a good suggestion [3:<4%) following topical application to the eye. 1 Onset Rapid onset (within minutes). 3 8 Elimination Metabolism Not metabolized. 1 Elimination Route Excreted principally unchanged in urine (70%) and feces (30%). 1 Stability Storage Ophthalmic Solution Tightly closed bottle at 2 25 C. 1 Actions Suppresses release of mediators (e.g., histamine) from cells involved in hypersensitivity reactions (including mast cells). 1 3 4 Decreases chemotaxis and activation of eosinophils. 1 3 4 Inhibits release of secondary inflammatory mediators from activated inflammatory cells (e.g., eosinophils, macrophages, neutrophils, monocytes). 1 3 4 Advice to Patients Importance of learning and adhering to proper administration techniques to avoid contamination of the solution container. 1 Importance of not wearing contact lenses in the presence of signs and symptoms of allergic conjunctivitis. 1 If contact lenses must be worn, delay insertion of soft contact lenses after instillation, since benzalkonium chloride preservative may be absorbed by some soft contact lenses. 3 Importance of administering different topical ophthalmic preparations at least 10 15 minutes apart. a Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed. 1 Importance of informing clinicians of existing or contemplated therapy, including prescription and OTC drugs, as well as any concomitant illnesses. Importance of informing patients of other important precautionary information. (See Cautions.) Preparations Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details. Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations. Nedocromil Routes Dosage Forms Strengths Brand Names Manufacturer Ophthalmic Solution 2% Alocril (with benzalkonium chloride) Allergan AHFS DI Essentials. Copyright 2017, Selected Revisions September 1, 2005. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814. References 1. Allergan, Inc. Alocril (nedocromil sodium) ophthalmic solution 2% prescribing information. Irvine, CA; 2000. 2. Allergan. A patient s guide to the treatment of itchy allergy eyes. From Allergan website (). 3. Allergan, Inc. Alocril (nedocromil sodium) formulary information. Irvine, CA; 2000. 4. Blumenthal M, Casale T, Dockhorn R et al. Efficacy and safety of nedocromil sodium ophthalmic solution in the treatment of seasonal allergic conjunctivitis. Am J Ophthalmol . 1992; 113:56-63. [PubMed 1309410] 5. Blumenthal MN, Schwartz RH, Kaiser H. Nedocromil sodium 2% ophthalmic solution for the treatment of ragweed pollen seasonal allergic conjunctivitis. Ocul Immunol Inflamm . 2000; 8:159-67. [PubMed 11120577] 6. Melamed J, Schwartz RH, Hirsch SR et al. Evaluation of nedocromil sodium 2% ophthalmic solution for the treatment of seasonal allergic conjunctivitis. Ann Allergy . 1994; 73:57-66. [PubMed 8030804] 7. Moller C, Berg IM, Berg T et al. Nedocromil sodium 2% eye drops for twice-daily treatment of seasonal allergic conjunctivitis: a Swedish multicentre placebo-controlled study in children allergic to birch pollen. Clin Exp Allergy . 1994; 24:884-7. [PubMed 7812890] 8. Alexander M, Rosen LJ, Yang WH. Comparison of topical nedocromil sodium and oral terfenadine for the treatment of seasonal allergic conjunctivitis. Clin Ther . 1999; 21:1900-7. [PubMed 10890262] 9. Ciprandi G, Buscaglia S, Cerqueti PM et al. Drug treatment of allergic conjunctivitis: a review of the evidence. Drugs . 1992; 43:154-76. [PubMed 1372215] 10. Morrow GL, Abbott RL. Conjunctivitis. Am Fam Physician . 1998; 57:735-46. [PubMed 9490996] 11. Titi MJ. A critical look at ocular allergy drugs. Am Fam Physician . 1996; 53:2637-42. [PubMed 8644576] 12. Galindez OA, Kaufman HE. Coping with the itchy-burnies: the management of allergic conjunctivitis. Ophthalmology . 1996; 103:1335-6. [PubMed 8841290] a. Allergan Inc; Irvine, CA: Personal communication. Next Pregnancy Warnings Print this page Add to My Med List More about Alocril (nedocromil ophthalmic) Side Effects During Pregnancy or Breastfeeding Dosage Information Support Group Pricing & Coupons En Español 1 Review Add your own review/rating Generic Availability Drug class: ophthalmic antihistamines and decongestants Consumer resources Alocril Alocril (Advanced Reading) Professional resources Alocril (FDA) Nedocromil eent (AHFS Monograph) Related treatment guides Conjunctivitis, Allergic> ] FEATURED: CAR-T Cell Therapy Overview Mechanism of Action KTE-C19 Studies KTE-C19 Cancer Targets Adverse Events Manufacturing Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturer Allergan plc Drug Class Ophthalmic antihistamines and decongestants Related Drugs Conjunctivitis, Allergic prednisone , prednisolone ophthalmic , azelastine ophthalmic , Deltasone , Zaditor , cromolyn ophthalmic , doxylamine , Optivar , Alaway , ketotifen ophthalmic , Bepreve , Lastacaft , Sterapred , triprolidine , bepotastine ophthalmic , carbinoxamine , alcaftadine ophthalmic , Equate Sleep Aid , Carboxine , Elestat , epinastine ophthalmic , Prednicot , Karbinal ER , More... 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