with regards to valdecoxib (Oral route) val-de-KOX-ib Oral route(Tablet) Serious skin reactions (eg, toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme) have been reported in patients receiving valdecoxib, some resulting in death. Patients appear to be at higher risk for these events during the first 2 weeks of treatment, but these may occur at any time. Valdecoxib should be discontinued at the first appearance of skin rash, mucosal lesions, or any other sign of hypersensitivity . Overview Side Effects Interactions Pregnancy Breastfeeding More User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Bextra Available Dosage Forms: Tablet Therapeutic Class: Analgesic Pharmacologic Class: Cyclooxygenase-2 Inhibitor Slideshow A Joint Effort: A Provider's Guide To Orthopedic Pain Options Uses For valdecoxib Valdecoxib is a non-steroidal anti-inflammatory drug. Nonsteroidal anti-inflammatory drugs (also called NSAIDs) are used to relieve some symptoms caused by arthritis (rheumatism), such as inflammation, swelling, stiffness, and joint pain. However, valdecoxib does not cure arthritis and will help you only as long as you continue to take it. It may also be used to treat pain associated with menstrual periods. valdecoxib was available only with your doctor's prescription. Valdecoxib was voluntarily withdrawn from the U.S. market on April 7, 2005 due to safety concerns of increased risk of serious heart problems and skin reactions . Before Using valdecoxib In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For valdecoxib, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to valdecoxib or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Studies on valdecoxib have been done only in adult patients, and there is no specific information comparing use of valdecoxib in children with use in other age groups. Geriatric valdecoxib has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking valdecoxib, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using valdecoxib with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Ketorolac Using valdecoxib with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab Aceclofenac Acemetacin Acenocoumarol Amiloride Amineptine Amitriptyline Amitriptylinoxide Amoxapine Amtolmetin Guacil Anagrelide Apixaban Ardeparin Argatroban Aspirin Balsalazide Bemiparin Bendroflumethiazide Benzthiazide Betamethasone Betrixaban Bismuth Subsalicylate Bivalirudin Bromfenac Budesonide Bufexamac Bumetanide Cangrelor Celecoxib Certoparin Chlorothiazide Chlorthalidone Choline Magnesium Trisalicylate Choline Salicylate Cilostazol Citalopram Clomipramine Clonixin Clopamide Clopidogrel Cortisone Cyclopenthiazide Cyclosporine Dabigatran Etexilate Dalteparin Danaparoid Deflazacort Desipramine Desirudin Desmopressin Desvenlafaxine Dexamethasone Dexibuprofen Dexketoprofen Diazoxide Dibenzepin Diclofenac Diflunisal Digoxin Dipyridamole Dipyrone Dothiepin Doxepin Droxicam Duloxetine Edoxaban Enoxaparin Eplerenone Epoprostenol Eptifibatide Escitalopram Ethacrynic Acid Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Feverfew Floctafenine Fluconazole Flufenamic Acid Fluocortolone Fluoxetine Flurbiprofen Fluvoxamine Fondaparinux Furosemide Ginkgo Gossypol Heparin Hydrochlorothiazide Hydrocortisone Hydroflumethiazide Ibuprofen Iloprost Imipramine Indapamide Indomethacin Ketoconazole Ketoprofen Lepirudin Levomilnacipran Lithium Lofepramine Lornoxicam Loxoprofen Lumiracoxib Magnesium Salicylate Meadowsweet Meclofenamate Mefenamic Acid Melitracen Meloxicam Mesalamine Methotrexate Methyclothiazide Methylprednisolone Metolazone Milnacipran Morniflumate Nabumetone Nadroparin Naproxen Nefazodone Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Nortriptyline Olsalazine Opipramol Oxaprozin Oxyphenbutazone Paramethasone Parecoxib Parnaparin Paroxetine Pemetrexed Pentosan Polysulfate Sodium Pentoxifylline Phenindione Phenprocoumon Phenylbutazone Phenyl Salicylate Piketoprofen Piroxicam Polythiazide Pralatrexate Prasugrel Prednisolone Prednisone Proglumetacin Propyphenazone Proquazone Protein C Protriptyline Reboxetine Reviparin Rivaroxaban Rofecoxib Salicylamide Salicylic Acid Salsalate Sertraline Sibutramine Sodium Salicylate Spironolactone Sulfasalazine Sulindac Tacrolimus Tenoxicam Tianeptine Tiaprofenic Acid Ticagrelor Ticlopidine Tinzaparin Tirofiban Tolfenamic Acid Tolmetin Torsemide Treprostinil Triamterene Trichlormethiazide Trimipramine Trolamine Salicylate Valdecoxib Venlafaxine Vilazodone Vorapaxar Vortioxetine Warfarin Xipamide Using valdecoxib with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Alacepril Atenolol Azilsartan Azilsartan Medoxomil Benazepril Betaxolol Bisoprolol Candesartan Captopril Carteolol Carvedilol Celiprolol Cilazapril Delapril Enalapril Enalaprilat Eprosartan Esmolol Ethinyl Estradiol Fosinopril Imidapril Irbesartan Labetalol Levobunolol Lisinopril Losartan Metipranolol Metoprolol Moexipril Nadolol Nebivolol Norethindrone Olmesartan Oxprenolol Penbutolol Pentopril Perindopril Pindolol Practolol Propranolol Quinapril Ramipril Sotalol Spirapril Telmisartan Temocapril Timolol Trandolapril Valsartan Zofenopril Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of valdecoxib. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse (or history of ) or Bleeding problems or Poor general health or Stomach ulcer or other stomach or intestinal problems or Tobacco use (or recent history of) The chance of side effects may be increased. Allergy to aspirin or other nonsteroidal anti-inflammatory medicines or Asthma with inflammation in the nose (with or without polyps) or with spasm in the breathing tubes caused by aspirin or other non-steroidal anti-inflammatory medicines or Skin rash after taking aspirin or NSAIDs Using valdecoxib with these medicines may cause these problems to become much worse. Allergy to sulfonamides (sulfamethoxazole and trimethoprim [e.g., Bactrim, Cotrim], sulfisoxazole [e.g., Gantrisin]) May be at greater risk of serious skin reactions. Anemia or Dehydration or Fluid retention (swelling of feet or lower legs) or Heart disease or High blood pressure or Kidney disease or Liver disease Valdecoxib may make these conditions worse. Pain after coronary artery bypass graft (CABG) surgery Higher risk of serious heart complications and infection in these patients. Valdecoxib should not be used. Proper Use of valdecoxib Dosing The dose of valdecoxib will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of valdecoxib. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. The following section is for information only, since the drug is no longer available. Oral dosage form (tablets): For dysmenorrhea (pain with your menstrual period) For osteoarthritis For rheumatoid arthritis Missed Dose If you miss a dose of valdecoxib, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using valdecoxib If you will be taking valdecoxib for a long time, it is very important that your doctor check you at regular visits. Stomach problems may be more likely to occur if you drink alcoholic beverages while being treated with valdecoxib. Therefore, do not regularly drink alcoholic beverages while taking valdecoxib, unless otherwise directed by your doctor. Serious side effects can occur during treatment with valdecoxib. Sometimes serious side effects can occur without any warning. However, possible warning signs often occur, including swelling of the face, fingers, feet, and/or lower legs; severe stomach pain, black, sticky stools, and/or vomiting of blood or material that looks like coffee grounds; unusual weight gain; and/or skin rash. Stop taking valdecoxib and check with your doctor immediately if you notice any of these warning signs. Serious skin reactions can occur during treatment with valdecoxib. Check with your doctor right away if you have any of the following symptoms while taking valdecoxib: blistering, peeling, loosening of skin, chills, cough, diarrhea, fever, itching, joint or muscle pain, red irritated eyes, red skin lesions, often with a purple center, sore throat, sores, ulcers, white spots in mouth or on lips, or unusual tiredness or weakness. Check with your doctor immediately if fever, drowsiness, itching of the skin, tiredness, nausea, or stomach pain occurs; these effects may be the first signs of liver toxicity. Valdecoxib may cause a serious type of allergic reaction called anaphylaxis. Although this is rare, it may occur often in patients who are allergic to aspirin, other nonsteroidal anti-inflammatory drugs, or sulfonamide-type drugs. Anaphylaxis requires immediate medical attention. The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, wheezing, or fainting. Other signs may include changes in color of the skin of the face; very fast but irregular heartbeat or pulse; hive-like swellings on the skin; and puffiness or swellings of the eyelids or around the eyes. If these effects occur, get emergency help at once. Do not try to drive yourself. Call an ambulance, lie down, cover yourself to keep warm, and prop your feet higher than your head. Stay in that position until help arrives. valdecoxib Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Bloating or swelling of face, arms, hands, lower legs, feet blood in urine bloody, black, or sticky stools blurred vision chills decreased or painful urination dizziness fever muscle aches and pains nausea nervousness pale skin pounding in the ears rapid weight gain severe stomach pain tingling of the hands or feet trouble breathing with exertion unusual bleeding or bruising unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds yellow eyes or skin Incidence not known Blistering, peeling, loosening of skin constipation cracks in the skin darkened urine difficulty swallowing fast heartbeat hives indigestion itching itching, puffiness, or swelling of the eyelids or around the eyes, face, lips, or tongue joint or muscle pain large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, sex organs loss of appetite loss of heat from the body nausea pains in stomach, side, or abdomen, possibly radiating to the back red skin lesions, often with a purple center red, irritated eyes red, swollen skin scaly skin shortness of breath skin rash sores, ulcers, or white spots in mouth or on lips tightness in chest vomiting wheezing yellow eyes or skin Symptoms of overdose Get emergency help immediately if any of the following symptoms of overdose occur: Bloody or black tarry stools continuing thirst dizziness drowsiness headache, severe or continuing nausea and/or vomiting shortness of breath stomach pain sudden decrease in the amount of urine swelling of face, fingers, and/or lower legs tightness in chest and/or wheezing troubled breathing unusual tiredness or weakness vomiting of blood or material that looks like coffee grounds weight gain Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Acid or sour stomach belching cough diarrhea ear congestion headache heartburn indigestion sore throat Less common Abdominal fullness accidental injury back pain bloating in the abdomen excess gas rash stuffy or runny nose Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. 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Next Side Effects Print this page Add to My Med List More about valdecoxib Side Effects During Pregnancy or Breastfeeding Drug Interactions Support Group 11 Reviews Add your own review/rating Drug class: cox-2 inhibitors Consumer resources Other brands: Bextra Professional resources Related treatment guides Osteoarthritis Pain Period Pain Rheumatoid Arthritis} Drug Status Availability Discontinued C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Cox-2 inhibitors Related Drugs Pain tramadol , acetaminophen , Tylenol , naproxen , oxycodone , More... Rheumatoid Arthritis Humira , hydroxychloroquine , Plaquenil , sulfasalazine , leflunomide , Enbrel , More... Period Pain naproxen , ibuprofen , diclofenac , Voltaren , Aleve , Celebrex , More... Osteoarthritis prednisone , naproxen , Cymbalta , aspirin , ibuprofen , meloxicam , More... Valdecoxib Rating 11 User Reviews 9.2 /10 11 User Reviews 9.2 Rate it! 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