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practical Cresemba (Oral) Generic Name: isavuconazonium (Oral route) eye-sa-vue-koe-na-ZOE-nee-um SUL-fate Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Cresemba Available Dosage Forms: Capsule Therapeutic Class: Antifungal Chemical Class: Isavuconazonium Slideshow Mammogram Memos: What You Need To Know Uses For Cresemba Isavuconazonium is used to treat serious fungal or yeast infections, such as invasive aspergillosis and invasive mucormycosis. This medicine works by killing the fungus or yeast and preventing its growth. This medicine is available only with your doctor's prescription. Before Using Cresemba In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of isavuconazonium in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of isavuconazonium in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Atazanavir Boceprevir Carbamazepine Clarithromycin Cobicistat Conivaptan Delavirdine Enzalutamide Fosphenytoin Idelalisib Indinavir Itraconazole Ketoconazole Lumacaftor Mephobarbital Mitotane Nefazodone Nelfinavir Phenytoin Posaconazole Rifampin Ritonavir Saquinavir St John's Wort Telaprevir Telithromycin Tipranavir Voriconazole Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atorvastatin Cyclosporine Digoxin Lopinavir Midazolam Quinidine Sirolimus Tacrolimus Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Bupropion Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following is not recommended. Your doctor may decide not to treat you with this medication, change some of the other medicines you take, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Heart rhythm problem (eg, familial short QT syndrome) Should not be used in patients with this condition. Liver disease Use with caution. May make this condition worse. Proper Use of Cresemba Take this medicine for the full time of treatment , even if you begin to feel better. Also, keep your appointments with your doctor for check-ups so that your doctor will be better able to tell you when to stop taking this medicine. This medicine comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. Swallow the capsule whole. Do not crush, break, dissolve, or open it. You may take this medicine with or without food. Keep using this medicine for the full treatment time , even if you feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For invasive aspergillosis and invasive mucormycosis: Adults At first, 372 milligrams (mg) (2 capsules) every 8 hours for 6 doses (48 hours). Then, your doctor will adjust your dose to 372 mg (2 capsules) per day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Cresemba It is important that your doctor check your progress after treatment . This is to make sure that the infection is cleared up completely, and to allow your doctor to check for any unwanted effects. Blood tests may be needed to check for unwanted effects. If your symptoms do not improve, or if they become worse, check with your doctor. You may need to take this medicine for several weeks or months before your infection gets better. Do not use this medicine together with carbamazepine (Tegretol ), ketoconazole (Nizoral ), phenobarbital (Luminal ), rifampin (Rifadin , Rimactane ), ritonavir (Norvir ), or St. John's wort. Using these medicines together may cause unwanted effects . Make sure your doctor knows if you are pregnant or planning to get pregnant before you start using this medicine. If you think you have become pregnant while using the medicine, tell your doctor right away. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Serious skin reactions can occur with this medicine. Check with your doctor right away if you have blistering, peeling, or loose skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin, or fever or chills while you are using this medicine. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Cresemba Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloating or swelling of the face, arms, hands, lower legs, or feet bloody urine blurred vision chest pain confusion convulsions decreased frequency or amount of urine dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position fast or irregular heartbeat loss of appetite lower back or side pain muscle pain or cramps muscle spasms (tetany) or twitching numbness or tingling in the hands, feet, or lips seizures severe nausea or vomiting sweating tightness in the chest tingling of the hands or feet trembling trouble breathing unusual tiredness or weakness Less common or rare Cough or hoarseness dark urine fever with or without chills hives, itching, or rash irritation joint pain, stiffness, or swelling light-colored stools red, swollen skin sore throat sores, ulcers, or white spots on the lips or in the mouth stomach pain unusual bleeding or bruising upper right abdominal or stomach pain yellow eyes and skin Incidence not known Blistering, peeling, or loosening of the skin chills diarrhea red skin lesions, often with a purple center red, irritated eyes Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach anxiety back pain headache heartburn or indigestion seeing, hearing, or feeling things that are not there stomach discomfort or upset trouble sleeping unusual excitement, nervousness, or restlessness Less common or rare Continuing ringing or buzzing or other unexplained noise in the ears decreased vision eye pain feeling of constant movement of self or surroundings hair loss or thinning of the hair hearing loss sensation of spinning Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Cresemba (isavuconazonium) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: azole antifungals Consumer resources Cresemba Cresemba (Isavuconazonium Sulfate Capsules) Cresemba (Isavuconazonium Sulfate Injection) Cresemba Intravenous (Advanced Reading) Professional resources Cresemba (AHFS Monograph) Cresemba (FDA) Related treatment guides Aspergillosis, Invasive Mucormycosis, Invasive} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug 2 years Approval History FDA approved 2015 Manufacturer Astellas Pharma US, Inc. Drug Class Azole antifungals Related Drugs Aspergillosis, Invasive itraconazole , voriconazole , amphotericin b , Sporanox , caspofungin , posaconazole , Noxafil , AmBisome , Abelcet , Vfend , Cancidas , Onmel , More... Mucormycosis, Invasive isavuconazonium , More... Cresemba Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Cresemba Images Cresemba isavuconazonium sulfate 186 mg (ISA Logo) View larger images Help and Support Looking for answers? Ask a question or go join the Cresemba support group to connect with others who have similar interests.} } sizeable


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