venture Clobetasol use while Breastfeeding Drugs containing Clobetasol: Temovate, Clobex, Olux, Dermovate, Clobeta+Plus Cream, Clobevate, Cormax, Temovate E, Clobeta+Plus Ointment, Clodan, Show all 16 Olux-E, Olux/Olux-E Kit, Embeline, Cormax Scalp, Temovate Emollient, Embeline E Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Support Group Q & A Compare Alternatives Pricing & Coupons Clobetasol Levels and Effects while Breastfeeding Summary of Use during Lactation Clobetasol has not been studied during breastfeeding. Since only extensive application of the most potent corticosteroids may cause systemic effects in the mother, it is unlikely that short-term application of topical corticosteroids would pose a risk to the breastfed infant by passage into breastmilk. However, it would be prudent to use the least potent drug on the smallest area of skin possible. It is particularly important to ensure that the infant's skin does not come into direct contact with the areas of skin that have been treated. Only the lower potency corticosteroids should be used on the nipple or areola where the infant could directly ingest the drugs from the skin; clobetasol should be avoided on the nipple.[1] Only water-miscible cream or gel products should be applied to the breast because ointments may expose the infant to high levels of mineral paraffins via licking.[2] Any topical corticosteroid should be wiped off thoroughly prior to nursing if it is being applied to the breast or nipple area. Drug Levels Maternal Levels. Relevant published information was not found as of the revision date. Infant Levels. Relevant published information was not found as of the revision date. Effects in Breastfed Infants Topical application of a corticosteroid with relatively high mineralocorticoid activity (isofluprednone acetate) to the mother's nipples resulted in prolonged QT interval, cushingoid appearance, severe hypertension, decreased growth and electrolyte abnormalities in her 2-month-old breastfed infant. The mother had used the cream since birth for painful nipples.[3] A woman who was nursing (extent not stated) her newborn infant was treated for pemphigus with oral prednisolone 25 mg daily, with the dosage increased over 2 weeks to 60 mg daily. She was also taking cetirizine 10 mg daily and topical betamethasone 0.1% twice daily to the lesions. Because of a poor response, the betamethasone was changed to clobetasol propionate ointment 0.05%. She continued breastfeeding throughout treatment and her infant was developing normally at 8 weeks of age and beyond.[4] Effects on Lactation and Breastmilk Relevant published information was not found as of the revision date. Alternate Drugs to Consider (Topical) Hydrocortisone , Topical References 1. Barrett ME, Heller MM, Fullerton Stone H, Murase JE. Dermatoses of the breast in lactation. Dermatol Ther. 2013;26:331-6. PMID: 23914890 2. Noti A, Grob K, Biedermann M et al. Exposure of babies to C(15)-C(45) mineral paraffins from human milk and breast salves. Regul Toxicol Pharmacol. 2003;38(3):317-25. PMID: 14623482 3. De Stefano B, Bongo IG, Borgna-Pignatti C et al. Factitious hypertension with mineralocorticoid excess in an infant. Helv Paediatr Acta. 1983;38:185-9. PMID: 6874387 4. Westermann L, Hugel R, Meier M et al. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012;39:168-71. PMID: 22379622 Clobetasol Identification Substance Name Clobetasol CAS Registry Number 25122-41-2 Drug Class Corticosteroids, Topical Glucocorticoids Anti-Inflammatory Agents Administrative Information LactMed Record Number 72 Last Revision Date 20150310 Disclaimer Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site. Print this page Disclaimer: This information is not intended as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. Use of this website signifies your agreement to the Terms of Use and Online Privacy Policy. More about clobetasol topical Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 99 Reviews Add your own review/rating Drug class: topical steroids Consumer resources Clobetasol topical Clobetasol Cream, Gel, and Ointment Clobetasol Emollient Foam Clobetasol Foam Clobetasol Lotion ... +4 more Other brands: Temovate , Clobex , Olux , Clobevate , ... +9 more Professional resources Clobetasol Propionate (AHFS Monograph) ... +11 more Related treatment guides Lichen Sclerosus Psoriasis Seborrheic Dermatitis Anal Itching ... +8 more Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Clobetasol topical Rating 99 User Reviews 9.0 /10 99 User Reviews 9.0 Rate it! Drug Class Topical steroids official
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