Related treatment guides Cold Symptoms} Drug Status Availability Discontinued N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug WADA Class Anti-Doping Classification Alka-Seltzer Plus Flu / Body Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Drug Class Upper respiratory combinations Related Drugs Cold Symptoms diphenhydramine , Benadryl , Promethazine DM , chlorpheniramine , echinacea , Tussionex Pennkinetic , Banophen , Benadryl Allergy , Chlor-Trimeton , Guaifenex , Triaminic , Promethazine with Dextromethorphan , Promethazine VC , Alka-Seltzer Plus Cold , Primatene , Promethazine with DM , Coricidin HBP Cold & Flu , brompheniramine , Aprodine , Virtussin DAC , chlorpheniramine / hydrocodone , Promethazine VC Plain , More... Related: Common Cold (Viral Rhinitis)} } twine


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Photo :Diastat Pediatric (Rectal)
look at Diastat Pediatric (Rectal) Generic Name: diazepam (Rectal route) dye-AZ-e-pam Overview Side Effects Dosage Interactions Pregnancy More Breastfeeding Warnings User Reviews Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Diastat Diastat Pediatric Available Dosage Forms: Gel/Jelly Kit Therapeutic Class: Anticonvulsant Pharmacologic Class: Benzodiazepine, Long Acting Slideshow Fashion Trends That Can Affect Your Health Uses For Diastat Pediatric Diazepam rectal gel is used to control certain seizure disorders such as epilepsy. Diazepam is a benzodiazepine. Benzodiazepines belong to the group of medicines called central nervous system (CNS) depressants, which are medicines that slow down the nervous system. This medicine is available only with your doctor's prescription. Before Using Diastat Pediatric In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of diazepam rectal gel in children below 2 years of age. Safety and efficacy have not been established. Use is not recommended in infants under 6 months of age. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of diazepam rectal gel in the elderly. However, severe drowsiness, clumsiness, or unsteadiness are more likely to occur in the elderly, which may require an adjustment in the dose for patients receiving diazepam rectal gel. Pregnancy Pregnancy Category Explanation All Trimesters D Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk. Breast Feeding Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Flumazenil Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfentanil Amobarbital Bromazepam Bromopride Buprenorphine Butabarbital Butalbital Butorphanol Calcifediol Carbinoxamine Carisoprodol Chloral Hydrate Chlorzoxazone Cobicistat Codeine Conivaptan Dantrolene Dihydrocodeine Doxylamine Eslicarbazepine Acetate Ethchlorvynol Etravirine Fentanyl Flibanserin Fosphenytoin Fospropofol Hydrocodone Hydromorphone Levorphanol Meclizine Meperidine Mephenesin Mephobarbital Meprobamate Metaxalone Methadone Methocarbamol Methohexital Mirtazapine Morphine Morphine Sulfate Liposome Nalbuphine Netupitant Orlistat Oxycodone Oxymorphone Pentazocine Pentobarbital Periciazine Phenobarbital Phenytoin Primidone Propofol Secobarbital Sodium Oxybate Sufentanil Tapentadol Thiopental Tramadol Zolpidem Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amitriptyline Amprenavir Clarithromycin Dalfopristin Disulfiram Erythromycin Fluvoxamine Ginkgo Isoniazid Quinupristin Rifapentine Roxithromycin St John's Wort Theophylline Troleandomycin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse, or history of, or Drug abuse or dependence, or history of Dependence on diazepam may develop. Breathing problems or lung diseases (e.g., asthma, pneumonia) Use with caution. May make this condition worse. Glaucoma, acute narrow angle Should not be used in patients with this condition. Kidney disease or Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of diazepam This section provides information on the proper use of a number of products that contain diazepam. It may not be specific to Diastat Pediatric. Please read with care. Apply this medicine only as directed by your doctor. Do not apply more of it, do not apply it more often, and do not apply it for a longer time than your doctor ordered. Never take rectal medicine by mouth. This medicine is not for daily use. After you use the medicine, it is best to wait at least 5 days before using it again. Do not use this medicine more than 5 times per month, unless your doctor tells you to. This medicine will need to be given to you while you are having a seizure. A family member or other caregiver will give the medicine to you since you will most likely be unable to give it to yourself. For caregivers administering this medicine: Discuss with the patient's medical doctor exactly when and how to use diazepam rectal gel. Discuss with the patient's medical doctor when you should call for emergency help. Read the instructions that you received with the medicine before you need to use it. Stay with the patient after administering diazepam rectal gel to check his or her condition as instructed by the doctor. This medicine comes in a prefilled plastic applicator. Remove the cap from the prefilled applicator before inserting it. To make the applicator easier to insert, use the lubricating gel that came with the medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For rectal dosage form (gel): For control of seizures: Adults, teenagers, and children 2 years of age and older Dose is based on body weight and must be determined by your doctor. Children younger than 2 years of age Use and dose must be determined by your doctor. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Destroy any medicine that you do not need by flushing it down the toilet. Precautions While Using Diastat Pediatric It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine will add to the effects of alcohol and other CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates (used for seizures); muscle relaxants; or anesthetics (numbing medicines), including some dental anesthetics. This effect may last for a few days after you stop taking this medicine. Check with your doctor before taking any of the above while you are using this medicine. This medicine may cause some people, especially older persons, to become drowsy, dizzy, lightheaded, clumsy, unsteady, or less alert than they are normally. Make sure you know how you react to diazepam before you drive, use machines, or do anything else that could be dangerous if you are not alert or able to think or see well . Diastat Pediatric Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Anxiety blurred vision changes in patterns and rhythms of speech confusion cough crying delusions dementia depersonalization difficulty breathing difficulty in speaking dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly dry mouth dysphoria euphoria false or unusual sense of well-being feeling of warmth or heat flushing or redness of skin, especially on face and neck headache hyperventilation irregular heartbeats irritability lack of coordination mental depression mood or mental changes nervousness noisy breathing paranoia quick to react or overreact emotionally rapidly changing moods restlessness seizures shakiness and unsteady walk shortness of breath slurred speech sweating tightness in chest trouble in speaking trouble sleeping unsteadiness, trembling, or other problems with muscle control or coordination unusual tiredness or weakness wheezing Rare Bladder pain bloody or cloudy urine difficult, burning, or painful urination fever or chills frequent urge to urinate increase in body movements lower back or side pain painful or difficult urination pale skin swollen, painful, or tender lymph glands in neck, armpit, or groin unusual bleeding or bruising Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Sleepiness or unusual drowsiness Less common Diarrhea feeling of constant movement of self or surroundings hiccups lack or loss of strength rash runny nose sensation of spinning sneezing stuffy nose Rare Bigger, dilated, or enlarged pupils (black part of eye) increased sensitivity of eyes to light itching skin loss of appetite vomiting weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Diastat Pediatric (diazepam) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: benzodiazepine anticonvulsants Consumer resources Diastat Pediatric Other brands: Valium , Diazepam Intensol , Zetran Professional resources Diazepam (AHFS Monograph) Diazepam Tablet (FDA) Other Formulations Diastat Diastat AcuDial Related treatment guides Alcohol Withdrawal Anxiety Endoscopy or Radiology Premedication ICU Agitation ... +9 more} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk 4 CSA Schedule Some potential for abuse Drug Class Benzodiazepine anticonvulsants Benzodiazepines Related Drugs Anxiety Xanax , Lexapro , Cymbalta , atenolol , alprazolam , lorazepam , More... Muscle Spasm cyclobenzaprine , Soma , tizanidine , baclofen , diazepam , Flexeril , More... Alcohol Withdrawal atenolol , diazepam , Valium , Tenormin , clorazepate , chlordiazepoxide , More... Endoscopy or Radiology Premedication diazepam , Valium , simethicone , hyoscyamine , Levsin , More... 7 more conditions... Diastat Pediatric Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the Diastat Pediatric support group to connect with others who have similar interests.} } workout


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many candidates Dextrostat (Oral) listening to

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Photo :Dextrostat (Oral)
temper Dextrostat (Oral) Generic Name: dextroamphetamine (Oral route) dex-troe-am-FET-a-meen Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Oral route(Capsule, Extended Release) Amphetamines have a high potential for abuse, and administration for prolonged periods of time may lead to drug dependence and must be avoided. Misuse of amphetamines may cause sudden death and serious cardiovascular adverse events . Commonly used brand name(s) In the U.S. Dexedrine Dexedrine Spansules Dextrostat Liquadd ProCentra Zenzedi Available Dosage Forms: Capsule, Extended Release Solution Tablet Therapeutic Class: CNS Stimulant Chemical Class: Amphetamine (class) Slideshow 10 Common Sleep Disorders: Treatments and Truths Uses For Dextrostat Dextroamphetamine is used to treat attention-deficit hyperactivity disorder (ADHD) and narcolepsy (uncontrollable desire for sleep or a sudden attack of deep sleep). It belongs to the group of medicines called central nervous system (CNS) stimulants. Dextroamphetamine works in the treatment of ADHD by increasing attention and decreasing restlessness in children and adults who are overactive, cannot concentrate for very long, or are easily distracted and impulsive. This medicine is used as part of a total treatment program that also includes social, educational, and psychological treatment. This medicine is available only with a doctor's prescription. Prescriptions cannot be refilled. A new prescription must be obtained from your doctor each time you or your child needs this medicine. Before Using Dextrostat In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of dextroamphetamine tablets to treat attention-deficit hyperactivity disorder in children younger than 3 years of age. Safety and efficacy have not been established. Dextroamphetamine sustained-release capsule is not recommended to treat attention-deficit hyperactivity disorder in children younger than 6 years of age. Geriatric No information is available on the relationship of age to the effects of dextroamphetamine in geriatric patients. . Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using this medicine. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Furazolidone Iproniazid Isocarboxazid Linezolid Methylene Blue Moclobemide Nialamide Phenelzine Procarbazine Rasagiline Safinamide Selegiline Sibutramine Tranylcypromine Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Acetazolamide Alfentanil Almotriptan Amineptine Amitriptyline Amitriptylinoxide Amoxapine Benzthiazide Brompheniramine Buprenorphine Bupropion Buspirone Butorphanol Carbamazepine Chlorothiazide Chlorpheniramine Cinacalcet Citalopram Clomipramine Cocaine Codeine Cyclobenzaprine Desipramine Desvenlafaxine Dextromethorphan Diazoxide Dibenzepin Difenoxin Dihydrocodeine Diphenoxylate Dolasetron Donepezil Doxepin Duloxetine Eletriptan Escitalopram Ethylmorphine Fentanyl Fluoxetine Fluvoxamine Frovatriptan Granisetron Hydrochlorothiazide Hydrocodone Hydroflumethiazide Hydromorphone Hydroxytryptophan Imipramine Ketobemidone Levomilnacipran Levorphanol Lithium Lofepramine Lorcaserin Melitracen Meperidine Methadone Milnacipran Mirabegron Mirtazapine Morphine Morphine Sulfate Liposome Nalbuphine Naratriptan Nefazodone Nicomorphine Nortriptyline Ondansetron Opipramol Opium Opium Alkaloids Oxycodone Oxymorphone Palonosetron Papaveretum Paregoric Paroxetine Pentazocine Piritramide Polythiazide Protriptyline Quinidine Quinine Remifentanil Rizatriptan Rolapitant Sertraline Sodium Bicarbonate St John's Wort Sufentanil Sumatriptan Tapentadol Terbinafine Tianeptine Tilidine Tramadol Trazodone Trichlormethiazide Trimipramine Tryptophan Venlafaxine Vilazodone Vortioxetine Xipamide Ziprasidone Zolmitriptan Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Agitation, severe or Anxiety, severe or Arteriosclerosis (hardening of the arteries), severe or Coronary artery disease or Drug abuse, history of or Glaucoma or Heart attack, recent or Heart failure or Heart or blood vessel disease (eg, cardiomyopathy) or Heart rhythm problems (eg, ventricular arrhythmia) or Hypertension (high blood pressure), moderate to severe or Hyperthyroidism (overactive thyroid) or Stroke, history of or Tension, severe Should not be used in patients with these conditions. Bipolar disorder (manic-depressive illness), or a family history of or Blood vessel problems (eg, Raynaud disease) or Depression, or a family history of or Hypertension (high blood pressure), mild or Mania, history of or Psychosis (mental illness), history of or Seizures, history of or Thyroid problems or Tourette's syndrome, or family history of Use with caution. May make these conditions worse. . Proper Use of dextroamphetamine This section provides information on the proper use of a number of products that contain dextroamphetamine. It may not be specific to Dextrostat. Please read with care. Take this medicine only as directed by your doctor . Do not take more or less of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming. If you or your child feel that the medicine is not working properly after you have taken it for several weeks, check with your doctor first and do not increase the dose. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Ask your pharmacist for the Medication Guide if you do not have one. If you or your child use the tablet form of this medicine, and you take it 2 or 3 times a day. Take the first dose in the morning. The other doses may be taken during the day with 4 to 6 hours between doses. It is best to take the sustained-release capsule in the morning. Taking this medicine in the afternoon or evening could make it harder for you to fall asleep. Swallow the sustained-release capsule whole. Do not crush, break, or chew it. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For attention-deficit hyperactivity disorder (ADHD): For oral dosage form (sustained-release capsules): Adults and children 6 years of age and older At first, 5 milligrams (mg) 1 or 2 times a day. Your doctor may adjust your dose if needed. Children younger than 6 years of age Use is not recommended. For oral dosage form (tablets): Adults and children 6 years of age and older At first, 5 milligrams (mg) 1 or 2 times a day. Your doctor may adjust your dose if needed. Children 3 to 5 years of age At first, 2.5 mg once a day. Your doctor may adjust your dose if needed. Children younger than 3 years of age Use and dose must be determined by your doctor. For narcolepsy: For oral dosage forms (sustained-release capsules or tablets): Adults and children 12 years of age and older At first, 10 milligrams (mg) once a day. Your doctor may adjust your dose if needed. Children 6 to 12 years of age At first, 5 mg once a day. Your doctor may adjust your dose if needed. Children younger than 6 years of age Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Dextrostat It is very important that your doctor check you or your child's progress at regular visits to make sure that your dose is right and that the medicine is helping you. Your doctor will need to check your or your child's blood, heart, and blood pressure for any problems or unwanted effects that may be caused by this medicine. You should not use this medicine if you or your child are using or have used an MAO inhibitor (MAOI) such as Eldepryl , Marplan , Nardil , or Parnate within the past 14 days. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Tell your doctor about all the medicines you or your child take or plan to take, including prescription and nonprescription (over-the-counter) medicines, dietary supplements, herbal remedies, or medicines for appetite control, asthma, colds, cough, hay fever, and sinus problems. This medicine may cause serious heart or blood vessel problems. This may be more likely in patients who have a family history of heart disease. Check with your doctor right away if you or your child have chest pain, trouble breathing, or fainting while taking this medicine. This medicine may cause some people to feel a false sense of well-being or to become dizzy, lightheaded, or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you . Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you or your child to have your eyes checked by an ophthalmologist (eye doctor). Tell your doctor right away if you or your family notices any unusual changes in behavior, such as an increase in aggression, hostility, agitation, irritability, or suicidal thinking or behaviors. Also tell your doctor if you or your child have hallucinations or any unusual thoughts, especially if they are new or getting worse quickly. If you or your child have been using this medicine for a long time and you think you may have become mentally or physically dependent on it, check with your doctor. Some signs that you may be dependent on dextroamphetamine are: A strong desire or need to continue taking the medicine. A need to increase the dose to receive the effects of the medicine. Withdrawal effects (for example, mental depression, nausea or vomiting, stomach cramps or pain, trembling, unusual tiredness or weakness) that occur after the medicine is stopped. This medicine may cause slow growth in children. If your child is using this medicine, the doctor will need to keep track of your child's height and weight to make sure that your child is growing properly. This medicine may cause a condition called Raynaud phenomenon. Check with your doctor right away if you or your child have tingling or pain in the fingers or toes when exposed to cold, paleness or a cold feeling in the fingertips and toes, or a skin color change in your fingers. Check with your doctor right away if you or your child have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of a serious condition called serotonin syndrome. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. If you or your child will be taking this medicine in large doses for a long time, do not stop taking it without first checking with your doctor . Your doctor may want you or your child to gradually reduce the amount you are taking before stopping it completely. Before you have any medical tests, tell the medical doctor in charge that you or your child are taking this medicine. The results of some tests may be affected by this medicine. Dextrostat Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Rare Agitation delusions seeing, hearing, or feeling things that are not there Incidence not known Blurred vision chest discomfort or pain difficulty breathing dizziness faintness false or unusual sense of well-being fast, pounding, or irregular heartbeat or pulse headache pounding in the ears shakiness in the legs, arms, hands, or feet swelling of the feet or lower legs trembling or shaking of the hands or feet twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs unable to sleep uncontrolled vocal outbursts and/or tics (uncontrolled repeated body movements) unusual tiredness or weakness Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Change in consciousness dark-colored urine diarrhea discouragement feeling sad or empty fever irritability lack of appetite loss of consciousness loss of interest or pleasure mood or mental changes muscle cramps or spasms muscle pain or stiffness nausea panic state physical attempt to injure rapid breathing seizures stomach cramps sweating trouble concentrating violent actions vomiting Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not known Bad, unusual, or unpleasant (after) taste change in taste constipation decreased interest in sexual intercourse dry mouth hives or welts, itching, or skin rash inability to have or keep an erection indigestion loss in sexual ability, desire, drive, or performance passing of gas redness of the skin weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Dextrostat (dextroamphetamine) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group 3 Reviews Add your own review/rating Drug class: CNS stimulants Consumer resources Other brands: Dexedrine , Zenzedi , ProCentra , Liquadd Professional resources Dextrostat (FDA) Dextroamphetamine Sulfate (AHFS Monograph) Related treatment guides ADHD Narcolepsy} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out 2 CSA Schedule High potential for abuse Approval History Drug history at FDA Drug Class CNS stimulants Related Drugs ADHD Adderall , methylphenidate , Vyvanse , Ritalin , Strattera , Concerta , amphetamine / dextroamphetamine , Adderall XR , Focalin , atomoxetine , dexmethylphenidate , Focalin XR , More... Narcolepsy Adderall , methylphenidate , Ritalin , modafinil , Concerta , dextroamphetamine , Provigil , amphetamine / dextroamphetamine , Adderall XR , Nuvigil , Dexedrine , More... Dextrostat Rating 3 User Reviews 9.2 /10 3 User Reviews 9.2 Rate it! Dextrostat Images Dextrostat 10 mg (RP 52) View larger images Related Questions & Answers Started taking dextrostat about a year ago for a dx of ADD... definitely am more upbeat with less or Latuda and Dextrostat? Moved out of the country where the meds taken is restricted. please help me? 5-year old with severe ADHD diagnosed just started Adderall? Why would the Dr prescribe 1mg TENEX 2x a day along with the 60mg of Adderrall Im already taking? Read more questions} } common


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Photo :OctreoScan
the hundreds OctreoScan Generic Name: indium In -111 pentetreotide Dosage Form: injection Overview Side Effects Dosage Professional Interactions More User Reviews Support Group Q & A Diagnostic - For Intravenous Use. Rx only OctreoScan Description OctreoScan is a kit for the preparation of indium In-111 pentetreotide, a diagnostic radiopharmaceutical. It is a kit consisting of two components: 1) A 10-mL OctreoScan Reaction Vial which contains a lyophilized mixture of: (i) 10 μg pentetreotide [N-(diethylenetriamine-N,N,N',N -tetraacetic acid-N -acetyl)-D-phenylalanyl-L-hemicystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-hemicystyl-L-threoninol cyclic (2 7) disulfide], (also known as octreotide DTPA), (ii) 2.0 mg gentisic acid [2, 5-dihydroxybenzoic acid], (iii) 4.9 mg trisodium citrate, anhydrous, (iv) 0.37 mg citric acid, anhydrous, and (v) 10.0 mg inositol. Pentetreotide has the following structural formula: Prior to lyophilization, sodium hydroxide or hydrochloric acid may have been added for pH adjustment. The vial contents are sterile and nonpyrogenic. No bacteriostatic preservative is present. 2) A 10-mL vial of Indium In-111 Chloride Sterile Solution, which contains: 1.1 mL or 111 MBq/mL (3.0 mCi/mL) indium In-111 chloride in 0.02N HCl at time of calibration. The vial also contains ferric chloride at a concentration of 3.5 μg/mL (ferric ion, 1.2 μg/mL). The vial contents are sterile and nonpyrogenic. No bacteriostatic preservative is present. Indium In-111 pentetreotide is prepared by combining the two kit components ( see INSTRUCTIONS FOR THE PREPARATION OF INDIUM In-111 PENTETREOTIDE ). Indium In-111 reacts with the diethylenetriaminetetraacetic acid portion of the pentetreotide molecule to form indium In 111 pentetreotide. The pH of the resultant indium In-111 pentetreotide solution is between 3.8 and 4.3. No bacteriostatic preservative is present. The indium In-111 pentetreotide solution is suitable for intravenous administration as is, or it may be diluted to a maximum volume of 3.0 mL with 0.9% Sodium Chloride Injection, U.S.P., immediately before intravenous administration. In either case, the labeling yield of indium In-111 pentetreotide should be determined before administration to the patient. A method recommended for determining the labeling yield is presented at the end of this package insert. Slideshow Type 1 Diabetes: Symptoms, Treatments, and Breakthroughs Physical Characteristics Indium In-111 decays by electron capture to cadmium-111 (stable) and has a physical half-life of 2.805 days (67.32 hours) ( see Table 2 ). 1 The principal photons that are useful for detection and imaging are listed in Table 1. Table 1. Principal Radiation Emission Data * * Kocher, David C., "Radioactive Decay Data Tables, DOE/TIC-11026, 115 (1981). Radiation Mean Percent Per Disintegration Energy (keV) Gamma-2 90.2 171.3 Gamma-3 94.0 245.4 The specific gamma ray constant for In-111 is 3.21 R/hr-mCi at 1 cm 1 . The first half-value thickness of lead (Pb) for In-111 is 0.023 cm. Selected coefficients of attenuation are listed in Table 2 as a function of lead shield thickness. For example, the use of 0.834 cm of lead will attenuate the external radiation by a factor of about 1000. Table 2. Radiation Attenuation by Lead Shielding Shield Thickness (Pb) cm Coefficient of Attenuation 0.023 0.5 0.203 0.1 0.513 0.01 0.834 0.001 1.12 0.0001 Table 3 lists fractions remaining at selected time intervals before and after calibration. This information may be used to correct for physical decay of the radionuclide. Table 3. Physical Decay Chart: Indium In-111, Half-life 2.805 Days (67.32 hours) * Calibration time Hours Fraction Remaining Hours Fraction Remaining -72 2.100 0 * 1.000 -60 1.854 3 0.970 -48 1.639 6 0.940 -36 1.448 12 0.885 -24 1.280 24 0.781 -12 1.131 36 0.690 -6 1.064 48 0.610 1 From Radiopharmaceutical Internal Dosimetry Information Center, Oak Ridge Associated Universities, Oak Ridge, TN 37831-0117, February 1985. OctreoScan - Clinical Pharmacology General Pentetreotide is a DTPA conjugate of octreotide, which is a long-acting analog of the human hormone, somatostatin. Indium In-111 pentetreotide binds to somatostatin receptors on cell surfaces throughout the body. Within an hour of injection, most of the dose of indium In-111 pentetreotide distributes from plasma to extravascular body tissues and concentrates in tumors containing a high density of somatostatin receptors. After background clearance, visualization of somatostatin receptor-rich tissue is achieved. In addition to somatostatin receptor-rich tumors, the normal pituitary gland, thyroid gland, liver, spleen and urinary bladder also are visualized in most patients, as is the bowel, to a lesser extent. Excretion is almost exclusively via the kidneys. Pharmacokinetics Radioactivity leaves the plasma rapidly; one third of the radioactive injected dose remains in the blood pool at 10 minutes after administration. Plasma levels continue to decline so that by 20 hours post-injection, about 1% of the radioactive dose is found in the blood pool. The biological half-life of indium In-111 pentetreotide is 6 hours. Half of the injected dose is recoverable in urine within six hours after injection, 85% is recovered in the first 24 hours, and over 90% is recovered in urine by two days. Hepatobiliary excretion represents a minor route of elimination, and less than 2% of the injected dose is recovered in feces within three days after injection. Metabolism For several hours after administration, plasma radioactivity is predominantly in parent form. Ten percent of the radioactivity excreted is nonpeptide-bound. Pharmacodynamics Indium In-111 pentetreotide binds to cell surface receptors for somatostatin. In nonclinical pharmacologic studies, the hormonal effect of OctreoScan in vitro is one-tenth that of octreotide. Since diagnostic imaging doses of indium In-111 pentetreotide are lower than the therapeutic doses of octreotide, indium In-111 pentetreotide is not expected to exert clinically significant somatostatin effects. Indium In-111 pentetreotide is cleared from the body primarily by renal excretion. Indium In-111 pentetreotide elimination has not been studied in anephric patients or in those with poorly functioning kidneys. It is not known whether indium In-111 pentetreotide can be removed by dialysis. Dosage adjustments in patients with decreased renal function have not been studied. Clinical Trials OctreoScan was studied in nine unblinded clinical studies in a total of 365 patients. Of these patients, 174 were male and 191 were female. Their mean age was 54.0 years (range 1.8 to 86 years). One patient was under the age of 2 and 2 patients were between the ages of 2 and 12; 223 patients (61.1%) were between 18 and 60 years; and 136 patients (37.3%) were older than 60 years. A racial distribution is not available. Eligible patients had a demonstrated or high clinical suspicion of a neuroendocrine tumor. The most common tumors were carcinoids (132 of 309 evaluable patients). Scintigraphic results were compared to results of conventional localization procedures (CT, ultrasound, MRI, angiography, surgery and/or biopsy). The mean dose of radioactivity administered was 173.4 MBq (4.7 mCi). OctreoScan results were consistent with the final diagnosis (success) in 267 of 309 evaluable patients (86.4%). Compared with carcinoids and gastrinomas, lower success rates were noted for localization of insulinomas, neuroblastomas, pituitary adenomas and medullary thyroid carcinomas. OctreoScan success was observed in 27 of 32 patients (84.4%) with clinically nonfunctioning neuroendocrine tumors (i.e., no symptom of a clinical syndrome mediated by abnormally elevated hormones). OctreoScan localized previously unidentified tumors in 57/204 patients. In 55/195 patients, indium In-111 pentetreotide uptake occurred in lesions not thought to have somatostatin receptors. In a small subgroup of 39 patients who had tissue confirmation, the sensitivity rate for OctreoScan scintigraphy was 85.7%; for CT/MRI the rate was 68%. The specificity rate for OctreoScan scintigraphy was 50%, the rate for CT/MRI was 12%. Larger studies are needed to confirm these comparisons. Overall, including all tumor types with or without the presence of somatostatin receptors, there were 3/508 false positives and 104/508 false negatives. Of the 309 patients, 87 had received octreotide for therapeutic purposes within 72 hours of OctreoScan administration. These patients had an overall 95% success rate. The effect of different dose levels of octreotide on success rates has not been evaluated. Indications and Usage for OctreoScan Indium In-111 pentetreotide is an agent for the scintigraphic localization of primary and metastatic neuroendocrine tumors bearing somatostatin receptors. Contraindications None known. Warnings DO NOT ADMINISTER IN TOTAL PARENTERAL NUTRITION (TPN) ADMIXTURES OR INJECT INTO TPN INTRAVENOUS ADMINISTRATION LINES; IN THESE SOLUTIONS, A COMPLEX GLYCOSYL OCTREOTIDE CONJUGATE MAY FORM. The sensitivity of scintigraphy with indium In-111 pentetreotide may be reduced in patients concurrently receiving therapeutic doses of octreotide acetate. Consideration should be given to temporarily suspending octreotide acetate therapy before the administration of indium In-111 pentetreotide and to monitoring the patient for any signs of withdrawal. Precautions General Therapy with octreotide acetate can produce severe hypoglycemia in patients with insulinomas. Since pentetreotide is an analog of octreotide, an intravenous line is recommended in any patient suspected of having an insulinoma. An intravenous solution containing glucose should be administered just before and during administration of indium In-111 pentetreotide. The contents of the two vials supplied with the kit are intended only for use in the preparation of indium In-111 pentetreotide and are NOT to be administered separately to the patient. Since indium In-111 pentetreotide is eliminated primarily by renal excretion, use in patients with impaired renal function should be carefully considered. To help reduce the radiation dose to the thyroid, kidneys, bladder, and other target organs, patients should be well hydrated before the administration of indium In-111 pentetreotide. They should increase fluid intake and void frequently for one day after administration of this drug. In addition, it is recommended that patients be given a mild laxative (e.g., bisacodyl or lactulose) before and after administration of indium In-111 pentetreotide ( see DOSAGE AND ADMINISTRATION section). Indium In-111 pentetreotide should be tested for labeling yield of radioactivity prior to administration. The product must be used within six hours of preparation. Components of the kit are sterile and nonpyrogenic. To maintain sterility, it is essential that directions are followed carefully. Aseptic technique must be used during the preparation and administration of indium In-111 pentetreotide. Octreotide acetate and the natural somatostatin hormone may be associated with cholelithiasis, presumably by altering fat absorption and possibly by decreasing motility of the gallbladder. A single dose of indium In-111 pentetreotide is not expected to cause cholelithiasis. As with any other radioactive material, appropriate shielding should be used to avoid unnecessary radiation exposure to the patient, occupational workers, and other persons. Radiopharmaceuticals should be used only by physicians who are qualified by specific training in the safe use and handling of radionuclides. Carcinogenesis, Mutagenesis, Impairment of Fertility Studies have not been performed with indium In-111 pentetreotide to evaluate carcinogenic potential or effects on fertility. Pentetreotide was evaluated for mutagenic potential in an in vitro mouse lymphoma forward mutation assay and an in vivo mouse micronucleus assay; evidence of mutagenicity was not found. Pregnancy Category C Animal reproduction studies have not been conducted with indium In-111 pentetreotide. It is not known whether indium In-111 pentetreotide can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Therefore, indium In-111 pentetreotide should not be administered to a pregnant woman unless the potential benefit justifies the potential risk to the fetus. Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when indium In-111 pentetreotide is administered to a nursing woman. Pediatric Use Safety and effectiveness in pediatric patients have not been established. Adverse Reactions The following adverse effects were observed in clinical trials at a frequency of less than 1% of 538 patients: dizziness, fever, flush, headache, hypotension, changes in liver enzymes, joint pain, nausea, sweating, and weakness. These adverse effects were transient. Also in clinical trials, there was one reported case of bradycardia and one case of decreased hematocrit and hemoglobin. Pentetreotide is derived from octreotide which is used as a therapeutic agent to control symptoms from certain tumors. The usual dose for indium In-111 pentetreotide is approximately 5 to 20 times less than for octreotide and is subtherapeutic. The following adverse reactions have been associated with octreotide in 3% to 10% of patients: nausea, injection site pain, diarrhea, abdominal pain/discomfort, loose stools, and vomiting. Hypertension and hyper- and hypoglycemia have also been reported with the use of octreotide. OctreoScan Dosage and Administration Before administration, a patient should be well hydrated. After administration, the patient must be encouraged to drink fluids liberally. Elimination of extra fluid intake will help reduce the radiation dose by flushing out unbound, labelled pentetreotide by glomerular filtration. It is also recommended that a mild laxative (e.g., bisacodyl or lactulose) be given to the patient starting the evening before the radioactive drug is administered, and continuing for 48 hours. Ample fluid uptake is necessary during this period as a support both to renal elimination and the bowel-cleansing process. In a patient with an insulinoma, bowel-cleansing should be undertaken only after consultation with an endocrinologist. The recommended intravenous dose for planar imaging is 111 MBq (3.0 mCi) of indium In-111 pentetreotide prepared from an OctreoScan kit. The recommended intravenous dose for SPECT imaging is 222 MBq (6.0 mCi) of indium In-111 pentetreotide. The dose should be confirmed by a suitably calibrated radioactivity ionization chamber immediately before administration. As with all intravenously administered products, OctreoScan should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Preparations containing particulate matter or discoloration should not be administered. They should be disposed of in a safe manner, in compliance with applicable regulations. Aseptic techniques and effective shielding should be employed in withdrawing doses for administration to patients. Waterproof gloves should be worn during the administration procedure. Do not administer OctreoScan in TPN solutions or through the same intravenous line. Radiation Dosimetry The estimated radiation doses 2 to the average adult (70 kg) from intravenous administration of 111 MBq (3 mCi) and 222 MBq (6 mCi) are presented in Table 4. These estimates were calculated by Oak Ridge Associated Universities using the data published by Krenning, et al. 3 Table 4. Estimated Absorbed Radiation Doses after Intravenous Administration of Indium In-111 Pentetreotide * to a 70 kg Patient * Assumes 4.8 hour voiding interval and International Commission on Radiological Protection (ICRP) 30 model for the gastrointestinal tract calculations. Estimated according to ICRP Publication 53. PLANAR SPECT Organ mGy/111 MBq rads/3 mCi mGy/222 MBq rads/6 mCi Kidneys 54.16 5.42 108.32 10.83 Liver 12.15 1.22 24.31 2.43 Spleen 73.86 7.39 147.73 14.77 Uterus 6.34 0.63 12.67 1.27 Ovaries 4.89 0.49 9.79 0.98 Testes 2.90 0.29 5.80 0.58 Red Marrow 3.46 0.35 6.91 0.69 Urinary Bladder Wall 30.24 3.02 60.48 6.05 GI Tract Stomach Wall 5.67 0.57 11.34 1.13 Small Intestine 4.78 0.48 9.56 0.96 Upper Large Intestine 5.80 0.58 11.59 1.16 Lower Large Intestine 7.73 0.77 15.46 1.55 Adrenals 7.55 0.76 15.11 1.51 Thyroid 7.43 0.74 14.86 1.49 mSv/111 MBq rem/3 mCi mSv/222 MBq rem/6 mCi Effective Dose Equivalent 13.03 1.30 26.06 2.61 2 Values listed include a correction for a maximum of 0.1% indium In-114m radiocontaminant at calibration. 3 E.P. Krenning, W.H. Bakker, P.P.M. Kooij, W.A.P. Breeman, H.Y. Oei, M. de Jong, J.C. Reubi, T.J. Visser, C. Bruns, D.J. Kwekkeboom, A.E.M. Reijs, P.M. van Hagen, J.W. Koper, and S.W.J. Lamberts, Somatostatin Receptor Scintigraphy with Indium-111-DTPA-D-Phe-1-Octreotide in Man: Metabolism, Dosimetry and Comparison with Iodine-123-Try-3-Octreotide, The Journal of Nuclear Medicine, Vol. 33, No. 5, May 1992, pp. 652-658. How is OctreoScan Supplied The OctreoScan kit (NDC 69945-050-40) is supplied with the following components: A 10-mL OctreoScan Reaction Vial which contains a lyophilized mixture of: (i) 10 μg pentetreotide [N-(diethylenetriamine-N,N,N',N -tetraacetic acid-N -acetyl)-D-phenylalanyl-L-hemicystyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-hemicystyl-L-threoninol cyclic (2 7) disulfide], (also known as octreotide DTPA), (ii) 2.0 mg gentisic acid [2, 5-dihydroxybenzoic acid], (iii) 4.9 mg trisodium citrate, anhydrous, (iv) 0.37 mg citric acid, anhydrous, and (v) 10.0 mg inositol. Before lyophilization, sodium hydroxide or hydrochloric acid may have been added for pH adjustment. The vial contents are sterile and nonpyrogenic. No bacteriostatic preservative is present. A 10-mL vial of Indium In-111 Chloride Sterile Solution, which contains 1.1 mL or 111 MBq/mL (3.0 mCi/mL) indium In-111 chloride in 0.02 N HCl at time of calibration. The vial also contains ferric chloride at a concentration of 3.5 μg/mL (ferric ion, 1.2 μg/mL). The vial contents are sterile and nonpyrogenic. No bacteriostatic preservative is present. In addition, the kit also contains the following items: (1) a 25 G x 5/8 needle (B-D, Monoject) used to transfer Indium In-111 Chloride Sterile Solution to the OctreoScan Reaction Vial, (2) pressure sensitive label, and (3) a package insert. Storage The OctreoScan kit should be stored refrigerated at 2 to 8 C (36 to 46 F). After reconstitution, store at or below 25 C (77 F). Indium In-111 pentetreotide must be used within six hours of preparation. INSTRUCTIONS FOR THE PREPARATION OF INDIUM In-111 PENTETREOTIDE Note: Read complete directions thoroughly before starting preparation. Procedure Precautions and Notes All transfers and penetrations of the vial stoppers by a needle must use aseptic technique. Wear waterproof gloves during the entire procedure and while withdrawing the patient-dose from the OctreoScan Reaction Vial. Transfer Indium In-111 Chloride Sterile Solution with an adequately shielded, sterile syringe using the transfer needle in the kit. Adequate shielding should be maintained at all times until the preparation is administered to the patient, disposed of in an approved manner, or allowed to decay to safe levels of radioactivity. A shielded, sterile syringe should be used for withdrawing and injecting the preparation. Do not inject into TPN administration bags or their intravenous lines. Procedure for the Preparation of Indium In-111 Pentetreotide Place the OctreoScan Reaction Vial in a lead dispensing shield (of minimum wall thickness 1/4 inch) fitted with a lid. Swab the rubber stopper of the reaction vial with an appropriate antiseptic and allow the vial to dry. Aseptically remove the contents of the Indium In-111 Chloride Sterile Solution vial using the needle provided and a shielded, sterile syringe. Inject the Indium In-111 Chloride Sterile Solution into the OctreoScan Reaction Vial. Gently swirl the OctreoScan Reaction Vial until the lyophilized pellet is completely dissolved. Incubate the indium In-111 pentetreotide solution at or below 25 C (77 F) for a minimum of 30 minutes. Note: A 30 minute incubation time is required. Shorter incubation periods may result in inadequate labeling. Using proper shielding, visually inspect the vial contents. The solution should be clear, colorless, and free of particulate matter. If not, the solution should not be used. It should be disposed in a safe and approved manner. Assay the indium In-111 pentetreotide solution using a suitably calibrated ionization chamber. Record the date, time, total activity, and patient identifier (e.g., patient name and number) on the radioassay information label and affix the label to the lead dispensing shield. The labeling yield of the reconstituted solution should be checked before administration to the patient, according to the instructions given below. If the radiochemical purity is less than 90%, the product should not be used. Store the reaction vial containing the indium In-111 pentetreotide solution at or below 25 C (77 F) until use. The indium In-111 pentetreotide must be used within six hours of preparation. If desired, the preparation can be diluted to a maximum volume of 3 mL with 0.9% Sodium Chloride Injection, U.S.P. immediately prior to injection. The sample should be drawn up into a shielded, sterile syringe and administered to the patient. RECOMMENDED METHOD FOR DETERMINATION OF LABELING YIELD OF INDIUM In-111 PENTETREOTIDE Required Materials Waters Sep-Pak C18 Cartridge, Part No. 51910 Methanol, 15 mL (Caution: toxic and flammable. Exercise due caution.) Distilled water, 20 mL Disposable syringes: 2 - 10-mL, no needle required 2 - 5-mL, no needle required 1 - 1-mL, with needle Three disposable culture tubes or vials, minimum 10-mL capacity Ion chamber Preparation of the Sep-Pak Cartridge Rinse the Sep-Pak cartridge with 10 mL methanol as follows: fill a 10-mL syringe with 10 mL methanol, attach the syringe to the longer end of the Sep-Pak cartridge, and push the methanol through the cartridge. Discard the eluate in a safe and approved manner. Similarly, rinse the cartridge with 10 mL water. Ensure that the cartridge is kept wet and that there is no air bubble present. If an air bubble is present, rinse the cartridge with additional 5 mL of water. Discard the eluate. Sample Analysis Using a 1-mL syringe with needle, withdraw 0.05 to 0.1 mL indium In-111 pentetreotide from the OctreoScan Reaction Vial. Apply the preparation to the Sep-Pak cartridge through the longer end of the cartridge. Make sure that the sample is migrating onto the column of the cartridge. Note: After this step, the cartridge and all solutions eluted from it will be radioactive. With a disposable 5-mL syringe, slowly (in dropwise manner) push 5 mL water through the longer end of the cartridge, collecting the eluate in a counting vial or tube. Label this eluate as Fraction 1. Similarly, elute the cartridge with 5 mL methanol. Be sure that this solution is pushed slowly through the longer end of the cartridge so that the elution occurs in a dropwise manner. Collect this fraction in a second culture tube or vial for counting. Label it as Fraction 2. Push two 5-mL portions of air through the longer end of the cartridge and collect the eluate with Fraction 2. Place the Sep-Pak cartridge in a third culture tube or vial for assay. Assay Assay the activity of Fraction 1 in a suitably calibrated ionization chamber. This fraction contains the hydrophilic impurities (e.g., unbound indium In-111). Assay the activity of Fraction 2. This fraction contains the indium In-111 pentetreotide. Assay the activity of the Sep-Pak cartridge. This component contains the remaining non-elutable impurities. Dispose of all of the materials used in the preparation, the sample analysis, and the assay in a safe and approved manner. Calculations Percent indium In-111 pentetreotide = (Fraction 2 Activity / Total Activity) x 100% Where Total Activity = Fraction 1 + Fraction 2 + activity remaining in Sep-Pak Note: If this value is less than 90%, do not use the preparation. Discard it in a safe and approved manner. Percent hydrophilic impurities = (Fraction 1 Activity / Total Activity) x 100% Percent non-elutable impurities = (Activity remaining in Sep-Pak cartridge / Total Activity) x 100% This radiopharmaceutical is licensed by the Illinois Department of Nuclear Safety for distribution to persons licensed pursuant to 330.260(a) for the radioactive material specified in 32 IL. Adm. Code 335.4010 or under equivalent licenses of the U.S. Nuclear Regulatory Commission, an Agreement State, or a Licensing State. Mallinckrodt, the M brand mark, the Mallinckrodt Pharmaceuticals logo and, except as otherwise stated, other brands are trademarks of a Mallinckrodt company. 2015 Mallinckrodt. Sep-Pak is a trademark of Waters Technologies Corporation. Manufactured by: Mallinckrodt Nuclear Medicine LLC Maryland Heights, MO 63043 Made in USA A050I0 Rev 10/2015 Mallinckrodt Pharmaceuticals PRINCIPAL DISPLAY PANEL - A050V0 OctreoScan Reaction Vial Sterile, non-pyrogenic. For intravenous use after drug preparation. See package insert for directions for use. Vial contains: 10 µg Pentetreotide 2.0 mg Gentisic Acid 4.9 mg Sodium Citrate, Anhydrous 0.37 mg Citric Acid, Anhydrous 10.0 mg Inositol Prior to lyophilization, sodium hydroxide or hydrochloric acid may be added for pH adjustment. The pH of the reconstituted drug is between 3.8 and 4.3. Contents are sealed under nitrogen. Manufactured by: Mallinckrodt Nuclear Medicine LLC Maryland Heights, MO 63043 Made in USA Store refrigerated at 2 to 8 C (36 -46 F). Protect from light. Use only with Indium In 111 Chloride Sterile Solution. Rx only Mallinckrodt Pharmaceuticals A050V0 R10/2015 PRINCIPAL DISPLAY PANEL - A117C0 Indium In 111 Chloride Sterile Solution Sterile, non-pyrogenic solution, contains no bacteriostatic preservation. NOT FOR DIRECT ADMINISTRATION For intravenous use after drug preparation. See package insert for directions for use. Vial contains 1.1 mL of 111 MBq/mL (3.0mCi/mL) aqueous indium In 111 chloride and 3.5 µg/mL ferric chloride (1.2 µg/mL ferric ion) in 0.02N hydrochloric acid. Store at or below 25 C (77 F). Rx only WARNING: Radioactive drugs must be handled only by qualified personnel in conformity with regulations of the U.S. Nuclear Regulatory Commission or state regulatory agencies where applicable. Bottle containing drug should be kept in this container or within a heavier shield. Manufactured by: Mallinckrodt Nuclear Medicine LLC Maryland Heights, MO 63043 Made in USA Mallinckrodt Pharmaceuticals CAUTION RADIOACTIVE MATERIAL A117C0 R10/2015 OctreoScan indium in -111 pentetreotide kit Product Information Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:69945-050 Packaging # Item Code Package Description 1 NDC:69945-050-40 1 KIT in 1 BOX Quantity of Parts Part # Package Quantity Total Product Quantity Part 1 1 VIAL, GLASS 1 mL Part 2 1 VIAL, GLASS 1 mL Part 1 of 2 OctreoScan REACTION VIAL pentetreotide injection, powder, lyophilized, for solution Product Information Route of Administration INTRAVENOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength INDIUM IN-111 PENTETREOTIDE (INDIUM IN-111 PENTETREOTIDE) PENTETREOTIDE 10 ug in 1 mL Inactive Ingredients Ingredient Name Strength GENTISIC ACID ANHYDROUS TRISODIUM CITRATE ANHYDROUS CITRIC ACID INOSITOL SODIUM HYDROXIDE HYDROCHLORIC ACID Packaging # Item Code Package Description 1 1 mL in 1 VIAL, GLASS Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020314 05/01/2007 Part 2 of 2 INDIUM IN-111 CHLORIDE indium in-111 chloride injection, solution Product Information Route of Administration INTRAVENOUS DEA Schedule Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength INDIUM CHLORIDE IN-111 (INDIUM CATION IN-111) INDIUM CATION IN-111 3 mCi in 1 mL Inactive Ingredients Ingredient Name Strength HYDROCHLORIC ACID FERRIC CHLORIDE Packaging # Item Code Package Description 1 1 mL in 1 VIAL, GLASS Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020314 05/01/2007 Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date NDA NDA020314 10/14/2015 Labeler - MALLINCKRODT NUCLEAR MEDICINE LLC (079875617) Revised: 10/2015 MALLINCKRODT NUCLEAR MEDICINE LLC Next Interactions Print this page Add to My Med List More about Octreoscan (indium pentetreotide in-111) Side Effects Dosage Information Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: diagnostic radiopharmaceuticals Consumer resources OctreoScan} FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Diagnostic radiopharmaceuticals Related Drugs diagnostic radiopharmaceuticals Xofigo , sodium fluoride f-18 , indium oxyquinoline in-111 , fludeoxyglucose f18 , Vizamyl Octreoscan Rating No Reviews - Be the first! 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is think about [1%):] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Pfizer Inc. Drug Class Miscellaneous topical agents Related Drugs miscellaneous topical agents epinephrine topical , vitamin e topical , tacrolimus topical , minoxidil topical , bimatoprost topical , capsaicin topical Atopic Dermatitis prednisone , fluticasone topical , triamcinolone topical , hydrocortisone topical , dexamethasone , methylprednisolone , clobetasol topical , betamethasone topical , doxepin topical , mometasone topical , Kenalog , fluocinonide topical , azathioprine , Medrol Dosepak , desonide topical , tacrolimus topical , Decadron , Elocon , Imuran , desoximetasone topical , Deltasone , Temovate , Diprolene , More... Eucrisa Rating 39 User Reviews 7.1 /10 39 User Reviews 7.1 Rate it! that supply


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looking ahead to Carbamide Peroxide Liquid Generic Name: Carbamide Peroxide Liquid (KAR ba mide per OKS ide) Brand Name: Cankaid, Gly-Oxide Overview Side Effects Pregnancy Breastfeeding Reviews More Uses of Carbamide Peroxide Liquid: It is used to treat canker sores. It is used to treat mouth irritation. Slideshow Aging Issues: 12 of the Most Common Health Concerns Affecting Seniors What do I need to tell my doctor BEFORE I take Carbamide Peroxide Liquid? If you have an allergy to carbamide peroxide or any other part of carbamide peroxide liquid. If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs. This medicine may interact with other drugs or health problems. Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take this medicine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. What are some things I need to know or do while I take Carbamide Peroxide Liquid? Tell all of your health care providers that you take carbamide peroxide liquid. This includes your doctors, nurses, pharmacists, and dentists. Do not use longer than you have been told by the doctor. This medicine may cause harm if a large amount is swallowed. If a large amount of this medicine is swallowed, call a doctor or poison control center right away. Talk with the doctor before giving carbamide peroxide liquid to a child younger than 2 years of age. Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant. Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby. How is this medicine (Carbamide Peroxide Liquid) best taken? Use carbamide peroxide liquid as ordered by your doctor. Read all information given to you. Follow all instructions closely. Follow how to use as you have been told by the doctor or read the package insert. Use this medicine after meals and at bedtime or as you have been told by your doctor. Do not swallow carbamide peroxide liquid. What do I do if I miss a dose? If you use this medicine on a regular basis, put on a missed dose as soon as you think about it. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. Do not use 2 doses at the same time or extra doses. Many times carbamide peroxide liquid is used on an as needed basis. Do not use more often than told by the doctor. What are some side effects that I need to call my doctor about right away? WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect: Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat. Very bad irritation where this medicine is used. What are some other side effects of Carbamide Peroxide Liquid? All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away: Irritation where carbamide peroxide liquid is used. These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch. Side Effects (complete list) If OVERDOSE is suspected: If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. How do I store and/or throw out Carbamide Peroxide Liquid? Store at room temperature. Store in the carton to protect from light. Protect from heat. Put the cap back on after you are done using your dose. Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets. Check with your pharmacist about how to throw out unused drugs. Consumer Information Use and Disclaimer If your symptoms or health problems do not get better or if they become worse, call your doctor. Do not share your drugs with others and do not take anyone else's drugs. Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor. Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins. Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider. If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened. This information should not be used to decide whether or not to take carbamide peroxide liquid or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to carbamide peroxide liquid. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine. Review Date: December 6, 2017 Next Side Effects Print this page Add to My Med List More about carbamide peroxide topical Side Effects During Pregnancy or Breastfeeding 0 Reviews Add your own review/rating Drug class: mouth and throat products Consumer resources Other brands: Cankaid , Gly-Oxide Related treatment guides Periodontitis Drug Status OTC Availability Over the counter N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Carbamide peroxide topical Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Drug Class Mouth and throat products Related Drugs Periodontitis doxycycline , minocycline , Peridex , chlorhexidine topical , Vibramycin , Monodox , carbamide peroxide topical , Arestin , Doryx , Periogard , Vibra-Tabs , Doryx MPC , Paroex , Periostat , Morgidox , More... reputable


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political opinions Alka-Seltzer Plus Night-Time Cold Generic Name: acetaminophen, dextromethorphan, doxylamine, and phenylephrine (ah EET a MIN oh fen, DEX troe me THOR fan, dox IL a meen, and FEN il EFF rin) Brand Name: Alka-Seltzer Plus Night-Time Cold, Delsym Adult Night Time Multi-Symptom, Mucinex Fast-Max Night Time Cold & Flu, NyQuil Severe Cold & Flu, Tylenol Cold Multi-Symptom Nighttime, Tylenol Warming Cold Multi-Symptom Nighttime Overview Side Effects Dosage Interactions Pregnancy More User Reviews Support Group Q & A What is Alka-Seltzer Plus Night-Time Cold (acetaminophen, dextromethorphan, doxylamine, and phenylephrine)? Acetaminophen is a pain reliever and fever reducer. Dextromethorphan is a cough suppressant. It affects the cough reflex in the brain that triggers coughing. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose. Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose). Acetaminophen, dextromethorphan, doxylamine, and phenylephrine is a combination medicine used to treat headache, fever, body aches, cough, runny nose, sneezing, itching, and watery eyes caused by allergies, the common cold, or the flu. This medicine will not treat a cough that is caused by smoking, asthma, or emphysema. Acetaminophen, dextromethorphan, doxylamine, and phenylephrine may also be used for purposes not listed in this medication guide. Slideshow Seasoned Pro: Be Mindful of These Winter Health Hazards What is the most important information I should know about this medicine? Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes). In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. What should I discuss with my healthcare provider before taking this medicine? You should not use this medicine if you are allergic to acetaminophen, dextromethorphan, doxylamine, or phenylephrine. Do not use this medicine if you have taken an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially: liver disease, cirrhosis, a history of alcoholism, or if you drink more than 3 alcoholic beverages per day; heart disease, coronary artery disease; blockage in your digestive tract (stomach or intestines); bladder obstruction or other urination problems; glaucoma; pheochromocytoma (tumor of the adrenal gland); overactive thyroid; or if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K). It is not known whether this medication will harm an unborn baby. Do not use this medicine without a doctor's advice if you are pregnant. Acetaminophen, dextromethorphan, doxylamine, and phenylephrine may pass into breast milk and may harm a nursing baby. Antihistamines and decongestants may also slow breast milk production. Do not use this medicine without a doctor's advice if you are breast-feeding a baby. How should I take this medicine? Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up. Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children. Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one. Drop the effervescent tablets into a glass of water (at least 4 ounces, or one-half cup). Stir this mixture and drink all of it right away. Do not take for longer than 7 days in a row. Stop taking the medicine and call your doctor if you still have a fever after 3 days of use, you still have pain after 7 days (or 5 days if treating a child), if your symptoms get worse, or if you have a skin rash, ongoing headache, or any redness or swelling. If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days. Store at room temperature away from moisture and heat. Do not allow liquid medicine to freeze. What happens if I miss a dose? Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of acetaminophen can be fatal. The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes. What should I avoid while taking this medicine? Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP. Avoid drinking alcohol. It may increase your risk of liver damage while you are taking acetaminophen, and can increase certain side effects of doxylamine. This medicine may cause blurred vision or impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert and able to see clearly. This medicine side effects Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. In rare cases, acetaminophen may cause a severe skin reaction that can be fatal. This could occur even if you have taken acetaminophen in the past and had no reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling. If you have this type of reaction, you should never again take any medicine that contains acetaminophen. Stop using this medicine and call your doctor at once if you have: pounding heartbeats or fluttering in your chest; a light-headed feeling, like you might pass out; anxiety, hallucinations, feeling of fear; little or no urinating; pale skin, unusual weakness; nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of your skin or eyes); or dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, uneven heartbeats, seizure). Common side effects may include: drowsiness; constipation, diarrhea, upset stomach, vomiting; or feeling restless or excited. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect this medicine? Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide. Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking acetaminophen, dextromethorphan, doxylamine, and phenylephrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures. Next Side Effects Print this page Add to My Med List More about acetaminophen/dextromethorphan/doxylamine/phenylephrine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group 0 Reviews Add your own review/rating Drug class: upper respiratory combinations Consumer resources Acetaminophen, dextromethorphan, doxylamine, and phenylephrine Acetaminophen/Doxylamine/Dextromethorphan/Phenylephrine Liquid Other brands: Vicks NyQuil Severe Cold & Flu , Delsym Night Time Multi-Symptom , Tylenol Cold Multi-Symptom Nighttime Liquid Related treatment guides Cold Symptoms Cough Cough and Nasal Congestion Nasal Congestion Pain/Fever Rhinorrhea Where can I get more information? Your pharmacist can provide more information about acetaminophen, dextromethorphan, doxylamine, and phenylephrine. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 1.03. Last reviewed: September 21, 2015 Date modified: December 03, 2017} Drug Status OTC Availability Over the counter N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug WADA Class Anti-Doping Classification Drug Class Upper respiratory combinations Related Drugs Cold Symptoms diphenhydramine , Benadryl , Promethazine DM , chlorpheniramine , echinacea , Tussionex Pennkinetic , More... Rhinorrhea ipratropium nasal , doxylamine , Coricidin HBP Cold & Flu , triprolidine , Atrovent Nasal , Equate Sleep Aid , More... Cough benzonatate , acetaminophen / hydrocodone , diphenhydramine , Benadryl , Mucinex , guaifenesin , More... Cough and Nasal Congestion Promethazine VC with Codeine , Bromfed DM , Mucinex D , Vanacof , More... 2 more conditions... Acetaminophen / dextromethorphan / doxylamine / phenylephrine Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the acetaminophen / dextromethorphan / doxylamine / phenylephrine support group to connect with others who have similar interests.} } to combustible


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