variety of obinutuzumab (Intravenous route) oh-bi-nue-TOOZ-ue-mab Intravenous route(Solution) Hepatitis B virus (HBV) reactivation can occur in patients receiving obinutuzumab or other CD20-directed cytolytic antibodies, which can progress to life-threatening or fatal fulminant hepatitis or hepatic failure. Screen patients at baseline for HBV infection. Monitor HBV-positive patients during and after treatment with obinutuzumab. If HBV reactivation occurs, discontinue obinutuzumab and concomitant medications. Life-threatening or fatal progressive multifocal leukoencephalopathy has also been reported . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Gazyva Available Dosage Forms: Solution Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Monoclonal Antibody Slideshow 2016 New Drug Approvals: The Year That Was Uses For obinutuzumab Obinutuzumab injection is used together with other medicines to treat chronic lymphocytic leukemia (CLL) and follicular lymphoma, which are cancers of the blood. It interferes with the growth of cancer cells, which are eventually destroyed by the body. Obinutuzumab is an antineoplastic agent (cancer medicine). obinutuzumab is to be given only by or under the direct supervision of your doctor. Before Using obinutuzumab In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For obinutuzumab, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to obinutuzumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of obinutuzumab injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of obinutuzumab injection in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of obinutuzumab. Make sure you tell your doctor if you have any other medical problems, especially: Hepatitis B infection, history of or Hypotension (low blood pressure) or Neutropenia (low white blood cells) or Thrombocytopenia (low platelet count) Use with caution. May make these conditions worse. Infection May decrease your body's ability to fight an infection. Proper Use of obinutuzumab A nurse or other trained health professional will give you obinutuzumab in a hospital or cancer treatment center. obinutuzumab is given through a needle placed in one of your veins. You may also receive medicines to help prevent unwanted side effects from the injection. Precautions While Using obinutuzumab It is very important that your doctor check your progress at regular visits to make sure obinutuzumab is working properly and to check for unwanted effects. Blood tests may be needed to check for unwanted effects. Check with your doctor right away if you have any symptoms of liver problems, such as yellow skin or eyes, dark brown-colored urine, right-sided stomach pain, fever, or severe tiredness. obinutuzumab may increase your risk of developing a serious and rare brain infection called progressive multifocal leukoencephalopathy (PML). Check with your doctor right away if you have vision changes, loss of coordination, clumsiness, memory loss, difficulty speaking or understanding what others say, or weak legs. obinutuzumab may cause an infusion reaction within a few hours after you receive it. Check with your doctor right away if you have chest pain, itching, hives, a rash, flushing of the face, dizziness, fainting, lightheadedness, trouble breathing, swelling of the face, tongue, and throat, a fever, or chills. obinutuzumab may cause a serious type of reaction called tumor lysis syndrome. Your doctor may give you a medicine to help prevent this. Call your doctor right away if you have a decrease or change in urine amount, joint pain, stiffness, or swelling, lower back, side, or stomach pain, a rapid weight gain, swelling of the feet or lower legs, or unusual tiredness or weakness. Obinutuzumab can temporarily lower the number of white blood cells in your blood, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting. If this occurs, there are certain precautions you can take, especially when your blood count is low, to reduce the risk of infection or bleeding: If you can, avoid people with infections. Check with your doctor immediately if you think you are getting an infection or if you get a fever or chills, cough or hoarseness, lower back or side pain, or painful or difficult urination. Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin. Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime. Be careful not to cut yourself when you are using sharp objects such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur. While you are being treated with obinutuzumab, and after you stop treatment with it, do not have any immunizations (vaccines) without your doctor's approval. Obinutuzumab may lower your body's resistance and the vaccine may not work as well or you might get the infection the vaccine is meant to prevent. In addition, you should not be around other persons living in your household who receive live virus vaccines because there is a chance they could pass the virus on to you. Some examples of live vaccines include measles, mumps, influenza (nasal flu vaccine), poliovirus (oral form), rotavirus, and rubella. Do not get close to them and do not stay in the same room with them for very long. If you have questions about this, talk to your doctor. obinutuzumab Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Back pain black, tarry stools bleeding gums blood in the urine or stools chest tightness chills cough or hoarseness fever flushing headache lower back or side pain nausea and vomiting painful or difficult urination pale skin pinpoint red spots on the skin sore throat trouble breathing troubled breathing with exertion ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness Less common Joint pain, stiffness, or swelling lower back, side, or stomach pain swelling of the feet or lower legs Incidence not known Blurred vision confusion convulsions dark urine dizziness drowsiness general tiredness and weakness headache light-colored stools upper right abdominal or stomach pain yellow eyes and skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Incidence not known Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about obinutuzumab Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: CD20 monoclonal antibodies Consumer resources Obinutuzumab Other brands: Gazyva Professional resources Obinutuzumab (AHFS Monograph) Obinutuzumab (Wolters Kluwer) Related treatment guides Follicular Lymphoma Chronic Lymphocytic Leukemia} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class CD20 monoclonal antibodies Related Drugs Chronic Lymphocytic Leukemia Rituxan , rituximab , cyclophosphamide , Imbruvica , Cytoxan , ibrutinib , bendamustine , Venclexta , Octagam , obinutuzumab , Leukeran , chlorambucil , More... Follicular Lymphoma Rituxan , rituximab , copanlisib , obinutuzumab , Gazyva , Zydelig , Intron A , idelalisib , Aliqopa , Rituxan Hycela , interferon alfa-2b , hyaluronidase / rituximab , More... Obinutuzumab Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? Ask a question or go join the obinutuzumab support group to connect with others who have similar interests.} } you acquire
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