taken aback Sinemet CR Generic Name: carbidopa and levodopa (KAR bi DOE pa and LEE voe DOE pa) Brand Name: Parcopa, Rytary, Sinemet, Sinemet CR Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons What is Sinemet CR (carbidopa and levodopa)? Carbidopa and levodopa is a combination medicine used to treat symptoms of Parkinson's disease, such as muscle stiffness, tremors, spasms, and poor muscle control. Parkinson's disease may be caused by low levels of a chemical called dopamine (DOE pa meen) in the brain. Levodopa is converted to dopamine in the brain. Carbidopa helps prevent the breakdown of levodopa before it can reach the brain and take effect. Carbidopa and levodopa is also used to treat Parkinson symptoms caused by carbon monoxide poisoning or manganese intoxication. Carbidopa and levodopa may also be used for purposes not listed in this medication guide. Slideshow Modafinil: Smart Drug For Decision Fatigue Or Workaholic Crutch What is the most important information I should know about Sinemet CR (carbidopa and levodopa)? You should not use carbidopa and levodopa if you have narrow-angle glaucoma. Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. What should I discuss with my healthcare provider before taking Sinemet CR (carbidopa and levodopa)? You should not use carbidopa and levodopa if you are allergic to it, or if you have: narrow-angle glaucoma. Do not use carbidopa and levodopa if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others. To make sure carbidopa and levodopa is safe for you, tell your doctor if you have: heart disease, high blood pressure, history of heart attack; liver or kidney disease; an endocrine (hormonal) disorder; asthma, chronic obstructive pulmonary disease (COPD), or other breathing disorder; a stomach or intestinal ulcer; open-angle glaucoma; or a history of depression, mental illness, or psychosis. People with Parkinson's disease may have a higher risk of skin cancer (melanoma). Talk to your doctor about this risk and what skin symptoms to watch for. It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant. Carbidopa and levodopa can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby. The carbidopa and levodopa disintegrating tablet may contain phenylalanine. Talk to your doctor before using this form of carbidopa and levodopa if you have phenylketonuria (PKU). How should I take Sinemet CR (carbidopa and levodopa)? If you already take levodopa, you must stop taking it at least 12 hours before you start taking carbidopa and levodopa. Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended. Carbidopa and levodopa can be taken with or without food. Take your doses at regular intervals to keep a steady amount of the drug in your body at all times. Get your prescription refilled before you run out of medicine completely. Do not crush, chew, break, or open a carbidopa and levodopa capsule . Swallow it whole. The tablet is sometimes broken in half to give the correct dose. Always swallow a whole or half tablet without chewing or crushing. To take the orally disintegrating tablet (Parcopa): Keep the tablet in the bottle until you are ready to take it. Use dry hands to remove the tablet and place it on your tongue. Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. Swallow several times as the tablet dissolves. It may take up to several weeks of using carbidopa and levodopa before your symptoms improve. For best results, keep using the medication as directed. Talk with your doctor if your symptoms do not improve after a few weeks of treatment. Also tell your doctor if the effects of this medication seem to wear off quickly in between doses. If you use this medicine long-term, you may need frequent medical tests at your doctor's office. This medicine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using carbidopa and levodopa. Do not stop using carbidopa and levodopa suddenly, or you could have unpleasant withdrawal symptoms. Ask your doctor how to safely stop using carbidopa and levodopa. Store at room temperature away from moisture, heat, and light. What happens if I miss a dose? Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. What should I avoid while taking Sinemet CR (carbidopa and levodopa)? This medicine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid taking iron supplements or eating a diet that is high in protein (protein sources include meat, eggs, and cheese). These things can make it harder for your body to digest and absorb carbidopa and levodopa. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medicine. Sinemet CR (carbidopa and levodopa) side effects Get emergency medical help if you have signs of an allergic reaction : hives; difficult breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have: uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement); worsening of tremors (uncontrolled shaking); severe or ongoing vomiting or diarrhea; confusion, hallucinations, unusual changes in mood or behavior; depression or suicidal thoughts; or severe nervous system reaction--very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out. Some people taking carbidopa and levodopa have fallen asleep during normal daytime activities such as working, talking, eating, or driving. Tell your doctor if you have any problems with daytime sleepiness or drowsiness. You may have increased sexual urges, unusual urges to gamble, or other intense urges while taking this medicine. Talk with your doctor if this occurs. You may notice that your sweat, urine, or saliva appears dark in color, such as red, brown, or black. This is not a harmful side effect, but it may cause staining of your clothes or bed sheets. Common side effects may include: jerky or twisting muscle movements; muscle contractions; or nausea. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. Side Effects (complete list) What other drugs will affect Sinemet CR (carbidopa and levodopa)? Other drugs may interact with carbidopa and levodopa, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using. Next Side Effects Print this page Add to My Med List More about Sinemet CR (carbidopa / levodopa) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 3 Reviews Add your own review/rating Generic Availability Drug class: dopaminergic antiparkinsonism agents Consumer resources Sinemet CR Sinemet CR (Advanced Reading) Other brands: Rytary , Parcopa , Duopa Professional resources Sinemet CR (FDA) Levodopa/Carbidopa (AHFS Monograph) Other Formulations Sinemet Related treatment guides GTP-CH Deficiency Neuroleptic Malignant Syndrome Parkinson's Disease Restless Legs Syndrome Where can I get more information? Your pharmacist can provide more information about carbidopa and levodopa. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Copyright 1996-2012 Cerner Multum, Inc. Version: 11.02. Date modified: December 03, 2017 Last reviewed: August 02, 2016} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Merck & Co., Inc. Drug Class Dopaminergic antiparkinsonism agents Related Drugs Parkinson's Disease Exelon , ropinirole , pramipexole , Sinemet , Requip , benztropine , carbidopa / levodopa , Mirapex , More... Neuroleptic Malignant Syndrome carbidopa , Sinemet , carbidopa / levodopa , Lodosyn , Parcopa , More... GTP-CH Deficiency carbidopa , Sinemet , carbidopa / levodopa , Lodosyn , Parcopa , More... Sinemet CR Rating 3 User Reviews 7.7 /10 3 User Reviews 7.7 Rate it! Sinemet CR Images Sinemet CR 50 mg / 200 mg (SINEMET CR 521) View all images Related Questions & Answers Can I take my Sinement CR tabs perscribed 3 times a day TO WORK EVENLY DURING MY DAYTIME HOURS? I take a combination of sinemet and sinemet cr. sometimes it takes 2 hours or more to take effect? My mom has in the last year gotten agressively worse. I am concerned that she is not tolerating the? Parkinson's Disease - Does anyone suffer from dark saliva (taking Sinemet CR)? Is it safe to take Kalms Night tablets (1 each night) to help sleep problems while taking sinemet CR Read more questions} } vacationers
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