weak spot didanosine (Oral route) dye-DAN-oh-seen Oral route(Capsule, Delayed Release;Powder for Solution) Fatal and nonfatal pancreatitis has occurred during therapy with didanosine. Didanosine should be suspended in patients with suspected pancreatitis and discontinued in patients with confirmed pancreatitis. Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported. Fatal lactic acidosis has been reported in pregnant women who received the combination of didanosine and stavudine with other antiretroviral agents. The combination of didanosine and stavudine should be used with caution during pregnancy and is recommended only if the potential benefit clearly outweighs the potential risk . Overview Side Effects Dosage Professional Interactions More Pregnancy Warnings Breastfeeding Warnings User Reviews Drug Images Support Group Q & A Pricing & Coupons Commonly used brand name(s) In the U.S. Videx Videx EC Videx Pediatric Available Dosage Forms: Powder for Suspension Tablet, Chewable Powder for Solution Capsule, Delayed Release Therapeutic Class: Antiretroviral Agent Pharmacologic Class: Nucleoside Reverse Transcriptase Inhibitor Slideshow 2016 New Drug Approvals: The Year That Was Uses For didanosine Didanosine is used in combination with other medicines for the treatment of human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). Didanosine will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay the development of problems usually related to AIDS or HIV disease. Didanosine will not keep you from spreading HIV to other people. People who receive didanosine may continue to have the problems usually related to AIDS or HIV disease. didanosine is available only with your doctor's prescription. The buffered tablets that are to be chewed, crushed or mixed with water are no longer available in the United States. This product was voluntarily discontinued, and it was not due to safety concerns. Didanosine delayed-release capsules (Videx EC) and pediatric powder for oral solution are still available. Before Using didanosine In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For didanosine, the following should be considered: Allergies Tell your doctor if you have ever had any unusual or allergic reaction to didanosine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully. Pediatric Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of didanosine in children 2 weeks of age and older. Geriatric Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of didanosine in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require caution and an adjustment in the dose for patients receiving didanosine. Pregnancy Pregnancy Category Explanation All Trimesters B Animal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus. Breast Feeding There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Interactions with Medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking didanosine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Using didanosine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Allopurinol Oxypurinol Ribavirin Using didanosine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Darunavir Hydroxyurea Orlistat Stavudine Tenofovir Disoproxil Fumarate Zalcitabine Using didanosine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Atazanavir Atevirdine Ciprofloxacin Delavirdine Enoxacin Ganciclovir Indinavir Itraconazole Ketoconazole Lomefloxacin Methadone Metoclopramide Moxifloxacin Nelfinavir Norfloxacin Ofloxacin Ranitidine Rifabutin Ritonavir Sulfamethoxazole Trimethoprim Trovafloxacin Mesylate Valganciclovir Interactions with Food/Tobacco/Alcohol Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Other Medical Problems The presence of other medical problems may affect the use of didanosine. Make sure you tell your doctor if you have any other medical problems, especially: Alcohol use, active or history of or Liver disease (including hepatitis) or Obesity (overweight) or Pancreatitis (inflammation of the pancreas), history of or Peripheral neuropathy (nerve disorder), history of Use with caution. May cause side effects to become worse. Kidney disease Use with caution. The effects may be increased because of slower removal of the medicine from the body. Portal hypertension (high blood pressure in the portal vein of the liver) Use with caution. May make this condition worse. Proper Use of didanosine Take didanosine exactly as directed by your doctor . Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Also, do not stop taking didanosine without checking first with your doctor. didanosine comes with a Medication Guide. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions. Keep taking didanosine for the full time of treatment , even if you begin to feel better. Only take medicine that your doctor has prescribed specifically for you. Do not share your medicine with other people. didanosine works best when there is a constant amount in the blood. To help keep the amount constant, do not miss any doses. If you need help in planning the best times to take your medicine, check with your doctor. Didanosine should be taken on an empty stomach since food may keep it from working properly. Didanosine oral liquid should be taken at least 30 minutes before or 2 hours after you eat. Swallow the delayed-release capsule whole. Do not break, crush, chew, or open it. Shake the oral liquid before use. Measure each dose with a specially marked measuring spoon or measuring cup. The average household teaspoon may not hold the right amount of liquid. Dosing The dose of didanosine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of didanosine. If your dose is different, do not change it unless your doctor tells you to do so. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. For HIV infection: For oral dosage form (delayed-release capsules): Adults, teenagers, and children who can swallow capsules Dose is based on body weight and must be determined by your doctor. For patients weighing 60 kilograms (kg) or more 400 milligrams (mg) once a day. For patients weighing 25 kg to less than 60 kg 250 mg once a day. For patients weighing 20 kg to less than 25 kg 200 mg once a day. Children weighing less than 20 kg The oral capsules are not given to small children. For oral dosage form (solution): Adults weighing 60 kilograms (kg) Dose is based on body weight and must be determined by your doctor. The usual dose is 200 milligrams (mg) two times a day or 400 mg once a day. Adults weighing less than 60 kg Dose is based on body weight and must be determined by your doctor. The usual dose is 125 mg two times a day or 250 mg once a day. Teenagers, children, and infants 8 months of age and older Dose is based on body size and must be determined by your doctor. The usual dose is 120 milligrams per square meter (mg/m(2)) two times a day. Infants 2 weeks to 8 months old Dose is based on body size and must be determined by your doctor. The usual dose is 100 mg/m(2) two times a day. Infants younger than 2 weeks old Use and dose must be determined by your doctor. Missed Dose If you miss a dose of didanosine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. Storage Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Store the delayed-release capsules in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Store the oral liquid in the refrigerator. Throw away any unused medicine after 30 days. Precautions While Using didanosine It is very important that your doctor check your or your child's progress at regular visits to make sure that didanosine is working properly. Blood tests may be needed to check for unwanted effects. Do not use didanosine if you or your child are also using allopurinol (Zyloprim ) or ribavirin (Copegus , Rebetol ). Using these medicines together may cause serious side effects . didanosine may cause a life-threatening condition called pancreatitis. Check with your doctor right away if you or your child have more than one of these symptoms: bloating, chills, constipation, darkened urine, a fast heartbeat, fever, indigestion, loss of appetite, nausea, pains in the stomach, side, or abdomen, possibly radiating to the back, vomiting, or yellow eyes or skin. Two rare but serious reactions to didanosine are lactic acidosis (too much acid in the blood) and liver toxicity, which includes an enlarged liver. These are more common if you are female, very overweight (obese), or have been taking anti-HIV medicines for a long time. Call your doctor right away if you or your child have more than one of these symptoms: abdominal or stomach discomfort or cramping, dark urine, decreased appetite, diarrhea, a general feeling of discomfort, light-colored stools, muscle cramping or pain, nausea, unusual tiredness or weakness, trouble breathing, vomiting, or yellow eyes or skin. Check with your doctor right away if you or your child have abdominal or stomach pain, black, tarry stools, bleeding gums, blood in the urine or stools, pinpoint red spots on the skin, or unusual bleeding or bruising. These may be symptoms of a condition called non-cirrhotic portal hypertension. Tell your doctor right away if you or your child start having numbness, tingling, or burning pain in your hands, arms, legs, or feet. These may be symptoms of a condition called peripheral neuropathy. Your immune system may get stronger when you start taking HIV medicines. Sometimes the immune system will start to fight infections that were hidden in your body, such as pneumonia or tuberculosis. Tell your doctor right away if you notice any changes in your health. didanosine may cause you or your child to have excess body fat. Tell your doctor right away if you notice changes in your body shape, including an increased amount of body fat in the neck or upper back, face, around the chest, or stomach area. You might also lose fat from your legs, arms, or face. Check with your doctor right away if you or your child start to see unusual colors or have blurred vision. Your doctor may want you to have your eyes checked regularly by an eye doctor (ophthalmologist). Do not drink alcohol while you are using didanosine. HIV may be acquired from or spread to other people through infected body fluids, including blood, vaginal fluid, or semen. If you are infected, it is best to avoid any sexual activity involving an exchange of body fluids with other people. If you do have sex, always wear (or have your partner wear) a condom ( rubber ). Only use condoms made of latex, and use them every time you have vaginal, anal, or oral sex. The use of a spermicide (such as nonoxynol-9) may also help prevent transmission of HIV if it is not irritating to the vagina, rectum, or mouth. Spermicides have been shown to kill HIV in lab tests. Do not use oil-based jelly, cold cream, baby oil, or shortening as a lubricant these products can cause the condom to break. Lubricants without oil, such as K-Y jelly, are recommended. Women may wish to carry their own condoms. Birth control pills and diaphragms will help protect against pregnancy, but they will not prevent someone from giving or getting the AIDS virus. If you inject drugs, get help to stop. Do not share needles or equipment with anyone. In some cities, more than half of the drug users are infected and sharing even 1 needle or syringe can spread the virus. If you have any questions about this, check with your doctor. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. didanosine Side Effects Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur: Less common Nausea and vomiting stomach pain tingling, burning, numbness, and pain in the hands or feet Rare Convulsions (seizures) fever and chills shortness of breath skin rash and itching sore throat swelling of the feet or lower legs unusual bleeding and bruising unusual tiredness and weakness yellow skin and eyes Incidence not known Abdominal or stomach discomfort anxiety black, tarry stools bleeding gums blindness bloating blood in the urine or stools blue-yellow color blindness blurred vision change in the color of the eye chest pain clay colored stools cold sweats coma confusion constipation cool, pale skin cough dark urine decreased appetite decreased vision depression diarrhea difficulty with moving difficulty with swallowing dizziness dry eyes dry mouth eye pain fast heartbeat fast, shallow breathing flushed, dry skin fruit-like breath odor general feeling of discomfort headache hives increased hunger increased thirst increased urination indigestion joint pain light-colored stools loss of appetite loss of consciousness muscle aching, cramping, or pain nightmares painful or difficult urination pains in the stomach, side, or abdomen, possibly radiating to the back pinpoint red spots on the skin puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue right upper abdominal or stomach pain and fullness shakiness sleepiness slurred speech sores, ulcers, or white spots on the lips or in the mouth stomachache sweating swollen glands swollen joints tightness in the chest troubled breathing with exertion unexplained weight loss unsteadiness or awkwardness weakness in the arms, hands, legs, or feet Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: More common Difficulty with sleeping irritability restlessness Incidence not known Acid or sour stomach belching excess air or gas in the stomach or intestines full feeling hair loss or thinning of the hair heartburn indigestion lack or loss of strength passing gas redistribution or accumulation of body fat Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088. Side Effects (complete list) The information contained in the Truven Health Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. 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Next Side Effects Print this page Add to My Med List More about didanosine Side Effects During Pregnancy or Breastfeeding Dosage Information Drug Images Drug Interactions Support Group Pricing & Coupons En Español 0 Reviews Add your own review/rating Drug class: nucleoside reverse transcriptase inhibitors (NRTIs) Consumer resources Didanosine Didanosine Delayed-Release Enteric-Coated Capsules Didanosine Oral Solution Other brands: Videx , Videx EC Professional resources Didanosine (AHFS Monograph) ... +4 more Related treatment guides HIV Infection Nonoccupational Exposure} Drug Status Rx Availability Prescription only B Pregnancy Category No proven risk in humans N/A CSA Schedule Not a controlled drug Approval History Drug history at FDA Manufacturers Mylan Pharmaceuticals Inc. Teva Pharmaceuticals USA, Inc. Aurobindo Pharma Limited Drug Class Nucleoside reverse transcriptase inhibitors (NRTIs) Related Drugs HIV Infection Truvada , Atripla , Norvir , Viread , Isentress , Prezista , Stribild , lamivudine , abacavir , tenofovir , Reyataz , Epzicom , More... Nonoccupational Exposure Truvada , Atripla , Viread , lamivudine , abacavir , tenofovir , Epzicom , Reyataz , zidovudine , emtricitabine , Kaletra , Sustiva , More... Didanosine Rating No Reviews - Be the first! 9.0 /10 No Reviews - Be the first! 9.0 Rate it! Didanosine Images Didanosine systemic 200 mg (barr 200mg 588) View all images Help and Support Looking for answers? Ask a question or go join the didanosine support group to connect with others who have similar interests.} } current
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