workplace [2:<12 years of age. a c Supervise children> <12 years of age during use of oral solution. b d Interactions for Carbamide Peroxide No formal drug interaction studies to date. Stability Storage Oral Topical Solution Tight, light-resistant container; protect from heat and direct sunlight. a b d Otic Solution Tight, light-resistant container; protect from heat and direct sunlight. a c Actions Effervescence from the release of oxygen mechanically removes debris from inaccessible regions. a Exposure to moisture (e.g., on the skin, in the mouth) slowly releases hydrogen peroxide and oxygen; release of oxygen results in weak antibacterial properties. a Probably inhibits odor-causing bacteria, resulting in deodorant activity. a For otic use, penetrates and softens cerumen while the release of oxygen provides a mild mechanical action resulting in loosening of the softened cerumen. a Advice to Patients Importance of discontinuing use of oral solution and contacting a clinician if swelling, rash, or fever develops; if irritation, pain, or redness persists; or if symptoms worsen or do not improve in 7 days. a b d Advise patients not to use oral preparations for> 7 days, unless otherwise directed by a clinician. a b d Importance of contacting a clinician before using otic solution if patient has ear drainage or discharge, ear pain or redness, rash, irritation, tenderness, or dizziness. a c Advise patients not to use otic solution if patient has an ear injury or perforated eardrum, or after ear surgery, unless directed by a clinician. a c Inform patients not to use otic solution for >4 consecutive days, unless otherwise instructed by a clinician. a c Importance of contacting clinician if excessive ear wax remains after using otic solution for 4 consecutive days. c Advise patients not to use cotton swabs, toothpicks, hairpins, or other instruments to remove wax from ear canal. c Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs and dietary or herbal supplements, as well as concomitant illnesses. b c d Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. Importance of informing patients of other important precautionary information. (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. * available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name Carbamide Peroxide Routes Dosage Forms Strengths Brand Names Manufacturer Otic Solution 6.5%* Auro Ear Wax Removal Aid (with anhydrous glycerin and propylene glycol) Del Debrox Drops (with glycerin and propylene glycol) GlaxoSmithKline E.R.O. Ear Drops (with anhydrous glycerin) Scherer Mollifene Ear Wax Removing Formula (with anhydrous glycerin and propylene glycol) Pfeiffer Murine Ear Drops (with alcohol 6.3% and anhydrous glycerin) Prestige Murine Ear Wax Removal System (with alcohol 6.3% and anhydrous glycerin; available with otic syringe) Prestige Oral (Topical Use Only) Solution 10%* Cankaid Mouth Treatment (with anhydrous glycerin) Dickinson Gly-Oxide (with glycerin and propylene glycol) GlaxoSmithKline 15% Orajel Perioseptic (with anhydrous glycerin, methylparaben, and propylene glycol) Del AHFS DI Essentials. Copyright 2017, Selected Revisions February 1, 2008. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. References a. AHFS drug information 2007. McEvoy GK, ed. Carbamide peroxide. Bethesda, MD: American Society of Health-System Pharmacists; 2007:2807. b. GlaxoSmithKline Consumer Healthcare, LP. Gly-Oxide liquid (carbamide peroxide 10%) antiseptic oral cleanser patient information. From website. Accessed 2007 Dec 12. c. Medteach Product, Inc. Murine for ear wax removal (carbamide peroxide 6.5%) drops patient information. From website. Accessed 2007 Dec 12. d. Del Pharmaceuticals. Orajel perioseptic spot treatment (carbamide peroxide 15%) oral cleanser patient information. From website. Accessed 2007 Dec 12. e. GlaxoSmithKline. Gly-Oxide information. From website. Accessed 2007 Dec 12. Next Pregnancy Warnings Print this page Add to My Med List More about carbamide peroxide otic Side Effects During Pregnancy or Breastfeeding Dosage Information Support Group Pricing & Coupons 5 Reviews Add your own review/rating Drug class: cerumenolytics Consumer resources Carbamide peroxide otic Carbamide Peroxide Otic Solution Professional resources Other brands: Auro Related treatment guides Ear Wax Impaction ] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx OTC Availability Rx and/or OTC N Pregnancy Category Not classified N/A CSA Schedule Not a controlled drug Manufacturers Sandoz Inc. Major Pharmaceuticals Drug Class Cerumenolytics Related Drugs Ear Wax Impaction Debrox , Murine Earwax Removal , Auraphene-B , Auro , antipyrine / benzocaine otic , Mollifene , More... Carbamide peroxide otic Rating 5 User Reviews 3.2 /10 5 User Reviews 3.2 Rate it! this faculty
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