the hundreds Aldurazyme (Intravenous) Generic Name: laronidase (Intravenous route) lar-ON-i-dase Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Pricing & Coupons Intravenous route(Solution) Life-threatening anaphylactic reactions have been reported in some patients during laronidase infusions. Therefore, when laronidase is administered, appropriate medical support should be readily available. Patients with compromised respiratory function or acute respiratory disease may be at risk of serious acute exacerbation of their respiratory condition due to infusion reactions and need additional monitoring . Commonly used brand name(s) In the U.S. Aldurazyme Available Dosage Forms: Solution Therapeutic Class: Endocrine-Metabolic Agent Pharmacologic Class: Enzyme Slideshow Shingles: Settling The Score Uses For Aldurazyme Laronidase is used to treat Hurler and Hurler-Schele syndrome forms of mucopolysaccharidosis (MPS I) disease caused by the lack of a certain enzyme called α-L-iduronidasein the body. Laronidase is available only with your doctor's prescription. Before Using Aldurazyme In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of laronidase in children younger than 5 years of age. Safety and efficacy have not been established . Geriatric Appropriate studies on the relationship of age to the effects of laronidase have not been performed in the geriatric population . Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine. Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Breathing problems or Lung disease Use with caution. May make these conditions worse . Proper Use of Aldurazyme A nurse or other trained health professional will give you this medicine. This medicine is given through a needle placed in one of your veins . You may also be given other medicines to keep you from having a fever or to prevent allergic reactions before you receive the injection . Precautions While Using Aldurazyme It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it . This medicine may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; lightheadedness; slow or irregular heartbeat; shortness of breath; trouble breathing; or chest pain or tightness after you get the injection . Aldurazyme Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor or nurse immediately if any of the following side effects occur: More common Abdominal or stomach pain accumulation of pus back pain black, tarry stools bleeding gums blood in urine or stools blurred vision chest pain chest tightness chills clay-colored stools confusion dark urine dizziness drowsiness facial swelling faintness fast, pounding, or irregular heartbeat or pulse fever flushing headache hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at injection site itching lightheadedness when getting up from a lying or sitting position suddenly loss of appetite nausea or vomiting pale skin pinpoint red spots on skin shortness of breath skin rash sweating swollen, red, or tender area of infection trouble breathing unpleasant breath odor unusual bleeding or bruising unusual tiredness or weakness vomiting of blood yellow eyes or skin Less common Cough difficulty breathing itching skin large, hive-like swelling on face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs noisy breathing redness of skin tightness in chest wheezing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bleeding, blistering, burning, coldness, or discoloration of skin blindness body aches or pain burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings decreased vision diarrhea difficulty in moving ear congestion feeling of pressure loss of voice muscle pain or stiffness nasal congestion overactive reflexes pain in joints runny nose sneezing sore throat swelling of legs and feet swelling or puffiness of face varicose or spider veins Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about Aldurazyme (laronidase) Side Effects During Pregnancy Dosage Information Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: lysosomal enzymes Consumer resources Aldurazyme Professional resources Aldurazyme (AHFS Monograph) Aldurazyme (FDA) Related treatment guides Mucopolysaccharidosis Type I} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Genzyme Corporation Sanofi-Aventis U.S. LLC BioMarin Pharmaceutical Inc. Drug Class Lysosomal enzymes Related Drugs Mucopolysaccharidosis Type I n/a Aldurazyme Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! Help and Support Looking for answers? 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