you'll adore [40:40 mg because of the addition of a loading dose, give loading dose in divided doses over 2 days. 1 Monitor trough whole blood concentrations at least 3 4 days after loading dose(s). 1 Although commercially available tablets and oral solution are not bioequivalent, 1 manufacturer states that 2-mg doses given as conventional tablets and as oral solution are therapeutically equivalent and may be interchangeable on a mg-per-mg basis at doses 2 mg. 1 Not known whether these formulations are therapeutically equivalent at doses >2 mg. 1 Administer sirolimus 4 hours after administration of cyclosporine formulations for emulsion (e.g., Neoral oral solution or liquid-filled capsules), since concomitant administration increases rate and extent of sirolimus absorption. 1 2 Oral Solution in Bottles Consult manufacturer s instructions regarding insertion of adapter assembly into bottle and withdrawal of prescribed dose (using syringe provided by manufacturer). 1 Empty contents of syringe into a glass or plastic cup containing 60 mL of water or orange juice; stir vigorously for 1 minute and administer immediately. 1 Refill container with 120 mL of the diluent, stir vigorously, and ingest rinse solution. 1 Use only glass or plastic containers. 1 Do not administer with grapefruit juice or use grapefruit juice as diluent (see Interactions); 1 do not use apple juice or other liquids as diluents. 1 Use syringe once and then discard. 1 If mouth of bottle must be wiped clean, use dry cloth to avoid introducing water or other liquid into the bottle. 1 Consult manufacturer s instructions if patient must carry a dose for subsequent administration. 1 Dosage When used for the prevention of renal allograft rejection, frequent sirolimus dosage adjustments based on non-steady-state sirolimus concentrations can lead to overdosing or underdosing since sirolimus has a long half-life. 1 Once maintenance dosage is adjusted, maintain patient on the new dosage for at least 7 14 days before making subsequent dosage adjustment based on drug concentrations. 1 Do not give >40 mg of sirolimus within any 1-day period. 1 If an estimated daily dose is >40 mg because of the addition of a loading dose, give loading dose over a 2-day period. 1 The manufacturer recommends monitoring trough whole blood concentrations of sirolimus at least 3 4 days after administering loading dose(s). 1 Pediatric Patients Renal Allotransplantation Concomitant Sirolimus and Cyclosporine Therapy in Patients at Low to Moderate Immunologic Risk Oral Children 13 years of age who weigh 40 kg: Loading dose should be equivalent to 3 times the maintenance dosage; e.g., 6 mg as a loading dose in de novo renal transplant recipients and a maintenance dosage of 2 mg daily. 1 No efficacy advantage with higher loading and maintenance dosages (loading dose of 15 mg followed by a maintenance dosage of 5 mg daily) in overall patient population. 1 14 (See Special Populations under Dosage and Administration.) 2-mg daily maintenance dosage associated with a superior safety profile compared with the 5-mg daily dosage. 1 Children 13 years of age who weigh] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Dr. Reddy's Laboratories, Inc. Greenstone LLC Zydus Pharmaceuticals (USA) Inc. Drug Class MTOR inhibitors Selective immunosuppressants Related Drugs Lymphangioleiomyomatosis Rapamune , More... Organ Transplant, Rejection Prophylaxis azathioprine , cyclosporine , tacrolimus , CellCept , mycophenolate mofetil , Imuran , Prograf , Rapamune , everolimus , Neoral , Gengraf , Sandimmune , More... Sirolimus Rating No Reviews - Be the first! 10 /10 No Reviews - Be the first! 10 Rate it! Sirolimus Images Sirolimus systemic 0.5 mg (1 ) View all images corporation
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