and so forth edoxaban (Oral route) e-DOX-a-ban Oral route(Tablet) Edoxaban should not be used in patients with nonvalvular arterial fibrillation who have a CrCl greater than 95 mL/min due to an increased risk of ischemic stroke. Premature discontinuation of oral anticoagulant therapy may increase the risk of ischemic events. If edoxaban is discontinued for reasons other than pathological bleeding or therapy completion, consider covering with an alternative anticoagulant. Epidural or spinal hematomas, possibly resulting in permanent paralysis, may occur with edoxaban use during neuraxial anesthesia or spinal puncture. Consider the risk of edoxaban use in patients undergoing spinal procedures . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Savaysa Available Dosage Forms: Tablet Therapeutic Class: Anticoagulant Pharmacologic Class: Factor Xa Inhibitor Slideshow Atrial Fibrillation - Stroke Prevention Guidelines & Treatment Options Uses For edoxaban Edoxaban is used to prevent stroke and blood clots in patients with a certain heart rhythm problem (eg, nonvalvular atrial fibrillation). Edoxaban is also used to treat deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and can become lodged in the blood vessels of the lungs, causing a condition called pulmonary embolism. edoxaban is used in patients who have been treated with an injectable blood thinner for 5 to 10 days. Edoxaban is a factor Xa inhibitor, an anticoagulant. It works by decreasing the clotting ability of the blood and helps preventing harmful clots from forming in the blood vessels. edoxaban is available only with your doctor's prescription. Before Using edoxaban In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For edoxaban, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to edoxaban or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of edoxaban in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of edoxaban in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking edoxaban, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using edoxaban with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Defibrotide Using edoxaban with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Abciximab Aceclofenac Acemetacin Acenocoumarol Alteplase, Recombinant Amtolmetin Guacil Anagrelide Anistreplase Apixaban Ardeparin Argatroban Aspirin Bemiparin Betrixaban Bivalirudin Bromfenac Bufexamac Cangrelor Celecoxib Certoparin Choline Salicylate Cilostazol Citalopram Clonixin Clopidogrel Dabigatran Etexilate Dalteparin Danaparoid Desirudin Desvenlafaxine Dexibuprofen Dexketoprofen Diclofenac Diflunisal Dipyridamole Dipyrone Droxicam Duloxetine Enoxaparin Epoprostenol Eptifibatide Escitalopram Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Fluoxetine Flurbiprofen Fluvoxamine Fondaparinux Heparin Ibuprofen Iloprost Indomethacin Ketoprofen Ketorolac Lepirudin Levomilnacipran Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Milnacipran Morniflumate Nabumetone Nadroparin Naproxen Nefazodone Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Orlistat Oxaprozin Oxyphenbutazone Parecoxib Parnaparin Paroxetine Phenindione Phenprocoumon Phenylbutazone Piketoprofen Piracetam Piroxicam Pranoprofen Prasugrel Proglumetacin Propyphenazone Proquazone Protein C Reteplase, Recombinant Reviparin Rifampin Rivaroxaban Rofecoxib Salicylic Acid Salsalate Selexipag Sertraline Sibutramine Sodium Salicylate Streptokinase Sulfinpyrazone Sulindac Tenecteplase Tenoxicam Tiaprofenic Acid Ticlopidine Tinzaparin Tirofiban Tolfenamic Acid Tolmetin Treprostinil Urokinase Valdecoxib Venlafaxine Vilazodone Vorapaxar Vortioxetine Warfarin Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of edoxaban. Make sure you tell your doctor if you have any other medical problems, especially: Artificial heart valve or Heart valve disease (mitral stenosis) or Kidney disease, severe or Liver disease, moderate or severe Use is not recommended in patients with these conditions. Bleeding, active Should not be used in patients with this condition. Bleeding problems, history of or Catheter insertion in the spine or Surgery (eg, spine), recent or history of Use with caution. The risk of bleeding may be increased. Kidney disease, moderate Use with caution. The effects may be increased because of slower removal of the medicine from the body. Proper Use of edoxaban Take edoxaban exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. When your supply of edoxaban is running low, contact your doctor or pharmacist ahead of time. Do not allow yourself to run out of edoxaban . edoxaban comes with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor if you have any questions. You may take edoxaban with or without food. If you are using another medicine to thin the blood (eg, heparin, warfarin, Coumadin , Jantoven ), your doctor will give you very specific instructions about how to switch to edoxaban. Carefully follow the instructions and ask your doctor if you have any questions. Dosing The dose of edoxaban will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of edoxaban. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For prevention of strokes and blood clots in patients with nonvalvular atrial fibrillation: Adults 60 milligrams (mg) once a day. Children Use and dose must be determined by your doctor. For treatment of deep venous thrombosis and pulmonary embolism: Adults 60 milligrams (mg) once a day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of edoxaban, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using edoxaban It is very important that your doctor check your progress at regular visits to make sure that edoxaban is working properly and to decide if you should continue to take it. Blood and urine tests may be needed to check for unwanted effects. Make sure any doctor who treats you knows that you are using edoxaban. You may need to stop using edoxaban for several days before having surgery, including dental procedures. Do not suddenly stop using edoxaban without asking your doctor . You might have a higher risk of stroke after you stop using edoxaban. Check with your doctor right away if you have any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, headache, dizziness, or weakness, pain, swelling, or discomfort in a joint, pinpoint red spots on your skin, unusual nosebleeds, or unusual vaginal bleeding that is heavier than normal. These may be signs of bleeding problems. edoxaban may increase risk of blood clot in the spine or epidural area, which may lead to long-term or permanent paralysis. This is more likely to occur if you have an epidural catheter placed in your back, are taking NSAID or blood clotting medicine, a history of repeated epidural punctures or problems with your spine, or have had surgery on your spine. Tell your doctor right away if you have back pain, loss of bladder or bowel control, tingling, numbness, or muscle weakness, especially in your legs and feet. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. edoxaban Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloody nose heavy non-menstrual vaginal bleeding pale skin troubled breathing with exertion unusual bleeding or bruising unusual tiredness or weakness Less common Bloody or black, tarry stools vomiting of blood or material that looks like coffee grounds Rare Confusion cough difficulty with speaking double vision fever headache, sudden, severe inability to move the arms, legs, or facial muscles inability to speak nausea and vomiting slow speech Incidence not known Back pain bowel or bladder dysfunction burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings leg weakness paralysis Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Less common Rash Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about edoxaban Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 1 Review Add your own review/rating Drug class: factor Xa inhibitors Consumer resources Edoxaban Other brands: Savaysa Professional resources Edoxaban Tosylate (AHFS Monograph) Edoxaban (Wolters Kluwer) Related treatment guides Pulmonary Embolism Atrial Fibrillation Deep Vein Thrombosis Prevention of Thromboembolism in Atrial Fibrillation} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Factor Xa inhibitors Related Drugs Atrial Fibrillation diltiazem , Xarelto , propranolol , digoxin , sotalol , flecainide , More... Prevention of Thromboembolism in Atrial Fibrillation aspirin , warfarin , Xarelto , Eliquis , Coumadin , More... Deep Vein Thrombosis Xarelto , Eliquis , Pradaxa , apixaban , Lovenox , enoxaparin , More... Pulmonary Embolism Xarelto , Eliquis , Pradaxa , apixaban , rivaroxaban , heparin , More... Edoxaban Rating 1 User Review 1.0 /10 1 User Review 1.0 Rate it! Help and Support Looking for answers? Ask a question or go join the edoxaban support group to connect with others who have similar interests.} } to flamable
an easy way edoxaban (Oral route) most beneficial
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