incidentally crizotinib (Oral route) kriz-OH-ti-nib Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Xalkori Available Dosage Forms: Capsule Therapeutic Class: Antineoplastic Agent Pharmacologic Class: Tyrosine Kinase Inhibitor Slideshow Checkpoint Inhibitors & Advanced Cancers: A Healthcare Professional's Guide Uses For crizotinib Crizotinib is used to treat metastatic (cancer that has already spread) non-small cell lung cancer that is caused by a defect in either a gene called anaplastic lymphoma kinase (ALK) or a gene called ROS1. It is an antineoplastic (cancer) agent. Crizotinib interferes with the growth of cancer cells, which are eventually destroyed by the body. crizotinib is available only with your doctor's prescription. Before Using crizotinib In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For crizotinib, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to crizotinib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of crizotinib in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of crizotinib in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking crizotinib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using crizotinib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Atazanavir Bepridil Boceprevir Cisapride Cobicistat Dronedarone Fluconazole Ketoconazole Lopinavir Mesoridazine Nelfinavir Pimozide Piperaquine Posaconazole Ritonavir Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using crizotinib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Alfentanil Alfuzosin Amiodarone Amitriptyline Amprenavir Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Artemether Asenapine Astemizole Atenolol Azithromycin Bedaquiline Betaxolol Bisoprolol Buserelin Carbamazepine Carteolol Carvedilol Celiprolol Ceritinib Chloroquine Chlorpromazine Cilostazol Ciprofloxacin Citalopram Clarithromycin Clomipramine Clonidine Clozapine Conivaptan Cyclobenzaprine Cyclosporine Dabrafenib Dasatinib Deflazacort Degarelix Delamanid Delavirdine Desipramine Deslorelin Deutetrabenazine Digoxin Dihydroergotamine Diltiazem Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Doxorubicin Doxorubicin Hydrochloride Liposome Droperidol Ebastine Efavirenz Eletriptan Eliglustat Enzalutamide Ergotamine Eribulin Erythromycin Escitalopram Esmolol Famotidine Felbamate Fingolimod Flecainide Fluoxetine Fosamprenavir Foscarnet Fosphenytoin Galantamine Gatifloxacin Gemifloxacin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Idelalisib Ifosfamide Iloperidone Imipramine Indinavir Itraconazole Ivabradine Ivacaftor Labetalol Lapatinib Leuprolide Levobunolol Levofloxacin Lumefantrine Lurasidone Mefloquine Methadone Metipranolol Metoprolol Metronidazole Mifepristone Mizolastine Moxifloxacin Nadolol Nafarelin Naloxegol Nebivolol Nefazodone Netupitant Nilotinib Norfloxacin Nortriptyline Octreotide Ofloxacin Olanzapine Olaparib Ondansetron Oxprenolol Paclitaxel Paliperidone Panobinostat Paroxetine Pasireotide Pazopanib Penbutolol Pentamidine Perhexiline Perphenazine Phenytoin Pimavanserin Pindolol Pitolisant Practolol Probucol Procainamide Prochlorperazine Promethazine Propafenone Propranolol Protriptyline Quetiapine Quinidine Quinine Ranolazine Ribociclib Rifabutin Rifampin Rilpivirine Risperidone Sertindole Sevoflurane Simeprevir Sirolimus Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol St John's Wort Sulpiride Sunitinib Tacrolimus Tamoxifen Telavancin Telithromycin Terodiline Tetrabenazine Timolol Tizanidine Tolterodine Tolvaptan Toremifene Trazodone Trifluoperazine Trimipramine Triptorelin Troleandomycin Vandetanib Vardenafil Vemurafenib Venlafaxine Verapamil Vilanterol Vinflunine Voriconazole Vorinostat Zuclopenthixol Using crizotinib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Midazolam Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using crizotinib with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use crizotinib, or give you special instructions about the use of food, alcohol, or tobacco. Grapefruit Juice Other Medical Problems The presence of other medical problems may affect the use of crizotinib. Make sure you tell your doctor if you have any other medical problems, especially: Bradycardia (slow heartbeat) or Congenital long QT syndrome (heart rhythm problem) or Congestive heart failure or Electrolyte or mineral imbalance or QT prolongation (abnormal heart rhythm) Use with caution. May cause side effects to become worse. Kidney disease, severe or Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of crizotinib Take crizotinib exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. crizotinib comes with a patient information leaflet. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand. Swallow the capsule whole. Do not crush, break, chew, or open it. You may take crizotinib with or without food. Do not eat grapefruit or drink grapefruit juice while you are using crizotinib. Grapefruit and grapefruit juice may change the amount of medicine that is absorbed in the body. Dosing The dose of crizotinib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of crizotinib. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (capsules): For treatment of non-small cell lung cancer: Adults 250 milligrams (mg) two times per day. Your doctor may adjust your dose as needed. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of crizotinib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. If you miss a dose and it is less than 6 hours until your next regular dose, wait until then to use the medicine and skip the missed dose. If you vomit after taking a dose, take the next dose at the regular time. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using crizotinib It is very important that your doctor check your progress at regular visits to make sure crizotinib is working properly. Blood tests may be needed to check for unwanted effects. Using crizotinib while you are pregnant can harm your unborn baby. The medicine may also cause birth defects if the father is using it when his sexual partner becomes pregnant. Use an effective form of birth control during therapy and for at least 45 to 90 days after the last dose. If a pregnancy occurs while you are using crizotinib, tell your doctor right away. crizotinib may cause swelling of the lungs (pneumonitis). Pneumonitis is a life-threatening condition and requires immediate medical attention. Check with your doctor right away if you have a cough with or without mucous, shortness of breath, troubled breathing, or a fever. Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a slow, fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. Cancer medicines can cause constipation, diarrhea, nausea, or vomiting in most people, sometimes even after receiving medicines to prevent it. Ask your doctor or nurse about other ways to control these side effects. crizotinib may cause dizziness, tiredness, blurred vision, or other vision problems (eg, flashes of lights, floaters, sensitivity of the eyes to light). If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well . Check with your doctor if visual changes occur. Your doctor may want you to have your eyes checked by an ophthalmologist (eye doctor). Talk with your doctor before using crizotinib if you plan to have children. Some men and women who use crizotinib have become infertile (unable to have children). Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. crizotinib Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Black, tarry stools bloating or swelling of the face, arms, hands, lower legs, or feet body aches or pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings chest pain or discomfort cough or hoarseness difficult or labored breathing ear congestion fever or chills headache increased sensitivity to pain or touch lightheadedness, dizziness, or fainting loss of voice lower back or side pain nerve pain painful or difficult urination pale skin rapid weight gain runny or stuffy nose slow or irregular heartbeat sneezing sore throat tightness in the chest ulcers, sores, or white spots in the mouth unsteadiness or awkwardness unusual bleeding or bruising unusual tiredness or weakness unusual weight gain or loss weakness in the arms, hands, legs, or feet Rare Bleeding gums blood in the urine or stools pinpoint red spots on the skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Abdominal or stomach discomfort, pain, or tenderness acid or sour stomach back pain belching change in taste decrease or change in vision decreased appetite diarrhea difficulty having a bowel movement (stool) difficulty with moving difficulty with swallowing heartburn increased sensitivity of the eyes to sunlight indigestion muscle pain or stiffness nausea pain in the joints pain or burning in the throat pain or discomfort in the chest, upper stomach, or throat problems with balance rash redness, swelling, or soreness of the tongue scaling, redness, burning, pain, chapping, swelling, or other signs of inflammation of the lips seeing flashes or sparks of light swelling or inflammation of the mouth trouble sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about crizotinib Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 4 Reviews Add your own review/rating Drug class: multikinase inhibitors Consumer resources Crizotinib Other brands: Xalkori Professional resources Crizotinib (AHFS Monograph) Crizotinib (Wolters Kluwer) Related treatment guides Non-Small Cell Lung Cancer} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Multikinase inhibitors Related Drugs Non-Small Cell Lung Cancer Avastin , methotrexate , Taxol , Opdivo , cisplatin , Taxotere , Tarceva , Keytruda , paclitaxel , nivolumab , gemcitabine , Gemzar , Abraxane , docetaxel , Alimta , bevacizumab , pembrolizumab , pemetrexed , erlotinib , Trexall , Tecentriq , Tagrisso , Cyramza , atezolizumab , More... Crizotinib Rating 4 User Reviews 9.5 /10 4 User Reviews 9.5 Rate it! Related Questions & Answers Has anybody had cough with mucus while on crizotinib? Wine can be drinked while taking crizotinib? Some other alcohol? Read more questions} } now and again
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