the diversity saxagliptin and dapagliflozin (Oral route) sax-a-GLIP-tin, dap-a-gli-FLOE-zin Overview Side Effects Dosage Interactions Pregnancy More User Reviews Support Group Q & A Commonly used brand name(s) In the U.S. Qtern Available Dosage Forms: Tablet Therapeutic Class: Antidiabetic Pharmacologic Class: Dipeptidyl Peptidase IV Inhibitor Slideshow Fertility Facts: Women's Fertility Issues Explained Uses For saxagliptin and dapagliflozin Saxagliptin and dapagliflozin combination is used with diet and exercise to treat high blood sugar (glucose) levels in patients with type 2 diabetes. Saxagliptin helps to control blood sugar levels by making the pancreas gland release more insulin. It also signals the liver to stop producing sugar when there is too much sugar in the blood. Dapagliflozin works in the kidneys to prevent absorption of glucose (blood sugar). This helps lower the blood sugar level. saxagliptin and dapagliflozin does not help patients who have insulin-dependent or type 1 diabetes. saxagliptin and dapagliflozin is available only with your doctor's prescription. Before Using saxagliptin and dapagliflozin In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For saxagliptin and dapagliflozin, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to saxagliptin and dapagliflozin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of saxagliptin and dapagliflozin combination in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of saxagliptin and dapagliflozin combination in the elderly. However, elderly patients are more likely to have kidney problems, which may require caution and an adjustment in the dose for patients receiving saxagliptin and dapagliflozin. Breast Feeding Studies in women breastfeeding have demonstrated harmful infant effects. An alternative to this medication should be prescribed or you should stop breastfeeding while using saxagliptin and dapagliflozin. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking saxagliptin and dapagliflozin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using saxagliptin and dapagliflozin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Balofloxacin Besifloxacin Ceritinib Ciprofloxacin Eliglustat Enoxacin Fleroxacin Flumequine Gatifloxacin Gemifloxacin Lanreotide Levofloxacin Lomefloxacin Moxifloxacin Nadifloxacin Norfloxacin Octreotide Ofloxacin Pasireotide Pazufloxacin Pefloxacin Prulifloxacin Rufloxacin Simeprevir Sparfloxacin Thioctic Acid Tosufloxacin Using saxagliptin and dapagliflozin with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Acebutolol Acetohexamide Atenolol Betaxolol Bisoprolol Carteolol Carvedilol Celiprolol Chlorpropamide Esmolol Gliclazide Glimepiride Glipizide Gliquidone Glyburide Insulin Insulin Aspart, Recombinant Insulin Bovine Insulin Degludec Insulin Detemir Insulin Glulisine Insulin Lispro, Recombinant Labetalol Levobunolol Metipranolol Metoprolol Nadolol Nebivolol Oxprenolol Penbutolol Pindolol Practolol Propranolol Sotalol Timolol Tolazamide Tolbutamide Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. Other Medical Problems The presence of other medical problems may affect the use of saxagliptin and dapagliflozin. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol abuse, history of or Pancreatic insulin deficiency, history of May increase risk for more serious side effects. Bladder cancer, history of or Dehydration or Dyslipidemia (high fats or cholesterol in the blood) or Genital yeast (fungus) infections (eg, balanitis, balanoposthitis, vulvovaginitis), history of or Hypotension (low blood pressure) or Ketoacidosis (high ketones and acid in the blood) or Kidney disease or Pancreas problems (eg, pancreatitis) or Urinary tract infection (eg, pyelonephritis, urosepsis), history of Use with caution. May make these conditions worse. Diabetic ketoacidosis (high ketones and acid in the blood) or Kidney disease, severe or Patients receiving dialysis or Type I diabetes Should not be used in patients with these conditions. Proper Use of saxagliptin and dapagliflozin Take saxagliptin and dapagliflozin only as directed by your doctor . Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. Do not change your dose unless directed by your doctor . saxagliptin and dapagliflozin should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions. Tell your doctor if you are on a low-salt diet. Swallow the tablet whole. Do not cut, break, or chew it. You may take saxagliptin and dapagliflozin with or without food. Dosing The dose of saxagliptin and dapagliflozin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of saxagliptin and dapagliflozin. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For oral dosage form (tablets): For type 2 diabetes: Adults At first, 1 tablet once a day, taken in the morning. Each tablet contains 5 milligrams (mg) of saxagliptin and 10 mg of dapagliflozin. Your doctor may adjust your dose as needed and tolerated. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of saxagliptin and dapagliflozin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using saxagliptin and dapagliflozin It is very important that your doctor check your progress at regular visits , especially during the first few weeks that you take saxagliptin and dapagliflozin. Blood and urine tests may be needed to check for unwanted effects. Pancreatitis (swelling and inflammation of the pancreas) may occur while you are using saxagliptin and dapagliflozin. Check with your doctor right away if you have sudden and severe stomach pain, chills, constipation, nausea, vomiting, fever, or lightheadedness. If you are rapidly gaining weight, having chest pain, extreme tiredness or weakness, irregular breathing, irregular heartbeat, or excessive swelling of the hands, wrist, ankles, or feet, check with your doctor immediately. These may be symptoms of a heart problem. Dizziness, lightheadedness, or fainting may occur with saxagliptin and dapagliflozin. This is more common if you have kidney disease, low blood pressure, or if you are taking a diuretic (water pill). Taking plenty of fluids each day may help. Drink plenty of water during exercise or in hot weather. Check with your doctor if you have severe nausea, vomiting, or diarrhea that does not stop. This may cause you to lose too much water. Ketoacidosis (high ketones and acid in the blood) may occur while you are using saxagliptin and dapagliflozin. This can be life-threatening and requires immediate medical attention. Your doctor may give you insulin, fluid, and carbohydrate replacement to treat this condition. Tell your doctor right away if you have nausea, vomiting, trouble breathing, increased thirst or urination, or stomach pain. Tell your doctor if you have bloody urine, decrease in how much or how often you urinate, painful or difficult urination, lower back or side pain, fever, chills, rapid weight gain, or swelling of the face, finger, or lower legs. These may be symptoms of a serious kidney problem. saxagliptin and dapagliflozin may increase risk of having urinary tract infections, including pyelonephritis or urosepsis. Check with your doctor right away if you have bladder pain, bloody or cloudy urine, difficult, burning, or painful urination, or lower back or side pain. saxagliptin and dapagliflozin may cause vaginal yeast infections in women and yeast infections of the penis in men. This is more common in patients who have a history of genital yeast infections or in men who are not circumcised. Women may have a vaginal discharge, itching, or odor. Men may have redness, itching, swelling, or pain around the penis, or a discharge with a strong odor from the penis. Check with your doctor right away if you have any of these symptoms. saxagliptin and dapagliflozin may cause hypoglycemia (low blood sugar). This is more common when saxagliptin and dapagliflozin is taken together with certain medicines. Low blood sugar must be treated before it causes you to pass out (unconsciousness). People feel different symptoms of low blood sugar . It is important that you learn which symptoms you usually have so you can treat it quickly. Talk to your doctor about the best way to treat low blood sugar. Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. High blood sugar can be very serious and must be treated right away . It is important that you learn which symptoms you have in order to treat it quickly. Talk to your doctor about the best way to treat high blood sugar. saxagliptin and dapagliflozin may cause serious allergic reactions, including anaphylaxis, angioedema, or certain skin conditions. These reactions can be life-threatening and require immediate medical attention. Call your doctor right away if you have a rash, itching, blistering, peeling, or loosening of the skin, fever or chills, trouble breathing or swallowing, or any swelling of your hands, face, mouth, or throat while you are using saxagliptin and dapagliflozin. saxagliptin and dapagliflozin may be associated with the development of bladder cancer and should not be used in patients with active bladder cancer. Check with your doctor right away if you have blood in your urine or pain while urinating. saxagliptin and dapagliflozin may cause severe joint pain. Call your doctor right away if you have severe joint pain with saxagliptin and dapagliflozin. saxagliptin and dapagliflozin may cause bullous pemphigoid. Tell your doctor if you have large, hard skin blisters while using saxagliptin and dapagliflozin. Make sure any doctor or dentist who treats you knows that you are using saxagliptin and dapagliflozin. saxagliptin and dapagliflozin may affect the results of certain medical tests (eg, urine glucose tests may not be accurate). Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. saxagliptin and dapagliflozin Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Bladder pain bloody or cloudy urine difficult, burning, or painful urination frequent urge to urinate lower back or side pain Less common Anxiety bloody urine blurred vision chills cold sweats coma confusion cool, pale skin decreased frequency or amount of urine depression dizziness fast heartbeat headache increased hunger increased thirst loss of appetite nausea nightmares seizures shakiness slurred speech swelling of the face, fingers, or lower legs troubled breathing unusual tiredness or weakness vomiting weight gain Incidence not known Agitation bloating chest pain constipation cough cracks in the skin darkened urine decreased urine output difficulty with swallowing dilated neck veins dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position dry mouth extreme fatigue fever flushed, dry skin fruit-like breath odor hives, itching, or skin rash hostility increased urination indigestion irregular breathing irregular heartbeat irritability large, hard skin blisters large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs lethargy loss of consciousness loss of heat from the body muscle twitching pains in the stomach, side, or abdomen, possibly radiating to the back puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue rapid weight gain red, swollen skin redness, itching, swelling, or pain around the penis scaly skin severe joint pain shakiness stupor sweating tightness in the chest unexplained weight loss yellow eyes or skin Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Body aches or pain ear congestion loss of voice nasal congestion runny nose sneezing sore throat Less common Back pain diarrhea Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. 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Next Side Effects Print this page Add to My Med List More about dapagliflozin/saxagliptin Side Effects During Pregnancy Dosage Information Drug Interactions Support Group En Español 0 Reviews Add your own review/rating Drug class: antidiabetic combinations Consumer resources Dapagliflozin and saxagliptin Other brands: Qtern Related treatment guides Diabetes, Type 2} Drug Status Rx Availability Prescription only N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Drug Class Antidiabetic combinations Related Drugs Diabetes, Type 2 metformin , insulin aspart , glipizide , glimepiride , Januvia , pioglitazone , Victoza , Actos , Tradjenta , Glucophage , glyburide , Janumet , Invokana , Amaryl , Welchol , Onglyza , sitagliptin , Trulicity , Jardiance , Lantus , Farxiga , Levemir , Tresiba , Glucotrol , Bydureon , More... Dapagliflozin / saxagliptin Rating No Reviews - Be the first! No Reviews - Be the first! Not Rated - Be the first! 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