facts Tafinlar (Oral) Generic Name: dabrafenib (Oral route) da-BRAF-e-nib Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Compare Alternatives Pricing & Coupons Commonly used brand name(s) In the U.S. Tafinlar Available Dosage Forms: Capsule Pharmacologic Class: BRAF Inhibitor Slideshow Looking Ahead: New Drug Approvals for 2017 Uses For Tafinlar Dabrafenib is used alone or in combination with trametinib to treat melanoma (skin cancer) that has spread or that cannot be removed by surgery. It is only used if the melanoma cells have the BRAF V600E or V600K mutations. It also treats non-small cell lung cancer (NSCLC) that has spread if the NSCLC cells have the BRAF V600E mutation in combination with trametinib. Your doctor will use a special test to look for these mutations. Dabrafenib belongs to the group of medicines, called antineoplastics (cancer medicines). This medicine is available only with your doctor's prescription. Before Using Tafinlar In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of dabrafenib in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of dabrafenib in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Cisapride Dronedarone Fluconazole Ketoconazole Mesoridazine Pimozide Piperaquine Posaconazole Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Acetate Alfuzosin Amiodarone Amitriptyline Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Azithromycin Bedaquiline Boceprevir Buserelin Ceritinib Chloroquine Chlorpromazine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Cobicistat Conivaptan Crizotinib Cyclobenzaprine Dasatinib Degarelix Delamanid Desipramine Deslorelin Desogestrel Deutetrabenazine Dienogest Disopyramide Dofetilide Dolasetron Dolutegravir Domperidone Donepezil Doxepin Droperidol Drospirenone Ebastine Efavirenz Eribulin Erythromycin Escitalopram Estradiol Ethinyl Estradiol Ethynodiol Etonogestrel Famotidine Felbamate Fingolimod Flecainide Fluoxetine Formoterol Foscarnet Fosphenytoin Galantamine Gatifloxacin Gemfibrozil Gemifloxacin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Idelalisib Iloperidone Imipramine Indinavir Itraconazole Ivabradine Lapatinib Leuprolide Levofloxacin Levonorgestrel Lopinavir Lumefantrine Medroxyprogesterone Mefloquine Mestranol Methadone Methotrimeprazine Metronidazole Mifepristone Mizolastine Moricizine Moxifloxacin Nafarelin Nefazodone Nelfinavir Netupitant Nilotinib Norelgestromin Norethindrone Norfloxacin Norgestimate Norgestrel Octreotide Ofloxacin Olanzapine Ondansetron Paliperidone Panobinostat Papaverine Paroxetine Pasireotide Pazopanib Pentamidine Perphenazine Pimavanserin Pipamperone Pitolisant Probucol Procainamide Prochlorperazine Progesterone Promethazine Propafenone Protriptyline Quetiapine Quinidine Quinine Ranolazine Ribociclib Rilpivirine Risperidone Ritonavir Sertindole Sevoflurane Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Sulpiride Sunitinib Tacrolimus Tamoxifen Telaprevir Telavancin Telithromycin Tetrabenazine Tizanidine Tolterodine Toremifene Trazodone Trimipramine Triptorelin Vandetanib Vardenafil Vemurafenib Venlafaxine Vilanterol Vinflunine Voriconazole Vorinostat Warfarin Zuclopenthixol Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Opicapone Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Dehydration or Hypotension (low blood pressure) or Kidney failure Use with caution. May cause side effects to become worse. Diabetes or Hyperglycemia (high blood sugar) or Iritis (eye problem) or Uveitis (eye problem) Use with caution. May make these conditions worse. Glucose-6-phosphate dehydrogenase (G6PD) deficiency (a hereditary metabolic disorder affecting red blood cells) May cause hemolytic anemia (blood disorder) in patients with this condition. Liver disease, moderate to severe Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of Tafinlar Medicines used to treat cancer are very strong and can have many side effects. Before using this medicine, make sure you understand all the risks and benefits. It is important for you to work closely with your doctor during your treatment. Take this medicine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. This medicine usually comes with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. Take this medicine at least 1 hour before or 2 hours after a meal. Swallow the capsule whole. Do not open, crush, or break it. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For melanoma (skin cancer) and non-small cell lung cancer: Adults 150 milligrams (mg) two times a day, taken 12 hours apart. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose and it is less than 6 hours until your next regular dose, skip the missed dose and go back to your regular dosing schedule. If you miss a dose and it is more than 6 hours until your next dose, take it as soon as possible and go back to your regular dosing schedule. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Tafinlar It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant can harm your unborn baby. Birth control pills may not work as well to prevent pregnancy when used with this medicine. Use another form of birth control (eg, condoms, diaphragms, contraceptive foams or jellies) along with your pills. Use an effective form of birth control during treatment with this medicine and for at least 2 weeks after the last dose. If you think you have become pregnant while using the medicine, tell your doctor right away. This medicine may cause fertility (ability to have children) problems in men and women. Talk to your doctor before using this medicine if you plan to have children. This medicine may increase your risk of having cutaneous squamous cell carcinoma (cuSCC) or other skin cancers. Check with your doctor right away if you develop any skin changes, including a new wart, change in size or color of a mole, or a skin sore or reddish bump that does not heal. Your doctor may want your skin be checked for new skin lesions before treatment, during treatment, and for up to 6 months after the last dose. This medicine may cause hemorrhage (severe bleeding) in the stomach and bowel areas or in the brain. Call your doctor right away if you have any unusual or unexplained bleeding. Dabrafenib may cause heart problems. Check with your doctor right away if you have chest discomfort or pain, dizziness or faintness, fast, irregular, or pounding heartbeat, swelling of the feet or lower legs, trouble with breathing, or unusual tiredness or weakness. Check with your doctor right away if eye pain or a change in vision occurs during treatment. This could be a sign of a serious eye problem. Your doctor may want your eyes be checked by an ophthalmologist (eye doctor). This medicine may cause fever, including severe fever that sometimes happens with low blood pressure, chills, dehydration, or kidney problems. Check with your doctor right away if you have a fever while using this medicine. This medicine may affect your blood sugar levels. Check with your doctor right away if you have increased thirst or increased urination. If you notice a change in the results of your urine or blood sugar tests, or if you have any questions, check with your doctor. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Tafinlar Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bleeding gums bloody or cloudy urine blurred vision coughing up blood difficulty in breathing or swallowing dizziness dry mouth fever flushed, dry skin fruit-like breath odor greatly decreased frequency of urination or amount of urine headache increased hunger increased thirst increased urination lump or growth on the skin nausea nosebleed prolonged bleeding from cuts red or dark brown urine red or black, tarry stools redness, swelling, or pain of the skin scaling of the skin on the hands and feet skin blisters skin rash stomach pain sweating swelling of the feet or lower legs tingling of the hands and feet ulceration of the skin unable to move unexplained weight loss unusual tiredness or weakness vomiting Less common Blurred vision or other change in vision change in color vision difficulty seeing at night eye pain increased sensitivity of the eyes to sunlight redness of the eye tearing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Back pain constipation cough difficulty having a bowel movement difficulty with moving fast heartbeat hair loss or thinning of the hair headache indigestion loss of appetite muscle aches muscle pain or stiffness pain in the joints pains in the stomach, side, or abdomen, possibly radiating to the back sore throat stuffy or runny nose yellow eyes or skin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about Tafinlar (dabrafenib) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Drug class: multikinase inhibitors Consumer resources Tafinlar Professional resources Tafinlar (AHFS Monograph) Tafinlar (FDA) Related treatment guides Melanoma, Metastatic} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug 4 years Approval History FDA approved 2013 Manufacturer Novartis Pharmaceuticals Corporation Drug Class Multikinase inhibitors Related Drugs Melanoma, Metastatic Opdivo , Keytruda , nivolumab , pembrolizumab , Yervoy , ipilimumab , Mekinist , trametinib , dabrafenib , Proleukin , dacarbazine , Zelboraf , vemurafenib , cobimetinib , PegIntron , Sylatron , Cotellic , aldesleukin , Imlygic , peginterferon alfa-2b , More... Tafinlar Rating 1 User Review 9.0 /10 1 User Review 9.0 Rate it! Tafinlar Images Tafinlar 50 mg (GS TEW 50 mg) View larger images Related Questions & Answers Is anyone on Tafinlar and Xarleto, but now Dr wants to switch them to Lovenox? Read more questions} } vacationers
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