enterprise sacubitril and valsartan (Oral route) sak-UE-bi-tril, val-SAR-tan Oral route(Tablet) Drugs that act directly on the renin-angiotensin system may cause fetal injury or death. Discontinue use immediately if pregnancy is detected . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Entresto Available Dosage Forms: Tablet Therapeutic Class: Cardiovascular Agent Pharmacologic Class: Angiotensin II Receptor Antagonist Slideshow Love Your Dad? Here's 10 Heart-Healthy Gifts For Father's Day Uses For sacubitril and valsartan Sacubitril and valsartan combination is used together with other medicines to treat chronic heart failure in adults and cut down on the number of hospital visits for heart problems. sacubitril and valsartan is available only with your doctor's prescription. Before Using sacubitril and valsartan In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For sacubitril and valsartan, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to sacubitril and valsartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of sacubitril and valsartan combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of sacubitril and valsartan combination in the elderly. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking sacubitril and valsartan, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using sacubitril and valsartan with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Aliskiren Benazepril Captopril Enalapril Enalaprilat Fosinopril Lisinopril Moexipril Perindopril Quinapril Ramipril Trandolapril Zofenopril Using sacubitril and valsartan with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Benazepril Captopril Enalapril Enalaprilat Fosinopril Lisinopril Lithium Moexipril Perindopril Quinapril Ramipril Simeprevir Trandolapril Trimethoprim Using sacubitril and valsartan with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Aceclofenac Acemetacin Amtolmetin Guacil Bromfenac Bufexamac Celecoxib Choline Salicylate Clonixin Dexibuprofen Dexketoprofen Diclofenac Diflunisal Dipyrone Droxicam Etodolac Etofenamate Etoricoxib Felbinac Fenoprofen Fepradinol Feprazone Floctafenine Flufenamic Acid Flurbiprofen Ibuprofen Indomethacin Ketoprofen Ketorolac Lornoxicam Loxoprofen Lumiracoxib Meclofenamate Mefenamic Acid Meloxicam Morniflumate Nabumetone Naproxen Nepafenac Niflumic Acid Nimesulide Nimesulide Beta Cyclodextrin Oxaprozin Oxyphenbutazone Parecoxib Phenylbutazone Piketoprofen Piroxicam Proglumetacin Propionic Acid Propyphenazone Proquazone Rofecoxib Salicylic Acid Salsalate Sodium Salicylate Sulindac Tenoxicam Tiaprofenic Acid Tolfenamic Acid Tolmetin Valdecoxib Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of sacubitril and valsartan. Make sure you tell your doctor if you have any other medical problems, especially: Angioedema caused by ACE inhibitor or ARB therapy, history of or Patients with diabetes who are also taking aliskiren (Tekturna ) Should not be used in patients with these conditions. Kidney disease, severe or Liver disease, moderate Use with caution. The effects may be increased because of slower removal of the medicine from the body. Liver disease, severe Use is not recommended in patients with this condition. Proper Use of sacubitril and valsartan Take sacubitril and valsartan exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. sacubitril and valsartan comes with a patient information insert. Read and follow the instructions carefully. Ask your doctor if you have any questions. Dosing Tell your doctor if you have ever had any unusual or allergic reaction to sacubitril and valsartan or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. For oral dosage form (tablets): For heart failure: Adults At first, one tablet two times a day. Your doctor may increase your dose as needed and tolerated. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of sacubitril and valsartan, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using sacubitril and valsartan It is very important that your doctor check your or your child's progress at regular visits to make sure that sacubitril and valsartan is working properly. Blood and urine tests may be needed to check for unwanted effects. Using sacubitril and valsartan while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using sacubitril and valsartan, tell your doctor right away. Do not take sacubitril and valsartan for at least 36 hours before or after you take an ACE inhibitor medicine . Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position or if you have been taking a diuretic (water pill). Make sure you know how you react to sacubitril and valsartan before you drive, use machines, or do anything else that could be dangerous if you are dizzy . If you feel dizzy, lie down so you do not faint. Then sit for a few moments before standing to prevent the dizziness from returning. Ask your doctor before you use medicines, supplements, or salt substitutes that contain potassium . Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. sacubitril and valsartan Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Abdominal or stomach pain blurred vision confusion difficult breathing dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position irregular heartbeat nausea or vomiting nervousness numbness or tingling in the hands, feet, or lips sweating unusual tiredness or weakness weakness or heaviness of the legs Less common Bloody urine decreased frequency or amount of urine increased thirst loss of appetite lower back or side pain swelling of the face, fingers, or lower legs weight gain Rare Large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Cough dizziness Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. 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Next Side Effects Print this page Add to My Med List More about sacubitril/valsartan Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 16 Reviews Add your own review/rating Drug class: angiotensin receptor blockers and neprilysin inhibitors Consumer resources Sacubitril and valsartan Other brands: Entresto Professional resources Sacubitril and Valsartan (AHFS Monograph) Sacubitril and Valsartan (Wolters Kluwer) Related treatment guides Heart Failure} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Angiotensin receptor blockers and neprilysin inhibitors Related Drugs Heart Failure amlodipine , lisinopril , furosemide , carvedilol , metoprolol , diltiazem , Lasix , spironolactone , warfarin , triamcinolone , Norvasc , nitroglycerin , valsartan , benazepril , hydralazine , digoxin , Nitrostat , Coreg , enalapril , Diovan , nifedipine , ramipril , Coumadin , isosorbide mononitrate , More... Sacubitril / valsartan Rating 16 User Reviews 5.1 /10 16 User Reviews 5.1 Rate it! Help and Support Looking for answers? Ask a question or go join the sacubitril / valsartan support group to connect with others who have similar interests.} } flattening
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