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forty six Safyral (Oral) Generic Name: drospirenone, ethinyl estradiol, and levomefolate (Oral route) droe-SPYE-re-none, ETH-i-nil es-tra-DYE-ol, lee-voe-me-FOE-late KAL-see-um, lee-voe-me-FOE-late KAL-see-um Oral route(Tablet) Cigarette smoking increases the risk of serious cardiovascular events from combination oral contraceptives (COC) use. This risk increases with age, particularly in women over 35 years of age, and with the number of cigarettes smoked. For this reason, COCs should not be used by women who are over 35 years of age and smoke . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Beyaz Safyral Available Dosage Forms: Tablet Slideshow Birth Control: Your Contraceptive Questions Answered Uses For Safyral Drospirenone, ethinyl estradiol, and levomefolate combination is used to prevent pregnancy. It is a birth control pill that contains two types of hormones, ethinyl estradiol and drospirenone, and when taken properly, prevents pregnancy. It works by stopping a woman's egg from fully developing each month. The egg can no longer accept a sperm and fertilization is prevented. This medicine is also used to treat premenstrual dysphoric disorder (PMDD) and acne in women at least 14 years of age. PMDD is a severe form of premenstrual syndrome (PMS). Patients with PMDD may have severe emotional and physical symptoms a few days before their menstrual flow starts. This medicine also contains levomefolate, which is a form of folic acid. Folic acid is one of the B vitamins that pregnant women need to help prevent neural tube defects in a baby. No contraceptive method is 100 percent effective. Birth control methods such as having surgery to become sterile or not having sex are more effective than birth control pills. Discuss your options for birth control with your doctor. This medicine does not prevent AIDS or other sexually transmitted diseases. It will not help as emergency contraception, such as after unprotected sexual contact. This medicine is available only with your doctor's prescription. Before Using Safyral In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies on the relationship of age to the effects of drospirenone, ethinyl estradiol, and levomefolate combination have not been performed in the pediatric population. However, pediatric-specific problems that would limit the usefulness of this medication in teenagers are not expected. This medicine may be used for birth control in teenage females but should not be used before the start of menstruation. Geriatric Appropriate studies on the relationship of age to the effects of drospirenone, ethinyl estradiol, and levomefolate combination have not been performed in the geriatric population. This medicine should not be used in elderly women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Boceprevir Dasabuvir Ombitasvir Paritaprevir Ritonavir Tranexamic Acid Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Anagrelide Aprepitant Boceprevir Bosentan Bupropion Carbamazepine Ceritinib Dabrafenib Darunavir Dexamethasone Donepezil Eliglustat Enzalutamide Fosphenytoin Griseofulvin Idelalisib Isotretinoin Lesinurad Lixisenatide Lumacaftor Mitotane Modafinil Oxcarbazepine Paclitaxel Paclitaxel Protein-Bound Phenytoin Piperaquine Pitolisant Prednisone Rifabutin Rifampin St John's Wort Sugammadex Theophylline Tizanidine Topiramate Ulipristal Valproic Acid Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alprazolam Amprenavir Atazanavir Bacampicillin Betamethasone Bexarotene Clarithromycin Colesevelam Cyclosporine Delavirdine Efavirenz Eslicarbazepine Acetate Etoricoxib Fosamprenavir Fosaprepitant Ginseng Lamotrigine Licorice Mycophenolate Mofetil Mycophenolic Acid Nelfinavir Parecoxib Prednisolone Rifapentine Ritonavir Roflumilast Rosuvastatin Rufinamide Selegiline Telaprevir Tipranavir Troglitazone Troleandomycin Valdecoxib Voriconazole Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco. Caffeine Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Abnormal or unusual vaginal bleeding or Adrenal disease or Blood disorders (e.g., hypercoagulopathy) or Breast cancer, active or history of or Diabetes with kidney, eye, nerve, or blood vessel damage or Heart attack, history of or Heart or blood vessel disease (e.g., coronary artery disease) or Heart rhythm problems or Hypertension (high blood pressure), uncontrolled or Kidney disease or Liver disease, including tumors or cancer or Migraine headache, new or worse or a new kind of headache or Problems with circulation or blood clots, now or in the past or Problems with heart valves or Stroke, history of Should not be used in patients with these conditions. Angioedema (swelling of the face, tongue, or throat), inherited or Chloasma gravidarum (skin disorder during pregnancy), history of or Cholestasis (bile problem) during pregnancy, history of or Depression, history of or Diabetes or Dyslipidemia (high cholesterol or fats in the blood), uncontrolled or Gallbladder disease or Hyperkalemia (high potassium in the blood) or Hypertension (high blood pressure), controlled Use with caution. May make these conditions worse. Proper Use of drospirenone, ethinyl estradiol, and levomefolate This section provides information on the proper use of a number of products that contain drospirenone, ethinyl estradiol, and levomefolate. It may not be specific to Safyral. Please read with care. To make using hormonal contraceptives as safe and reliable as possible, you should understand how and when to use them and what effects may be expected. This medicine comes with patient instructions. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. This medicine is available in blister packs. Each blister pack contains 28 tablets with different colors that need to be taken in the same order as directed on the blister pack. When you begin using this medicine, your body will require at least 7 days to adjust before a pregnancy will be prevented. Use a second form of contraception, such as a condom, spermicide, or diaphragm, for the first 7 days of your first cycle of pills. Take this medicine at the same time each day, after the evening meal or at bedtime. You may take this medicine with or without food. Do not skip or delay taking your pill by more than 24 hours . If you miss a dose, you could get pregnant. Ask your doctor for ways to help you remember to take your pills or about using another method of birth control. You may have light bleeding or spotting when you first take the pill. You may feel sick or nauseous, especially during the first few months that you take this medicine. If your nausea is continuous and does not go away, call your doctor. If you vomit or have diarrhea within 3 to 4 hours of taking this medicine, follow the instructions in the patient leaflet or call your doctor. If you are switching from a combination hormonal method (e.g., another pill, patch, vaginal ring) to using Beyaz or Safyral , take this medicine on the first day of your period. If you do not start your period, see your doctor for a pregnancy test. If you have used a vaginal ring or patch, take the pill on the day the ring or patch is removed. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take this medicine. If you are switching from a progestin-only method (e.g., progestin-only pill, implant, injection, intrauterine system) to using Beyaz or Safyral , take the medicine on the day you would have taken your next progestin-only pill, or on the day your implant or IUD is removed, or on the day you would have your next injection. You must also use a second method of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days you take this medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Your doctor may ask you to begin your dose on the first day of your menstrual period (called Day 1 Start) or on the first Sunday after your menstrual period starts (called Sunday Start). When you begin on a certain day it is important that you follow that schedule, even if you miss a dose. Do not change your schedule on your own. If the schedule that you use is not convenient, check with your doctor about changing it. For a Sunday start, you need to use another form of birth control (e.g., condom, diaphragm, spermicide) for the first 7 days. For oral dosage form (tablets): For contraception (to prevent pregnancy), PMDD, or acne: Adults and teenagers One tablet taken at the same time each day for 28 days. Children Use and dose must be determined by your doctor. Missed Dose Call your doctor or pharmacist for instructions. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Safyral It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and does not cause unwanted effects. These visits will usually be every 6 to 12 months, but some doctors require them more often. Your doctor may also want to check your blood pressure while taking this medicine. Although you are using this medicine to prevent pregnancy, you should know that using this medicine while you are pregnant could harm the unborn baby. If you think you have become pregnant while using the medicine, tell your doctor right away. Vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is sometimes called spotting when slight, or breakthrough bleeding when heavier. If this should occur, continue with your regular dosing schedule. The bleeding usually stops within 1 week. Check with your doctor if the bleeding continues for more than 1 week. If bleeding continues after you have been taking hormonal contraceptives on schedule and for more than 3 months, check with your doctor. Check with your doctor right away if you miss a menstrual period. Missed periods may occur if you skip one or more pink tablets and have not taken your pills exactly as directed. If you miss two periods in a row, talk to your doctor. You might need a pregnancy test. If you suspect that you may be pregnant, stop using this medicine immediately and check with your doctor . You should continue to take folate supplements. Do not use this medicine if you smoke cigarettes or if you are over 35 years of age. If you smoke while using birth control pills containing drospirenone, you increase your risk of having a blood clot, heart attack, or stroke. Your risk is even higher if you are over age 35, if you have diabetes, high blood pressure, high cholesterol, or if you are overweight. Talk with your doctor about ways to stop smoking. Keep your diabetes under control. Ask your doctor about diet and exercise to control your weight and blood cholesterol level. Using this medicine may increase your risk of having blood clotting problems, especially in the first 6 months of use. This risk may be higher if you are using a birth control pill containing drospirenone and ethinyl estradiol. Stop using this medicine and check with your doctor right away if you have pain in the chest, groin, or legs, especially the calves, difficulty with breathing, a sudden, severe headache, slurred speech, a sudden, unexplained shortness of breath, a sudden loss of coordination, or vision changes while using this medicine. Check with your doctor immediately if you have problems wearing contact lenses or if blurred vision, difficulty with reading, or any other change in vision occurs during or after treatment . Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Stop using this medicine and check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Check with your doctor before refilling an old prescription, especially after a pregnancy. You will need another physical examination and your doctor may change your prescription. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or certain medical tests. This medicine may cause skin discoloration. Use a sunscreen when you are outdoors. Avoid sunlamps and tanning beds. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (e.g., St. John's wort) or vitamin supplements. Safyral Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Breast pain or tenderness headache, severe and throbbing heavy non-menstrual vaginal bleeding irregular menstrual periods nausea normal menstrual bleeding occurring earlier, possibly lasting longer than expected Less common Longer or heavier menstrual periods unusual tiredness or weakness vomiting Incidence not known Abdominal or stomach pain chills clay-colored stools dark urine difficulty with breathing dizziness fever headache itching loss of appetite pain in the chest, groin, or legs, especially the calves rash slurred speech sudden loss of coordination sudden, severe weakness or numbness in the arm or leg sudden, unexplained shortness of breath unpleasant breath odor unusual tiredness or weakness vision changes vomiting of blood yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Crying decreased interest in sexual intercourse delusions of persecution, mistrust, suspiciousness, and/or combativeness false or unusual sense of well-being inability to have or keep an erection irritability loss in sexual ability, desire, drive, or performance mental depression quick to react or overreact emotionally rapidly changing moods weight gain Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. 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Next Side Effects Print this page Add to My Med List More about Safyral (drospirenone / ethinyl estradiol / levomefolate calcium) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 62 Reviews Add your own review/rating Generic Availability Drug class: contraceptives Consumer resources Safyral Other brands: Beyaz , Rajani Professional resources Safyral (FDA) Related treatment guides Birth Control} Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA WADA Class Anti-Doping Classification Drug Class Contraceptives Related Drugs Birth Control medroxyprogesterone , Provera , Depo-Provera , norethindrone , Mirena , Nexplanon , Sprintec , levonorgestrel , NuvaRing , Ortho Tri-Cyclen , Yasmin , Yaz , TriNessa , Aviane , Lo Loestrin Fe , Apri , Alesse , Mononessa , Microgestin Fe 1 / 20 , Xulane , Camila , Seasonique , Lutera , Levora , Ortho Evra , More... Safyral Rating 62 User Reviews 6.0 /10 62 User Reviews 6.0 Rate it! Safyral Images Safyral drospirenone 3 mg / ethinyl estradiol 0.03 mg / levomefolate calcium 0.451 mg (Y+ ) View larger images Related Questions & Answers Safyral - Has anyone taking this pill noticed any weight gain from it at all? I have a history with depression and taking depression meds, so what b.c. pill is right for me? Almost 3 week with Safyral, should I use backup method while taking the light orange pills? How long did breakthrough bleeding last while on safyral? Drospirenone/ethinyl Estradiol/levomefolate Calcium - will safyral help increase breast size? Read more questions} } official


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