easiest way sarilumab (Subcutaneous route) sar-IL-ue-mab Subcutaneous route(Solution) Serious infections leading to hospitalization or death including bacterial, viral, invasive fungal, and other opportunistic infections have occurred in patients receiving sarilumab.If a serious infection develops, interrupt sarilumab until the infection is controlled.Cases of tuberculosis (TB) have been reported. Prior to starting sarilumab, test for latent TB; if positive, start treatment for TB.Closely monitor patients for signs and symptoms of infection during treatment with sarilumab . Commonly used brand name(s) In the U.S. Kevzara Available Dosage Forms: Solution Therapeutic Class: Antirheumatic Pharmacologic Class: Monoclonal Antibody Uses For sarilumab Sarilumab injection is used alone or together with other medicines (eg methotrexate) to treat symptoms of moderate to severe rheumatoid arthritis. Sarilumab helps keep joint damage from getting worse after other medicines have been used and did not work well. It is a monoclonal antibody. sarilumab is available only with your doctor's prescription. Before Using sarilumab In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sarilumab, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to sarilumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of sarilumab injection in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sarilumab injection in the elderly. However, elderly patients are more likely to have serious infections, which may require caution in patients receiving sarilumab injection. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sarilumab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using sarilumab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Adenovirus Vaccine Bacillus of Calmette and Guerin Vaccine, Live Cholera Vaccine, Live Influenza Virus Vaccine, Live Measles Virus Vaccine, Live Mumps Virus Vaccine, Live Poliovirus Vaccine, Live Rotavirus Vaccine, Live Rubella Virus Vaccine, Live Smallpox Vaccine Typhoid Vaccine Varicella Virus Vaccine Yellow Fever Vaccine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of sarilumab. Make sure you tell your doctor if you have any other medical problems, especially: Cancer, or history of or Hyperlipidemia (high fats in the blood) or Liver disease or Neutropenia (low level of white blood cells) or Stomach or bowel disease (eg, diverticulitis, ulcer) or Thrombocytopenia (low number of platelets in the blood) or Weak immune system (eg, HIV, cancer, steroid use) Use with caution. May make these conditions worse. Herpes zoster, history of or Tuberculosis, history of Use with caution. May cause infections to come back (reactivate). Infections (eg, hepatitis B, bacteria, virus, fungus), active or recurring or Liver disease, active Should not be used in patients with these conditions. Proper Use of sarilumab sarilumab is given as a shot under your skin. Sarilumab may sometimes be given at home to patients who do not need to be in the hospital. If you or your child are using sarilumab at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand exactly how to use sarilumab. sarilumab comes with a Medication Guide and patient instructions. Read and follow these instructions carefully. Ask your doctor if you have any questions. If you use sarilumab at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems. Allow the medicine to warm to room temperature for 30 minutes before using it. Do not warm sarilumab in any other way. Check the liquid in the prefilled syringe. It should be clear and colorless or slightly yellow. Do not use sarilumab if it is cloudy, discolored, if there are particles in it, or if the prefilled syringe is damaged or broken. Do not shake the medicine. Do not inject into skin areas that are red, bruised, tender, hard, or have scars or stretch marks. Throw away used needles in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets. Dosing The dose of sarilumab will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of sarilumab. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For injection dosage form: For moderate to severe rheumatoid arthritis: Adults At first, 200 milligrams (mg) injected under your skin once every 2 weeks. Your doctor may reduce the dose to 150 mg once every 2 weeks as needed. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of sarilumab, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store in the refrigerator. Do not freeze. Keep the medicine in the original package until you are ready to use it. You may also keep the medicine at room temperature, away from heat, after removing it from the refrigerator. Throw away unused medicine after 14 days. Precautions While Using sarilumab It is very important that your doctor check your progress at regular visits to make sure that sarilumab is working properly. Blood tests may be needed to check for unwanted effects. Sarilumab injection will lower the number of some types of blood cells in your body. Because of this, you may bleed or get infections more easily. To help with these problems, avoid being near people who are sick or have infections. Wash your hands often. Stay away from rough sports or other situations where you could be bruised, cut, or injured. Brush and floss your teeth gently. Be careful when using sharp objects, including razors and fingernail clippers. Tell your doctor if you have any kind of infection before you start using sarilumab. Also tell your doctor if you have ever had an infection that would not go away or an infection that keeps coming back. Call your doctor right away if you start to have a cough that will not go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. These may be signs that you have an infection. You will need to have a skin test for tuberculosis before you start using sarilumab. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test. sarilumab may cause serious stomach and bowel problems, especially if you have a history of ulcers or diverticulitis (inflammation of the intestines). Check with your doctor right away if you start having severe stomach cramps or pain, black, tarry stools, diarrhea, fever, or vomiting that is severe and sometimes bloody while being treated with sarilumab. sarilumab may increase the amount of cholesterol and fats in your blood. If this condition occurs, your doctor may give you some medicines that can lower the amount of cholesterol and fats in the blood. Sarilumab injection may increase your risk of having certain cancers. Talk to your doctor if you have unusual bleeding, bruising, or weakness, swollen lymph nodes in the neck, underarms, or groin, or unexplained weight loss. Also, check with your doctor right away if your skin has red, scaly patches, or raised bumps that are filled with pus. sarilumab may cause serious allergic reactions, including anaphylaxis. This can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after using sarilumab. Do not have any live vaccines (immunizations) while you are being treated with sarilumab. Check with your doctor before having any vaccines. sarilumab Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bloody, black, or tarry stools chills cough fever lower back or side pain painful or difficult urination pale skin sore throat ulcers, sores, or white spots in the mouth unusual bleeding or bruising unusual tiredness or weakness Less common Bladder pain bloody or cloudy urine body ache or pain difficulty breathing ear congestion frequent urge to urinate headache loss of voice nasal congestion painful cold sores or blisters on the lips runny nose sneezing Rare Difficulty swallowing dizziness fast heartbeat heartburn hives, itching, skin rash indigestion nausea puffiness or swelling of the eyelids or around the eyes, face, lips or tongue severe stomach pain, cramping, or burning tightness in the chest vomiting of material that looks like coffee grounds, severe and continuing Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Print this page The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved.} Recently Approved Lonhala Magnair Lonhala Magnair (glycopyrrolate) is a long-acting muscarinic antagonist (LAMA) bronchodilator for... Ozempic Ozempic (semaglutide) is a glucagon-like peptide-1 (GLP-1) analog administered once-weekly for the... Ogivri Ogivri (trastuzumab-dkst) is a HER2 / neu receptor antagonist biosimilar to Herceptin indicated for... Sublocade Sublocade (buprenorphine) is a once-monthly injectable partial opioid agonist formulation for the... More Help and Support Looking for answers? Ask a question} } and have become
ask for forgiveness sarilumab (Subcutaneous route) even though
EmoticonEmoticon