skill arsenic trioxide (Intravenous route) AR-se-nik trye-OX-ide Intravenous route(Solution) Some patients with acute promyelocytic leukemia (APL) treated with arsenic trioxide have experienced symptoms similar to a syndrome called the retinoic-acid-acute promyelocytic leukemia (RA-APL) or APL differentiation syndrome, characterized by fever, dyspnea, weight gain, pulmonary infiltrates and pleural or pericardial effusions, with or without leukocytosis. This syndrome can be fatal. At the first signs that could suggest the syndrome, immediately initiate high dose steroids (dexamethasone 10 mg IV twice daily). Arsenic trioxide can cause QT-interval prolongation and complete atrioventricular block. QT prolongation can lead to a torsade de pointes-type ventricular arrhythmia, which can be fatal. Prior to initiating therapy, perform a 12-lead ECG, assess serum electrolytes (potassium, calcium, and magnesium) and creatinine, and correct electrolyte abnormalities. Consider discontinuation of concomitant QT interval-prolonging drugs . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Trisenox Available Dosage Forms: Solution Therapeutic Class: Antineoplastic Agent Slideshow Leukemia Symptoms And Lessons: Is A Solution In Sight? Uses For arsenic trioxide Arsenic trioxide injection is used to treat a type of leukemia (cancer of the blood cells) called acute promyelocytic leukemia (APL) in patients who have not responded to other medication regimens. It may also be used to treat other kinds of cancer, as determined by your doctor. Arsenic trioxide belongs to the general group of medicines called antineoplastics. It interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by arsenic trioxide, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Before you begin treatment with arsenic trioxide, you and your doctor should talk about the benefit of arsenic trioxide as well as the risks of using it. arsenic trioxide is to be given only by or under the immediate supervision of your doctor. Before Using arsenic trioxide In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For arsenic trioxide, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to arsenic trioxide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of arsenic trioxide injection in children. However, safety and efficacy have not been established in children younger than 4 years of age. Geriatric Although appropriate studies on the relationship of age to the effects of arsenic trioxide injection have not been performed in the geriatric population, geriatric-specific problems are not expected to limit the usefulness of arsenic trioxide injection in the elderly. However, elderly patients are more likely to have age-related kidney or liver problems, which may require caution in patients receiving arsenic trioxide. . Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving arsenic trioxide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using arsenic trioxide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Cisapride Dronedarone Foscarnet Lidoflazine Mesoridazine Pimozide Piperaquine Saquinavir Sparfloxacin Terfenadine Thioridazine Ziprasidone Using arsenic trioxide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acecainide Acetazolamide Ajmaline Alfuzosin Amiloride Amiodarone Amitriptyline Amoxapine Amphotericin B Anagrelide Apomorphine Aprindine Aripiprazole Aripiprazole Lauroxil Artemether Asenapine Astemizole Atazanavir Azimilide Azithromycin Azosemide Bedaquiline Bemetizide Bendroflumethiazide Benzthiazide Bretylium Bumetanide Buserelin Buthiazide Canrenoate Canrenone Chloral Hydrate Chloroquine Chlorothiazide Chlorpromazine Chlorthalidone Ciprofloxacin Citalopram Clarithromycin Clomipramine Clopamide Clozapine Crizotinib Cyclobenzaprine Cyclothiazide Dabrafenib Dasatinib Degarelix Delamanid Desipramine Deslorelin Deutetrabenazine Diazoxide Dibenzepin Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Droperidol Ebastine Efavirenz Encainide Enflurane Eplerenone Eribulin Erythromycin Escitalopram Ethacrynic Acid Etozolin Famotidine Felbamate Fenquizone Fingolimod Flecainide Fluconazole Fluoxetine Fosphenytoin Furosemide Galantamine Gatifloxacin Gemifloxacin Glycerin Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Halothane Histrelin Hydrochlorothiazide Hydroflumethiazide Hydroquinidine Hydroxychloroquine Hydroxyzine Ibutilide Iloperidone Imipramine Indapamide Isoflurane Isradipine Itraconazole Ivabradine Ketoconazole Lapatinib Leuprolide Levofloxacin Levomethadyl Lopinavir Lorcainide Lumefantrine Mannitol Mefloquine Methadone Methyclothiazide Metolazone Metronidazole Mifepristone Mizolastine Moxifloxacin Nafarelin Nelfinavir Nilotinib Norfloxacin Nortriptyline Octreotide Ofloxacin Olanzapine Ondansetron Paliperidone Panobinostat Paroxetine Pasireotide Pazopanib Pentamidine Perphenazine Pimavanserin Pipamperone Piretanide Pirmenol Pitolisant Polythiazide Posaconazole Prajmaline Probucol Procainamide Prochlorperazine Promethazine Propafenone Protriptyline Quetiapine Quinethazone Quinidine Quinine Ranolazine Ribociclib Rilpivirine Risperidone Ritonavir Salmeterol Sematilide Sertindole Sevoflurane Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol Spiramycin Spironolactone Sulfamethoxazole Sulpiride Sultopride Sunitinib Tacrolimus Tamoxifen Tedisamil Telaprevir Telavancin Telithromycin Tetrabenazine Ticrynafen Tizanidine Tolterodine Toremifene Torsemide Trazodone Triamterene Trichlormethiazide Trifluoperazine Trimethoprim Trimipramine Triptorelin Urea Vandetanib Vardenafil Vasopressin Vemurafenib Venlafaxine Vinflunine Voriconazole Vorinostat Xipamide Zotepine Zuclopenthixol Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of arsenic trioxide. Make sure you tell your doctor if you have any other medical problems, especially: Congestive heart failure or Heart block or Heart rhythm problems (eg, prolonged QT interval or torsade de pointes), history of or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) These medical problems may increase the risk of experiencing a life threatening heart rhythm problem while taking arsenic trioxide. Kidney disease, severe or Liver disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of arsenic trioxide A nurse or other trained health professional will give you or your child arsenic trioxide in a hospital or cancer clinic. arsenic trioxide is given through a needle placed in one of your veins. Arsenic trioxide often causes nausea and vomiting. However, it is very important that you continue to receive the medicine, even if you have an upset stomach. Ask your doctor for ways to lessen these effects. Precautions While Using arsenic trioxide It is very important that your doctor check your or your child's progress at regular visits to make sure that arsenic trioxide is working properly. Blood and urine tests may be needed to check for unwanted effects. You should not receive arsenic trioxide if you are pregnant. Using arsenic trioxide while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during and after treatment. If you think you or your sexual partner have become pregnant while using the medicine, tell your doctor right away. Tell your doctor right away if you have chest pain or discomfort, chills, cough, difficulty with breathing, eye pain, fever, general feeling of illness, headache, sore throat, unusual tiredness or weakness, or weight gain while using arsenic trioxide. These may be symptoms of a serious condition called retinoic-acid-APL (RA-APL) or APL differentiation syndrome. arsenic trioxide can cause serious heart rhythm problems and heart arrhythmias. Your doctor will monitor you during treatment to assess for heart rhythm problems. Talk to your doctor if you have concerns about this. Using arsenic trioxide may increase your risk of getting other cancers. Talk to your doctor if you have concerns about this risk. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. arsenic trioxide Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Chills convulsions (seizures) cough decreased urine output dry mouth eye pain general feeling of illness headache increased thirst irregular heartbeat loss of appetite mood changes muscle pain or cramps nausea or vomiting numbness or tingling in hands, feet, or lips sore throat trouble breathing unusual tiredness or weakness Less common Abdominal or stomach cramps black, tarry stools bluish lips or skin blurred vision chest pain dizziness or lightheadedness fever flushed, dry skin fruit-like breath odor increased hunger increased urine output irregular or pounding heartbeat or pulse painful or difficult urination sores, ulcers, or white spots on the lips or in the mouth stomachache sweating swollen glands unexplained weight loss unusual bleeding or bruising unusual weight gain Rare Anxiety behavior changes similar to drunkenness bleeding blood in the urine or stools bluish fingernails, palms, or nailbeds bruising cloudy urine cold sweats cool pale skin drowsiness headache large hives or rash persistent bleeding or oozing from puncture sites, mouth, or nose severe nausea shakiness sore mouth or tongue swelling of the eyelids, lips, or face vomiting of blood or material that looks like coffee grounds white patches in the mouth or on the tongue Get emergency help immediately if any of the following symptoms of overdose occur: Symptoms of overdose Confusion convulsions (seizures) muscle weakness, severe Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Diarrhea Less common Acid or sour stomach back pain belching bloating or swelling of the face, hands, lower legs, or feet bone pain constipation flushing heartburn heavy non-menstrual vaginal bleeding indigestion injection site pain, redness, or swelling itching itchy, red skin joint or muscle pain limb pain loss of appetite mental depression neck pain nosebleeds pale skin shivering chills trouble sleeping or getting to sleep weight gain Rare Agitation blisters inside the mouth coughing or spitting up blood earache eye dryness, redness, or pain loss of bowel or bladder control night sweats rapid, shallow breathing ringing in the ears small red or purple spots on skin swelling of the abdominal or stomach area swelling or puffiness of the face or eyelids swollen, painful, or tender lymph glands in the neck, armpit, or groin Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about arsenic trioxide Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: miscellaneous antineoplastics Consumer resources Arsenic trioxide Other brands: Trisenox Professional resources Arsenic Trioxide (AHFS Monograph) Arsenic Trioxide (Wolters Kluwer) Related treatment guides Acute Promyelocytic Leukemia} Drug Status Rx Availability Prescription only D Pregnancy Category Positive evidence of risk N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Miscellaneous antineoplastics Related Drugs Acute Promyelocytic Leukemia tretinoin , Trisenox , arsenic trioxide , Vesanoid , More... Arsenic trioxide Rating 1 User Review 9.0 /10 1 User Review 9.0 Rate it! Help and Support Looking for answers? 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