slumbering Desyrel Dividose (Oral) Generic Name: trazodone (Oral route) TRAZ-oh-done Overview Side Effects Dosage Interactions Pregnancy More Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Oral route(Tablet, Extended Release;Tablet) Antidepressants increased the risk compared to placebo of suicidal thinking and behavior in children, adolescents, and young adults with major depressive disorder (MDD) and other psychiatric disorders in short-term studies. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared with placebo in adults beyond age 24, and there was a reduction in risk with antidepressants compared with placebo in adults aged 65 or older. The use of trazodone hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Closely monitor patients of all ages for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Not approved for pediatric use . Commonly used brand name(s) In the U.S. Desyrel Desyrel Dividose Oleptro Available Dosage Forms: Tablet Tablet, Extended Release Therapeutic Class: Antidepressant Chemical Class: Triazolopyridine Slideshow Flexeril (cyclobenzaprine): How to Safely Use This Muscle Relaxant Uses For Desyrel Dividose Trazodone is used to treat depression. It is thought to work by increasing the activity of serotonin in the brain. Trazodone is an antidepressant. This medicine is available only with your doctor's prescription. Before Using Desyrel Dividose In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies have not been performed on the relationship of age to the effects of trazodone in the pediatric population. Safety and efficacy have not been established. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of trazodone extended-release tablets in the elderly. However, elderly patients are more likely to have hyponatremia (low sodium in the blood), which may require caution in patients receiving trazodone. No information is available on the relationship of age to the effects of trazodone regular tablets in the elderly. Pregnancy Pregnancy Category Explanation All Trimesters C Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Amifampridine Amisulpride Bepridil Bromopride Cisapride Dronedarone Fluconazole Furazolidone Iproniazid Isocarboxazid Ketoconazole Linezolid Mesoridazine Methylene Blue Metoclopramide Moclobemide Nelfinavir Pargyline Phenelzine Pimozide Piperaquine Posaconazole Procarbazine Rasagiline Safinamide Saquinavir Selegiline Sparfloxacin Terfenadine Thioridazine Tranylcypromine Ziprasidone Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Alfentanil Alfuzosin Almotriptan Amiodarone Amitriptyline Amoxapine Amphetamine Anagrelide Apomorphine Aripiprazole Aripiprazole Lauroxil Arsenic Trioxide Asenapine Astemizole Azithromycin Benzphetamine Brompheniramine Buprenorphine Buserelin Buspirone Butorphanol Carbamazepine Ceritinib Chloroquine Chlorpheniramine Ciprofloxacin Citalopram Clarithromycin Clomipramine Clozapine Cobicistat Cocaine Codeine Conivaptan Crizotinib Cyclobenzaprine Dabrafenib Darunavir Dasatinib Degarelix Delamanid Desipramine Deslorelin Desvenlafaxine Deutetrabenazine Dextroamphetamine Dextromethorphan Dihydrocodeine Disopyramide Dofetilide Dolasetron Domperidone Donepezil Doxepin Droperidol Duloxetine Efavirenz Eletriptan Erythromycin Escitalopram Fenfluramine Fentanyl Fingolimod Flecainide Fluoxetine Fluvoxamine Foscarnet Frovatriptan Gatifloxacin Gemifloxacin Ginkgo Gonadorelin Goserelin Granisetron Halofantrine Haloperidol Histrelin Hydrocodone Hydromorphone Hydroxychloroquine Hydroxytryptophan Hydroxyzine Ibutilide Idelalisib Iloperidone Imipramine Ivabradine Lapatinib Leuprolide Levofloxacin Levomilnacipran Levorphanol Lisdexamfetamine Lithium Lopinavir Lorcaserin Lumefantrine Mefloquine Methadone Methamphetamine Metronidazole Mifepristone Milnacipran Mirtazapine Morphine Morphine Sulfate Liposome Moxifloxacin Nafarelin Nalbuphine Naratriptan Nefazodone Netupitant Nilotinib Norfloxacin Nortriptyline Octreotide Ondansetron Oxycodone Oxymorphone Paliperidone Palonosetron Panobinostat Paroxetine Pasireotide Pazopanib Pentazocine Pimavanserin Pitolisant Procainamide Propafenone Propoxyphene Protriptyline Quetiapine Quinidine Quinine Ranolazine Remifentanil Ribociclib Rizatriptan Salmeterol Sertraline Sevoflurane Sibutramine Sodium Phosphate Sodium Phosphate, Dibasic Sodium Phosphate, Monobasic Solifenacin Sorafenib Sotalol St John's Wort Sufentanil Sulpiride Sumatriptan Sunitinib Tacrolimus Tapentadol Telithromycin Tetrabenazine Toremifene Tramadol Trimipramine Triptorelin Tryptophan Vandetanib Vardenafil Vemurafenib Venlafaxine Vilazodone Vinflunine Voriconazole Vortioxetine Zolmitriptan Zuclopenthixol Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atazanavir Chlorpromazine Digoxin Fosphenytoin Foxglove Indinavir Phenytoin Ritonavir Tipranavir Trifluoperazine Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially: Behavior or mood changes (eg, aggression, panic attacks) or Bipolar disorder (mood disorder with mania and depression), or risk of or Glaucoma (angle closure type) or Heart rhythm problems (eg, QT prolongation) or Hyponatremia (low sodium in the blood) or Hypotension (low blood pressure) or Mania or hypomania (mood disorders), history of or Priapism (painful or prolonged erection of the penis) Use with caution. May make these conditions worse. Heart attack, recent Use is not recommended in patients with this condition. Heart disease or Heart rhythm problems (eg, QT prolongation), family history of or Hypokalemia (low potassium in the blood) or Hypomagnesemia (low magnesium in the blood) Use with caution. May cause side effects to become worse. Proper Use of trazodone This section provides information on the proper use of a number of products that contain trazodone. It may not be specific to Desyrel Dividose. Please read with care. Take this medicine only as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor or pharmacist if you have any questions. To lessen stomach upset and to reduce dizziness and lightheadedness, take the regular tablet with or shortly after a meal or light snack. Take the extended-release tablet at the same time each day, preferably at bedtime, without food. The tablet can be swallowed whole or given as a half tablet by breaking the tablet along the score line. Do not break the tablet unless your doctor tells you to. Do not crush or chew the tablet. Dosing The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For depression: For oral dosage form (extended-release tablets): Adults At first, 150 milligrams (mg) per day as a single dose. Your doctor may adjust your dose as needed. However, the dose is usually not more than 375 mg per day. Children Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults At first, 150 milligrams (mg) per day, given in divided doses. Your doctor may adjust your dose as needed. However, the dose is usually not more than 400 mg per day. Children Use and dose must be determined by your doctor. Missed Dose If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Precautions While Using Desyrel Dividose It is very important that your doctor check your progress at regular visits , to allow for changes in your dose and to help manage any unwanted effects. Do not take trazodone with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan ], linezolid (Zyvox ), methylene blue, phenelzine [Nardil ], selegiline [Eldepryl ], tranylcypromine [Parnate ]). Do not start taking trazodone during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping trazodone before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Trazodone may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use trazodone with buspirone (Buspar ), fentanyl (Abstral , Duragesic ), lithium (Eskalith , Lithobid ), tryptophan, St. John's wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova , Maxalt , Relpax , Zomig ). For some teenagers and young adults, this medicine can increase thoughts of suicide. Tell your doctor right away if you start to feel more depressed or have thoughts about hurting yourself or others. Report any unusual thoughts or behaviors that trouble you, especially if they are new or get worse quickly. Make sure the doctor knows if you have trouble sleeping, get upset easily, have a big increase in energy, or start to act reckless. Also tell the doctor if you have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. Let the doctor know if you or anyone in your family have bipolar disorder (manic-depressive disorder) or have tried to commit suicide. Check with your doctor right away if you have anxiety, restlessness, a fast heartbeat, fever, sweating, muscle spasms, twitching, nausea, vomiting, diarrhea, or see or hear things that are not there. These may be symptoms of serious conditions called serotonin syndrome and neuroleptic malignant syndrome-like reactions. Your risk may be higher if you also take certain other medicines that affect serotonin levels in your body. Contact your doctor right away if you have any changes in your heart rhythm such as feeling dizzy or faint, or having a fast, pounding, or uneven heartbeat. These could be symptoms of a heart problem called QT prolongation. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If this problem continues or gets worse, check with your doctor. Do not stop taking this medicine without first checking with your doctor . Your doctor may want you to gradually reduce the amount you are using before stopping it completely. This may help prevent a worsening of your condition and reduce the possibility of withdrawal symptoms such as anxiety, irritability, restlessness, or trouble sleeping. This medicine may cause some people to become drowsy or less alert than they are normally. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert . This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine . Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking trazodone together with anesthetic medicines (numbing medicines) that are used during surgery, dental treatments, or emergency treatments may cause an increase in CNS depressant effects. Trazodone may cause dry mouth. For temporary relief, use sugarless gum or candy, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. Desyrel Dividose Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: More common Blurred vision confusion dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position lightheadedness sweating unusual tiredness or weakness Less common Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings confusion about identity, place, and time decreased concentration fainting general feeling of discomfort or illness headache lack of coordination muscle tremors nervousness pounding in the ears shortness of breath slow or fast heartbeat swelling Rare Skin rash unusual excitement Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Dry mouth (usually mild) muscle or bone pain trouble sleeping trouble with remembering unpleasant taste Less common Constipation continuing ringing or buzzing or other unexplained noise in the ears diarrhea hearing loss muscle aches or pains weight loss Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. Copyright 2017 Truven Health Analytics, Inc. All Rights Reserved. Next Side Effects Print this page Add to My Med List More about Desyrel Dividose (trazodone) Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group 2 Reviews Add your own review/rating Drug class: phenylpiperazine antidepressants Consumer resources Other brands: Oleptro Professional resources Trazodone Hydrochloride (AHFS Monograph) Trazodone (FDA) Other Formulations Desyrel Oral Related treatment guides Depression Fibromyalgia Major Depressive Disorder Reflex Sympathetic Dystrophy Syndrome Sedation} Drug Status Rx Availability Prescription only C Pregnancy Category Risk cannot be ruled out N/A CSA Schedule Not a controlled drug Drug Class Phenylpiperazine antidepressants Related Drugs Sedation trazodone , promethazine , lorazepam , hydroxyzine , Ativan , fentanyl , Vistaril , Phenergan , More... Major Depressive Disorder trazodone , sertraline , Zoloft , Lexapro , Cymbalta , Prozac , Wellbutrin , fluoxetine , More... Depression trazodone , sertraline , Xanax , citalopram , Zoloft , Lexapro , Cymbalta , Celexa , More... Desyrel Dividose Rating 2 User Reviews 8.2 /10 2 User Reviews 8.2 Rate it! Desyrel Dividose Images Desyrel Dividose 150 mg (MJ 778 50 50 50) View larger images Help and Support Looking for answers? Ask a question or go join the Desyrel Dividose support group to connect with others who have similar interests.} } to combustible
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