manicure [60:<60 years of age who do not have contraindications for use (Stuenkel 2015). Patients should be reevaluated as clinically appropriate to determine if treatment is still necessary. Available data related to treatment risks are from Women s Health Initiative (WHI) studies, which evaluated oral CE 0.625 mg with or without MPA 2.5 mg relative to placebo in postmenopausal women. Other combinations and dosage forms of estrogens and progestins were not studied. Outcomes reported from clinical trials using CE with or without MPA should be assumed to be similar for other doses and other dosage forms of estrogens and progestins until comparable data becomes available. Women who are early in menopause, who are in good cardiovascular health, and who are at low risk for adverse cardiovascular events can be considered candidates for estrogen with or without progestin therapy for the relief of menopausal symptoms (ACOG 565 2013). Women at high risk of cardiovascular disease or intermediate to high risk of breast cancer should use nonhormonal therapy to treat vasomotor symptoms of menopause (Stuenkel 2015). Use of a transdermal product should be considered over an oral agent in women requiring systemic therapy who have moderate risk factors for coronary heart disease (ACOG 556 2013; Schenck-Gustafsson 2011; Stuenkel 2015). Nonoral routes of therapy are recommended for women at increased risk for venous thromboembolism (Stuenkel 2015; Tremollieres 2011) Vulvar and vaginal atrophy use: Moderate to severe symptoms of vulvar and vaginal atrophy include vaginal dryness, dyspareunia, and atrophic vaginitis. [The combined conditions of vulvovaginal atrophy and urinary tract dysfunction is also referred to as genitourinary syndrome of menopause (GSM) (Portman 2014; Stuenkel 2015)]. When used solely for the treatment of vulvar and vaginal atrophy, topical vaginal products should be considered (NAMS 2012; NAMS 2013; Stuenkel 2015). Monitoring Parameters Routine physical examination that includes blood pressure and Papanicolaou smear, breast exam, mammogram. Monitor for signs of endometrial cancer in female patients with a uterus. Adequate diagnostic measures, including endometrial sampling, if indicated, should be performed to rule out malignancy in all cases of undiagnosed abnormal genital bleeding. Monitor for loss of vision, sudden onset of proptosis, diplopia, migraine; signs and symptoms of thromboembolic disorders; glycemic control in patients with diabetes; lipid profiles in patients being treated for hyperlipidemias; thyroid function in patients on thyroid hormone replacement therapy. Menopausal symptoms: Assess need for therapy at 3- to 6-month intervals Prevention of osteoporosis: Bone density measurement Note: Monitoring of FSH and serum estradiol is not useful when managing vasomotor symptoms associated with menopause or vulvar and vaginal atrophy. Pregnancy Considerations Use is contraindicated in pregnant women. In general, the use of estrogen and progestin as in combination hormonal contraceptives has not been associated with teratogenic effects when inadvertently taken early in pregnancy. Patient Education Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?) Patient may experience hair loss, abdominal cramps, bloating, tender breasts, anxiety, weight loss, joint pain, decreased libido, or dark patches on face. Have patient report immediately to prescriber signs of severe cerebrovascular disease (change in strength on one side is greater than the other, difficulty speaking or thinking, change in balance, or vision changes), signs of DVT (edema, warmth, numbness, change in color, or pain in the extremities), signs of liver problems (dark urine, fatigue, lack of appetite, nausea, severe abdominal pain, light-colored stools, vomiting, or jaundice), angina, edema, shortness of breath, excessive weight gain, swelling in the arms or legs, coughing up blood, severe headache, severe nausea, vomiting, severe dizziness, passing out, vision changes, blindness, bulging eyes, contact lens discomfort, lump in breast, breast soreness or pain, nipple discharge, abnormal vaginal bleeding, vaginitis, depression, mood changes, or memory impairment (HCAHPS). Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions. Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for health care professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience, and judgment in diagnosing, treating, and advising patients. Next Interactions Print this page Add to My Med List More about estropipate Side Effects During Pregnancy Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 3 Reviews Add your own review/rating Drug class: estrogens Consumer resources Estropipate Professional resources Estropipate (FDA) Other brands: Ogen Related treatment guides Atrophic Vaginitis Atrophic Urethritis Hypoestrogenism Oophorectomy ... +3 more> ] Drug Status Rx Availability Prescription only X Pregnancy Category Not for use in pregnancy N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Estropipate Rating 3 User Reviews 10 /10 3 User Reviews 10 Rate it! Manufacturer Teva Pharmaceuticals USA, Inc. Drug Class Estrogens Related Drugs estrogens estradiol , Premarin , Estrace , Vagifem Postmenopausal Symptoms estradiol , Premarin , Estrace , Prempro , conjugated estrogens topical , More... Osteoporosis hydrochlorothiazide , alendronate , calcium carbonate , estradiol , Fosamax , More... Atrophic Vaginitis estradiol topical , Premarin , Estrace , Vagifem , Prempro , More... 3 more conditions... Estropipate Images Estropipate systemic 0.75 mg (barr 555 727) View all images encouraged
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