a unusual rifabutin (Oral route) rif-a-BUE-tin Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Mycobutin Available Dosage Forms: Capsule Therapeutic Class: Antitubercular Chemical Class: Rifamycin Slideshow Hep C and Harvoni: 11 Facts About Your Treatment Uses For rifabutin Rifabutin is used to help prevent Mycobacterium avium complex (MAC) disease from causing disease throughout the body in patients with advanced human immunodeficiency virus (HIV) infection. MAC is an infection caused by two similar bacteria, Mycobacterium avium and Mycobacterium intracellulare. Mycobacterium avium is more common in patients with HIV infection. MAC also may occur in other patients whose immune system is not working properly. Symptoms of MAC in people with acquired immunodeficiency syndrome (AIDS) include fever, night sweats, chills, weight loss, and weakness. Rifabutin is an antibiotic and works to kill or prevent the growth of certain bacteria. It will not help against viruses. rifabutin is available only with your doctor's prescription. Before Using rifabutin In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For rifabutin, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to rifabutin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of rifabutin in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of rifabutin in the elderly. However, elderly patients are more likely to have kidney, liver, or heart disease which may require caution and an adjustment in the dose for patients receiving rifabutin. Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking rifabutin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using rifabutin with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Artemether Delamanid Lumefantrine Lurasidone Maraviroc Ranolazine Voriconazole Using rifabutin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abiraterone Amprenavir Apremilast Atazanavir Atovaquone Bedaquiline Boceprevir Bortezomib Bosutinib Ceritinib Cholera Vaccine, Live Clarithromycin Cobicistat Conivaptan Crizotinib Cyclosporine Daclatasvir Darunavir Dasatinib Delavirdine Desogestrel Dienogest Doxorubicin Doxorubicin Hydrochloride Liposome Drospirenone Efavirenz Elvitegravir Enzalutamide Erlotinib Estradiol Ethinyl Estradiol Ethynodiol Etonogestrel Etravirine Exemestane Fluconazole Fosamprenavir Gestodene Idelalisib Ifosfamide Indinavir Irinotecan Irinotecan Liposome Ixabepilone Ketoconazole Lapatinib Ledipasvir Levonorgestrel Linagliptin Lopinavir Macitentan Mestranol Mifepristone Naloxegol Nelfinavir Netupitant Nifedipine Nilotinib Norethindrone Norgestimate Norgestrel Olaparib Panobinostat Pazopanib Perampanel Piperaquine Ponatinib Posaconazole Rilpivirine Ritonavir Romidepsin Saquinavir Sonidegib Sorafenib Sunitinib Tacrolimus Tasimelteon Telaprevir Tenofovir Alafenamide Tipranavir Tofacitinib Tolvaptan Ulipristal Vandetanib Velpatasvir Vilazodone Vincristine Vincristine Sulfate Liposome Vortioxetine Using rifabutin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Azithromycin Dapsone Didanosine Nevirapine Ospemifene Sirolimus Sulfamethoxazole Trimetrexate Warfarin Zidovudine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of rifabutin. Make sure you tell your doctor if you have any other medical problems, especially: Diarrhea or Myositis (inflammation of the muscle) or Uveitis (an eye problem) Use with caution. May make these conditions worse. Kidney disease, severe Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of rifabutin Take rifabutin exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance for side effects. rifabutin should not be given to patients with active tuberculosis (TB). If you know you have TB or think you may have active TB, tell your doctor. Rifabutin may be taken on an empty stomach (either 1 hour before or 2 hours after a meal). However, if rifabutin upsets your stomach, you may want to take it with food. If you cannot swallow the capsule, you may open it and the contents of the capsules may be mixed with applesauce. Be sure to take all the food to get the full dose of medicine. To help prevent MAC disease, it is very important that you keep using rifabutin for the full time of treatment . You may have to take it every day for many months. It is important that you do not miss any doses. Dosing The dose of rifabutin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of rifabutin. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For the prevention of Mycobacterium avium complex (MAC): Adults 300 milligrams (mg) once a day, or 150 mg two times a day with food. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of rifabutin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using rifabutin It is very important that your doctor check your progress at regular visits . Blood and urine tests may be needed to check for unwanted effects. Rifabutin will cause your urine, stools, saliva, skin, sputum, sweat, and tears to turn reddish-orange to brown-orange. This is to be expected while you are taking rifabutin. This effect may cause soft contact lenses to become permanently discolored. Standard cleaning solutions may not take out all the discoloration. It is best not to wear soft contact lenses while taking rifabutin. Hard contact lenses are not discolored by rifabutin. If you have any questions about this, check with your doctor. Check with your doctor immediately if blurred vision, difficulty in reading, or any other change in vision occurs during or after treatment. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). rifabutin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using rifabutin. Do not take any medicine to treat diarrhea without first checking with your doctor. If you have any questions or if mild diarrhea continues or gets worse, check with your doctor. Rifabutin can lower the number of white blood cells in your blood temporarily, increasing the chance of getting infection. It can also lower the number of platelets, which are necessary for proper blood clotting. These problems may result in a greater chance of getting certain infections, slow healing, and bleeding of the gums. Be careful when using a regular toothbrush, dental floss, or toothpick. Dental work should be delayed until your blood counts have returned to normal. Check with your medical doctor or dentist if you have any questions about proper oral hygiene (mouth care) during treatment. Birth control pills may not work properly if you take them while you are taking rifabutin. Unplanned pregnancies may occur. Use a different means of birth control while you are taking rifabutin. If you have any questions about this, check with your doctor. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. rifabutin Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Black, tarry stools chest pain chills cough diarrhea fever heartburn indigestion itching or skin rash loss of appetite painful or difficult urination sore throat ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness Less common Loss of strength or energy muscle pain Rare Bruising or purple spots on the skin change in taste eye pain joint pain loss of vision lower back or side pain muscle swelling or pain pale skin yellow skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach pain bad, unusual, or unpleasant (after) taste in the mouth belching bloated or full feeling change in taste discoloration of the urine excess air or gas in the stomach or intestines headache nausea passing gas trouble sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. 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Next Side Effects Print this page Add to My Med List More about rifabutin Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Drug class: rifamycin derivatives Consumer resources Rifabutin Other brands: Mycobutin Professional resources Rifabutin (AHFS Monograph) Rifabutin (FDA) Rifabutin (Wolters Kluwer) Related treatment guides Mycobacterium avium-intracellulare, Prophylaxis Mycobacterium avium-intracellulare, Treatment Tuberculosis, HIV Positive Tuberculosis, Prophylaxis} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Greenstone LLC Lupin Pharmaceuticals, Inc. Drug Class Rifamycin derivatives Related Drugs Mycobacterium avium-intracellulare, Treatment ciprofloxacin , azithromycin , Zithromax , clarithromycin , More... Tuberculosis, HIV Positive n/a Tuberculosis, Prophylaxis rifampin , isoniazid , bcg , Rifadin , Nydrazid , More... Mycobacterium avium-intracellulare, Prophylaxis azithromycin , Zithromax , clarithromycin , Biaxin , ethambutol , More... Rifabutin Rating 1 User Review 3.0 /10 1 User Review 3.0 Rate it! Rifabutin Images Rifabutin systemic 150 mg (LU R01) View larger images Related Questions & Answers What is the difference between rifampin and rifabutin? Read more questions} } encouraged
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