continually [100:<24 hours) Warnings/Precautions Concerns related to adverse effects: Pulmonary effects: Acute pneumonitis and acute respiratory distress syndrome (ARDS), including fatalities have been reported with intrapleural sterile talc; most cases of ARDS occurred with talc doses of 10 g via a chest tube. Systemic sterile talc exposure may be affected by the visceral pleura integrity and may be increased if sterile talc is administered following mechanical pleura abrasion or biopsy. Talc particle size distribution may correlate with the risk of toxicities. Products are for intrapleural use only; IV administration (not recommended) is associated with pulmonary hypertension and lung parenchymal disease. Silicosis or asbestosis-like conditions (chronic bronchitis, bronchogenic carcinoma, and pleural plaques) are associated with inhaled talc. Dosage form specific issues: Sclerosol: Contents under pressure and should be kept away from any heat source or open flame; do not puncture canister. Steritalc: Lead exposure: Steritalc contains lead (as an impurity). The primary target organ for lead toxicity is the central nervous system, although lead exposure may also have an impact on blood pressure, renal function, anemia, and male fertility. The threshold for minimum risk exposure levels has not been fully established in humans. Pediatric patients are more sensitive to lead toxicity (than adults); a safe blood level has not been established in children. Cognitive and neurobehavioral deficits are observed in children exposed to lead. Lead exposure during pregnancy may also cause adverse events. Other warnings/precautions: Appropriate use: Should not be used for potentially curable malignancies where systemic therapy would be more appropriate (sterile talc does not have antineoplastic activity). Clinicians should evaluate need for future diagnostic or surgical procedures before use; sclerosis of pleural space may preclude or complicate subsequent ipsilateral surgery and diagnostic procedures (eg, pneumonectomy for transplantation). Pregnancy Risk Factor B (manufacturer specific) Pregnancy Considerations Steritalc is contraindicated in pregnancy; Steritalc contains lead (as an impurity); lead exposure during pregnancy may result in miscarriage, premature birth, low birth weights, and slow/impaired mental childhood development. Women of reproductive potential should use effective contraception during Steritalc treatment and for 5 months following the final Steritalc dose. Steritalc may impair fertility in males (decreased sperm production). Adverse events were not observed in animal reproduction studies following oral administration with other sterile talc formulations; use during pregnancy only if clearly needed. Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Patient may experience application site irritation. Have patient report immediately to prescriber signs of a severe pulmonary disorder (lung or breathing problems like difficulty breathing, shortness of breath, or a cough that is new or worse) or abnormal heartbeat (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Next User Reviews Print this page Add to My Med List More about sterile talc Side Effects Support Group Pricing & Coupons 0 Reviews Add your own review/rating Drug class: miscellaneous uncategorized agents Consumer resources Sterile Talc Talc (Sterile) Talc Intrapleural (Advanced Reading) Professional resources Talc (AHFS Monograph) Sterile Talc (FDA) Other brands: Sclerosol Related treatment guides Pleural Effusion> ] Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Sterile talc Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Drug Class Miscellaneous uncategorized agents Related Drugs miscellaneous uncategorized agents Accutane , isotretinoin , anagrelide , Esbriet , Claravis Pleural Effusion doxycycline , Vibramycin , Monodox , Doryx , Vibra-Tabs , Doryx MPC , Morgidox , Steritalc , sterile talc , More... at risk of
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