kept away from [5:40 years of age. 166 Diphtheria uncommon in US, but C. diphtheriae continues to circulate in US areas where the disease previously was endemic. 100 105 166 228 Reported worldwide, particularly in tropical countries; 166 endemic in many countries in Asia, the South Pacific, the Middle East, and Eastern Europe and in Haiti and Dominican Republic. 115 Consult CDC Travelers' Health website () for information regarding where diphtheria is endemic. 115 During the 1920s (before widespread immunization against diphtheria was initiated), there were approximately 100,000 200,000 cases of diphtheria and 13,000 15,000 diphtheria-related deaths each year in US. 166 Most diphtheria cases occur in individuals unvaccinated or incompletely vaccinated against diphtheria. 100 105 115 166 Tetanus is a potentially fatal disease caused by a neurotoxic exotoxin (tetanospasmin) produced by Clostridium tetani . 105 115 166 C. tetani spores are ubiquitous in the environment worldwide; found in soil and in intestinal tracts of humans and animals (e.g., horses, sheep, cattle, dogs, cats, rats, guinea pigs, chickens). 100 105 115 166 195 The spores can contaminate open wounds, especially puncture wounds or those with devitalized tissue; anaerobic wound conditions allow spores to germinate and produce exotoxins that disseminate through blood and lymphatic system. 105 166 195 Neonatal tetanus (tetanus neonatorum) occurs in infants born under nonsterile conditions to inadequately vaccinated women; infection usually involves a contaminated umbilical stump and occurs because infant does not have passively acquired maternal antibodies against tetanus. 100 105 166 195 205 Obstetric tetanus occurs within 6 weeks after delivery or termination of pregnancy because of contaminated wounds or abrasions or unclean deliveries or abortions. 205 Generalized tetanus is characterized by rigidity and convulsive muscle spasms that usually involve the jaw (lockjaw) and neck and then become generalized. 100 166 195 Tetanus occurs worldwide; 115 166 reported most frequently in densely populated regions in hot, damp climates with soil rich in organic matter. 166 Marked decrease in mortality from tetanus occurred in US from the early 1900s to the late 1940s when immunization against tetanus became part of routine childhood immunization. 166 Average of 29 cases reported each year in US from 2001 through 2008 (case fatality rate 13%). 166 Most US cases occur following an acute wound, usually a puncture or contaminated, infected, or devitalized wound. 166 Almost all reported cases occur in individuals unvaccinated or inadequately vaccinated against the disease. 105 115 166 Pertussis (whooping cough) is an acute respiratory tract infection caused by Bordetella pertussis . 105 115 166 197 201 205 Risk for severe pertussis and death highest among infants] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Vaccine combinations Related Drugs Diphtheria Prophylaxis Boostrix (Tdap) , Adacel (Tdap) , Pediarix , Tenivac (Td) , Decavac (Td) , Infanrix (DTaP) , Daptacel (DTaP) , More... Pertussis Prophylaxis azithromycin , Zithromax , clarithromycin , Biaxin , Boostrix (Tdap) , Adacel (Tdap) , Pediarix , More... Tetanus Prophylaxis Boostrix (Tdap) , Tetanus Toxoid Adsorbed , tetanus toxoid , Adacel (Tdap) , Pediarix , Tenivac (Td) , Infanrix (DTaP) , More... Diphtheria toxoid / pertussis, acellular / tetanus toxoid Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! corporation
sparsely Diphtheria and Tetanus Toxoids and Acellular Pertussis Vaccine Adsorbed, Tetanus Toxoid and Reduced Diphtheria Toxoid and Acellular Pertussis Vaccine Adsorbed employer
EmoticonEmoticon