most pretty [1%:1 vaccine on the same day at different anatomic sites) of all age-appropriate vaccines (live or inactivated) for which a person is eligible at a single clinic visit, unless contraindications exist. The ACIP prefers each dose of a specific vaccine in a series come from the same manufacturer when possible; however vaccination should not be deferred because a specific brand name is unavailable (ACIP [Kroger 2017]). Special populations: Adults: Not intended for use in adults. Immunocompromised family members: Virus from live virus vaccines may be transmitted to nonvaccinated contacts; use with caution in the presence of immunocompromised family members. Viral shedding occurs within the first weeks of administration; peak viral shedding generally occurs ~7 days after the first dose. The ACIP recommends vaccination of infants living in households with persons who are immunocompromised (CDC/ACIP [Cortese 2009]). Immunocompromised infants: Severely immunocompromised patients (eg, patients receiving chemo/radiation therapy or other immunosuppressive therapy [including high-dose corticosteroids]) generally should not receive live vaccines; may have a reduced response to vaccination or may have an adverse event secondary to replication. May be administered with topical corticosteroids or inhaled steroids, or to infants with primary and acquired immunodeficiencies (including HIV/AIDS, cellular immune deficiencies, hypogammaglobulinemic and dysgammaglobulinemic states). Household and close contacts of persons with altered immunocompetence may receive most age appropriate vaccines. Live vaccines should be administered 4 weeks prior to planned immunosuppression and avoided within 2 weeks of immunosuppression when feasible; live vaccines should not be administered for at least 3 months after immunosuppressive therapy (ACIP [Kroger 2017]). Specific recommendations for use of this vaccine in immunocompromised patients as well as contacts of immunocompromised patients are available from the IDSA (IDSA [Rubin 2014]). Dosage form specific issues: Latex: Some packaging may contain natural latex/natural rubber Other warnings/precautions: Antipyretics: Antipyretics have not been shown to prevent febrile seizures; antipyretics may be used to treat fever or discomfort following vaccination (ACIP [Kroger 2017]). One study reported that routine prophylactic administration of acetaminophen prior to vaccination to prevent fever decreased the immune response of some vaccines; the clinical significance of this reduction in immune response has not been established (Prymula 2009). Appropriate use: Administration errors have been reported. This vaccine is for oral administration only; doses inadvertently administered by injection are not considered valid and an oral replacement dose should be given according to the appropriate age and schedule (CDC [Hibbs 2014]). Effective immunity: Vaccination may not result in effective immunity in all patients. Response depends upon multiple factors (eg, type of vaccine, age of patient) and may be improved by administering the vaccine at the recommended dose, route, and interval. Vaccines may not be effective if administered during periods of altered immune competence (ACIP [Kroger 2017]). Postexposure prophylaxis: Information is not available for use in postexposure prophylaxis. Pregnancy Risk Factor C Pregnancy Considerations Reproduction studies have not been conducted. Not indicated for use in women of reproductive age. Infants living in households with pregnant women may be vaccinated (CDC/ACIP [Cortese, 2009]). Patient Education Discuss specific use of vaccine and side effects with caregiver as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Patient may experience irritability, rhinorrhea, lack of appetite, abnormal crying, or pharyngitis. Have caregiver report immediately to prescriber ear pain, wheezing, cough, blood in stool, severe diarrhea, vomiting, abdominal pain, or signs of Kawasaki disease (high fever, rash, red eyes or mouth, swollen glands, or swelling in the arms or legs) (HCAHPS). Educate caregiver about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Caregiver should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Next Interactions Print this page Add to My Med List More about rotavirus vaccine Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: viral vaccines Consumer resources Rotavirus vaccine, live Rotavirus Oral Vaccine Rotavirus vaccine, live (Advanced Reading) Professional resources Rotavirus Vaccine Live Oral (AHFS Monograph) Other brands: RotaTeq , Rotarix Related treatment guides Gastroenteritis] Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Rotavirus vaccine Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! 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