the plain Epclusa (Oral) Generic Name: sofosbuvir and velpatasvir (Oral route) soe-FOS-bue-vir, vel-PAT-as-vir Oral route(Tablet) Test all patients for evidence of current or prior hepatitis B virus (HBV) infection before initiating treatment with sofosbuvir/velpatasvir. HBV reactivation has been reported in HCV/HBV coinfected patients who were undergoing or had completed treatment with HCV direct acting antivirals and were not receiving HBV antiviral therapy. Some cases have resulted in fulminant hepatitis, hepatic failure, and death. Monitor HCV/HBV coinfected patients for hepatitis flare or HBV reactivation during HCV treatment and post-treatment follow-up. Initiate appropriate patient management for HBV infection as clinically indicated . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Drug Images Support Group Q & A Compare Alternatives Pricing & Coupons Commonly used brand name(s) In the U.S. Epclusa Available Dosage Forms: Tablet Therapeutic Class: Antiviral Pharmacologic Class: Hepatitis C Virus NS5A Inhibitor Slideshow The Top 10 Most Expensive Disease Treatments Uses For Epclusa Sofosbuvir and velpatasvir combination is used with or without ribavirin to treat chronic hepatitis C infection in adults (including with or without cirrhosis). This medicine is available only with your doctor's prescription. Before Using Epclusa In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of sofosbuvir and velpatasvir combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sofosbuvir and velpatasvir combination in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Amiodarone Bosentan Carbamazepine Dexlansoprazole Efavirenz Enzalutamide Esomeprazole Fosphenytoin Lansoprazole Mitotane Modafinil Nafcillin Netupitant Omeprazole Oxcarbazepine Pantoprazole Phenobarbital Phenytoin Primidone Rabeprazole Rifabutin Rifampin Rifapentine St John's Wort Tipranavir Topotecan Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Digoxin Rosuvastatin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Heart disease Use with caution. May make this condition worse. Hepatitis B, or history of Use with caution. May cause this condition to become active again. Proper Use of Epclusa Take this medicine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a patient information leaflet. Read and follow the information carefully. Ask your doctor if you have any questions. You may take this medicine with or without food. Swallow the tablet whole. Do not crush, break, or chew it. To help clear up your infection completely, sofosbuvir and velpatasvir combination must be taken for the full time of treatment , even if you begin to feel better after a few days. Also, it is important to keep the amount of medicine in your body at a steady level. To help keep the amount constant, this medicine must be used on a regular schedule. If you take an antacid that contains aluminum or magnesium, take it 4 hours before or after you take this medicine. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For hepatitis C virus infection: Adults One tablet once a day, taken for 12 weeks. Each tablet contains sofosbuvir 400 milligrams (mg) and velpatasvir 100 mg. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Epclusa It is very important that your doctor check your progress at regular visits . This is to make sure that this medicine is working properly and to check for unwanted effects. Do not take this medicine together with other products containing sofosbuvir (eg, Sovaldi ). Amiodarone can cause serious side effects (such as cardiac arrest, slow heartbeat, conditions that need pacemaker) if used together with sofosbuvir in combination with simeprevir or daclatasvir, or if you have used it recently. This is more likely to occur in patients with heart disease or advanced liver disease. Tell your doctor if you are taking amiodarone before using this medicine. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements. Epclusa Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Incidence not known Chest pain or discomfort lightheadedness, dizziness or fainting slow or irregular heartbeat trouble breathing unconsciousness unusual tiredness Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Headache unusual tiredness or weakness Less common Diarrhea discouragement feeling sad or empty irritability lack of appetite, nausea lack or loss of strength loss of interest or pleasure rash trouble concentrating trouble sleeping Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. 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Next Side Effects Print this page Add to My Med List More about Epclusa (sofosbuvir / velpatasvir) Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Compare Alternatives Support Group Pricing & Coupons En Español 75 Reviews Add your own review/rating Drug class: antiviral combinations Consumer resources Epclusa Professional resources Epclusa (AHFS Monograph) Epclusa (FDA) Related treatment guides Hepatitis C} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Gilead Sciences, Inc. Drug Class Antiviral combinations Related Drugs Hepatitis C Harvoni , ribavirin , Zepatier , Mavyret , Sovaldi , sofosbuvir , ledipasvir / sofosbuvir , Vosevi , Viekira Pak , daclatasvir , Daklinza , Pegasys , Intron A , Ribasphere , Olysio , sofosbuvir / velpatasvir , Rebetol , simeprevir , Moderiba , PegIntron , elbasvir / grazoprevir , glecaprevir / pibrentasvir , RibaPak , More... Epclusa Rating 75 User Reviews 8.0 /10 75 User Reviews 8.0 Rate it! Epclusa Images Epclusa sofosbuvir 400 mg / velpatasvir 100 mg (GSI 7916) View larger images Related Questions & Answers How much does Epclusa cost? What is the NDC for Epclusa? Epclusa - Hey guys I just started taking this new medication my 1st week. How are you all doing with Epclusa - I have Medicare and GHI (Emblem Health) insurance. Will this mediine be covered under my? Can I take turmeric while on Epclusa? Read more questions} } classic
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