positive [40:40 kg: 16 mg/kg/dose as a single dose Dosing: Geriatric Refer to adult dosing Dosing: Pediatric Anthrax, inhalational: Infants, Children and Adolescents: IV: Note: Premedicate with diphenhydramine prior to infusion. 15 kg: 32 mg/kg/dose as a single dose >15 kg to 40 kg: 24 mg/kg/dose as a single dose >40 kg: 16 mg/kg/dose as a single dose Dosing: Renal Impairment There are no dosage adjustments provided in the manufacturer's labeling Dosing: Hepatic Impairment There are no dosage adjustments provided in the manufacturer's labeling Reconstitution IV bag for infusion: Volume of prepared solution for infusion is based upon patient weight. Select an appropriate size bag of NS (outlined below) and withdraw a volume of solution from the bag equal to the calculated volume of obiltoxaximab needed for the patient dose. Discard the solution that was withdrawn from the bag. Inject obiltoxaximab dose into the bag and gently invert to mix; do not shake. IV syringe for infusion: Volume of prepared solution for infusion is based upon patient weight. Select an appropriate size syringe for the total volume of infusion (outlined below). Withdraw obiltoxaximab dose into syringe, then withdraw an appropriate volume of NS into syringe to equal the total infusion volume needed. Gently mix the solution; do not shake. Total obiltoxaximab infusion volume by body weight: 31 kg or adult: 250 mL 11 to 30 kg: 100 mL 5 to 10 kg: 50 mL 3.1 to 4.9 kg: 25 mL 2.1 to 3 kg: 20 mL 1.1 to 2 kg: 15 mL 1 kg or less: 7 mL Administration Premedication with diphenhydramine is recommended. Administer prepared solution (IV infusion bag or syringe) using a 0.22 micron inline filter over 1 hour and 30 minutes. Flush the line with NS at the end of the infusion. Storage Store in refrigerator at 2 C to 8 C (36 F to 46 F); protect from light. Do not freeze or shake. Prepared solution in NS in an IV bag for infusion is stable at room temperature or refrigerated for up to 4 hours after admixture. Prepared solution in a syringe for infusion should be administered immediately; do not store. Drug Interactions There are no known significant interactions. Adverse Reactions >10%: Central nervous system: Headache (8% to 16%) 1% to 10%: Cardiovascular: Chest discomfort (] Recently Approved Lonhala Magnair Lonhala Magnair (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator for... Ozempic Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) analog administered once-weekly for the... Ogivri Ogivri (trastuzumab-dkst) is a HER2 / neu receptor antagonist biosimilar to Herceptin indicated for... Sublocade Sublocade (buprenorphine) is a once-monthly injectable partial opioid agonist formulation for the... More remorseful about
can not seem to Obiltoxaximab optimum
EmoticonEmoticon