stumbled on canakinumab (Subcutaneous route) kan-a-KIN-ue-mab Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Ilaris Available Dosage Forms: Powder for Solution Solution Therapeutic Class: Immune Modulator Pharmacologic Class: Monoclonal Antibody Slideshow Juvenile Arthritis: The Big Disease In A Little Body Uses For canakinumab Canakinumab injection is used to treat cryopyrin-associated periodic syndromes (CAPS). This also includes familial cold auto-inflammatory syndrome (FCAS) and Muckle-Wells syndrome (MWS). CAPS is a rare, inherited disease of the immune system. It occurs when the body produces too much of a chemical called interleukin-1 beta. This chemical causes inflammation, and patients with CAPS may have a fever, headache, skin rash, joint or muscle pain, or unusual tiredness or weakness. Canakinumab helps prevent inflammation by keeping the interleukin-1 beta from working properly. canakinumab also treats adults and children with other autoinflammatory periodic fever syndromes, such as tumor necrosis factor receptor associated periodic syndrome (TRAPS), hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), and familial Mediterranean fever (FMF). Canakinumab is also used to treat active systemic juvenile idiopathic arthritis (SJIA) in children 2 years of age and older. canakinumab is to be given only by or under the direct supervision of a doctor. Before Using canakinumab In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For canakinumab, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to canakinumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of canakinumab injection in children with TRAPS, HIDS/MKD, and FMF. However, safety and efficacy have not been established in children with CAPS, FCAS, or MWS younger than 4 years of age and in children with SJIA younger than 2 years of age. Geriatric Appropriate studies on the relationship of age to the effects of canakinumab injection have not been performed in the geriatric population. However, no geriatric-specific problems have been documented to date. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of canakinumab. Make sure you tell your doctor if you have any other medical problems, especially: Hepatitis B, history of or Hepatitis C, history of or Immune system problem (eg, HIV or AIDS) or Infection, active or Tuberculosis, active or history of Use with caution. May make these conditions worse. Proper Use of canakinumab A nurse or other trained health professional will give you or your child canakinumab in a hospital or clinic setting. canakinumab is given as a shot under your skin. canakinumab is given every 8 weeks for CAPS and every 4 weeks for TRAPS, HIDS/MKD, FMF, and SJIA. canakinumab comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand. Precautions While Using canakinumab It is very important that your doctor check your or your child's progress at regular visits to make sure that canakinumab is working properly. You will need to have a skin test for tuberculosis before you or your child start using canakinumab. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis test. Your body's ability to fight an infection may be reduced while you are being treated with canakinumab. It is very important that you call your doctor right away if you or your child have a fever, chills, cough, hoarseness, lower back or side pain, or painful or difficult urination. Using canakinumab may increase your risk of cancer. Talk to your doctor if you have concerns about this risk. Canakinumab may cause allergic reactions. Tell your doctor right away if you have a rash, itching, lightheadedness or dizziness, swelling of the face, tongue, and throat, trouble breathing or swallowing, or chest pain after you or your child receive the medicine. Do not get any immunizations (vaccines), especially the live vaccines (eg, nasal flu virus vaccine) without your doctor's approval while you are being treated with canakinumab. canakinumab may cause a life-threatening condition called macrophage activation syndrome (MAS). This usually occurs in patients with rheumatic conditions, including SJIA, and must be treated immediately. Tell your doctor right away if you have a fever that lasts longer than 3 days, a cough that does not go away, redness in one part of your body, or warm feeling or swelling of your skin. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. canakinumab Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Body aches or pain chills congestion cough diarrhea dryness or soreness of the throat fever headache hoarseness joint pain loss of appetite muscle aches and pains nausea shivering shortness of breath sneezing stuffy or runny nose sweating tender, swollen glands in the neck tightness in the chest trouble sleeping trouble swallowing unusual tiredness or weakness voice changes vomiting Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site dizziness or lightheadedness feeling of constant movement of self or surroundings increased weight muscle or bone pain sensation of spinning weakness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about canakinumab Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: interleukin inhibitors Consumer resources Canakinumab Other brands: Ilaris Professional resources Canakinumab (AHFS Monograph) Canakinumab (Wolters Kluwer) Related treatment guides Cryopyrin-Associated Periodic Syndromes Familial Cold Autoinflammatory Syndrome Familial Mediterranean Fever Hyperimmunoglobulin D Syndrome ... +3 more} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Interleukin inhibitors Related Drugs Familial Mediterranean Fever colchicine , Colcrys , Ilaris , canakinumab , More... Familial Cold Autoinflammatory Syndrome Ilaris , canakinumab , Arcalyst , More... Cryopyrin-Associated Periodic Syndromes Kineret , anakinra , Ilaris , canakinumab , Arcalyst , More... Muckle Wells Syndrome Ilaris , canakinumab , Arcalyst , More... 3 more conditions... Canakinumab Rating No Reviews - Be the first! 10 /10 No Reviews - Be the first! 10 Rate it! Help and Support Looking for answers? Ask a question or go join the canakinumab support group to connect with others who have similar interests.} } costs
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